Thyroid diseases are relatively common, occurring in about 10% of the population in the Western world. Many are simple to diagnose and treat, while others are not. In this comprehensive work, the author draws upon personal experience, teaching, and a distillation of the literature to provide clinicians with advice on how to handle specific patient-related problems. The book begins with a summary of basic information on the structure, function, development, abnormal development, and physiology of the thyroid gland. It then reviews tests of thyroid function and clinical examinations before proceeding to chapters on disease states. Chapters on clinical problems include hyper- and hypothyroidism, thyroid nodules, thyroid cancer, thyroiditis, goitre, and iodine deficiency disorders. The chapters on hyper- and hypothyroidism are designed to aid the physician in defining the specific cause and management of patients with these conditions. Evaluation and treatment of thyroid nodules and thyroid cancer arouse considerable differences of opinion; these differences are reviewed and specific recommendations are outlined. Flow diagrams are included for the work up of different clinical situations, and each chapter concludes with a section of key facts. The last two chapters cover clinically related issues. Since non-thyroid illnesses, both physical and mental, can distort thyroid function tests, the author provides advice on how to avoid a misdiagnosis. Because some diagnostic tests and treatments involve administering radioactive iodine to the patient, the final chapter discusses radiation biology and the thyroid. This cohesive volume will be of value to endocrinologists and clinicians who treat patients with thyroid disease, as well as to medical students and physicians in training.

Iron is indispensable for the growth, development and well-being of almost all living organisms. Biological systems from bacteria, fungi and plants to humans have evolved systems for the uptake, utilisation, storage and homeostasis of iron. Its importance for microbial growth makes its uptake systems a natural target for pathogenic microorganisms and parasites. Uniquely, humans suffer from both iron deficiency and iron overload, while the capacity of iron to generate highly reactive free radicals, causing oxidative stress, is associated with a wide range of human pathologies, including many neurodegenerative diseases. Whereas some essential metal ions like copper and zinc are closely linked with iron metabolism, toxic metals like aluminium and cadmium can interfere with iron metabolism. Finally, iron metabolism and homeostasis are key targets for the development of new drugs for human health. The 4th edition of Iron Metabolism is written in a lively style by one of the leaders in the field, presented in colour and covers the latest discoveries in this exciting area. It will be essential reading for researchers and students in biochemistry, molecular biology, microbiology, cell biology, nutrition and medical sciences. Other interested groups include biological inorganic chemists with an interest in iron metabolism, health professionals with an interest in diseases of iron metabolism, or of diseases in which iron uptake systems are involved (eg. microbial and fungal infections, cancer, neurodegenerative disorders), and researchers in the pharmaceutical industry interested in developing novel drugs targeting iron metabolism/homeostasis.

Current knowledge relevant to the understanding of thyroid autoimmunity is summarized in this book. Some of the world's leading scientists in this field review recent data from four subject areas: immunogenetics, thyroid peroxidase as an antigen, environmental factors, and cytokines. Much ongoing and as yet unpublished work is described, especially in the discussion included after each article. This information is of particular interest since the body of knowledge in these fields is growing very rapidly. The book is based on a workshop in which researchers from 13 countries took part. One major aim was to raise controversial points and to develop ideas for their potential solution. At the workshop it became apparent that a great deal of the information given in textbooks is outdated. This is an important update for researchers who are interested in the above topics and in understanding the etiology and pathogenesis of thyroid autoimmunity.

The articles in Issue 4 of Journal of Inherited Metabolic Disease, Vol. 14 (1991) contain the main lectures presented at the 28th Annual Symposium of the Society for the Study of Inborn Errors of Metabolism, Birmingham, UK, 1990, which was dedicated to `The Liver and Inherited Metabolic Disease' with a half-day workshop on `Screening and Economics'. The subjects covered include metabolic functions of the liver, bile acids, alpha-1-antitrypsin deficiency, tyrosinaemia type I, Crigler-Najjar disease type I and Niemann-Pick disease type C, providing updates on a wide range of metabolic disorders and illustrating the importance of the complementary contributions from professionals in different disciplines. Also covered in detail is the exciting potential of liver transplantation as treatment for several inborn errors of metabolism. This state-of-the-art review will be of interest to clinicians and research workers alike.

