Bone Marrow Diagnosis, Third Edition, is an essential resource for pathologists and haematologists who need to report bone marrow trephine biopsies. Practical and highly illustrated this edition has been comprehensively updated whilst remaining succinct and concentrating on the core information necessary to make an accurate diagnosis. The text provides comparisons of the common methods of sample collection, fixation and staining, and a clear description of how to examine a trephine section. Applying a consistent approach, the chapters cover the range of disorders of bone marrow, discussing the clinical features, histopathology of bone marrow and diagnostic problems of each condition. Each chapter closes with a summary of key points and each diagnostic entity is accompanied by high quality images, over 900 in all, showing typical and more unusual examples of histological features. This compact text, oriented at diagnosis and comprehensively accompanied by usable illustrations, is an invaluable reference tool for the trainee and practicing histopathologists, pathologists and haematologists. * A practical guide aimed at allowing a busy pathologist to easily find the essential description and illustration of the most common bone marrow diseases seen in trephines * Covers new treatment for chronic myeloid leukaemia, B-cell lymphoma and antibody treatments * High quality colour images accompany each diagnostic entity * Coverage of cytology in sections relating to myeloid dysplasias and acute leukaemias * Addresses lymphoma categorization and individual lymphoma entities * Incorporates new WHO classifications of lymphomas and leukaemias

Now in a revised and expanded third edition, this case-based guide emphasizes the latest investigative advances in both imaging and molecular diagnostics and new treatment approaches for a wide variety of common and complex endocrine conditions. Utilizing unique clinical case histories, each main endocrine condition and disorder is curated by a senior Section Editor with an introduction to his or her area covering both physiology and pathophysiology. This introductory chapter is followed by a number of case histories written by invited experts and designed to cover the important relevant pathophysiology, following a consistent chapter format for ease of use, including bulleted objectives, case presentations, review of the diagnosis, lessons learned, and 3-5 multiple-choice review questions. Section headings include the pituitary, thyroid (overactivity, underactivity and cancer) and parathyroid, adrenal disorders, metabolic bone disease, type 2 diabetes, lipid abnormalities, obesity, and pregnancy. Topics new to this edition include PCOS, transgender medicine and the endocrine effects of viral infections. With a focus on covering major parts of the APDEM curriculum, A Case-Based Guide to Clinical Endocrinology remains a tremendous resource for junior and veteran clinicians alike.

There is great concern regarding the reproductive and health hazards of endocrine disruptors. Research indicates that men are experiencing declining fertility and an increased incidence of prostate cancer, while women are dealing with increased infertility, early menopause, and breast cancer. As new research reveals the previously unknown risks of these endocrine disruptors, it is imperative to update our knowledge of these controversial chemicals. Endocrine Disruptors: Effects on Male and Female Reproductive Systems, Second Edition examines the reproductive and health hazards of endocrine-disrupting environmental chemicals from epidemiology to etiology, concluding with future directions. Divided into two sections, the first part of the book describes the effects of environmental toxicants on the female reproductive system, with an emphasis on the effects and mechanisms of their action on sex differentiation during development, fertility, and breast cancer. The second part addresses the effects of endocrine disruption on the male reproductive system, focusing on male fertility and the development of benign prostate hyperplasia (BPH) and prostate cancer. Leading authorities contribute expert analyses and up-to-date information on a topic that has become a major concern among the scientific community and the general public. This second edition supplies the most current, critical knowledge on the real risks that endocrine disruptors pose to the population.

Clearly presented and thoroughly up to date, this important text provides an overview of current knowledge of the polycystic ovary syndrome (PCOS) - its etiology, pathology, and the implications for effective medical management. In contrast with existing titles, this book focuses on the difficulty in making an accurate diagnosis and the consequential problem of identifying the most effective program of management. Key features: * coherent approach, integrating international contributions * first book on PCOS since the Rotterdam Consensus meeting * focuses on clinical manifestations of disease, diagnostic criteria and options for management * illustrated with tables, graphs and charts to explain physiologic principles. Among the most important consequences of PCOS is infertility, and the authors provide clear guidance on the role of new assisted reproductive technologies to overcome this problem.

