Lifestyle - the manner in which people live - is fundamental to health, wellness, and prevention of disease. It follows that attention to lifestyle is critically important to effective and successful health care. But here's the challenge: health care professionals receive very little, if any, formal training about lifestyle counseling and therefore are ill equipped to incorporate lifestyle issues into clinical practice. In response, "Lifestyle Medicine" is evolving as a means to fill this knowledge gap. Lifestyle medicine approaches health and wellness by harnessing the power of lifestyle-related behaviors and influencing the environment we live in. It is a formal approach that promises to enhance and strengthen a re-invigorated health care system that is still outpaced by the epidemic proportions and complexity of chronic diseases like obesity, diabetes, depression, hypertension, and cancer, among others. Lifestyle Medicine: A Manual for Clinical Practice presents this formal approach in a pragmatic context. This unique and practical manual provides clear and succinct guidance on nearly all aspects of lifestyle medicine. The approach is both explanatory and pragmatic, providing case studies and bulleted translation of academic information into clinical practice recommendations. There is an emphasis on scientific evidence wherever possible as well as opinions by the expert chapter authors who practice lifestyle medicine. There is a "how-to" rationality to the book, consistent with a premise that any and all health care professionals should, and perhaps must, incorporate lifestyle medicine. A valuable checklist is included at the close of the book that summarizes key points and provides a practical tool for routine patient encounters.

This volume starts with an elementary introduction covering stem cell methodologies used to produce specific types of neurons, possibilities for their therapeutic use, and warnings of technical problems. In addition the authors report successes in achieving the derivation of a specific type of neuron. The dopamine neuron offers an important example and is discussed in more detail. Additional chapters cover problems obviously approachable with cells derived from stem cells, including their need in surgeries for pituitary cancers. The last chapter provides an overview of this particular field of research and presents a vision for its future directions.

Presenting the most current and relevant information on the diagnosis and management of primary ovarian insufficiency, also known as premature ovarian failure (POI/POF), this book presents two equally important voices. The first is the scientific, evidence-based voice discussing the latest information on POI/POF in a concise and logical fashion: etiologies, symptoms, genetics, mechanisms, associated conditions, as well as psychological and lifestyle considerations. The second voice presents the first-person stories of affected women, who are often faced with a diagnosis of irreversible infertility at a very young age and who somehow learn to live with great uncertainty about their ability to create a family - a core identity issue for many women. It is thus not simply a clinical, case-based presentation, but a more collaborative effort between clinicians who are well-versed in the field and women who have POI/POF. Primary Ovarian Insufficiency: A Clinical Guide to Early Menopause will therefore be an excellent practical yet personal reference for OB/GYNs, reproductive medicine specialists, and any clinician, nurse or health care worker treating women living with POI/POF.

This book examines how post-transcriptional mechanisms control endocrine function. This includes newly identified regulatory mechanisms involved in hormone biosynthesis, control of hormone receptors and the outputs of hormone mediated signal transduction. Chapters address endocrine hormones including protein peptide/peptide, steroid, and non-steroidal hormones. The impacts of these mechanisms on disease and health are covered, providing a novel update to the scientific literature. Post-transcriptional regulatory mechanisms play an essential role in controlling dynamic gene expression. The outcome of this regulation includes control of the amount, timing, and location of protein expression. Regulation is mediated by cis-acting RNA sequences and structures and transacting RNA binding proteins and non-coding RNAs, including microRNAs. Recent advances in characterization of these regulatory factors have revealed enormous regulatory potential.

