This highly practical, full color teaching tool is focused on best surgical practice in thyroid surgery, including the key issue of prevention and management of surgical complications. An accompanying website contains twenty step-by-step surgical videos of thyroid surgery in action. Several chapters are included on brand new surgical techniques, such as robotic and image-localized surgery.

This book brings together the most up-to-date information about the physiology of progestogens. Addressing the bidirectional communication between hormones, fertility, tumors, and autoimmunity, it provides the basic science and clinical perspectives of progestogens which have not been previously available in one volume. In addition to estrogens, androgens, mineralocorticoids and glucocorticoids, progestogens are a major class of steroid hormone. While present in certain phases of estrous and menstrual cycles, progestogens are named for their function in maintaining pregnancy. This book is essentially practical in orientation, addressing the specific issues that confront the practitioner, and provides information to Obstetricians, Gynecologists, Reproductive endocrinologists, as well as Gynecological Oncologists and Rheumatologists. Contributions are from an international team of experts in the field, now completely updated in this new edition with new developments in primary dysmenorrhea and contraception.

This book provides a complete guide to laparoscopic sleeve gastrectomy and the management of obesity. The chapters discuss guidelines for healthcare providers for the management of patients with obesity, the rationale behind choosing patients, performing the procedure in line with the patient's condition, the perioperative period, postoperative requirements, and postoperative complications. This book aims to give readers an understanding of the surgical techniques involved in laparoscopic sleeve gastrectomy and the wider treatment options available. It is relevant to bariatric, metabolic, and general surgeons, physicians, clinical nutritionists as well as students.

Hormones, Regulators and Hippocampus, Volume 118 in the Vitamins and Hormones serial highlights new advances in the field, with this new volume presenting interesting chapters, including Thyroid hormone regulation of adult hippocampal neurogenesis - putative molecular and cellular mechanisms, Synergistic gene regulation by thyroid hormone and glucocorticoid in the hippocampus, Oxytocin and vasopressin in the hippocampus, Steroid hormones and hippocampal neurogenesis in the adult mammalian brain, Steroidogenic enzymes in the hippocampus: transcriptional regulation aspects, Ectonucleotidases in the hippocampus: spatial distribution and expression after ovariectomy and estradiol replacement, and much more.

Cytokines are polypeptide mediators which act as communication signals among cells of the immune system as well as among other cells and tissues in the body. They are a heterogeneous and complex group and include interferons, tumor necrosis factor and chemokines. They play a key role in homeostasis and in host defense and are involved in such inflammatory and autoimmune diseases such as rheumatoid arthritis as well as infectious diseases such as HIV infection and spetic shock. Modulation of the production and action of cytokines, as well as their exploitation of therapeutic agents has been the object of intense and competitive research. This book overviews the field of cytokine research and describes the various approaches that have been taken to develop the pharmacology of these novel mediators. The pharmacology of cytokines is an exploding area which is entering the clinical arena. The book in the framework of the immunobiology of cytokines, examines the interactions with the cytokine system of a variety of compounds ranging from simple synthetic chemicals to biotechnological products. In addition to examining individual agents and approaches, the book examines the pathophysiology of individual body systems and analyzes specific contexts for the pathophysiology of individual body systems and analyzes specific contexts for the pathophysiology of these mediators as well as pharmacological approaches for their control.

This book is an essential handbook on bisphosphonates, the most widely used new class of drugs for osteoporosis therapy. It reviews basic physiology in addition to the indications and adverse reactions of these drugs. Bisphosphonates in Bone Disease, 4E, discusses the compounds' chemistry, mechanisms of action, and animal toxicology before presenting a clinical picture of the diseases treated by bisphosphonates. The book provides a table listing the trade names of the commercially available bisphosphonates, registered indications, and the available forms for various countries. The revised Fourth Edition contains approximately 50% new material, including information on all of the latest drugs.
* The revised fourth edition contains approximately 50% new material
* Includes information on all the latest drugs

The Aging Skeleton is a comprehensive and timely book on all aspects of the skeleton as it ages, including basic mechanisms and pathways as well as pathobiology. Chapters cover general aspects and models of aging, determinants and maintenance of peak bone mass, mechanisms of age-related bone loss, quantifiable manifestations of age-related bone loss, fractures, and therapeutics.
Key Features
* Covers all aspects of the aging skeleton in one comprehensive volume
* Looks at the influence of genetics, nutrition, environment, hormones, and other factors on bone mass
* Provides a thorough discussion of fractures, one of the major consequences of the aging skeleton
* Reviews current therapeutic approaches and methods
* Written by internationally renowned authors and edited by leaders in the field
* Is the only book available on this subject