Dementia of Alzheimer type (DAT), multiinfarct dementia (MID) and dementia occurring in the course of Parkinson's disease (PD +D) now make up one of the largest categories of chronic diseases in the elderly. In addition to the burden those illnesses impose on the affected individuals and their families they consume large socio-economic re- sources. In the light of all the above mentioned features, it seemed to us that a Symposium on behalf of the 125th Anniversary of Birth of Aloys Alzheimer was particularly well-suited to help to advance research on Alzheimer's disease and other dementias. This International Symposium combined with a Satellite Symposium about "Clinical Aspects of Alz- heimer Dementias" took place in June 1989 in Wiirzburg and has been organized by the Psychiatric Departments of the Universities of Wiirzburg and Munich (H. Beckmann, K. Maurer, P. Riederer, H. Hippius and H. Lauter) and the Department of Pathochemistry and General Neurochemistry of the University of Heidelberg (S. Hoyer). In the chapters which follow, thorough reviews of recognized authorities in the field of dementia are given in the four main fields of epidemiology, neuropathology, neurochemistry and clinics. This Symposium and the edition of this book would not have been possible without the generous support of E. Merck, Darmstadt. In particular we gratefully acknowledge the efforts undertaken by Mr. Hernandez-Meyer to organizing this symposium and to publish this book. Furthermore we are grateful to the secretarial help by Mrs. Moeslein, Miss Philipp and Miss Grabner.

Endorphins and other endogenous opioids appear to be the connecting link between reproductive functions and stress adaption of the human organism. This book contains the con- tributions of an international group of biologists, bioche- mists, and endocrinologists on the opioidergic control me- chanisms in reproduction and stress physiology. Main topics covered are: endogeneous opioids and the pituitary-gonadal system; ovarian endorphinsecretion; pregnancy-associated changes of plasma endorphin; and opioid control of the hypo- thalamo-pituitary-adrenal axis. Although all chapters give an excellent review on various studies in basic opioid re- search, there are numerous clinical implications mentioned in this book.

Although impotence may be the most widely recognized manifestation of male sexual dysfunction, many other forms of sexual disorders do not involve the erectile mechanism, from deficiencies of desire to disturbances in ejaculatory function to the failure of detumescence. With such a myriad-and often co-existing-number of disorders, the successful treatment of male sexual dysfunction requires not only a thorough understanding of the underlying physiology and pathophysiology, but also the coordinated efforts of multiple specialties, including endocrinology, andrology, urology, radiology, sex therapy, and even sometimes psychiatry, cardiology, or oncology. Male Sexual Dysfunction: Pathophysiology and Treatment presents the collective expertise of more than 60 international authorities in a single landmark text. From foundations in the anatomy of the male genital tract to the latest neuroimaging data, readers will appreciate the comprehensive information detailing the tremendous advances made in the delineation of sexual function and its disorders as well as the expert descriptions of practical and cost-effective medical, surgical, and psychological strategies for the treatment of all forms of male sexual dysfunction.

The European School of Oncology came into existence to respond to a need for informa tion, education and training in the field of the diagnosis and treatment of cancer. There are two main reasons why such an initiative was considered necessary. Firstly, the teaching of oncology requires a rigorously multidisciplinary approach which is difficult for the Univer sities to put into practice since their system is mainly disciplinary orientated. Secondly, the rate of technological development that impinges on the diagnosis of cancer has been so rapid that it is not an easy task for medical faculties to adapt their curricula flexibly. With its residential courses for organ pathologies and its seminars on new techniques or on the principal therapeutic controversies, it is the ambition of the European School of Oncology to fill a cultural and scientific gap and, thereby, create a bridge between the Uni versity and Industry and between these two and daily medical practice. One of the more recent initiatives of the ESO is the Intercity Meetings. The concept of Inter city Meetings was first put forward with the idea of creating total coverage throughout Europe of certain tumours at the forefront of research and, in some cases, controversy."

Hypoglycemia simply means "low blood-sugar," but without concrete symptoms it's very hard to diagnose. It is nevertheless a condition that should be watched over carefully. People react differently to low blood sugar as well as to the treatment they receive. Hypoglycemia for Dummies explores this fickle condition and shows you how to manage your blood sugar to feel better. This no-nonsense, plain-English guide lays out the facts you need to maintain a healthy body. It offers expert advice on identifying symptoms, changing lifestyles, and also extensive coverage on diet, exercise, alternative treatments, and the link between low blood sugar and diabetes. This expanded 2nd edition provides: * A thorough explanation of hypoglycemia and how it affects your body * Exercise routines that lead to a healthier lifestyle * Diet suggestions on what to eat and how often * A basis for choosing a doctor that's right for you * Vitamins and supplements that treat your symptoms * Ways to manage hypoglycemia in the workplace * An explanation of how hypoglycemia affects family and friends * Methods to de-stress yourself Complete with tips on helping other hypoglycemics and myth-debunking facts about the disease, Hypoglycemia for Dummies is the fast and simple way to learn and treat the condition, with the help of the most up-to-date medical information available. Escape the blood sugar blues and starting feeling better in no time!

