Gigantism and Acromegaly brings together pituitary experts, taking readers from bench research, to genetic analysis, clinical analysis, and new therapeutic approaches. This book serves as a reference for growth hormone over-secretion and its diagnosis and treatment for endocrinologists, pediatricians, internists, and neurosurgeons, and for geneticists. Pharmaceutical companies may use it as a reference for drug development and research. Students, residents and fellows in medicine and endocrinology and genetics will also find it valuable as it provides a single up-to-date review of the molecular biology of gigantism and acromegaly as well as recommended approaches to evaluation and management. Acromegaly is a rare pituitary disorder that slowly changes its adult victim's appearance over time: larger hands and feet, bigger jaw, forehead, nose, and lips. Generally, a benign pituitary tumor is the cause and symptoms of acromegaly can vary from patient to patient, making a diagnosis difficult and prolonging suffering for years. Early detection is key in the management of acromegaly as the pathologic effects of increased growth hormone (GH) production are progressive and can be life-threatening as the result of associated cardiovascular, cerebrovascular, and respiratory disorders and malignancies.

The syndrome X or metabolic syndrome may be defined as a constellation of several interrelated risk factors of metabolic origin which includes centrally distributed obesity, decreased high density lipoprotein cholesterol, elevated triglycerides, elevated blood pressure and hyperglycemia. Persons with syndrome X are at twice the risk of developing cardiovascular disease, and are at about five-fold the risk of type 2 diabetes mellitus as compare to persons with this syndrome. There are considerable evidences of important ethnic differences in the prevalence of syndrome X, its components and sequelae. The prevalence varied between ethnic groups even within the same geographical location. Apart from multifactorial (genetic vs. environmental) nature, there are intriguing metabolic and anthropometric differences found across different ethnic groups. The estimates vary by ethnicity, for instance, high prevalence in nonaEuropean groups such as Black AfricanaCaribbeans, Hispanics, indigenous populations of North America, South Asians, and the Western Pacific Region and lower prevalence in Chinese populations, and EuropeanaWhite. Public health strategies that are well known to be important for chronic disease prevention in general can substantially reduce the prevalence of syndrome X. Population-specific studies will be important in identifying subgroups for which syndrome X is a health issue and for which disease management strategies are needed. Simultaneously, studies to identify different biomarkers associated with syndrome X that are linked with the development of specific chronic diseases, such as CVD and diabetes, will significantly enhance the early detection of these diseases. Existing preventions strategies, if implemented in population subgroups at highest risk, may have a substantial effect on reducing these trends. The prevalence of syndrome X increases with advancing age suggests that the efforts to increase awareness of prevention strategies must begin early. Intensive treatment and effective targeting efforts would help in avoiding future sequelae of syndrome X across different ethnicity. This book will be an assemblage of similarities and differences in the risk of syndrome X and related disorders among different ethnic groups worldwide, and reviews potential mechanisms for ethnic differences. It would certain help in translational research for early intervention and better prevention of syndrome X and its associated public health burden worldwide.

The market-leading text, An Introduction to Behavioral Endocrinology, Sixth Edition provides an updated, integrated presentation of the study of hormone-behavior-brain interactions. Maintaining a comparative approach, the text explores the endocrine mechanisms that have evolved in both human and nonhuman animals to solve common problems in survival and reproduction. The text describes interactions among hormones, brain, and behavior from a historical perspective, emphasizing connections among key theories and tracing the emergence of important hypotheses. The book is organized around the conceptual theme that hormones affect behavior by influencing one or more of three "components" of behaving animals-input mechanisms (such as sensory or perceptual processes), the central processing mechanisms of the nervous system (either directly, or by affecting its development or structure), and output mechanisms (such as effectors or peripheral structures). Despite increased coverage of molecular and cellular approaches, the book strives for accessibility for non-biological science students. An Introduction to Behavioral Endocrinology, Sixth Edition, is appropriate for upper-level undergraduate and graduate courses in psychology, biology, anthropology, or zoology. It contains several important pedagogical features: *Learning objectives are set out at the beginning of each chapter and now include 3 multiple choice questions per objective in the enhanced ebook. *Learning Activity in each chapter (new to this edition) *Key terms are defined in the margins throughout the text. *The text is richly illustrated with color photographs and drawings. *Chapter-end summaries restate important points. *Discussion questions and suggested further readings are also included in each chapter. *The text contains nearly 2,400 references to the literature in behavioral endocrinology. RESOURCES For Students As with previous editions, the book is accompanied by animations, video, web links, sound files, a complete glossary, and graphics-accessible via Oxford Learning Link-to aid in understanding the material in the text. This edition will also include an enhanced ebook. For Instructors -The Instructor's Resource Library includes electronic versions of all the textbook's figures and tables. All images are provided as both high- and low-resolution JPEGs, formatted and optimized for excellent legibility when projected. All figures and tables are also provided in ready-to-use PowerPoint presentations. -The Test Bank includes multiple-choice, short-answer, and essay questions for each chapter of the textbook. Prepared by the author, these questions are a helpful resource that can greatly speed the process of preparing exams and quizzes for the course.

