Internationally recognized experts, pioneers, and opinion makers in evidence-based medicine (EBM) provocatively recast endocrine policy and practice in the light of EBM philosophy and principles. The authors explain the past, present, and future of EBM; consider its practical implications for endocrinology; demonstrate what the "evidence base" is in EBM; and present illustrative case studies by practicing evidence-based clinicians. Highlights include essays on why cost-effective analyses are problematic, the contrast between clinical investigations and large randomized trials, the role of Cochrane reviews and meta-analyses, and the curriculum requirements for training evidence-based endocrinologists.

Over the last decade it has been shown that orphan G protein-coupled receptors (GPCRs) can be used as targets to discover novel neuropeptides. A dozen neuropeptides have been identified through this approach. Each of these neuropeptides has opened new doors for our understanding of fundamental physiological or behavioral responses. For example the orexins, MCH and ghrelin carry fundamental roles in regulating food intake while neuropeptide S, neuromedin S, the prokineticins and the orexins are major players in modulating sleep and circadian rhythms. The chapters of this book review the latest research in the field, most of them are written by the original discoverers of the respective novel neuropeptide. Emphasis is set not only on their discovery but also on their functional significance. Since many of these neuropeptides are part of drug discovery programs, this book impacts academic as well as pharmaceutical research. Written for: Neurobiologists, endocrinologists, pharmaceutical companies

The book is in question and answer format, very easy and comfortable to read. It incorporates objective structures practical examination (OSPE) and other format on Endocrinology questions. Contents of the book have been updated as per the latest guidelines by various endocrine organizations all over the world, especially American Association of Clinical Endocrinology (AACE) guidelines, American Diabetes Association (ADA), European Association for the Study of Diabetes (EASD), American Thyroid Association (ATA) guidelines, and other organizations of the world.

Presently, there is so much focus on diabetes and cardiovascular disease, that the clinical intervention that is required towards its precursor, metabolic syndrome, is often not realised. a oeMetabolic Syndrome in Clinical Practicea will draw the attention of clinicians towards the importance of diagnosing metabolic syndrome, and therapeutic (including lifestyle) intervention that could be enforced earlier on to prevent its consequences and complications. In doing so, the understanding of present diagnostic criteria and how various metabolic risk factors play their role in its pathogenesis is crucial.

Graves' disease is one of several causes of hyperthyroidism. In "Graves' Disease And Hyperthyroidism," Dr. Zaidi, a leading endocrinologist, describes how to accurately diagnose and treat Graves' disease as well as other causes of hyperthyroidism. The medical treatment of Graves' disease has not changed in over 50 years. Sad, but true The standard, usual treatment with Radioactive iodine is a superficial, myopic approach. It almost always makes you hypothyroid (underactive thyroid state). Then, you need to be on thyroid pills for the rest of your life. In addition, radioactive iodine does not treat the underlying root cause of Graves' disease - autoimmune dysfunction, which continues to smolder and easily erupts into another autoimmune disease. Anti-thyroid drugs do not treat autoimmune dysfunction either. They provide only temporary relief. Often, symptoms return once you stop these drugs. Surgery also does not treat autoimmune dysfunction. It often leads to hypothyroidism as well as many other complications. Over the last ten years, Dr. Zaidi developed a truly breakthrough approach to get rid of Graves' disease at its roots - autoimmune dysfunction. His patients have benefited tremendously from this approach. Now, its time for you to learn about this ground breaking discovery. Dr. Zaidi reveals what really causes autoimmune dysfunction that ultimately leads to Graves' disease. His revolutionary treatment strategy consists of five components: His unique Diet for Graves' disease (including original recipes), the link between Vitamin D deficiency and Graves' disease, the connection between Graves' disease and Vitamin B12 deficiency, how Stress causes Graves' disease (and Dr. Zaidi's unique strategy to manage stress) and the Judicious use of Anti-Thyroid drugs. Dr. Zaidi also explains: What are thyroid antibodies? What are the tests to diagnose various causes of hyperthyroidism? What causes Graves' eye disease and what is its proper treatment? How do you accurately diagnose and manage Graves' disease during pregnancy?

