This atlas draws on a multidisciplinary approach to provide a comprehensive overview on endocrine disorders of the head and neck, with particular emphasis on the role of imaging and image-guided procedures. The first section discusses the basic characteristics of the imaging methods and other techniques used for evaluation and diagnosis. The remainder of the book focuses on application of these methods in thyroid, parathyroid, and other endocrine disorders of the head and neck. The coverage is wide ranging, encompassing Graves' disease, toxic multinodular goiter, toxic adenoma, thyroiditis, non-toxic goiter, benign nodules, and the different forms of thyroid carcinoma, as well as parathyroid adenoma, hyperplasia, and carcinoma and paragangliomas. Informative, high-quality images are provided by international experts in endocrine disorders, including endocrinologists, pathologists, radiologists, nuclear medicine physicians, and surgeons, who also discuss sample cases and provide syntheses of the relevant scientific literature.

This book is designed to capture and clinically review the comprehensive database of clinical research articles that support and do not support the utilization of a variety of dietary supplements and other complementary medicines that physicians are exposed to in their daily practice. The growing list of CAM products that could interfere with surgery (anesthesia, bleeding, outcomes...) and/or conventional medicines is very large and is provided in each section of the book. Additionally, the list of dietary supplements that could be utilized to improve quality of life for breast cancer patients is also emphasized. The various sub-specialty groups in breast are adequately represented, which allows for a physician to rapidly and thoroughly investigate their topic of interest regardless of whether the topic is prevention, treatment, or a specific side effect of treatment. The practical nature of Integrative Medicine for Breast Cancer: An Evidence-Based Assessment cannot be overstated. Chapters include a general overview of the CAM agent, whether or not it has data in medicine and oncology, and a list of potential drug interactions and specific clinical scenarios where it can be utilized or discouraged in the specialty. Thus, this book will become the gold standard evidence based text for use in teaching, not only for the students interested in oncology and breast cancer, but for all current oncology health providers.

In this second volume, the Biennial Review of Infertility brings together the most up-to-date research and clinical information on male and female infertility, emerging assisted reproductive techniques, and controversial issues in reproductive medicine. This volume includes discussion of cutting-edge topics such as epigenetics, proteomics, and the role of the environment in fertility, as well as insightful evidence-based discussion of common clinical procedures. It is the cumulative effort of a preeminent panel of experts presenting each chapter in a clear and well-balanced manner. Created to provide an ongoing appraisal of current knowledge, the Biennial Review of Infertility stimulates communication amongst all those working to help couples resolve their infertility.

Atlas of Thyroid Lesions provides a broad overview of the variety of lesions in the thyroid gland and their different characteristics and features, in the unique combination of ultrasound, cytologic and histologic appearance. Nodules in the thyroid gland are quite common. Studies estimate that more than 70% of the adult population in the United States has thyroid lesions when examined by ultrasound. More than 80% of thyroid nodules are benign. Too many benign nodules are surgically resected due to insufficient diagnostics, and too many malignant tumors do not get adequate primary surgical treatment. This book demonstrates how multidisciplinary approaches can increase the quality of the complex thyroid diagnoses and thereby secure correct treatment. This atlas presents: *Comprehensive description and overview of all thyroid lesions, tumor types, nodules and neck lymph node metastases *High quality ultrasound and pathology images *Easy to find images of anticipated tumor types *Didactic tools for how to improve diagnostic accuracy in the field

Surgical pathology is the cornerstone in the management of neoplastic disorders. Written for the practicing surgical pathologist in mind, Surgical Pathology of Endocrine and Neuroendocrine Tumors provides an up-to-date text on surgical pathology of endocrine and neuroendocrine tumors. The text begins with radiological imaging of tumors, followed by a section on fine needle aspiration biopsy. The main section focuses on surgical pathology of endocrine and neuroendocrine tumors. The volume closes with applications of molecular techniques and their potential for the future. Surgical Pathology of Endocrine and Neuroendocrine Tumors is written by a panel of internationally recognized pathologists who are not only experts in their fields, but who also contribute their own valuable insights making this new book an essential resource for practicing general and specialist surgical pathologists and pathologists in training.

