A full-color guide to the entire field of clinical endocrinology and its scientific underpinnings - updated with the latest breakthroughs and developments Greenspan's Basic & Clinical Endocrinology delivers a succinct, leading-edge overview of the underlying molecular biology of the endocrine system and the latest perspectives on the diagnosis and treatment of specific diseases and disorders. Featuring an enhanced design that includes hundreds of full-color illustrations and clinical photographs, Greenspan's is a true must-have during traditional or integrated courses in endocrinology, endocrinology rotation, or exam prep in internal medicine and endocrinology and as reference for disease management. Greenspan's provides clinically relevant coverage of metabolic bone disease, pancreatic hormones and diabetes mellitus, hypoglycemia, obesity, geriatric endocrinology, and many other diseases and disorders. Supporting this essential material is a handy appendix of normal hormone reference ranges across the lifespan. Here's why Greenspan's is an essential tool for learning how to manage endocrine patients: * The Tenth Edition is enhanced by updated content throughout each chapter * NEW CHAPTERS on Transgender Endocrinology and Disorders of Sexual Determination and Differentiation * Important chapter on Evidence-Based Endocrinology and Clinical Epidemiology * Concise, balanced coverage of both scientific and clinical principles that guide patient management * The best source for current concepts in endocrine pathophysiology to aid clinical decision making * The most practical, current insights into diagnostic testing * More than 270 full-color illustrations and clinical photographs If you are in need of a well-illustrated, completely up-to-date guide to the entire field of clinical endocrinology, this trusted classic belongs on your desk or computer.

Symposium on Lipoprotein Metabolism, held in Heidelberg, September 10-13, 1975

Endocrinology is a rapidly developing field with many new concepts. In addition, many new hormones have been described since 1960. The structural analysis and synthesis of several intestinal hormones such as gastrin, secretin, glucagon and cholecystokinin have been achieved. Several hypothalamic hormones controlling pituitary function have been identified and in certain cases synthesized. The existence of hormonal peptides se creted from ectopic sites has been recognized. The development of new techniques of hormone assay has stimulated studies on the effects of anesthetics on the endocrine system. Although the endocrine response to anesthesia is less than its response to major surgical procedures, the effects of anesthesia on metabolism and on the autonomie nervous system are substantial. The primary purpose of this book is to increase the safety of patients undergoing anesthesia by making available the latest developments in this field. The major subjects examined in the book are endocrine responses to anesthesia and surgery, the effects of endocrine disease on anesthesia and sur gery, and pre-operative and post-operative management of patients with endocrine disease. The book is designed for students, residents and practicing physicians in the field of anesthesia and surgery. Many tables and figures are empIoyed to improve the presentation, particuIarly those relating to pharmacology and to the practical aspects of therapy."

The Hunt for the Parathyroid Gland is a part fact, part fiction overview of the discovery of the parathyroid gland by a Swedish scientist in 1880.

The discovery of the parathyroid gland in humans in 1880 by an unknown Swedish medical student, Ivar Viktor Sandstrom, ended a 30 year search for its exact location within the human body, following its discovery in an Indian rhino 30 years before. It is one of the most engaging and remarkable stories in the history of medicine. This book offers a fascinating insight into its discovery.

Endocrinologists and ENT health professionals, both in clinical practice and researchers, as well as anyone with an interest in the history of medicine, will find this a fascinating insight into one of the 19th century's key medical discoveries.

This 7th edition is a milestone in the series of Inborn Metabolic Diseases (IMD), recognised as the standard textbook for professionals involved in the diagnosis and management of IMD. Within the last 5 years a Copernican revolution in our understanding of IMD has changed the definition, concepts, paradigms, and classification. This new edition now extends the concept of IMD to include those disturbances in molecular machinery diagnosed by molecular techniques but currently without measurable metabolic markers. The book presents a clinical and biochemical approach to the diagnosis and management of IEM with many diagnostic algorithms for patients of all ages and with a particular focus on neurological presentations. It includes separate, comprehensive sections on IEM classified in 3 major pathophysiological categories: disorders of energy metabolism, both mitochondrial and non-mitochondrial; small molecule disorders, mostly diagnosed with metabolic markers; and complex molecules disorders, mostly diagnosed with molecular techniques. Two new chapters were added, describing around 600 disorders of nucleic acid metabolism, tRNA metabolism, ribosomal biogenesis, and cellular trafficking.