Part of the recognised Clinical Focus Series, this book is a guide to the management of diabetes mellitus. Beginning with discussion on the role of exercise and nutrition, the next chapters look at the characteristics of Type 1 and Type 2 diabetes. The following sections cover the management of long-term complications of diabetes including diabetic retinopathy, diabetic neuropathy, cardiovascular disease, diabetic nephropathy, hypoglycaemia, and more. The final chapters discuss the role of bariatric surgery, and retaining and regaining pancreatic -cells in the management of diabetes. Up to date reviews of current practice recommendations for management of the disease and its complications are included. Key points Guide to the management of diabetes mellitus covering various long-term complications Part of the recognised Clinical Focus Series Reviews current practice recommendations Internationally recognised editor team from Eastern Virginia Medical School, US

The syndrome X or metabolic syndrome may be defined as a constellation of several interrelated risk factors of metabolic origin which includes centrally distributed obesity, decreased high density lipoprotein cholesterol, elevated triglycerides, elevated blood pressure and hyperglycemia. Persons with syndrome X are at twice the risk of developing cardiovascular disease, and are at about five-fold the risk of type 2 diabetes mellitus as compare to persons with this syndrome. There are considerable evidences of important ethnic differences in the prevalence of syndrome X, its components and sequelae. The prevalence varied between ethnic groups even within the same geographical location. Apart from multifactorial (genetic vs. environmental) nature, there are intriguing metabolic and anthropometric differences found across different ethnic groups. The estimates vary by ethnicity, for instance, high prevalence in nonaEuropean groups such as Black AfricanaCaribbeans, Hispanics, indigenous populations of North America, South Asians, and the Western Pacific Region and lower prevalence in Chinese populations, and EuropeanaWhite. Public health strategies that are well known to be important for chronic disease prevention in general can substantially reduce the prevalence of syndrome X. Population-specific studies will be important in identifying subgroups for which syndrome X is a health issue and for which disease management strategies are needed. Simultaneously, studies to identify different biomarkers associated with syndrome X that are linked with the development of specific chronic diseases, such as CVD and diabetes, will significantly enhance the early detection of these diseases. Existing preventions strategies, if implemented in population subgroups at highest risk, may have a substantial effect on reducing these trends. The prevalence of syndrome X increases with advancing age suggests that the efforts to increase awareness of prevention strategies must begin early. Intensive treatment and effective targeting efforts would help in avoiding future sequelae of syndrome X across different ethnicity. This book will be an assemblage of similarities and differences in the risk of syndrome X and related disorders among different ethnic groups worldwide, and reviews potential mechanisms for ethnic differences. It would certain help in translational research for early intervention and better prevention of syndrome X and its associated public health burden worldwide.

Aphasia, Volume 185 covers important advances in our understanding of how language is processed in the brain and how lesions or degeneration in the left hemisphere affect language processing. This new release reviews research regarding how language recovers from brain injury, along with new interventions developed to enhance recovery, including language rehabilitation, noninvasive brain stimulation and medications. Sections cover neuroanatomy and neurophysiology of language networks, focus on mechanisms of recovery (and decline) of language, and include chapters on intervention, including recently developed behavioral therapies, brain stimulation, medications, and a review of studies of treatment for both post-stroke aphasia and primary progressive aphasia.

The first STG report to embody scenarios on population aging, health and care appeared in 1985. This report describes developments since 1985, reviewing the current position and setting out updated scenarios. The 1985 report set out three scenarios, in which the central focus was on the developing future pattern of demand for care by the elderly. The present report too sets out three scenarios, centring on the demand for care, in which account is taken of a variety of factors; it also details four strategic scenarios whose central focus is on the developing supply of care and which set supply and demand one against the other. Three of the strategic scenarios -- emphasizing respectively intramural, extramural and informal care -- suppose the demand for care to be met in full; the fourth scenario, which rolls current policies on the care of the elderly forward into the future, pinpoints discrepancies between the need for care and the extent to which that need is likely to be met, making clear in so doing that a review of long-term policy for the elderly is urgently needed.