It is no secret that the United States is facing an obesity epidemic with the obesity rates continuing to rise year after year. According to the Center for Disease Control, one third of Americans are now obese. It is no longer sufficient to simply point out the health risks of obesity to our patients as the reason to lose weight. Patients are seeking guidance in terms of what specific diet plan to follow and what foods should be eaten. There are thousands of diets on the market with new ones introduced daily. Not all diet plans have proven results, nor will they work for every patient. More importantly, not all diets marketed to the public are safe to follow for an extended timeframe. In fact, research shows us that diet composition is not the key to long term success, but compliance to a calorie deficient diet is the solution. So how does one choose which diet plan to recommend to patients? Finally, a book for clinicians is here to help answer this question. This book provides information to help patients understand several different research proven diets on the market today including: the Atkins diet, the DASH (Dietary Approaches to Stop Hypertension) diet, the I diet, the Mediterranean diet, Paleo Diets, South Beach, Vegetarian diets, Weight Watchers, and the Zone diet. Each diet is carefully and thoroughly reviewed in this book by some of America's top obesity medicine and weight management specialists to provide health practitioners a knowledge of the diet composition, current research evaluating the diet, typical weight loss results, the pros and cons of the diet as well as which patients would most benefit from each diet plan. This book provides the necessary tools for clinicians to feel comfortable discussing several of the more popular and scientifically researched diets with patients. This book offers solid information to advise patients, based on their specific health history, on which diet will afford the greatest chance for success.

Providing experimental methods and protocols for performing pheromone research in a variety of organisms ranging from invertebrates to vertebrates, Pheromone Signaling: Methods and Protocols covers a wide spectrum of experimental approaches necessary for handling pheromone molecules, measuring receptor response and neural activation, and analyzing behavioral output. A great deal of progress has been made in understanding the molecular mechanisms underlying pheromone action, largely due to the discovery of receptor genes, the advancement of imaging techniques, and key multi-disciplinary approaches including aspects of organic chemistry, biochemistry, molecular biology, electrophysiology, and behavioral science. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips for troubleshooting and avoiding known pitfalls. Authoritative and practical, Pheromone Signaling: Methods and Protocols details the key methodologies utilized in laboratories all over the world, making them accessible to those who want to begin investigation in the area of pheromone research.

1.1 Historischer UEberblick.- 1.2 Wirkungsmechanismus.- Indikationen.- 2.1 Benigne Erkrankungen.- 2.1.1 Struma mit Euthyreose.- 2.1.2 Funktionelle Autonomie.- 2.1.3 Immunogene Hyperthyreose.- 2.2 Maligne Erkrankungen.- Praktische Durchfuhrung.- 3.1 Strahlenschutzvoraussetzungen/ neue gesetzliche Bestimmungen.- 3.2 Dosiskalkulation - Radiojodtest.- 3.3 Durchfuhrung der Therapie.- 3.4 Bauliche Voraussetzungen.- Ergebnisse.- 4.1 Benigne Erkrankungen.- 4.1.1 Euthyreote Struma.- 4.1.2 Funktionelle Autonomie.- 4.1.3 Immunogene Hyperthyreose.- 4.2 Maligne Erkrankungen.- Nebenwirkungen.- 5.1 Benigne Erkrankungen.- 5.2 Maligne Erkrankungen.- Nachsorge und medikamentoese Nachbehandlung.- 6.1 Benigne Erkrankungen.- 6.2 Maligne Erkrankungen.- Literatur.- Anhang A Verzeichnis der deutschen Therapiezentren.- Anhang B Leitlinien zur Radiojodtherapie.- Leitlinien der Deutschen Gesellschaft fur Nuklearmedizin Leitlinie zur Radiojodtherapie (RIT) beim differenzierten Schilddrusenkarzinom (Stand des Entwurfs 25.1.99).- Leitlinien der Deutschen Gesellschaft fur Nuklearmedizin Leitlinie zur Radiojodtherapie (RIT) bei benignen Schilddrusenerkrankungen (Stand des Entwurfs 25.1.99).- Sachferzeichnis.

Mammalian Endocrinology and Male Reproductive Biology provides comprehensive and current coverage of the area of endocrinology and male reproductive biology, covering not just humans, but mammals in general. Written by international experts in their respective fields, this multi-author book also covers the latest developments in genomics of androgen action and male infertility. The book begins by covering sexual dimorphism in the central nervous system; structure, control of secretion and function of GnRH; and gonadotropins of pituitary origin and their role in gonadal functions. This is followed by an account of hormonal regulation of spermatogenesis, and the role of apoptosis in this process. Subsequent chapters center around epididymis, regulation of growth and function, and sperm motility regulation. The last chapters in the book discuss the structure and function of male accessory sex glands with associated pathologies as well as recent updates in male contraception, mechanism of androgen action, and genomics of male infertility. Wherever necessary, tables and figures have been added for a better understanding. Each chapter is appropriately referenced and contains current information on the latest developments in the field.