How the Endocrine System Works is not another standard introduction to endocrinology, but an innovative and fun way to learn about the importance of the key glands in the human body and the hormones they control. It is explained in 9 easy-to-understand lectures, with additional material on the treatment and management of endocrine disorders. How the Endocrine System Works: Is designed for those in need of a concise introduction to this fascinating area of medicine Has been rigorously updated to reflect today s endocrinology teaching Includes more focus on the treatment and management of endocrine disorders Features more on evidence-based medicine, obesity, epidemiology, and biostatistics Includes summaries of key research which affects diagnostic criteria Includes brand new case-based review questions at the end of each chapter Features full-color diagrams throughout How the Endocrine System Works is the perfect introduction for all medical students, as well as for students of bioscience, and other healthcare disciplines.

It is no secret that the United States is facing an obesity epidemic with the obesity rates continuing to rise year after year. According to the Center for Disease Control, one third of Americans are now obese. It is no longer sufficient to simply point out the health risks of obesity to our patients as the reason to lose weight. Patients are seeking guidance in terms of what specific diet plan to follow and what foods should be eaten. There are thousands of diets on the market with new ones introduced daily. Not all diet plans have proven results, nor will they work for every patient. More importantly, not all diets marketed to the public are safe to follow for an extended timeframe. In fact, research shows us that diet composition is not the key to long term success, but compliance to a calorie deficient diet is the solution. So how does one choose which diet plan to recommend to patients? Finally, a book for clinicians is here to help answer this question. This book provides information to help patients understand several different research proven diets on the market today including: the Atkins diet, the DASH (Dietary Approaches to Stop Hypertension) diet, the I diet, the Mediterranean diet, Paleo Diets, South Beach, Vegetarian diets, Weight Watchers, and the Zone diet. Each diet is carefully and thoroughly reviewed in this book by some of America's top obesity medicine and weight management specialists to provide health practitioners a knowledge of the diet composition, current research evaluating the diet, typical weight loss results, the pros and cons of the diet as well as which patients would most benefit from each diet plan. This book provides the necessary tools for clinicians to feel comfortable discussing several of the more popular and scientifically researched diets with patients. This book offers solid information to advise patients, based on their specific health history, on which diet will afford the greatest chance for success.

100 years of Human Chorionic Gonadotropin: Reviews and New Perspectives is a collection of articles written by some of the world's leading experts on the pregnancy hormone and cancer marker hCG. In 2019 it is difficult to ignore the effect that our understanding of hCG has had on the lives of millions of people worldwide. The hCG immunoassay, in one form or another, is now one of the most common medical tests conducted and is often the first indication that a mother-to-be is pregnant. Not only a marker of pregnancy, hCG is utilized in the diagnosis and monitoring in oncology and presents a potential target for novel cancer therapeutics. 100 years ago, in 1919, Hirose was demonstrating gonadotropic functions which resulted from a chorionic factor. Over the last century this factor has become defined as hCG and more recently explored as not one molecule but a group of molecules with variable structure and variable functions in both pregnancy and cancer. hCG is a multi-faceted molecule that has clinical and therapeutic implications but can be a challenging topic for researchers and physicians alike. This text covers the different structures and functions of hCG exploring the genes and evolution of the molecule, the different protein and glycosylation structures which can exist and their effect on structure, detection and quantification. 100 Years of hCG is not an attempt to recount the history of every publication on hCG, but rather a collection of reviews and new perspectives by "hCG-ologists", the term used by Hussa to describe biochemists working on HCG in the first book written on the topic over 30 years ago. Some of the authors have been around a while, some not so long, but others are just beginning their journey with a most beguiling molecule.

A comprehensive guide to addressing the growing epidemic of thyroid disease from the perspective of the Ayurvedic tradition In this comprehensive guide for practitioners and those concerned with thyroid health, Marianne Teitelbaum, D.C., integrates the ancient medicine of Ayurveda with modern scientific findings to address the growing epidemic of thyroid disease. Revealing how the thyroid is the victim of many factors that conspire to create ill health--and how many cases of thyroid disease go undiagnosed--Teitelbaum focuses not only on treating thyroid problems and symptoms but also on diagnosing them at their earliest, most reversible stages. She outlines the basic principles of Ayurveda, including pulse diagnosis, a key tool for early detection, and explains the successful treatment protocols she has developed over more than 30 years of Ayurvedic practice. She details the underlying reasons for thyroid malfunction, such as inflammation, malnutrition, and toxins, and how the thyroid is connected with the health of the rest of body, including the liver and gall bladder. She explores the Ayurvedic treatment of thyroid-related conditions, such as Hashimoto's disease, hypothyroidism, and hyperthyroidism, offering guidance on the targeted use of herbs, specific dietary recommendations, proper detoxification, and Ayurvedic recipes. She also includes treatments and remedies for common symptoms of thyroid disease, including insomnia, depression, fatigue, and osteoporosis, as well as for luxurious hair growth and weight loss. Based on the treatment of more than 90,000 patients, this book also shares success stories of thyroid healing and the scientific studies that support the author's Ayurvedic thyroid protocols. Offering an easy-to-follow yet comprehensive guide, Teitelbaum shows that optimum thyroid health as well as overall health are within everyone's reach.