International experts are brought together in this book to give basic as well as clinical data on obesity and cachexia, and an integrated picture of the regulation of intermediary metabolism in both situations. The data provide evidence that tissue catabolism and anabolism are regulated by similar mechanisms, which again are the target of different hormonal and metabolic factors. This joint discussion of the similarities evident in both areas will greatly benefit future understanding and research in obesity and cachexia.

1.1 Outline of the Study In this study the influence of psychotropic drugs on anterior pituitary hormone (APR) secretion was investigated in healthy subjects and in depressed patients. The basis for this study is formed by pharmacological investigations which indicate that the therapeutic effect of psychotropic drugs can be attributed to their functional influence on central nervous aminergic impulse transmission (stimuli) as well as by endocrinological investigations which show that central nervous aminergic neurons influence APR secretion in man. The purpose was to frod out if psychotropic drugs with differing pharmacological actions also influence APR secretion differently, even though the complex processes of central nervous stimuli transmission, the effect of psychotropic drugs on these processes, as well as the action of aminergic neuronal systems on APR secretion are not completely understood. Furthermore, it was investigated if it is possible to reach conclusions on the effects of drugs on central nervous aminergic neurons based upon APR secretion data. Specifically, the effects of various antidepressants, neuroleptics, and benzodiazepine-type tranquilizers on the secretion of growth hormone (GR), prolactin (PRL), adrenocorticotropic hormone (ACTR), and cortisol were investigated in healthy male subjects. The first part of this study presents in detail the results of these experiments and also incorporates the results of other investigators. It is endeavored to answer the question whether and to what extent the different psychotropic drugs influence APR secretion and whether the APR secretion profiles of the different psychotropic drugs can serve as a possible pharmacoendocrinological model in humans.

394 finding by Dr C. Jakobs, Amsterdam, was elevated plasma galactitol and/or sorbitol levels in some cataract patients with quite normal activities of the galactose-degrading enzymes and sorbitol dehydrogenase in RBC. Inherited disorders of glycoprotein metabolism were reviewed by Dr M. Cantz, Heidelberg, followed by detailed presentations on selected disorders. The meeting was closed by two exciting lectures, given by Dr J. R. Hobbs, London, and Dr F. Ledley, Houston, on the outcome of bone marrow transplantation and on future aspects of gene therapy in patients with inborn errors of metabolism. Each year the 'Mini' Symposium preceding the main topics attracts increasing numbers and in Munich more than half of the 281 active participants also attended on "Maternal Phenylketonuria," organized by Dr the highly interesting workshop D. Brenton, London. This four-hour workshop included international practical experiences in the treatment of maternal phenylketonuria as well as the results of amino acid transport and animal experiments.

This book contains the necessary knowledge and tools to incorporate nutrition into primary care practice. As a practical matter, this effort is led by a dedicated primary care physician with the help of motivated registered dietitians, nurses, psychologists, physical therapists, and office staff whether within a known practice or by referral to the community. It is essential that the nutrition prescription provided by the physician be as efficient as possible. While many team members have superior knowledge in the areas of nutrition, exercise, and psychology, the health practitioner remains the focus of patient confidence in a therapy plan. Therefore, the endorsement of the plan rather than the implementation of the plan is the most important task of the physician. This book proposes a significant change in attitude of primary health care providers in terms of the power of nutrition in prevention and treatment of common disease. It features detailed and referenced information on the role of nutrition in the most common conditions encountered in primary care practice. In the past, treatment focused primarily on drugs and surgery for the treatment of disease with nutrition as an afterthought. Advanced technologies and drugs are effective for the treatment of acute disease, but many of the most common diseases such as heart disease, diabetes, and cancer are not preventable with drugs and surgery. While there is mention of prevention of heart disease, this largely relates to the use of statins with some modest discussion of a healthy diet. Similarly, prevention of type 2 diabetes is the early introduction of metformin or intensive insulin therapy.