An exciting contribution to the field, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement is designed with two overriding objectives: to help readers understand the impact of vision impairment in people living daily with diabetes rather than considering diabetic retinopathy solely as a medical problem, and to explore what we know and don't know about the ways diabetes affect the eye. With the plethora of new information being generated, there are still a series of fundamental questions that must be addressed if effective treatments for diabetic retinopathy are to be found and applied. Developed by a renowned group of authorities, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement offers responses and context for a range of questions, such as: do metabolic factors beyond glucose contribute to vision-threatening diabetic retinopathy? If so, how do these lead to vision impairment? Is diabetic retinopathy a response to systemic metabolic abnormalities or are there unique ocular problems related to insulin resistance? What is the relationship between the neural, vascular, and inflammatory abnormalities in diabetic retinopathy? Do they represent a pathological cascade induced sequentially or simultaneous responses to one or more metabolic perturbations? The authors note that if we do not address these types of questions, it is possible that the long process of developing new therapeutic s will target only one arm of the pathology and leave the retina open to damaging consequences of the others. State-of-the-art, comprehensive, and an invaluable addition the research and clinical literature, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement offers guidance and a significant step toward new scientific approaches that can lessen the devastating vision impairment associated with diabetes.

This book encompasses many different diagnoses as well as several specialties of practicing surgeons in the United States. Over the last ten years many advances have been made in preoperative assessment including imaging and diagnostic techniques, operative approaches including "minimally invasive" and robotic surgery, and post operative care. Controversies in Thyroid Surgery explores some of the controversies that arise as the result of these new findings and applications. The book is divided into the two categories of benign diagnosis and cancer topics. Both of these areas lend themselves to separate analysis of specific problems in the areas mentioned above. The text reviews recent data about advances in diagnostic techniques as well as outcomes with specific regards to the newer operative techniques. The textbook will serve as a resource for medical and surgical colleagues involved in the treatment of a wide variety of thyroid diseases. Authors that are experts in their field and have published extensively provide balanced and non-biased views of topics that are admittedly controversial. Controversies in Thyroid Surgery will be of great value and utility to practicing endocrinologists, general surgeons and otolaryngologists.

Insulin-like growth factors (IGFs), their binding proteins and their receptors play important roles in regulating growth, metabolism, proliferation and survival for many cells and tissues throughout lifespan in humans and other species. Circulating IGF1 is known to be an endocrine regulator, with metabolic effects related to, and partly convergent with, insulin signalling. IGF1 also mediates many of the growth promoting effects of GH, and there is an ongoing debate as to the relative contributions of endocrine-, vs locally-derived IGF1 for systemic growth. More recently however, it has become clear that IGFs may be key local growth and cellular survival factors for many different tissues, active from early in embryonic development, essential for normal maturation and growth during foetal life. IGFs continue to play important roles throughout adult life in many diverse processes such as tissue repair, cellular proliferation, tissue remodelling and metabolic regulation. IGF systems are tightly regulated; orderly control of cellular repair and metabolism is central to healthy ageing, whilst uncontrolled proliferation can lead to cancer.

This book is based on the authors' extensive practical experience in the use of modern radiological methods to diagnose parathyroid diseases and the application of advanced surgical techniques. Detailed attention is devoted to the embryological background to emphasize the significance of diagnostic and surgical peculiarities. Pre- and intraoperative imaging is discussed in depth, with a special focus on localizing techniques. Ultrasound-guided minimally invasive techniques, including percutaneous laser ablation, are fully considered. This up-to-date and richly illustrated book will interest and assist specialists in ultrasound diagnostics, radiologists, endocrinologists, and surgeons.

This book is a unique resource that will help pediatric radiologists, pediatricians, and pediatric endocrinologists to optimize the work-up and treatment of pediatric patients with endocrine disorders. Acclaimed experts in the field present and discuss the imaging findings obtained in disorders of the various endocrine systems, including the hypothalamo-pituitary axis, the thyroid and parathyroids, the adrenals, and the pancreas. Detailed advice is also provided on the assessment of bone growth and on imaging of the fetal glands, ambiguous genitalia, and the female pelvis in the context of precocious puberty. Throughout, care is taken to highlight characteristic findings and diagnostic clues. All of the currently used imaging techniques are covered, with clear explanation of their benefits and limitations. The informative text is supported by a wealth of high-quality illustrations, the large majority of them in color.

This book focuses on the state of the art in fully grasping precocious puberty and its consequences, incorporating advances in the areas of endocrinology, genetics, imaging and therapeutics to offer an indispensable tool for all physicians interested in the latest advances in this field. The authors present the latest findings on early puberty in girls and boys. The dynamic process of maturation is influenced by many signals and reshapes growing children's role within their environment. Readers will benefit from the educational value and level of depth of the individual chapters; written by respected experts and in a self-contained format, they can also be read separately to address specific interests.