There is great concern regarding the reproductive and health hazards of endocrine disruptors. Research indicates that men are experiencing declining fertility and an increased incidence of prostate cancer, while women are dealing with increased infertility, early menopause, and breast cancer. As new research reveals the previously unknown risks of these endocrine disruptors, it is imperative to update our knowledge of these controversial chemicals. Endocrine Disruptors: Effects on Male and Female Reproductive Systems, Second Edition examines the reproductive and health hazards of endocrine-disrupting environmental chemicals from epidemiology to etiology, concluding with future directions. Divided into two sections, the first part of the book describes the effects of environmental toxicants on the female reproductive system, with an emphasis on the effects and mechanisms of their action on sex differentiation during development, fertility, and breast cancer. The second part addresses the effects of endocrine disruption on the male reproductive system, focusing on male fertility and the development of benign prostate hyperplasia (BPH) and prostate cancer. Leading authorities contribute expert analyses and up-to-date information on a topic that has become a major concern among the scientific community and the general public. This second edition supplies the most current, critical knowledge on the real risks that endocrine disruptors pose to the population.

Clearly presented and thoroughly up to date, this important text provides an overview of current knowledge of the polycystic ovary syndrome (PCOS) - its etiology, pathology, and the implications for effective medical management. In contrast with existing titles, this book focuses on the difficulty in making an accurate diagnosis and the consequential problem of identifying the most effective program of management. Key features: * coherent approach, integrating international contributions * first book on PCOS since the Rotterdam Consensus meeting * focuses on clinical manifestations of disease, diagnostic criteria and options for management * illustrated with tables, graphs and charts to explain physiologic principles. Among the most important consequences of PCOS is infertility, and the authors provide clear guidance on the role of new assisted reproductive technologies to overcome this problem.

Bone Marrow Diagnosis, Third Edition, is an essential resource for pathologists and haematologists who need to report bone marrow trephine biopsies. Practical and highly illustrated this edition has been comprehensively updated whilst remaining succinct and concentrating on the core information necessary to make an accurate diagnosis. The text provides comparisons of the common methods of sample collection, fixation and staining, and a clear description of how to examine a trephine section. Applying a consistent approach, the chapters cover the range of disorders of bone marrow, discussing the clinical features, histopathology of bone marrow and diagnostic problems of each condition. Each chapter closes with a summary of key points and each diagnostic entity is accompanied by high quality images, over 900 in all, showing typical and more unusual examples of histological features. This compact text, oriented at diagnosis and comprehensively accompanied by usable illustrations, is an invaluable reference tool for the trainee and practicing histopathologists, pathologists and haematologists. * A practical guide aimed at allowing a busy pathologist to easily find the essential description and illustration of the most common bone marrow diseases seen in trephines * Covers new treatment for chronic myeloid leukaemia, B-cell lymphoma and antibody treatments * High quality colour images accompany each diagnostic entity * Coverage of cytology in sections relating to myeloid dysplasias and acute leukaemias * Addresses lymphoma categorization and individual lymphoma entities * Incorporates new WHO classifications of lymphomas and leukaemias

Maternal-Fetal and Neonatal Endocrinology: Physiology, Pathophysiology, and Clinical Management systematically examines the normal and abnormal endocrinology of the pregnant and lactating female and of the fetus and neonate. This reference volume expands coverage of specific disorders and diseases beyond the current endocrinology content on the market, which in most cases has a paragraph or no mention at all about pregnancy or aspects of fetal/neonatal development.

This textbook presents for the first time a comprehensive body of the latest knowledge in the field of neuropeptides and their action on energy balance. It contains a detailed and comprehensive account of the specific hypothalamic peptides in regards to their roles in energy balance, food intake control and co-morbidities, to better understand the patho-physiology of obesity. The textbook includes an examination the history of the evolution of human society from a thin to the obese phenotype and, within that context, how modern society habits and industrial food production did not respect the evolutionary trait resulting in changes in the energy balance set point. It provides a novel conceptualization of the problem of obesity when considering the biochemistry of peptide hormones and entertaining novel ideas on multiple approaches to the problems of energy balance, as well as demonstrates and explains why alterations in pro-hormone processing are paramount to understand metabolic disease. This text is excellent material for teaching graduate and medical school courses, as well as a valuable resource for researchers in biochemistry, cell, and molecular biology, neuroscientists, physician endocrinologists, and nutritionists.