This long overdue title provides a comprehensive, up-to-date, state-of-the art review of approved biologic therapies, with coverage of mechanisms of action, Indications for therapy, immunogenicity and a detailed examination of adverse effects and safety of the many and diverse therapeutic agents presented in a total of 13 chapters. It is predicted that by 2016, biologics will make up half of the world's 20 top-selling drugs and by 2018, biologic medicine sales will account for almost half of the world's 100 biggest selling drugs. Recombinant proteins dominate the growing list of the more than 200 approved biotherapeutic agents with targeted antibodies, fusion proteins and receptors; cytokines; hormones; enzymes; proteins involved in blood-clotting, homeostasis and thrombosis; vaccines; botulinum neurotoxins; and, more recently, biosimilar preparations, comprising the majority of approved biologics. Written with clinicians, other health care professionals, and researchers in mind, Safety of Biologics Therapy examines, in a single volume, the full range of issues surrounding the safety of approved biologic therapies. A good understanding of the risks and safety issues of modern biologics therapy is increasingly being demanded of all those connected with their development, handling, prescribing, administration and subsequent patient management. In addition to being of great value to clinicians in all branches of medicine, and to nurses, pharmacists and researchers, this book will prove invaluable for students taking undergraduate and graduate courses in the above disciplines and in the biomedical sciences.

This book presents the state of the art of type 2 diabetes genetics, from the process of genetic discovery to its interpretation and clinical application, and illustrates a model for other complex human phenotypes.The first section explores genome-wide association studies, the extension of this method to less accessible phenotypes and the arrival of next-generation sequencing. A further section goes beyond genetics to illustrate how other data sources can help interpret genetic data, such as leveraging population diversity, the correlation of genetic associations with physiological measurements, gene expression modulation, environmental factors and our microbial commensals. The third section describes advances in elucidating the complex path from association to function using in-depth sequencing and functional studies of the cellular and molecular effects of genes in the loci identified by genetics. The final section links our current understanding with clinically relevant questions, such as prediction, interactions with drugs or nutrients, and disease prevention, and paints a realistic but hopeful vision of the future.

In order to maximize the chance of IVF success, couples need to ensure that their preconceptual health is optimal to increase the quality of gametes and reproductive fitness. This text reviews the medical and lifestyle factors that can affect the body at preconception stage, such as micronutrients, stress, hormonal and gynecologic assessment, as well as environmental factors such as optimal weight and age for childbirth. This book will enable all medical practitioners and healthcare professionals to give evidence-based advice to influence the success rate of subsequent IVF cycles, and ensure that every child is born in the best possible condition. Part of a four-book series on optimizing different aspects of the IVF cycle, this book focusses on preparing the body for assisted conception. Other books in the series focus on the egg and embryo, the endometrium, and the sperm.

Providing the latest evidence-based information on etiology, evaluation and treatment, this unique text provides an in-depth, comprehensive discussion of the epidemiology, genetic and endocrinologic factors and medical and surgical management of recurrent pregnancy loss (RPL). Taking a multidisciplinary approach including psychological treatment and patient perspectives, all aspects of current RPL prevention and treatment are elucidated. Detailed chapters provide real-world illustrative material and cover the set-up and management of RPL clinics and databases, containing practical tips. Recurrent Pregnancy Loss will be an excellent resource for OB-GYN specialists, general and reproductive endocrinologists, radiologists, hematologists, psychiatrists, psychologists, and any other investigators or clinicians treating patients confronted with this emotionally and physically trying condition.

The Practical Manual of In Vitro Fertilization: Advanced Methods and Novel Devices is a unique, accessible title that provides a complete review of the most well-established and current diagnostic and treatment techniques comprising in vitro fertilization. Throughout the chapters, a uniform structure is employed, including a brief abstract, a keyword glossary, a step-by-step protocol of the laboratory procedures, several pages of expert commentary, key issues of clinical concern, and a list of references. The result is a readily accessible, high quality reference guide for reproductive endocrinologists, urologists, embryologists, biologists and research scientists. The Manual also offers an excellent description of novel procedures that will likely be employed in the near future. An indispensable resource for physicians and basic scientists, the Practical Manual of In Vitro Fertilization: Advanced Methods and Novel Devices is an invaluable reference and addition to the literature.