Ein Screening auf angeborene endokrine und metabole Stoerungen ermoeglicht die Fruherkennung von Krankheiten wie Hypothyreose, AGS (adrenogenitales Syndrom), Phenylketonurie, Galaktosamie, Biotinidasemangel, Cystische Fibrose oder Homocystinurie. Je nach Land und politischen Bestimmungen unterscheiden sich jedoch die routinemassig durchgefuhrten Untersuchungen. Dieses Handbuch beschreibt praxisbezogen die biochemischen Grundlagen, die Grundsatze der Labor- und Bestatigungsdiagnostik sowie Therapiemoeglichkeiten zu insgesamt zwoelf Krankheiten. Daruber hinaus werden praanalytische Fragen, wie Zeitpunkt und Art der Blutentnahme oder moegliche Stoerfaktoren, umfassend behandelt. Der allgemeine Teil geht auf ethische und psychosoziale Aspekte des Screenings ein. Ein Verzeichnis der Screeningzentren und jener Labors, die fur die Bestatigungsdiagnostik Dienste anbieten, sowie ein Adressenverzeichnis von Elterngruppen und Informationsquellen im Internet komplettieren dieses Buch.

A number of clinical and epidemiological studies have shown that disorders of lipoprotein metabolism constitute one of the most important risk factors for the development of atherosclerosis and coronary heart disease. This volume examines the state of the art of lipoprotein subclass metabolism and its relation to these diseases. The authors also report on new developments concerning the role of lipoprotein recptors, macrophages and apolipoprotein E polymorphism in cholesterol homeostasis. The combination of general outline form and very specific aspects of cholesterol transport will interest those in other disciplines following developments in the field, as well as those directly involved in lipoprotein research.

This book records the proceedings of the 5th International Symposium on cancer topics organised in collaboration with the Association for International Cancer Research, a cancer charity based in the United Kingdom. The Symposium was held at the Klinikum Steglitz, Free University of West Berlin, Germany, between 1 and 3 October 1987. The Organising and Scientific Committees are deeply grateful to the President of the Free University, Professor Heckelmann, for allowing us to meet in the Klinikum Steglitz and for the University's generous financial support. It was a special pleasure to have a positive and generous input from the West Berlin Senate. Their support was crucial in making the Symposium a scientific success. The Symposium received financial support from a number of sponsors, and we are indeed happy to acknowledge our gratitude to them: Behringwerke AG, Bert- hold AG, Boehringer Mannheim GmbH, the British Council, Deutsche Abbott GmbH, Deutsche Bank AG, Du Pont De Nemours GmbH, Knoll AG, Krewel- werke GmbH, Nunc GmbH, Schering AG, Schwarz GmbH and Varian GmbH. The Symposium was the most ambitious so far mounted by the Association for International Cancer Research. The organisation and planning were carried through by an Organising Committee including Professor J. Hammerstein, Profes- sor K. D. Asmus, Barbara Steiger and Renate Nigam. The Scientific Committee included Dr. D. C. H. McBrien, Professor T. Dormandy, Professor K. R. Rees, Pro- fessor M. U. Dianzani and Professor H. Esterbauer. We thank these colleagues very much for their dedication, hard work and expert input.

Starting with the morphology of the myoendocrine cell and the biochemistry and physiology of cardiac hor mones, the book describes pathophysiological findings and discuss their clinical relevance in congestive heart failure, arterial hypertension, renal insufficiency, and cirrhosis of the liver. Furthermore, evidence is presented for the role of the heart as a target organ for various endocrine factors such as thyroid hormones, catecholamines, renin-angiotensin, growth hormones and endogenous opioids.

His scientific contributions are regarded as classics: the studies about the insulin effect on adipose tissue (together with George F. Cahill Jr. ), his work on the biosyn- thesis and secretion of insulin (together with Lelio Orci and Claes W ollheim) and his studies on various spontaneous and induced diabetes syndromes in rodents (together with Bernard Jeanrenaud and Eleazar Shafrir). Albert Renold will be remembered for a long time by all who knew him for his achievements, for his kindness and his humanity. We dedicate the Proceedings of this symposium to his memory. Werner Creutzfeldt Pierre Lefebvre G6ttingen Liege History and Philosophy of Bayer Pharmaceutical Research W. -D. Busse Fachbereich Forschung Pharma, Bayer AG, D-5600 Wuppertal, FRG Research has a long tradition at Bayer. This year, 1988, marks 100 years of our pharmaceutical activities. In 1888 the first Bayer drug - phenacetin, an antipyreti- was synthesized, starting from a by-product of dye manufacture. This finding led to the establishment of a Pharmaceutical Department within Friedrich Bayer and Co. in Elberfeld, with all its associated facilities (Fig. 1). The beginning of the company itself, however, dates back to 1863. In that year, Friedrich Bayer started the produc- tion of aniline dyestuffs in his private house in Barmen-Rittershausen. During the 125 years of the company's life and the 100 years of pharmaceuticals, many developments and products have been discovered by Bayer researchers and launched by Bayer.