Oxidative modification of lipids and phospholipids-including radical damage, halogenation, and nitration-result in significant changes to the chemical properties of the molecules, which in turn have a major effect on their biochemical functions. Lipid oxidation has long been regarded as a deleterious process responsible for lipid rancidity, loss of function, and generation of toxic products. However in recent years, research has also focused on the non-detrimental physiological and pathological effects of these chemical reactions. Lipid Oxidation in Health and Disease provides an up-to-date review of the role of oxidized lipid products in physiological and pathophysiological processes. Covering the diverse topics that contribute to research in this important field, this book explores: The mechanisms of lipid oxidation, both enzymatic and non-enzymatic Antioxidant defenses and lipid oxidation Lipid oxidation products and cell signaling The roles of oxidized lipids in specific diseases-including cardiovascular, neurodegenerative, and metabolic disorders, as well as in cancer Drug targeting and the therapeutic potential of oxidized lipids Accurate measurement of the formation of lipid oxidation products and investigation of their biological effects and roles in disease are critical to biomedical science and new targeted therapeutics. Written by acknowledged experts in the field, this book provides a broad survey of both established knowledge and recent findings on the action of oxidized lipid products on cell signaling and gene expression in health and disease.

Model Animals in Neuroendocrinology: From Worm to Mouse to Man offers a masterclass on the opportunities that different model animals offer to the basic understanding of neuroendocrine functions and mechanisms of action and the implications of this understanding. The authors review recent advances in the field emanating from studies involving a variety of animal models, molecular genetics, imaging technologies, and behavior assays. These studies helped unravel mechanisms underlying the development and function of neuroendocrine systems. The book highlights how studies in a variety of model animals, including, invertebrates, fish, birds, rodents and mammals has contributed to our understanding of neuroendocrinology. Model Animals in Neuroendocrinology provides students, scientists and practitioners with a contemporary account of what can be learnt about the functions of neuroendocrine systems from studies across animal taxonomy. This is the seventh volume in the Masterclass in Neuroendocrinology Series, a co-publication between Wiley and the INF (International Neuroendocrine Federation) that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology.

The European Workshop on Molecular and Cellular Endocrinology of the Testis was organized for the first time at Geilo, Norway, 8-11 April 1980. Since then, these meetings have been held in Holland, France, Italy, England, Sweden/Finland (Aland), Germany, and Bel- gium. This year the circle has been closed: The 9th European Testis Workshop is back in the Norwegian mountains where it all started. The Scientific Committee of the First European Testis Workshop included Dr. H.J. van der Molen (Rotterdam), Dr. V. Hansson (Oslo), Dr. B. Cooke (London), Dr. V. Monesi (Rome), Dr. E.M. Ritzen (Stockholm), and Dr. J.M. Saez (Paris). Since then, two of the founders have left the Scientific Committee. Dr. Monesi died suddenly on 29 December 1979, 3 1/2 months before the first workshop took place. Thus, in spite of being one of the founders, he never experienced a Eu- ropean Testis Workshop. Dr. Mario Stefanini, from the same research institute in Rome, replaced Dr. Monesi on the Scientific Committee. Another founder of this workshop series, Dr. H.J. van der Molen (Rot- terdam), is one of the pioneers in research on molecular endocrinology of the testis in Europe. He left the Scientific Committee due to a change in his scientific career and was replaced by Dr. F.F.G. Rom- merts, whose lectures on "Testomania" have been a characteristic fea- ture of these meetings.

This book covers the scope of cranial nerve monitoring of all cranial nerves that are of practical importance in head, neck, and thyroid surgery. It discussed enhanced patient outcomes in a wide array of surgical procedures in the head and neck that require the maintenance of complex regional functions by protecting cranial nerve integrity. Organized into four parts, the book begins with Part I offering historical perspectives on the subject while simultaneously reviewing various basic and advanced electrophysiology. Part II thoroughly reviews the extra-temporal bone facial nerve (CN VII), Glossopharyngeal Nerve (CN IX), Vagal/Recurrent Laryngeal Nerve (CN X), Spinal Accessory Nerve (CN XI), and Hypoglossal Nerve (CN XII). Subsequent chapters in Part III provide a complete and applied understanding of the neurophysiological principles that facilitate the surgeon's ability to monitor any nerve and intraoperative neural stimulation and nerve monitoring. The book presents various techniques as the standard of care to provide optimal neural detection, understand the neural functional real-time status during surgery and optimize specific surgical outcomes such as thyroid surgical outcomes. Closing chapters offer essential conversations regarding ethical considerations in nerve monitoring and medical malpractice. Filling a gap in the literature, Intraoperative Cranial Nerve Monitoring in Otolaryngology: Head and Neck Surgery provides a single source for surgeons who wish to optimize their outcomes in patient care and accelerate their learning curve to the level of more experienced surgeons.

This unique pocket guide to endocrinology and diabetes has been fully revised for the new edition. Written in conjunction with the Oxford Textbook of Edncrinology and Diabetes, it covers clinical investigation and management of both common and rare conditions, and includes the protocols and explicit clinical information necessary for the management of individual patients with endocrine and diabetic disorders.
The second edition includes new chapters on complementary therapies, chronic fatigue, and endocrine replacement therapies, as well as the latest guidelines and information on new therapies. There are also epxanded section on paediatrics, thyroid disorders, and reproduction--including male and female HRT. Numerous diagrams are included to illustrate important conditions, and the revised design and layout aid quick reference with useful summary boxes. Fully reviewed by an expert panel of referees, ensuring that it continues to provide high-quality information of international standing, this is the indispensable companion for all those caring for patients with endocrine or diabetic problems.