Sleep Loss and Obesity: Intersecting Epidemics represents a major contribution to the field of sleep medicine. It is a comprehensive review of the neurobiology of sleep, circadian timing and obesity, the deleterious effects of sleep loss and obesity on health, and the worrisome associated social and medical costs in a range of patient populations and overall to society. The number of individuals who are obese has reached alarming levels. As a result, the incidence of Type 2 diabetes, cardiovascular disorders, heart disease, and kidney failure have also increased. The surgeon general estimates that the total annual cost of obesity in the US is about $117 billion. This cost is expected to escalate significantly because the number of overweight and obese children is increasing rapidly. Indeed, the new generation is expected to have a shorter life-span then their parents. In addition, sleep loss is emerging as an important contributing factor to obesity. People who sleep less or are sleep deprived tend to eat more, especially carbohydrates, and have a higher body mass index. Increased weight restricts the upper airway, causing obstructive sleep apnea and further sleep loss. In the end there is a vicious cycle of weight gain and sleep loss. In the past few years there has been a tremendous growth in our understanding of brain mechanisms controlling energy metabolism. Interestingly the neurons regulating waking also regulate feeding. There is also a mechanism that regulates the timing of feeding and sleep. In shift-workers this system is likely to be disturbed, and this has an adverse impact on both feeding and sleep. Sleep Loss and Obesity: Intersecting Epidemics is the first title to clearly examine how obesity and sleep loss are interacting epidemics. This fascinating title makes the link between energy metabolism, sleep and circadian timing; identifies poor sleep as a risk-factor for obesity in children and adults and offers treatment strategies for obstructive sleep apnea and obesity. This book will be a vital source of information for all physicians interested in sleep disorders and obesity. It will also be of value to neuroscientists, health system administrators, and policy makers.

Principles of Research Methodology: A Guide for Clinical Investigators is the definitive, comprehensive guide to understanding and performing clinical research. Designed for medical students, physicians, basic scientists involved in translational research, and other health professionals, this indispensable reference also addresses the unique challenges and demands of clinical research and offers clear guidance in becoming a more successful member of a medical research team and critical reader of the medical research literature. The book covers the entire research process, beginning with the conception of the research problem to publication of findings. Principles of Research Methodology: A Guide for Clinical Investigators comprehensively and concisely presents concepts in a manner that is relevant and engaging to read. The text combines theory and practical application to familiarize the reader with the logic of research design and hypothesis construction, the importance of research planning, the ethical basis of human subjects research, the basics of writing a clinical research protocol and scientific paper, the logic and techniques of data generation and management, and the fundamentals and implications of various sampling techniques and alternative statistical methodologies. Organized in thirteen easy to read chapters, the text emphasizes the importance of clearly-defined research questions and well-constructed hypothesis (reinforced throughout the various chapters) for informing methods and in guiding data interpretation. Written by prominent medical scientists and methodologists who have extensive personal experience in biomedical investigation and in teaching key aspects of research methodology to medical students, physicians and other health professionals, the authors expertly integrate theory with examples and employ language that is clear and useful for a general medical audience. A major contribution to the methodology literature, Principles of Research Methodology: A Guide for Clinical Investigators is an authoritative resource for all individuals who perform research, plan to perform it, or wish to understand it better.

The field of microbial endocrinology is expressly devoted to understanding the mechanisms by which the microbiota (bacteria within the microbiome) interact with the host ("us"). This interaction is a two-way street and the driving force that governs these interactions are the neuroendocrine products of both the host and the microbiota. Chapters include neuroendocrine hormone-induced changes in gene expression and microbial endocrinology and probiotics. This is the first in a series of books dedicated to understanding how bi-directional communication between host and bacteria represents the cutting edge of translational medical research, and hopefully identifies new ways to understand the mechanisms that determine health and disease.