Das Spektrum der in den westlichen Industrienationen filhren- den Krankheiten und der darauf basierenden Thdesursachen hat sich in den letzten J ahrzehnten gewandelt. Wahrend frliher die Infektionskrankheiten und speziell die Thberkulose den hochsten Todeszoll forderten, sind in den Jahrzehnten nach dem zweiten Weltkrieg mit steigendem Wohlstand die Herz- und GefaBkrankheiten an die erste Stelle gerlickt. Trotz gewis- ser Erfolge in der Pravention in einigen Uindern wie z. B. in den USA, Kanada, Australien; aber auch in einigen Gebieten West- europas, in denen die Zahl der tOdlichen Hirnschlage und Herzinfarkte inzwischen wieder rlicklaufig ist, wird die Spit- zenposition in der Todesursachenstatistik hier auch weiterhin von diesen Krankheiten eingenommen. In anderen Uindern wie z. B. in Osteuropanehmen die Erkrankungsraten weiter zu. Wenn man sich fragt, was getan werden kann, urn weitere Er- fqlge auf diesem Gebiet zu erzielen, dann ist ein Blick in die Lander des Fernen Ostens hilfreich. In der Volksrepublik Chi- na undin J apanliegt die Sterblichkeit an koronarer Herzkrank- heit bzw. an Herzinfarkten flinf- bis zehnmal niedriger als in der Bundesrepublik Deutschland. Arteriosklerotische Durch- blutungsstorungen der unteren Extremitaten, auch diabeti- sche GefaBerkrankungen kommen dort kaum vor. Vergleicht man die Lebensweise der Bevolkerung in diesen Uindern mit den Verhaltnissen in den westlichen Industriena- tionen, so fallenerhebliche Unterschiedeinder Ernahrungauf. Wahrend in China Fleisch und Molkereiprodukte in deutlich geringeren Mengen als bei uns verzehrt werden, besteht der Hauptanteil der Ernahrung aus einer an pflanzlichem EiweiB und Schlackenstoffen reichen Kost.

"Endocrine and Metabolic Disease" is in two sections. The first is a systematic review of clinical and therapeutic aspects of endocrine diseases, whilst the second considers the clinical pharmacology of drugs used in endocrinology. All the major areas of endocrinology and metabolism are covered. Thyroid, adrenal and pancreatic disease are discussed in depth and there are separate chapters on the ovary and testes as well as on the pituitary gland and parathyroids. There is a useful pharmacopoeia of drugs used in endocrinology at the end of the volume.

The authors have provided an overview of the relationships between hormones that are physiologic constituents of the body as well as their pharmacologic use in replacement therapies and related endocrine dys function. Principles of Endocrine Pharmacology concerns itself with the ther apeutic use of hormones, and hormone like substances, or drugs that can act either by suppressing or enhancing the metabolism of certain glands of internal secretion. Other drugs used for nonendocrine ther apies can likewise affect the endocrine system. Endocrine pharmacology emerged in the early 1900s with the use of crude pituitary extracts. By the mid-1900s several investigators had isolated and begun to synthesize hormones or hormonelike substances. Recognizing the limited supply of hormones that could be obtained both from animal sources and human autopsy material, the search for so called hormone substitutes also began early in the 1900s. Recently, re combinant DNA technologies have been used to provide alternative therapeutic sources of human insulin and human growth hormone. Aside from insulin, perhaps no other use of hormonally-active sub stance is better exemplified by those drugs which affect fertility. The synthesis of an orally-effective steroid represented one of the first major breakthroughs in the chemical suppression of ovulation. Since the orally active 19-norsteroids were introduced in the 1950s, several oral contra ceptive steroid preparations have been marketed. Indeed, the advent of oral contraceptives for birth control has led to a renewed interest in endocrine pharmacology."