This book addresses and summarizes the main andrological disorders (genital, reproductive or sexual diseases) that may originate in childhood or adolescence. Since many of the andrological diseases that occur in adulthood originate before the age of 18 and sometimes even during gestation, andrological evaluation is essential during childhood to highlight anomalies in the genital organs. During puberty, evaluation can help to monitor growth and secondary sex characteristics, and to assess e.g. the possible presence of an eunucoid habitus, gynecomastia, testicular hypotrophy or varicocele, a very common pathology in young people. During adolescence, the assessment of risk factors, such as those related to certain lifestyles, is of fundamental importance for primary prevention. Moreover, in late adolescence the focus shifts to preventing sexually transmitted infections, or to dealing with possible discomforts related to the sexual sphere. Finally, ensuring young people's genital and sexual health also means protecting their fertility. Written by respected experts in the field, this book constitutes an innovative resource, combining updated, reliable and comprehensive information with agile consultation in order to provide a streamlined approach to the care of children and adolescents with such disorders.

This book will provide readers with up-to-date information on thyroid diseases, obesity and metabolic syndrome. The innovative element is the presentation and exploration of possible connections linking thyroid diseases and metabolism dysfunction. Starting from the classification and diagnosis of thyroid diseases, obesity and metabolic syndrome, techniques to study and treat each of the mentioned diseases are given in an easy-to-use way. This volume will be a useful tool for endocrinologists, diabetologists, dieticians, and any professionals involved in the treatment of thyroid diseases.

In this book the authors share the strategies and procedures they use in their clinical daily practice to assess and treat complex cases of eating disorders. The strategic and pragmatic approach to the management of medical and psychiatric comorbidity coexisting with eating disorders, while relying on enhanced cognitive behavioral therapy (CBT-E) - an evidence-based treatment recommended for all eating disorder categories both in adults and adolescents-, can also be used by clinicians who adhere to different theoretical models. The book is divided into two main parts. Part I describes the eating disorder psychopathology and its consequences: an essential knowledge essential to understanding whether the patients have true comorbidity or spurious comorbidity. Then it gives an overview of CBT-E and how to implement it at different levels of care and in a multidisciplinary team. Part II illustrates the general strategies to address comorbidity in patients with eating disorders, and the specific strategies and procedures for managing the most common mental and general medical conditions coexisting with eating disorders. This volume is a valuable and useful tool for all clinicians - endocrinologists, nutritionists, dietitians, psychologists, psychiatrists - who deal with obesity and eating disorders.

This book aims to address a number of controversies concerning the use of testosterone treatment. It explains topics that clinicians regularly encounter such as whether to use free or total testosterone in the evaluation of the patient with testosterone deficiency; what factors actually impact testosterone levels, polycythemia, gynecomastia, bone density, and hyperprolactinemia in the testosterone deficient patient; critical analysis of the numerous questionnaires that are available to clinicians; and the impact of testosterone therapy on male fertility, cardiovascular disease, and prostate events including prostate cancer. Guiding the reader in both evaluation and management, the book also illuminates novel concepts in the T space such as testosterone use in the transgender population, T therapy as an endothelial modulator, bipolar testosterone therapy in the patient with advanced prostate cancer, and testosterone therapy as a performance enhancer. Controversies in Testosterone Deficiency is intended for any clinician involved in the care of patients with testosterone deficiency, exploring hot topics and correcting existent misinformation in the routine care of patients.

This new volume in the Reproductive Medicine for Clinicians series focuses on the practical clinical impact of problems linked to infertility, discussing topics such as luteal support in ART cycles, ovulation induction using pulsatile administration of GnRH, how to deal with the metabolic changes in PCOS, treatment to restore fertility in endometriosis and how to improve implantation, which are common aspects of daily clinical practice. It also addresses significant novel areas like the biological clock in human reproduction, reproduction at advanced parental age and medical and social egg freezing, offering valuable insights for patients and their doctors. Further, the book covers various areas of growing importance, such as how to access the uterine cavity; the future of imaging in reproduction; non-invasive prenatal testing; ART and male infertility; as well as breast cancer and fertility preservation. Last but not least, it examines the medical, ethical and legal aspects of a number of challenges for current and future reproductive medicine, including uterine transplantation and human genetic modification. Bringing together updates on some of the most important problems in reproductive medicine and also covering ethical and legal bases, this book offers an overview of potential treatments for infertility. As such, it is a valuable resource for gynecologists, obstetricians, endocrinologists and all specialists dealing with reproductive health.