Over the past few decades, cardiovascular disease and diabetes have emerged as major public health problems, both as distinct clinical entities and as comorbid conditions. As a result, the fields of vascular biology and endocrinology are working more closely now than ever before. With chapters by renowned experts, Cardiovascular Endocrinology: Shared Pathways and Clinical Crossroads emphasizes the considerable physiological interrelationships and clinical correlations between the specialties of cardiovascular medicine and endocrinology. Offering a wealth of information, Cardiovascular Endocrinology: Shared Pathways and Clinical Crossroads provides a range of insights, including a novel view of the hormonal regulation of the vascular system and the disruption of the nitric oxide signaling system. It also addresses the role of fatty acids and cytokines in the development of this problem. Importantly, this unique title also provides a state-of-the-art update on the importance of other hormones such as thyroid hormone and steroids, as well as the pathophysiology of cardiovascular disease and controversies surrounding the use of hormone replacement therapy. In all, Cardiovascular Endocrinology: Shared Pathways and Clinical Crossroads is a first-of-its-kind title that discusses and summarizes important clinical topics in cardiology and endocrinology. It offers clinicians and researchers an important resource for navigating the increasingly interrelated pathways of cardiovascular and endocrinologic disorders. The authors discuss a range of important issues from epidemiology to bench research to translation of this research to clinical practice.

Recently, understanding the molecular pathogenesis of malignant lymphomas has led to improvement in the diagnostic precision and to the identification of a variety of molecular therapeutic targets. In addition, new drugs have been approved in the US and Europe, resulting in changes in the standard of care of several types of lymphoid malignancies. Comprehensive in scope and developed by a team of internationally renowned authors, Lymphoma: Diagnosis and Treatment provides a timely update on the most important advances in the biology, diagnosis, and therapy of lymphomas. As part of the Current Clinical Oncology series, Lymphoma: Diagnosis and Treatment will be of value to medical oncologists, hematologists, radiation oncologists, and all physicians involved in the care of patients with lymphoid malignancies.

In Diabetes and Peripheral Vascular Disease, a panel of distinguished leaders in the field of medicine, podiatry, and vascular and endovascular therapy assimilate the latest literature on these issues and others for an in-depth review of the management of peripheral vascular disease. Providing an overview of the management of diabetes and diabetic foot changes as well as providing a view of cutting-edge and emerging topics in optimization of arterial status, this important title addresses pathophysiology, anatomy, diagnosis and management of diabetic peripheral vascular disease, emphasizing a multi-disciplinary approach. The first chapter of the book provides an overview of this complex disease process and discusses the teamwork required for optimal management. The chapters continue with the basic pathophysiology of diabetic atherosclerosis and a contemporary review of the management of diabetes. The genesis of diabetic foot ulceration and prevention and management strategies is covered, as is the effects of neuropathy and microvascular changes in the diabetic foot. In addition, Diabetes and Peripheral Vascular Disease covers the microbiology of diabetic foot infections, the role of endovascular interventions and vascular surgery as well as the management of the complications of these procedures, the process of amputation for those patients who have progressed beyond a limb salvage situation, and the effects of diabetes on the cerebrovascular system as well as its implications in patients with aortoiliac disease. An invaluable addition to the literature on diabetes and peripheral vascular disease, the book will be of great interest internists, family practitioners, surgeons, podiatrists, wound care specialists, and vascular specialists. Students, residents, and fellows in surgical and medical specialties should also find this book of significant value and interest.

Comprised exclusively of clinical cases covering the diagnosis and treatment of thyroid cancer and related clinical issues, this concise, practical casebook will provide clinicians in endocrinology and oncology with the best real-world strategies to properly manage the various forms of thyroid cancer that they may encounter. Each chapter is a case report, written by recognized experts, that opens with a unique clinical presentation, followed by a description of the diagnosis, assessment and therapy, as well as the case outcome, literature review, clinical pearls and pitfalls, and bibliography. All recommendations are based on evidence-based clinical practice guidelines and recent literature. Cases included illustrate treatment for both low and high risk differentiated thyroid cancer, including surgical approaches, radioiodine therapy, and novel chemotherapies and targeted therapies, as well as postoperative follow-up and special issues. Additional cases demonstrate the management of medullary thyroid cancer, thyroid lymphoma and anaplastic thyroid cancer. Pragmatic and reader-friendly, Thyroid Cancer: A Case-Based Approach will be an excellent resource for clinical endocrinologists and oncologists, endocrine fellows, residents and students alike.