Crash Course - your effective every-day study companion PLUS the perfect antidote for exam stress! Save time and be assured you have the essential information you need in one place to excel on your course and achieve exam success. A winning formula now for over 20 years, each series volume has been fine-tuned and fully updated - with an improved full-colour layout tailored to make your life easier. Especially written by senior students or junior doctors - those who understand what is essential for exam success - with all information thoroughly checked and quality assured by expert Faculty Advisers, the result are books which exactly meet your needs and you know you can trust. Each chapter guides you succinctly through the full range of curriculum topics, integrating clinical considerations with the relevant basic science and avoiding unnecessary or confusing detail. A range of text boxes help you get to the hints, tips and key points you need fast! A fully revised self-assessment section matching the latest exam formats is included to check your understanding and aid exam preparation. The accompanying enhanced, downloadable eBook completes this invaluable learning package. Series volumes have been honed to meet the requirements of today's medical students, although the range of other health students and professionals who need rapid access to the essentials of metabolism and nutrition will also love the unique approach of Crash Course. Whether you need to get out of a fix or aim for a distinction Crash Course is for you! Provides the exam syllabus in one place - saves valuable revision time Written by senior students and recent graduates - those closest to what is essential for exam success Quality assured by leading Faculty Advisors - ensures complete accuracy of information Features the ever popular 'Hints and Tips' boxes and other useful aide-memoires - distilled wisdom from those in the know Updated self-assessment section matching the latest exam formats - confirm your understanding and improve exam technique fast

In 1920, Hirose demonstrated the luteinising effect of placental tissue and one year later, Evans and Long described luteinised ovaries in rats treated with hypophysial extracts. In 1926, Zondek and Aschheim as well as Smith, independently of each other, showed that a gonad-stimulating hormone was secreted by the adenohypophysis. In 1927, Aschheim and Zondek found their "Prolan" in human pregnancy urine and the first reliable pregnancy test was available. In the following years it could be demonstrated that the gonadotropic hormones from pituitary and from pregnancy urin were not of identical structure. During the years 1931 - 1933 Fevold and coworkers prepared follicle stimulating hormone from sheep pituitaries which were free of other hormone activities. Already in 1934, Collip found "antihormones" in animals treated with proteinhormones from animals of another species. It could be shown that they were antibodies against these hormones and this was the future basis for the immunological era starting in 1960. The quantitative determination of gonadotropins has been performed over several decades by difficult bioassays and since 1960 immunological and later radioimmunological assays became available. Since that time a new field was opened for the studies of gonadotropins. During this time, highly purified preparations of gonadotropins were available for research and clinical treatment. I recall the first successful attempt of inducing follicle growth and ovulation by Gemzell and coworkers 1958 as well as by Lunenfeld and Bettendorf at about the same time.

Der innersekretorische EinfluB auf Stimmung, Befindlichkeit und Leistungsfahigkeit des Menschen ist ein faszinierendes Aufga- benfeld der forschenden und praktizierenden Medizin; er ist auch fOr die betroffenen Menschen von groBtem Interesse und groBer Bedeutung. Mit den damit zusammenhangenden Fragen befassen sich besonders die Arbeitsmedizin und in den letzten Jahren zuneh- mend auch die Sportmedizin. Dieses Engagement ergibt sich einmal aus der Bedeutung der Leistungsfahigkeit fOr diese Berei- che, zum anderen methodisch aus der Moglichkeit, innersekreto- rischen Parametern exakte Werte der Arbeit und des Leistens gegen 0 berzustellen. Gerade beim weltweiten Phanomen stark ansteigender Zahlen im Frauensport und der gleichzeitigen rasanten Entwicklung der Spitzenleistungen treten verstarkt Probleme innersekretorischer Regulationen aus frauenheilkundlicher Sicht in Erscheinung. Vielerorts wird von Arzten, Trainern und Sportlern mit Hormon- wirkungen argumentiert, ohne daB solchen Aussagen immer auch gesicherte Fakten zugrundeliegen. Der Deutsche Leichtathletikverband, darOber hinaus aber der Sport schlechthin haben allen AnlaB, der Universitatsfrauenklinik in TObingen fOr ihr Engagement auf diesem Sektor zu danken. Die im Rahmen dieses Symposiums ausgetauschten Kenntnisse, Erfahrungen und Anregungen werden dazu beitragen, die in Frage stehenden Zusammenhange aufzuklaren. Das aber wirQ nicht nur fOr den Sport von Nutzen sein, sondern Vorteile fOr Diagnostik und Therapie in Klinik-, Fach- und Aligemeinpraxis bringen konnen.