Exploring behaviour through bones has always been a fascinating topic to those that study human remains. Human bodies record and store vast amounts of information about the way we move, where we live, and our experiences of health and socioeconomic circumstances. We see it every day, and experience it, but when it comes to past populations, understanding behaviour is largely mediated by our ability to read it in bones. Behaviour in Our Bones: How Human Behaviour Influences Skeletal Morphology examines how human physical and cultural actions and interactions can be read through careful analyses of skeletal human remains. This book synthesises the latest research on reconstructing behaviour in the past. Each chapter is dedicated to a specific region of the human body, guiding the reader from head to toe and highlighting how evidence found on the skull, shoulder, thorax, spine, pelvis, and the upper and lower limbs has been used to infer patterns of activity and other behaviour. Chapter authors expertly summarise and critically discuss a range of methodological, theoretical, and interpretive approaches used to read skeletal remains and interpret a wide variety of behaviours, including tool use, locomotion, reproduction, health, pathology, and beyond.

Handbook of Obesity in Obstetrics and Gynecology addresses all aspects of general obstetrics and gynecology in obese patients, providing evidence-based guidance for the treatment and management of gynecological problems and pregnancy-related care in obese women. The book is a valuable resource for junior doctors, residents and obstetricians and gynecologists looking for a comprehensive guide that addresses the most relevant aspects of obstetric and gynecologic care that are impacted by obesity, an increasingly prevalent condition. The rising prevalence of global obesity is of public health concern, hence obese women suffer from a higher incidence of menstrual disorders, polycystic ovaries, infertility issues, and more. In pregnancy, obesity is associated with an increased risk of early pregnancy loss, recurrent pregnancy loss, fetal developmental abnormalities, thrombo-embolic disease, gestational diabetes, dysfunctional labor, post-partum hemorrhage and difficult operative deliveries.

The Thinking Healthcare System: Artificial Intelligence and Human Equity details the global modern trends shaping the evolution of the modern health system in its final form, an AI-driven thinking system. Written by a dual PhD-trained physician-data scientist and philosopher, and author of the first AI global bioethics book, this indispensable resource makes sense of how technology, economics and ethics are already producing the future's health system, along with how to ensure it works for every patient, community and culture. Providing clear descriptions and concrete examples, this book covers AI-informed precision medicine, population medicine, telemedicine, patient safety, information technology, global and vertical integration, health economics, and much more. Researchers, students, practitioners and policymakers in the fields of bioinformatics, health policy, public health, and economics will find this book to be a great resource on how to grow AI-driven health systems for the future.

Although normally thought of as a sex hormone, recent research has highlighted the numerous and significant effects that oestrogen has on the CNS, extending far beyond its important reproductive role. It has been shown that oestrogen acts as a neural growth factor with important influences on the survival, plasticity, regeneration and ageing of the mammalian brain.
This exciting book brings together leading clinicians and researchers to discuss oestrogen's basic mechanisms of action, the extrahypothalmic brain regions it affects, and its influence on cognitive functions in animals and humans. Finally, recent research on the role of oestrogens in ageing and dementia, including the significance of oestrogen action in Alzheimer's disease, is discussed. The 15 papers contained in this book, together with the extensive discussion sessions that follow them, reveal much new and exciting work in this area, and identify promising new research directions.

Serotonin: The Mediator That Spans Evolution provides a comprehensive review of the widespread roles for serotonin in respiratory, cardiovascular and thermoregulatory control, and for growth and development in early life. This important resource highlights serotonin's role in normal (unstressed) conditions, and in response to a variety of physiological stressors. It focuses on new animal models, comparing and contrasting data from mice and rats. In addition, the book compares and contrasts the physiological effects of brain and blood serotonin systems and includes new data suggesting that the influence of serotonin is in part through the regulation of gene expression. Finally, it discusses the role of serotonin system dysfunction in a variety of pathophysiological conditions, including sleep apnea, obesity and hypertension, and presents compelling evidence that this dysfunction is involved in Sudden Infant Death Syndrome (SIDS).