Most endocrine diseases can be treated successfully, and the patient's state of well-being can usually be improved. Not surprisingly, the earlier the diagnosis is made the more positive the clinical response. Early Diagnosis and Treatment ( f Endocrine Disorders focuses on early signs and symptoms of endocrine disorders and surveys the appropriate tests to document the diseases as well as current recommendations for therapy. Each chapterreviews the pathophysiology of the endocrine disease-important for understanding each disorder as well as the rationale for early therapy-and the basis for the early recognition and treatment of each condition. Although the practicing endocrinologist is likely to be quite knowledgeable regarding many of these diseases, Early Diagnosis and Treatment of Endocrine Disorders includes treatment of those conditions only recently classified as endocrine disorders, such as polycystic ovarian syndrome, obesity, and hypogonadism. The book also provides new approaches that are urgently needed to slow the epidemic of type 2 diabetes, which should be an overriding concern for all clinicians. Until now, no other endocrinology text has focused primarily on the details of early recognition and therapy of endocrine disorders. The information in Early Diagnosis and Treatment of Endocrine Disorders is presented in an orderly and easy-to-follow manner, which should greatly facilitate the early recognition of endocrine diseases by medical students, house staff, primary care physicians, and endocrinologists, the four groups of clinical personnel to which this book is specificall y directed.

This book is a guide to endocrine surgery for practising and trainee endocrinologists. Divided into 45 chapters, the text begins with an overview of applied embryology, physiology, and surgical anatomy of the endocrine glands. The next section explains thyroid function tests and their interpretation. Each of the following chapters covers the surgical management of a different thyroid-related disorder. The final sections discuss allied topics including endocrine radiology, pathology, the role of nuclear medicine in endocrine surgery, and radiotherapy. Each chapter concludes with clinical pearls to assist learning. With an internationally recognised editor and author team, the comprehensive text is highly illustrated with photographs, radiographic images, flow charts, and diagrams.

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Wenn bei einem Kind Diabetes diagnostiziert wird, fragen sich Eltern, wie sie sich der Verantwortung stellen koennen und wie sich der Familienalltag verandern wird. Die Autoren, zwei Kinder- und Jugendarzte und eine Psychologin, geben luckenlos Antwort und helfen Eltern, ihre AEngste abzubauen. Sie begleiten sechs Kinder und Jugendliche mit Diabetes und zeigen, wie das Familienleben mit der Krankheit organisiert werden kann. Mit vielen Tipps und Hinweisen zu allen Fragen, die die Lebensgestaltung und die Zukunft eines Kindes mit Diabetes betreffen.

Selected as a Doody's Core Title for 2022! Ideal for all health care professionals who evaluate, diagnose, treat, or refer patients with endocrine disease or disorders, Manual of Endocrinology and Metabolism, Fifth Edition , brings together nearly 150 global authorities who share their knowledge and expertise on endocrine disorders in children, adolescents, and adults. Using a concise outline format, this thoroughly updated manual presents clinical information and protocols needed in everyday practice, with an emphasis on diagnosis and treatment. Succinct chapters and an abundance of tables and diagrams make complex information easy to find and understand. Includes coverage of fundamental understandings and treatment modalities as well as recent therapies, new methods of treatment, new understandings of endocrine physiology, and new surgical approaches to disease states Covers evaluation, pathophysiology, management, and treatment at every age of life, along with short- and long-term goals of reversibility and prevention New chapters include transgender medicine, flushing and sweating, nasal administration of hormones, the growth plate, as well as traumatic brain injury and hypopituitarism New topics include galactorrhea; preoperative, intraoperative, and postoperative management following pituitary surgery; growth hormone in adults, polycystic ovary syndrome, hypercalcemic crisis, parathyroid hormone-related protein, congenital hyperinsulinism, and hypokalemic periodic and non-periodic paralysis New and expanded coverage of diabetes mellitus includes hypoglycemia-associated autonomic failure, glucocorticoid-induced hyperglycemia, C-peptide, cystic fibrosis-related diabetes, the artificial pancreas, glycated proteins, inhaled insulin, and the application of stem cells in diabetes mellitus Serves as an excellent resource for board preparation, as well as a concise daily reference for endocrinologists, general practitioners, internists, pediatricians, physician assistants, nurse practitioners, and others who see patients with primary or underlying endocrine disease Enrich Your eBook Reading Experience with Enhanced Video, Audio and Interactive Capabilities! Read directly on your preferred device(s ), such as computer, tablet, or smartphone Easily convert to audiobook , powering your content with natural language text-to-speech Adapt for unique reading needs , supporting learning disabilities, visual/auditory impairments, second-language or literacy challenges, and more