Cellular Endocrinology in Health and Disease, Second Edition, describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases. Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work explores and dissects the function of a number of cellular systems. The new edition provides an understanding of how endocrine glands function by integrating information resulting in biological effects on both local and systemic levels, also providing new information on the molecular physiopathogenesis of endocrine neoplasic cells. The new edition expands the most used chapters from the first edition and proposes a series of substitutions and additions to the table of contents. New chapters cover signaling, brown adipose tissue, hypothalamic cell models, cellular basis of insulin resistance, genetics and epigenetics of neuroendocrine tumors, and a series of chapters on endocrine-related cancer. Providing content that crosses disciplines, Cellular Endocrinology in Health and Disease, Second Edition, details how cellular endocrine function contributes to system physiology and mediates endocrine disorders. A methods section proves novel and useful approaches across research focus that will be attractive to medical students, residents, and specialists in the field of endocrinology, as well as to those interested in cellular regulation. Editors Alfredo Ulloa-Aguirre and Ya-Xiong Tao, experts in molecular and cellular aspects of endocrinology, deliver contributions carefully selected for relevance, impact, and clarity of expression from leading field experts

This innovative textbook provides a readable, contemporary and fully integrated introduction to endocrine glands, their hormones and how their function relates to homeostasis. It explores the pathology of endocrine disease by relating the underpinning science through a wealth of clinical scenarios and examples. The book integrates basic and clinical aspects for a range of endocrine glands and their hormones and includes a number of specialist chapters that also address areas of intense research and clinical interest including the regulation of salt, appetite and endocrine-immune interactions.

Provides a fully-integrated, scientific and clinical introduction to endocrinology. Includes a wealth of colour illustrations to reinforce key concepts.Introduces clinical scenarios and leading questions to engage interest and illustrate the relevance of the underpinning science.Includes key references and suggestions for further reading at the end of each chapter.

Written by a highly respected and experienced author team this new textbook will prove invaluable to students needing an original, integrated introduction to the subject across a variety of disciplines including biomedical science, pharmacology, bioengineering and pre-clinical medicine.

Biomarkers in Bipolar Disorders summarizes cutting-edge findings in biomarkers' research, emphasizing the most promising findings, tools and technologies relevant to drug development and personalized medicine. Key findings cover different levels of evidence such as genes, molecules, cells, systems, brain and behavior related to diagnosis (state and trait/endophenotypes), prediction of treatment response and follow-up outcomes, along with the most promising perspectives in each area. Each section includes a comprehensive and focused overview on the state-of-the-art and perspectives. The book concludes with a section on practical applications, encompassing diagnostics development (genetic testing, biomarkers), and new drug development. Edited by Dr. Rodrigo Machado-Vieira and Dr. Jair C. Soares, and contributed by leading experts in the field of biomarker research, this book will be become the leading tool for all researchers and clinicians in Bipolar Disorder.

In this issue of Medical Clinics, guest editors Silvio Inzucchi and Elizabeth Holt bring their considerable expertise to the topic of Endocrinology. Provides in-depth, clinical reviews in Endocrinology, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

Diabetes mellitus is one of the leading causes of blindness worldwide, with diabetic retinopathy (DR) remaining the most common cause of eye disease for people with diabetes. Current guidelines state that all patients with diabetes should be screened for retinal problems. Diabetic Retinopathy, second edition, offers a practical, clinically focused guide to DR. Featuring 20 concise chapters this resource covers the basics of diabetes mellitus and ocular anatomy, why screening is required, the epidemiology and nature of diabetic retinopathy, as well as associated ocular diseases. It has been fully updated to include the latest trial data and newest developments in the management of diabetic retinopathy, as well as three new chapters covering patients of concern, imaging techniques in diabetic retinopathy, and an overview of treatment strategies for diabetic eye disease. Part of the Oxford Diabetes Library series, this pocketbook is a concise companion for professionals involved in screening and treating diabetic retinopathy.

Most endocrine diseases can be treated successfully, and the patient's state of well-being can usually be improved. Not surprisingly, the earlier the diagnosis is made the more positive the clinical response. Early Diagnosis and Treatment ( f Endocrine Disorders focuses on early signs and symptoms of endocrine disorders and surveys the appropriate tests to document the diseases as well as current recommendations for therapy. Each chapterreviews the pathophysiology of the endocrine disease-important for understanding each disorder as well as the rationale for early therapy-and the basis for the early recognition and treatment of each condition. Although the practicing endocrinologist is likely to be quite knowledgeable regarding many of these diseases, Early Diagnosis and Treatment of Endocrine Disorders includes treatment of those conditions only recently classified as endocrine disorders, such as polycystic ovarian syndrome, obesity, and hypogonadism. The book also provides new approaches that are urgently needed to slow the epidemic of type 2 diabetes, which should be an overriding concern for all clinicians. Until now, no other endocrinology text has focused primarily on the details of early recognition and therapy of endocrine disorders. The information in Early Diagnosis and Treatment of Endocrine Disorders is presented in an orderly and easy-to-follow manner, which should greatly facilitate the early recognition of endocrine diseases by medical students, house staff, primary care physicians, and endocrinologists, the four groups of clinical personnel to which this book is specificall y directed.