This practical book aims to cover the whole scope of clinical endocrinology, including both common and selected rare but important diseases, with an emphasis on practical clinical management. A number of different questions and problems in clinical routine are discussed in this book in an unconventional format. Each topic begins with the presentation of a typical clinical case, and then the topic is approached in a question and answer format linked to the clinical case presented, highlighting the most important questions in diagnosis, differential diagnosis and therapy. Numerous figures and tables are included to help understanding. The book is chiefly intended for doctors in training (preparing for boarding exam in endocrinology or internal medicine), but also for established clinicians who want to broaden or refresh their skills. University students of medicine can also find this book interesting.

Oncofertility integrates the two previously distinct fields of cancer treatment and fertility research and aims to explore and expand the reproductive future of cancer survivors. In order to achieve the goal of fertility preservation, the Oncofertility community must focus on communication and the way data is provided and received. Concomitant with the rapidly changing technology of Oncofertility, there have been radical shifts and advances in the way health educators and clinicians can produce and share information. As success rates of reproductive techniques such as egg freezing and banking continue to rise, providing increasing opportunities for young cancer patients to preserve their fertility prior to the onset of cancer treatments, communication among professionals in oncology, reproductive medicine, and psychosocial work, among others, becomes crucial, and clinical demand for Oncofertility information is expected to rise considerably. Oncofertility Communication describes and addresses the myriad channels through which the multiple audiences involved in Oncofertility can be served with appropriate and accurate information about cancer-related fertility issues. The text answers frequently asked questions and provides invaluable insights to scientific and health care professionals about communication among the diverse Oncofertility audiences. It incorporates timely discussions about traditional and emerging electronic communication tools and discusses the impact of health care policy changes on the Oncofertility field.

Providing the most up-to-date research and current clinical knowledge of diabetic bone disease and the challenges still facing the research and clinical care communities, this book unites insights from endocrinology and orthopedics to create a truly unique text. The first part covers clinical and pre-clinical applications and research. The first two chapters present the clinical and epidemiological data about diabetic bone disease, evaluated and reviewed for type 1 and type 2, respectively. This is followed by discussions of how the propensity to fracture in diabetic bone disease can impact fracture risk assessments and how it can be adjusted for using current clinically relevant fracture risk models. A comprehensive overview of orthopedic complications observed in diabetes is next, as well as a focus on the consequences of diabetes on periodontal disease. Other topics include the utility of skeletal biomarkers in assessing diabetic bone disease, how drugs used to treat diabetes may also have skeletal consequences, and the possibility that diabetes may fundamentally impact early progenitor cells of various bone lineages and thus globally impact bone. The second part covers biomechanics and bone quality in diabetes: how diabetes ultimately may impact the architecture, integrity, and quality of bone. Utilizing the expertise of top researcher and clinicians in diabetic bone disease in one comprehensive text, this volume will be a useful and thought-provoking resource for endocrinologists and orthopedic surgeons alike.

This gold standard text has kept its readers abreast of rapid advancements in reproductive medicine and surgery since 1983. Continuing this tradition, this fifth edition has been fully updated and revised to provide clear, didactic advice on best practice for a variety of clinical situations faced by practitioners across many specialties - including urologists, gynecologists, reproductive endocrinologists, medical endocrinologists and many in internal medicine and family practice who see men with suboptimal fertility and reproductive problems. Completely restructured to include pedagogical features such as easily accessible key concepts that cement understanding and real-world use. Covering everything from foundations of anatomy and embryology, through clinical evaluation, diagnostic approaches, treatment and fertility care in context within the healthcare system and society, thrilling advances and future directions are also included. This new edition is an essential reference for all who are working in this young and rapidly evolving field.

This highly illustrated book, complete with comprehensive clinical references and annotated images, will serve as a leading text to educate head and neck surgeons, endocrinologists, and radiologists on the basics and nuances of thyroid and parathyroid ultrasound. It emphasizes the use of ultrasound as an office-based modality by clinicians and radiologists who actively care for this special set of patients. This text uniquely combines the collaboration between a clinician/surgeon and radiologist who share their extensive experience in head and neck ultrasound.

In the past, pregnancy after cancer was largely unheard of. Today, it is increasingly a possibility. Oncofertility has emerged as an interdisciplinary field bridging biomedical and social sciences, and examining issues regarding an individual's fertility options, choice and goals in light of cancer diagnosis, treatment and survivorship. Written by leaders in this evolving field, the volume covers various aspects: medical, ethical and social.

