A critical review by prominent experts of both the cutting-edge of stem cell biology and the application of stem cells to endocrine diseases, including diabetes, infertility, and liver-associated metabolic disorders. The authors discuss current research to modify stem cells, develop an endocrine-like cell, and use adult bone marrow stem cells to treat autoimmune diseases, including endocrine-based autoimmune diseases. Topics of interest include a review of all stem cell subtypes and their characteristics, approaches to promoting endocrine development from stem cells, and evidence for endocrine cell function from stem cells. The authors also outline how best to develop preclinical studies that will determine the safety and efficacy of stem cell therapies for endocrine disorders.

This volume starts with an elementary introduction covering stem cell methodologies used to produce specific types of neurons, possibilities for their therapeutic use, and warnings of technical problems. In addition the authors report successes in achieving the derivation of a specific type of neuron. The dopamine neuron offers an important example and is discussed in more detail. Additional chapters cover problems obviously approachable with cells derived from stem cells, including their need in surgeries for pituitary cancers. The last chapter provides an overview of this particular field of research and presents a vision for its future directions.

This book reviews the pathophysiology and physical manifestations of acromegaly and discusses the multiple treatment options now available for the management of the patient with acromegaly. The book contains an ample number of illustrations that help to emphasize points of particular interest, including radiological, histopathological, and physical diagnosis images. Sections are devoted to detailing important topics including determinants of pathological effects of disease activity in acromegaly, individual therapeutic choices and criteria for diagnosis, and disease control.

This book provides andrologists and other practitioners with reliable, up-to-date information on all aspects of male infertility and is designed to assist in the clinical management of patients. Clear guidance is offered on classification of infertility, sperm analysis interpretation and diagnosis. The full range of types and causes of male infertility are then discussed in depth. Particular attention is devoted to poorly understood conditions such as unexplained couple infertility and idiopathic male infertility, but the roles of diverse disorders, health and lifestyle factors and environmental pollution are also fully explored. Research considered stimulating for the reader is highlighted, reflecting the fascinating and controversial nature of the field. International treatment guidelines are presented and the role of diet and dietary supplements is discussed in view of their increasingimportance. Clinicians will find that the book s straightforward approach ensures that it can be easily and rapidly consulted."

Endocrine disruption represents one of the most controversial environmental issues of our time. Mounting evidence stemming from more than 10 years of experimental, epidemiological and clinical studies has transformed the once generally discounted subject of endocrine disruptors into an issue of tremendous concern not only within the scientific community but among society as a whole. Following initial evidence from basic research, endocrine disruption in humans has now emerged as a major medical challenge. In this respect, puberty, a crucial developmental stage, has been definitively identified as a key window of vulnerability with regard to endocrine disruptors. Written by leading authorities in the field, Endocrine Disruptors and Puberty offers an engaging and comprehensive overview of this fascinating and rapidly growing problem. An indispensable resource for all clinicians and scientists interested in this challenging endocrinologic topic, Endocrine Disruptors and Puberty is a timely contribution that will help navigate a path toward understanding the problem and developing solutions.

Analyzes various reproductive and gynecological disorders encountered in the care of women who do not wish to conceive, as well as those who have difficulty with conception, early pregnancy, and menopause. Discusses the latest strategies in the treatment of infertility, pelvic pain, ectopic pregnancy, and osteoporosis.

The clinical benefits of hormone replacement therapy in women have to be carefully balanced against the possible risks, and a particular theoretical concern relates to risks associated with various forms of female oncology. Because of conflicting reports, gynecologists and oncologists especially need a single, authoritative resource of up-to-date information. Hormone Replacement Therapy and Cancer, published in association with the International Menopause Society, provides the very consensus statement that clinicians need in this difficult and complex area.

Many of the world's leading specialists have contributed important chapters that provide state-of-the-art knowledge about the effects of hormones on women and possible cancer risks. The introductory section deals with carcinogenesis, and the other main sections cover HRT and breast cancer, endometrial cancer, colon cancer, melanoma and epithelial ovarian cancer. The concluding chapters discuss the benefits and risks of specific therapies. An authoritative clinical reference with extensive bibliographic references and index, Hormone Replacement Therapy and Cancer covers all aspects of HRT and cancer based on the research available up to June 2001.