Oxidants, Antioxidants and Impact of the Oxidative Status in Male Reproduction is an essential reference for fertility practitioners and research and laboratory professionals interested in learning about the role of reactive oxygen species in sperm physiology and pathology. The book focuses on unravelling the pathophysiology of oxidative stress mediated male infertility, recruiting top researchers and clinicians to contribute chapters. This collection of expertise delves into the physico-chemical aspects of oxidative stress, including a new focus on reductive stress. Furthermore, the inclusion of clinical techniques to determine oxidative stress and the OMICS of reductive oxidative stress are also included. This is a must-have reference in the area of oxidative stress and male reproductive function.

Obesity: Oxidative Stress and Dietary Antioxidants cover the science of oxidative stress in obesity and associated conditions, including metabolic syndrome, bariatric surgery, and the potentially therapeutic usage of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are not described in isolation, but in concert with other processes, such as apoptosis, cell signaling and receptor mediated responses. This approach recognizes that diseases are often multifactorial and oxidative stress is but a single component. The book is designed for nutritionists, dietitians, food scientists, physicians and clinical workers, health care workers and research scientists.

Understanding endocrinology is central to understanding the key processes that affect normal reproductive function, while an understanding of normal endocrinology and the pathophysiology of endocrine disorders is important when dealing with reproductive disorders. This book provides a comprehensive background for all gynaecologists, covering: sexual differentiation and intersex disorders; adrenal disorders; normal puberty and adolescence; abnormal puberty; the menstrual cycle; disorders of menstruation; amenorrhoea; polycystic ovary syndrome; anovulatory fertility and ovulation induction; lactation and lactational amenorrhoea; hyperprolactinaemia; thyroid disease; diabetes; lipid metabolism and lipoprotein transport; premature ovarian failure; and calcium metabolism and its disorders. The book is primarily designed to provide a comprehensive summary for candidates preparing for the Part 2 MRCOG examination, and as such covers the RCOG curriculum for reproductive endocrinology. It is also a valuable guide for all healthcare professionals working in the field, including trainees, consultants and any health professional coming into contact with women.

The Handbook of Lymphoma is an in-depth and comprehensive guide to the diagnosis, staging, treatment, and management of patients with the disease. The Handbook aims to provide healthcare professionals with an informative and up-to-date guide to the latest developments in the treatment of patients with both Hodgkin and non-Hodgkin lymphoma. Lymphoma is a cancer of the lymphatic system and, as with other cancers, is a disease of the body's cells. Usually, cells divide in the body in an orderly and controlled manner, however when this process gets out of control and the cells carry on dividing in an abnormal manner a tumor can form known as lymphoma in one or more groups of lymph nodes. This field has seen increasing development in the available options for treating patients with lymphoma particularly in the recent emergence and approval of targeted therapies. In this clinically focused Handbook, the authors address these advances by looking at treatment recommendations for both Hodgkin and non-Hodgkin lymphoma, and also making suggestions on the future outlook for patients with this disease. This Handbook is an invaluable and educational source of topical information for all medical and healthcare professionals with an interest in lymphoma.

Endocrine and Hormonal Toxicology Edited by Philip W. Harvey, Kevin C. Rush and Andrew Cockburn AgrEvo UK Ltd, Saffron Walden, UK This is the first book to consider the integrated role of the classical endocrine system and hormones (including those from tissues outside the classical endocrine system) in toxicological responses. Although focusing on the latest knowledge on endocrine glands as target organs and the mechanistic and molecular basis for toxicity in these organs, Endocrine and Hormonal Toxicology has been written to cover toxicological responses at the whole body level mediated by endocrine or hormonal mechanisms. This whole body, multi--organ approach significantly broadens the relevance of this volume to toxicologists. Following an introductory section on the types of endocrine toxicity including primary, secondary and indirect mechanisms, the next section deals with endocrine organs as toxicological targets. International contributions focus on the pituitary, thyroid and parathyroids, adrenals, testes, ovaries and the pancreas, and comparative endocrine carcinogenesis. A third section of the book develops the whole body approach, in which chapters are devoted to hormonal mechanisms of toxicity to the immune, nervous, cardiovascular, gastrointestinal and reproductive systems, as well as to the liver, kidney and skin. The final section covers human and environmental health perspectives discussing endocrine disrupting chemicals, hormonal mechanisms in breast cancer and current regulatory trends in endocrine and hormonal toxicology. The comprehensive nature of Endocrine and Hormonal Toxicology makes it accessible to both specialist and general toxicologists, and to those within the fields of endocrinology, pharmacology and pathology.