Presenting an overview of the current understanding of the pathophysiology of PCOS and a paradigm for the clinical evaluation and management of the disorder, Polycystic Ovary Syndrome is written in an easy to digest, concise format that, with bulleted key points introducing each chapter, is suitable for the trainee and the busy clinician. The breadth and depth of coverage of today's queries and controversies will be of particular interest to the specialist and researcher. An international group of leading experts addresses the varied etiologies of PCOS, comprehensively covering the contemporary treatment approaches and long-term implications of PCOS, a common yet poorly understood disorder. Chapters on treatment will be of particular relevance to the clinician and the trainee as they cover conventional therapies, lifestyle, and diet, as well as address emerging strategies such as the use of statins and surgery in PCOS management. Spanning the breadth of clinical presentations and morbidities related to the diagnosis of PCOS, Polycystic Ovary Syndrome is an exceptional resource for primary care providers, gynecologists, reproductive endocrinologists, and others involved in the care of these patients, and provides the essential tools to aid clinicians in initiating a timely diagnostic workup and appropriate interventions to address both the immediate and long-term sequelae related to PCOS.

Urolithiasis: A Comprehensive History provides a historical sojourn into the varied manifestations of kidney stone disease. Utilizing historical sources and integrating classic material with new concepts, this new volume provides depth and details on stone disease not found in modern overviews on the topic. This volume serves as a very useful tool for physicians and researchers dealing with kidney stone disease. Written by a renowned expert in the field, Urolithiasis: A Comprehensive History is an in depth resource that heightens our medical understanding of this ancient disease and is of great value to urologists, nephrologists, endocrinologists interested in stone disease.

This book presents, in a stepwise and interactive fashion, approximately 75 cases that reflect the wide spectrum of pathology encountered in this region. Each case description commences with a concise clinical scenario. High-quality radiologic, laboratory, and histopathologic images depicting the differentiating features of the lesion subtype in question are then presented, and key operative and clinical management pearls are briefly reviewed. The interdisciplinary nature of this easy-to-use color atlas and textbook reflects the fact that the management of patients with sellar and parasellar lesions is itself often interdisciplinary. The format is unique in that no similar interdisciplinary book is available on lesions of this region of the brain. Atlas of Sellar and Parasellar Lesions: Clinical, Imaging, and Pathologic Correlations is of great value for practitioners and trainees in a range of medical specialties, including radiology, neurology, endocriniology, pathology, oncology, radiation oncology, and neurosurgery.

"International Practices in Pancreatic Surgery" describes in great detail general and specific technical aspects of the standard resection procedures of the pancreas. Each surgical step during the pancreatic operation is precisely outlined and accompanied by drawings and photographs. The main chapters on pancreatic carcinoma, chronic and acute pancreatitis are written by the editors. An international faculty complements the texts by describing their own personal techniques. This concept offers the greatest possible overview of the techniques used by experienced surgeons.

Written by internationally acclaimed specialists, Breast, Endocrine and Surgical Oncology provides pertinent and concise procedure descriptions spanning benign and malignant problems and minimally invasive procedures. Complications are reviewed when appropriate for the organ system and problem, creating a book that is both comprehensive and accessible. Stages of operative approaches with relevant technical considerations are outlined in an easily understandable manner. The text is illustrated throughout by photographs that depict anatomic or technical principles. Forming part of the series, Surgery: Complications, Risks and Consequences, this volume Breast, Endocrine and Surgical Oncology provides a valuable resource for all general surgeons and residents in training. Other healthcare providers will also find this a useful resource.

Nuclear Receptors focuses on the structural analysis of nuclear receptors from the initial work using isolated protein domains to the more recent exciting developments investigating the conformational shape of full-length receptor complexes. The book also reviews the structure of key nuclear receptor co-regulatory proteins. It brings together, for the first time, a comprehensive review of nuclear receptor structure and the importance of receptor conformation underpinning allosteric regulation by different ligands (hormone, drugs, DNA response elements, protein-protein interactions) and receptor activity. The nuclear receptor superfamily, including receptors for steroid hormones and non-steroid ligands, are pivotal to normal physiology, regulating processes as diverse as reproduction, metabolism, the immune system and brain development. The first members of the family were cloned over 25 years ago, which heralded in the idea of a superfamily of intracellular receptor proteins that bound small molecule ligands: classical steroid hormones, vitamins, fatty acids and other products of metabolism. These signals are then transmitted through multiprotein receptor-DNA complexes, leading to the regulation of target genes, often in a cell-selective manner. The cloning of the receptor cDNAs also ushered in an era of unparalleled analysis of the mechanisms of action of these ligand-activated transcription factors.