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Physiology and Physiopathology of Adipose Tissue (Paperback, 2013 ed.)
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Physiology and Physiopathology of Adipose Tissue (Paperback, 2013 ed.)
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The scientific advances in the physiology and pathophysiology of
adipose tissue over the last two decades have been considerable.
Today, the cellular and molecular mechanisms of adipogenesis are
well known. In addition, adipose tissue is now recognized as a real
endocrine organ that produces hormones such as the leptin acting to
regulate food intake and energy balance in the central nervous
system, a finding that has completely revolutionized the paradigm
of energy homeostasis. Other adipokines have now been described and
these molecules are taking on increasing importance in physiology
and pathophysiology. Moreover, numerous works have shown that in
obesity, but also in cases of lipodystophy, adipose tissue was the
site of a local low-grade inflammation that involves immune cells
such as macrophages and certain populations of lymphocytes. This
new information is an important step in the pathophysiology of both
obesity and related metabolic and cardiovascular complications.
Finally, it is a unique and original work focusing on adipose
tissue, covering biology and pathology by investigating aspects of
molecular and cellular biology, general, metabolic, genetic and
genomic biochemistry.
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