The Endocrine System chart describes the components and functions of the system that regulates bodily processes. The main image depicts the overall transport system (the vascular system) and associated organs. The action of hormones is shown as a feedback loop and through the concept of target cells. Heavy cover stock with protective varnish for durability.

Wenn bei einem Kind Diabetes diagnostiziert wird, fragen sich Eltern, wie sie sich der Verantwortung stellen koennen und wie sich der Familienalltag verandern wird. Die Autoren, zwei Kinder- und Jugendarzte und eine Psychologin, geben luckenlos Antwort und helfen Eltern, ihre AEngste abzubauen. Sie begleiten sechs Kinder und Jugendliche mit Diabetes und zeigen, wie das Familienleben mit der Krankheit organisiert werden kann. Mit vielen Tipps und Hinweisen zu allen Fragen, die die Lebensgestaltung und die Zukunft eines Kindes mit Diabetes betreffen.

Das Buch hebt auch in der 2. komplett uberarbeiteten und aktualisierten Auflage den interdisziplinaren Charakter der Behandlung des diabetischen Fusssyndroms hervor. Nur in einem ausgewogenen Zusammenspiel von operativ und nicht-operativ tatigen AErzten sowie den entsprechenden medizinischen Assistenzberufen ist eine umfassende und die Extremitat erhaltende Therapie moeglich. Die Umsetzung des Gelesenen in die Praxis erleichtern die therapeutischen Algorithmen und die vielen Handlungsempfehlungen, die die Autoren geben. Zahlreiche Abbildungen/Bildserien veranschaulichen daruber hinaus die Inhalte.

Epidemiology of Thyroid Disorders provides comprehensive, clinical knowledge to professionals dealing with thyroid disorders. The book focuses on the pathophysiology of thyroid disorders, the prevalence and incidence of various diseases, and their prevention. This focused analysis on thyroid disorders raises awareness of this global problem that, once diagnosed or misdiagnosed, can sometimes lead to over-treatment and cardiovascular complications, especially in the elderly. This succinct, targeted reference gives the reader excellent information on the epidemiology of global thyroid disorders, as well as up-to-date treatment data and a special focus on prevention.

This book is a quick-reference guide to osteoporosis that equips the reader with easy-to-follow guidelines for lifelong maintenance of skeletal structure and function, with an emphasis on the diagnosis, therapy and prevention of osteoporosis. Organized into 20 chapters it provides a concise, yet complete evidence-based overview of osteoporosis prevention and management “from paediatrics to geriatrics”. This practical guide is aimed at raising awareness and educate physicians across disciplines about this preventable, treatable and now even curable disease and emphasizing how every doctor can contribute to stop the “osteoporosis treatment gap” recognized over the last ten years. Covering bone biology, pathophysiology, secondary and drug-induced osteoporosis, as well as risk factors, diagnostic measurements, treatment and monitoring strategies, new drugs, management of osteoporotic fractures, and much more, this book is a must-have for all those involved in the prevention and care of this global threat.

Hormonal Signaling in Biology and Medicine: Comprehensive Modern Endocrinology covers the endocrine secretions produced by every organ. This extensive collection of knowledge is organized by tissue, addressing how certain hormones are synthesized in multiple tissues, along with their structure, function and pathways, which are very applicable for researchers in drug design who need to focus on a specific step along the pathway. This is a must have reference for researchers in endocrinology and practicing endocrinologists, but it is also ideal for biochemists, pharmacologists, biologists and students.

This is the second of two "Annals" volume (see also Volume 1262) of papers by speakers at the 8th International Society for Neuroimmodulation Congress held in Dresden, Germany, October 2011. The papers focus on interactions among the immune, endocrine, and nervous systems that occur at multiple levels, from intracellular pathways by immune and neuro-endocrine mediators, to the exchange of information between the three systems that results in physiologic and adaptive effects. In certain instances, however, these interactions may be unbalanced or even disrupted, which can contribute to pathology, and aspects of such pathobiology are presented in some of the contributions. This volume aims focuses on translational science aspects of immune-neuro-endocrine interactions.

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