Now in a revised and expanded second edition, this concise, straightforward and clearly written text presents the latest information on the evaluation and management of common issues and conditions in pediatric endocrinology. Endocrinologists, pediatricians, family physicians, residents, fellows and medical students will all benefit from the discussion of endocrine physiology and its application to common clinical practice. As in the original edition, the text presents the major signs and symptoms in the diagnosis and management of pediatric endocrine disorders, often allowing the practitioner to avoid an unnecessary consultation and preparing a provider for informed communication with parents of a child with an endocrine condition. The concepts covered in the text are designed to address the first 10 headings in the content outline of the Sub-board of Pediatric Endocrinology of The American Board of Pediatrics: disorders of the hypothalamic-pituitary axis, growth, calcium metabolism and bone, the thyroid gland, puberty, and the adrenal gland, among others. Concluding each chapter is a Suggested Reading section, directing the reader to outstanding larger and more detailed texts, manuscripts and websites that offer increased detail. Practical and user-friendly, Pediatric Endocrinology, Second Edition is not simply a checklist of everything that could be done but leads the reader toward a more specific goal of what should be done.

Volume 2 has focused on aspects of the pituitary gland both anterior (growth hormone and prolactin receptors, and GH action) and posterior (vasopressin) pituitary. In addition, thyroid cancer and steroidogenic enzymes and precocious puberty are covered. Finally, the "hot topics" include leptin and growth factor signaling.

Building on the groundbreaking work Lifestyle Medicine (2016), this unique new book bridges the gap between theory and practice by providing detailed information on the real-world development and creation of a Lifestyle Medicine Center, whether independently or as part of an established medical program or department. Part one sets the stage by establishing the rationale for creating a Lifestyle Medicine Center as well as the medical and economic burden it seeks to alleviate. The construction of the physical facility and all of the myriad details of the program and its key players are covered in part two, from the structural to the aesthetic, including informatics, developing patient resources and education tools, current technologies and applications, the role of the dietitian and exercise physiologist, inpatient consultation, the importance of community engagement, and more. Part three is comprised of case studies of existing, successful Lifestyle Medicine Centers across the country, with detailed descriptions of their history, development, programs and challenges. Chapters are supported with plentiful figures, tables and useful links. The burden of chronic disease in the U.S. and globally is growing, with pervasive direct and indirect multi-scale adverse effects on health and well-being, economics, and quality of life. Notwithstanding the remarkable progress in biomedical technology, the role of lifestyle medicine in managing chronic disease in a preventive care model is paramount; however, the relevant and effective education in lifestyle medicine is lacking. Translating the theory into action steps, instantiated by case studies with critical interpretations and problem-solving tools, Creating a Lifestyle Medicine Center is the go-to resource for family and primary care physicians, internal medicine physicians, and all clinical specialties interested in planning and developing a lifestyle medicine program.

Intragastric balloons are steadily gaining popularity among the medical treatments available for obesity. Their efficacy and safety are reinforced by growing body of evidence obtained around the globe. Intragastric balloons are now considered one of the safest and most effective medical procedures for weight reduction. Additionally, the reduced potential for side effects and low invasiveness (compared to bariatric surgeries) are important considerations. This book is edited by renowned surgeons and endoscopists from Brazil, a country known for its reputation on the field of bariatric endoscopy and surgery. Such reputation is especially valid where the use of intragastric balloons is concerned. These devices, approved by the FDA only in 2015, have been used in Brazil since the 1990s, attesting to Brazilian expertise in the field. This book describes the various types of intragastric balloons used for the treatment of obesity, an alternative to bariatric surgery and other more invasive methods. It addresses their indications, procedures and outcomes, providing readers an overview of the therapeutic options available worldwide. It is divided into seven main sections: I - Introductory Issues; II - Devices; III - Technical Procedures and Related Issues; IV - Acute Complications and Treatment; V - Chronic Complications and Treatment; VI - Special Populations; and VII - Miscellaneous. This structure helps to promote a better knowledge construction and a reasonable flow of ideas throughout the book, guiding the reader from introductory topics to surgical procedures and complications. The book ultimately intends to offer an essential reference guide for all physicians and surgeons interested in the treatment of obese patients. It is intended for both experienced professionals looking for in-depth information and for trainees and residents seeking to broaden their perspectives concerning the treatment of obesity.