This is the second of two "Annals" volume (see also Volume 1262) of papers by speakers at the 8th International Society for Neuroimmodulation Congress held in Dresden, Germany, October 2011. The papers focus on interactions among the immune, endocrine, and nervous systems that occur at multiple levels, from intracellular pathways by immune and neuro-endocrine mediators, to the exchange of information between the three systems that results in physiologic and adaptive effects. In certain instances, however, these interactions may be unbalanced or even disrupted, which can contribute to pathology, and aspects of such pathobiology are presented in some of the contributions. This volume aims focuses on translational science aspects of immune-neuro-endocrine interactions.

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This unique source of reference provides a comprehensive guide to the adverse side-effects of many commonly prescribed drugs on fertility and sexual health. More than 150 drugs are listed in this compilation, and the evidence linking them with infertility and sexual dysfunction is carefully reviewed. The volume is designed to provide a rapid source of reference to alert doctors and pharmacists to these hazardous side-effects. The volume also includes an introductory account of the reproductive process and a review of the mechanisms by which these drugs can interfere or inhibit reproduction. Another important theme of the volume is the effect of social and recreational drugs and environmental agents on reproductive health.

Addressing controversial and topical issues in the field of salivary gland disease and surgical management of salivary gland disease, this new edition integrates the newest clinical findings with the historical pathological records, and attempts to resolve any conflicts between the two. Fully-illustrated and updated since the first edition in 2002, it is particuarly useful for trainees sitting their final exam, because it deals with new controversial subjects which are topical at all the conferences and exam vivas.

This color atlas is a detailed guide on how to perform open, endoscopic, and robotic thyroidectomy techniques safely and effectively. Each chapter offers step-by-step descriptions of essential surgical procedures and techniques. Relevant information is included on surgical anatomy, and clear guidance is provided on preoperative set-up, draping, instrumentation, and complications and their treatment. The description of endoscopic thyroidectomy techniques focuses on the bilateral axillo-breast approach (BABA), while in the case of robotic thyroidectomy both BABA and the bilateral axillo-postauricular approach are described. In each case, the evidence supporting the technique is carefully examined. In the closing chapter, the role of new energy sources in thyroid surgery is discussed. The lucid text is supported by more than 200 full-color illustrations clarifying surgical anatomy, instrumentation, and procedures, and surgical video clips are also available to readers via a website. This atlas will be invaluable in enabling surgeons to achieve optimal outcomes when performing thyroid surgery.

In a field where even experts may find that years have elapsed since they last encountered a child with a given disorder, it is essential for the clinician to have a comprehensive source of practical and highly illustrated information covering the whole spectrum of metabolic disease to refer to. The content is divided into sections of related disorders, including disorders of amino acid metabolism, lipid storage disorders, and mitochondrial diseases for ease of reference, with an introductory outline where appropriate summarizing the biochemical features and general management issues. Within the sections, each chapter deals with an individual disease, opening with a useful summary of major phenotypic expression including clear and helpful biochemical pathways, identifying for the reader exactly where the defect occurs. Throughout the book, plentiful photographs, often showing extremely rare disorders, are an invaluable aid to diagnosis. Key Features * Fully updated to incorporate all new developments in the field * Brand new chapters cover methylmalonic aciduria of ACSF3 deficiency, branched chain keto acid dehydrogenase deficiency, serine deficiencies, purine nucleoside phosphorylase deficiency, antiquitin deficiency, and others * Excellent and detailed clinical descriptions, with numerous valuable hints and suggestions for management * Helpful explanatory algorithms and decision trees, and high-quality illustrative material including biochemical pathways and an unrivaled photographic collection, which enhance clinical applicability The fourth edition of this highly regarded book, authored by two of the foremost authorities in pediatric metabolic medicine, continues to provide incomparable insight into the problems associated with metabolic diseases and remains invaluable to pediatricians, geneticists, and general clinicians worldwide.