This atlas draws on a multidisciplinary approach to provide a comprehensive overview on endocrine disorders of the head and neck, with particular emphasis on the role of imaging and image-guided procedures. The first section discusses the basic characteristics of the imaging methods and other techniques used for evaluation and diagnosis. The remainder of the book focuses on application of these methods in thyroid, parathyroid, and other endocrine disorders of the head and neck. The coverage is wide ranging, encompassing Graves' disease, toxic multinodular goiter, toxic adenoma, thyroiditis, non-toxic goiter, benign nodules, and the different forms of thyroid carcinoma, as well as parathyroid adenoma, hyperplasia, and carcinoma and paragangliomas. Informative, high-quality images are provided by international experts in endocrine disorders, including endocrinologists, pathologists, radiologists, nuclear medicine physicians, and surgeons, who also discuss sample cases and provide syntheses of the relevant scientific literature.

This book is designed to capture and clinically review the comprehensive database of clinical research articles that support and do not support the utilization of a variety of dietary supplements and other complementary medicines that physicians are exposed to in their daily practice. The growing list of CAM products that could interfere with surgery (anesthesia, bleeding, outcomes...) and/or conventional medicines is very large and is provided in each section of the book. Additionally, the list of dietary supplements that could be utilized to improve quality of life for breast cancer patients is also emphasized. The various sub-specialty groups in breast are adequately represented, which allows for a physician to rapidly and thoroughly investigate their topic of interest regardless of whether the topic is prevention, treatment, or a specific side effect of treatment. The practical nature of Integrative Medicine for Breast Cancer: An Evidence-Based Assessment cannot be overstated. Chapters include a general overview of the CAM agent, whether or not it has data in medicine and oncology, and a list of potential drug interactions and specific clinical scenarios where it can be utilized or discouraged in the specialty. Thus, this book will become the gold standard evidence based text for use in teaching, not only for the students interested in oncology and breast cancer, but for all current oncology health providers.

Integrative Weight Management: A Guide for Clinicians intends to educate physicians and nutritionists about the wide ranges of approaches to weight control from non-traditional sources. The options for weight management in conventional practices are limited to a small number of medications, a confusing array of dietary approaches and surgical procedures with their inherent risks and complications. Unfortunately medical practitioners are not exposed to nutrition and weight control principles during training and thus are reluctant to manage their patients weight control issues. This volume is structured into 4 sections: Introduction to Weight Management Disorders; Morbidity and Mortality of Obesity; Therapy of Obesity; and Integrative Medicine and Obesity. Integrative Weight Management: A Guide for Clinicians represents a powerful collaboration of dozens of leading experts in the fields of nutrition, weight management and integrative medicine who have managed countless numbers of patients and summarized the research from thousands of articles to create an up-to- date state of the art guide for healthcare practitioners, allied health professionals and public health authorities who manage those who are overweight/obese along with the associated metabolic consequences.

Immunoendocrinology is a rapidly developing field of research that seeks to understand the intersection of the immune and endocrine systems. Immunoendocrinology: Scientific and Clinical Aspects explores in detail the current knowledge of immunoendocrinology, namely endocrine disorders produced by disorders of immune function. Chapters cover both basic pathophysiology informed by studies of animal models as well as current understanding of multiple related clinical diseases-their pathophysiology, diagnosis, and therapy. Immunoendocrinology: Scientific and Clinical Aspects captures the central role of immunoendocrinologic processes in the pathogenesis of not only type 1 diabetes but in a range of other autoimmune and endocrine disorders.

Surgical pathology is the cornerstone in the management of neoplastic disorders. Written for the practicing surgical pathologist in mind, Surgical Pathology of Endocrine and Neuroendocrine Tumors provides an up-to-date text on surgical pathology of endocrine and neuroendocrine tumors. The text begins with radiological imaging of tumors, followed by a section on fine needle aspiration biopsy. The main section focuses on surgical pathology of endocrine and neuroendocrine tumors. The volume closes with applications of molecular techniques and their potential for the future. Surgical Pathology of Endocrine and Neuroendocrine Tumors is written by a panel of internationally recognized pathologists who are not only experts in their fields, but who also contribute their own valuable insights making this new book an essential resource for practicing general and specialist surgical pathologists and pathologists in training.