Neuropeptide Y (NPY) is a ubiquitous and important messenger in the nervous system, with a wide range of physiological roles. It is involved in the body energy balance and is one of the most potent stimuli of food intake known. NPY also acts to regulate central and peripheral autonomic functions.
This book, written by academic and industrial experts in the field, links the most recent basic experimental knowledge about NPY and its receptors with areas of clinical importance.
This book will be of interest to those working in all areas of research affected by NPY, such as food intake and energy homeostasis, cardiovascular regulation and G-protein-coupled receptors, as well as those interested in the development of drugs as NPY targets.
Key Features
* The hypothalamic role of NPY and its relationship with eating disorders and diabetes
* The sympathetic nervous system role of NPY and its involvement in cardiovascular disorders
* Characterization of NPY receptor types and their brain distribution, molecular biology and pharmacology
* Development of peptide and non-peptide receptor antagonists

This volume presents and analyses the ongoing arguments, controversies, challenges and debates on thyroid disease with a view to clarifying some uncertainties, and to making suggestions that will help resolve others.Issues such as thyroid disease during pregnancy, Hashimoto's disease, Hurthle cell lesions, solitary thyroid nodules, retrosternal goiter, thyroid cancer, recurrent thyroid disease, thyroidectomy techniques, post-thyroidectomy hypocalcemia, and thyroid auto-transplantation are thoroughly explored. Richly illustrated, the book offers an invaluable tool for all specialists and trainees entrusted with the care of patients suffering from thyroid disease.

Vitamins and Hormones series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors

In this volume contemporary methods designed to provide insights into, mathematical structure for, and predictive inferences about neuroendocrine control mechanisms are presented.
Key Features
* Collates an array of contemporary techniques for analysis of neuroendocrine data
* Discusses current problems in and solutions to neurohormone pulse analysis
* Identifies relevant software available

Hormones and Aging, Volume 115 in the Vitamins and Hormones series, highlights advances in the field, with this new volume presenting timely topics, including hypothalamic aging and hormones, endocannabinoids and aging-inflammation, neuroplasticity, mood and pain, the impact of hormones and bone loss across the menopause transition, and much more.

This book offers a step-by-step guide to mental health assessment for bariatric surgery patients. A general introduction explains the concepts of bariatric psychology and psychiatry, their relevance in contemporary bariatric surgery, and reasons to include psychologists and psychiatrists in multidisciplinary teams taking care of bariatric patients. The following four chapters address the aspects of mental health that are investigated by bariatric psychology. The psychological processes analyzed here play a major role in influencing patients' perception of the outcomes of bariatric surgery and in determining their commitment to lifestyle changes and follow-up programs. The second part of the book includes nine chapters addressing the clinical conditions relevant to bariatric psychiatry. For each condition, the major focus is on the impact of psychopathology on bariatric surgery outcomes (weight loss, weight regain, quality of life) and the impact of surgery on its course (remission, worsening, de novo onset). Each chapter in this part includes a discussion of the diagnostic instruments (i.e., structured interviews, clinician-rated tests, and patient-rated tests) that should be used to obtain a valid assessment of the patient's mental status. Separate chapters focus on psychiatric complications (e.g., suicide and addiction transfer) and psychological problems related to quality of life (e.g., body image dissatisfaction) that may emerge postoperatively. Data on these postsurgery conditions has been reported only recently and, therefore, no published book deals with them. The final chapter offers an overview of unsolved issues in bariatric psychology and psychiatry and reviews emerging research findings that are likely to change assessment and care of bariatric patients' mental health in the near future. Given its scope-and its wealth of tables, diagrams, mnemonics, and key fact boxes-the book will be an invaluable reference tool for clinicians.

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed. This volume focuses on hormone and transport systems.

This 2006 handbook of neonatal endocrinology provides a wealth of practical information on the diagnosis and management of suspected endocrine pathology. Interpretation of endocrine function in the newborn period can be difficult, because of the transition following hormonal influences of the mother and placenta. The situation is even more complex in infants born prematurely. The unique format presented here is clinically orientated from presentation, diagnosis and management, including immediate, medium and long-term. It clearly explains and describes how and when samples should be taken, order of priority, sample volumes required, length of time one can expect before results are available and normal values. This book gives guidance as to what to tell parents, providing addresses of support groups. This is very much a practical 'hands-on, how-to' approach with flow-charts. It also provides a formulary and investigation methodology section and a brief description of physiology.

The subject of smoking and the hormone disorders associated with it are of relatively recent interest. Its importance increases as the average age at death of the population increases and many of those people will have had a lifetime smoking. The book provides summaries of the present status of research into the effects of smoking and the apparent protection offered against certain diseases. Some research workers have suggested ways of predicting trends of disease patterns such as osteoporetic fractures. Not all the disorders discussed are adverse effects of smoking and these have provided impetus for developing non-tobacco methods of disease prevention. As the smoking population diminishes and the availability of lower tar brands increases, a reduction in many of the adverse disorders is expected and will form the basis for continued monitoring.

Vitamins and Hormones serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.