Diabetes mellitus is one of the leading causes of blindness worldwide, with diabetic retinopathy (DR) remaining the most common cause of eye disease for people with diabetes. Current guidelines state that all patients with diabetes should be screened for retinal problems. Diabetic Retinopathy, second edition, offers a practical, clinically focused guide to DR. Featuring 20 concise chapters this resource covers the basics of diabetes mellitus and ocular anatomy, why screening is required, the epidemiology and nature of diabetic retinopathy, as well as associated ocular diseases. It has been fully updated to include the latest trial data and newest developments in the management of diabetic retinopathy, as well as three new chapters covering patients of concern, imaging techniques in diabetic retinopathy, and an overview of treatment strategies for diabetic eye disease. Part of the Oxford Diabetes Library series, this pocketbook is a concise companion for professionals involved in screening and treating diabetic retinopathy.

Developed by a renowned group of international authors, this engaging, case-based title once again offers readers a wide range of thought-provoking case studies that reflect contemporary, challenging, hands-on clinical care. Expanded and fully updated, Endocrinology and Diabetes: A Problem Oriented Approach, 2nd Edition addresses the complete range of endocrinologic problems found in patient care, offering the reader a convenient and pointed way to solve clinical problems in a timely manner. Due to its comprehensive coverage and practical focus, this title has developed a special place in the field of endocrinology and will again be of great interest to endocrinologists, diabetologists, internal medicine physicians, family physicians, fellows, and residents. The enthusiastic reception and warm welcome of the first edition of this book was overwhelming and gratifying. Despite many standard texts that cover physiology and clinical aspects of endocrinology, this book found a special place because it focused on patient care and practical aspects of endocrine practice. In the current volume we were fortunate to again have the honor of collaboration by international authors who pride themselves foremost as clinical endocrinologists. We hope our readers will find this updated, improved edition worthwhile, and use it for the benefit of their patients.

Whether you are a student of biomedicine or medicine, trainee, resident, or endocrinology fellow, Clinical Endocrinology provides you with the core information you need to understand this notoriously complex subject. The book describes the biochemistry, physiology, and anatomy that underpin clinical practice and then integrates genuine clinical cases to show the application of this basic science in diagnosis and treatment. Key features include: a flowing narrative that leads you through the basic science boxes that provide core reference information advanced boxes that provide additional material suitable for residents and fellows case studies that link with the text and describe the presentation, diagnosis, and management of real patients further clinical material that builds on the basic science and describes the causes of endocrine disorders, their clinical features, and treatment options coverage of the latest advances and discoveries self-assessment questions to test understanding The book is lavishly illustrated throughout with line drawings and clinical photographs. The authors, one a scientist and the other a clinician, guide you through the complexities of physiology and biochemistry so that you can understand the nature and management of endocrine pathologies. At all times they relate basic science to clinical medicine in a clear and lucid style that is both practical and clinically relevant. From reviews: "Clinical Endocrinology is very well written and beautifully illustrated." Lancet Diabetes Endocrinology, January 2013 "All in all this is an excellent, essential textbook which does the job admirably in terms of synthesising the essence of human physiology and excreting a patient-centred approach to addressing the clinical manifestations of endocrine hypo- and hyper-function." The Endocrinologist, December 2013 "This book would appeal particularly to medical students or endocrinologists in training... [It] provides a useful review of endocrinology in a comprehensive manner starting from basic science principles and ending with clinical applications." Doody's Notes, May 2013 About the authors: Professor Saffron Whitehead is Professor of Endocrine Physiology at St George's Medical School, University of London Dr John Miell is a Consultant Endocrinologist at University Hospital Lewisham, London

Improving glycemic, lipid, and blood pressure outcomes is the essence of diabetes care. Maintaining consistently positive results is an ongoing challenge for every healthcare professional. After years of clinical practice, Mayer Davidson, MD, has developed a series of algorithmic techniques that can increase positive results. Based on the American Diabetes Association's Standards of care, this book offers detailed treatment algorithms that have been shown to be clinically effective in improving outcomes in people with diabetes.In this second edition, Davidson has revised and updated the algorithms to match the ever-changing ADA Standards of Care. Sections include: Laying the Groundwork: Background for Evidence-Based ADA Guidelines forStandards of Diabetes Care, Evidence-Based Principles of Dietary Therapy, Glycemia, Dyslipidemia, and Hypertension.