An exciting contribution to the field, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement is designed with two overriding objectives: to help readers understand the impact of vision impairment in people living daily with diabetes rather than considering diabetic retinopathy solely as a medical problem, and to explore what we know and don't know about the ways diabetes affect the eye. With the plethora of new information being generated, there are still a series of fundamental questions that must be addressed if effective treatments for diabetic retinopathy are to be found and applied. Developed by a renowned group of authorities, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement offers responses and context for a range of questions, such as: do metabolic factors beyond glucose contribute to vision-threatening diabetic retinopathy? If so, how do these lead to vision impairment? Is diabetic retinopathy a response to systemic metabolic abnormalities or are there unique ocular problems related to insulin resistance? What is the relationship between the neural, vascular, and inflammatory abnormalities in diabetic retinopathy? Do they represent a pathological cascade induced sequentially or simultaneous responses to one or more metabolic perturbations? The authors note that if we do not address these types of questions, it is possible that the long process of developing new therapeutic s will target only one arm of the pathology and leave the retina open to damaging consequences of the others. State-of-the-art, comprehensive, and an invaluable addition the research and clinical literature, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement offers guidance and a significant step toward new scientific approaches that can lessen the devastating vision impairment associated with diabetes.

Insulin-like growth factors (IGFs), their binding proteins and their receptors play important roles in regulating growth, metabolism, proliferation and survival for many cells and tissues throughout lifespan in humans and other species. Circulating IGF1 is known to be an endocrine regulator, with metabolic effects related to, and partly convergent with, insulin signalling. IGF1 also mediates many of the growth promoting effects of GH, and there is an ongoing debate as to the relative contributions of endocrine-, vs locally-derived IGF1 for systemic growth. More recently however, it has become clear that IGFs may be key local growth and cellular survival factors for many different tissues, active from early in embryonic development, essential for normal maturation and growth during foetal life. IGFs continue to play important roles throughout adult life in many diverse processes such as tissue repair, cellular proliferation, tissue remodelling and metabolic regulation. IGF systems are tightly regulated; orderly control of cellular repair and metabolism is central to healthy ageing, whilst uncontrolled proliferation can lead to cancer.

This book is based on the authors' extensive practical experience in the use of modern radiological methods to diagnose parathyroid diseases and the application of advanced surgical techniques. Detailed attention is devoted to the embryological background to emphasize the significance of diagnostic and surgical peculiarities. Pre- and intraoperative imaging is discussed in depth, with a special focus on localizing techniques. Ultrasound-guided minimally invasive techniques, including percutaneous laser ablation, are fully considered. This up-to-date and richly illustrated book will interest and assist specialists in ultrasound diagnostics, radiologists, endocrinologists, and surgeons.

The decade that has passed since publication of the second edition of this textbook has not only witnessed a tremendous increase in knowledge within the ? eld of and- logy, but also seen the ? eld itself achieve a newfound status within the medical p- fession. Knowledge and status have been of mutual bene? t to the ? eld and the growing critical mass of diagnostic and therapeutic possibilities have caused andrology to be recognized as a medical subspecialty in some countries such as Germany, Poland, and Estonia. The European Academy of Andrology (EAA) served as a pacemaker for this development and continues to strive for establishment of andrology as a clinical ? eld. Well-designed curricula and qualifying examinations have contributed to the of? cial recognition of andrology as a speciality. This recognition of the ? eld helps patients with andrological problems to ? nd the specialist they seek. This textbook summarizes the current state of knowledge in the ? eld of andrology. It is a source of knowledge to all those who are or want to become andrologists. In addition, as andrology is clearly an interdisciplinary ? eld, this book may serve as a compendium and source of reference for all those physicians and biologists active in neighboring areas, who want to obtain an overview of andrology and who require information on special problems. The extensive references are timely and up to date.