This comprehensive book on Endocrine Surgery covers disorders of thyroid, parathyroid, adrenal glands along with neuroendocrine tumors of pancreas and gastrointestinal tract. It is a comprehensive, up-to-date treatise covering embryology, anatomy, etiology, clinical manifestations, diagnoses, and treatment modalities of surgical endocrine diseases. The authors explore the pertinent surgical endocrinology topics with a South Asian perspective. Color illustrations, flowcharts and tables make the topics lucid for professionals. This book provides the essential information surgeons require for evaluation and management of patients, both with straight forward, and complex endocrine problems. Key Features Focusses on concise yet comprehensive, up-to-date coverage of surgical endocrine diseases Discusses Robot Assisted Endocrine Surgery and explores its impact on healthcare finances Highlights the difference between practices used in western and resource limited countries by incorporating a South Asian perspective for region specific diseases.

This book covers the scope of cranial nerve monitoring of all cranial nerves that are of practical importance in head, neck, and thyroid surgery. It discussed enhanced patient outcomes in a wide array of surgical procedures in the head and neck that require the maintenance of complex regional functions by protecting cranial nerve integrity. Organized into four parts, the book begins with Part I offering historical perspectives on the subject while simultaneously reviewing various basic and advanced electrophysiology. Part II thoroughly reviews the extra-temporal bone facial nerve (CN VII), Glossopharyngeal Nerve (CN IX), Vagal/Recurrent Laryngeal Nerve (CN X), Spinal Accessory Nerve (CN XI), and Hypoglossal Nerve (CN XII). Subsequent chapters in Part III provide a complete and applied understanding of the neurophysiological principles that facilitate the surgeon's ability to monitor any nerve and intraoperative neural stimulation and nerve monitoring. The book presents various techniques as the standard of care to provide optimal neural detection, understand the neural functional real-time status during surgery and optimize specific surgical outcomes such as thyroid surgical outcomes. Closing chapters offer essential conversations regarding ethical considerations in nerve monitoring and medical malpractice. Filling a gap in the literature, Intraoperative Cranial Nerve Monitoring in Otolaryngology: Head and Neck Surgery provides a single source for surgeons who wish to optimize their outcomes in patient care and accelerate their learning curve to the level of more experienced surgeons.

Frank Nawroth thematisiert das Social Freezing und die zugehoerige Beratung, die nicht nur Chancen, sondern auch denkbare Komplikationen und Grenzen der Methode aufzeigen muss. Zum Beispiel haben die gesellschaftspolitisch nicht optimal geloeste Problematik des moeglichen Karriere-Nachteils einer berufstatigen Mutter oder die haufig bestehende Schwierigkeit, den geeigneten Partner zu finden, bei gleichzeitig verbesserten Kryokonservierungsmethoden dazu gefuhrt, dass Frauen ohne medizinische Indikation uber das Einfrieren ihrer Eizellen nachdenken. Die Technologie selbst ist seit Langerem Routine vor fertilitatsbeeintrachtigenden Therapien onkologischer Erkrankungen (Operation, Strahlen- und/oder Chemotherapie) im reproduktiven Alter.

Written primarily for 16-19 year old students, this primer aims to extend students' knowledge and inspire them to take their school-level learning further. It explores topics that are familiar from the curriculum and also introduces new ideas, giving students a first taste of the study of biology beyond school-level and demonstrating how concepts frequently encountered at school are relevant to and applied in current research. This is the ideal text to support students who are considering making the transition from studying biology at school to university. This primer introduces students to key elements of the endocrine system, including the structure and function of the major types of hormones. It explores the role of hormones in disease, in development, in reproduction and in behaviour. Although humans are its main focus, it draws on illuminating examples from a range of other species, including sex changes and aggression in fish, metamorphosis in amphibians, induction of ovulation in different species, and bonding behaviour in birds. The final section of the book looks at ways in which hormones can be used in medicine and agriculture, and can be abused to enhance sporting performance and weight loss. This primer will expand the breadth and depth of student understanding of the endocrine system, its variety, and its huge importance.

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