Structure, Expression, and Regulation of the IGF-I Gene.- Differential Regulation of IGF-I Leader Exon Transcription.- Insulin and IGF-I Analogs: Novel Approaches to Improved Insulin Pharmacokinetics.- Analysis of the Interaction of Igf-I Analogs with the IGF-I Receptor and IGF Binding Proteins.- Synthesis and Characterization of IGF-II Analogs: Applications in the Evaluation of IGF Receptor Function and IGF-Independent Actions of IGFBPS.- Towards Identification of a Binding Site on Insulinlike Growth Factor-II for IGF-Binding Proteins.- Transcriptional and Post-Transcriptional Regulation of the Human IGF-II Gene Expression.- Significant Species Differences in Local IGF-I and -II Gene Expression.- Transcriptional Regulation of the Insulin Receptor Gene Promoter.- The Regulation of IGF-I Receptor Gene Expression by Positive and Negative Zinc-Finger Transcription Factors.- Cell Cycle Control by the IGF-1 Receptor and Its Ligands.- The Insulin Receptor Family.- IRR: a Novel Member of the Insulin Receptor Family.- Molecular Properties of Insulin/IGF-1 Hybrid Receptors.- Immunological Studies of Type I IGF Receptors and Insulin Receptors: Haracterisation of Hybrid and Atypical Receptor Subtypes.- Insulin like Growth Factor 1 Receptor Signal Transduction to the Nucleus.- Molecular Cloning of pp120/ ECTO-ATPase, An Endogenous Substrate of the Insulin Receptor Kinase.- The Insulin-like Growth Factor-II/mannose-6-Phosphate Receptor: Structure, Function and Differential Expression.- Parental Imprinting of the Genes for IGF-II and Its Receptor.- Multihormonal Regulation of IGFBP-1 Promoter Activity.- Insulin-like Growth Factor Binding Protein-1: Identification, Purification, and Regulation in Fetal and Adult Life.- Rapid Regulation of Insulin-like Growth Factor Binding Protein-1 Transcription by Insulin In Vito and In Vivo.- IGF Binding Protein-3 and the ACID-labile Subunit: Formation of the Ternary Complex In Vitro and In Vivo.- Role of Post Translational Modifications in Modifying the Biologic Activity of Insulin like Growth Factor Binding Proteins.- Cellular Actions of Insulin-like Growth Factor Binding Protein-3.- Gene Expression of the IGF Binding Proteins during Post-Implantation Embryogenesis of the Mouse: Comparison with the Expression of IGF-I and -II and Their Receptors in Rodent and Human.- Hormonal Regulation of Insulin-like Growth Factor Binding Protein-1 Expression and the Development of Transgenic Mouse Models to Study IGFBP-1 Function.- Limited Proteolysis of Insulin-like Growth Factor Binding Protein-3 (IGFBP-3): A Physiological Mechanism in the Regulation of IGF Bioavailability.- Effects of Insulin-like Growth Factor 1 (IGF-I) Administrations on Serum IGF Binding Proteins (IGFBPS) in Patients with Growth Hormone Deficiency.- Metabolic Effects of rhIGF-1 in Normal Human Subjects.- IGFS and Muscle Differentiation.- IGF-II in the Pathogenesis of Rhabdomyosarcoma: a Prototype of IGFS Involvement in Human Tumorigenesis.- The Physiology and Pathophysiology of IGF-I in the Kidney.- Regulation of IGFBP-4 and -5 Expression in Rat Granulosa Cells.- Insulin-like Growth Factor (IGF) Binding Protein-1 Is an Antigonadotropin: Evidence that Optimal Follicle-Stimulating Hormone Action in Ovarian Granulosa Cells Is Contingent upon Amplification by Endogenously-Derived IGFS.- Insulin-like Growth Factor-I and Insulin-like Growth Factor Binding Proteins in the Zucker Fatty Rat: a case for Differential Tissue Regulation.- Characterization of the IGF Regulatory System in Bone.- Regulation of IGF Activity in Bone.

Intragastric balloons are steadily gaining popularity among the medical treatments available for obesity. Their efficacy and safety are reinforced by growing body of evidence obtained around the globe. Intragastric balloons are now considered one of the safest and most effective medical procedures for weight reduction. Additionally, the reduced potential for side effects and low invasiveness (compared to bariatric surgeries) are important considerations. This book is edited by renowned surgeons and endoscopists from Brazil, a country known for its reputation on the field of bariatric endoscopy and surgery. Such reputation is especially valid where the use of intragastric balloons is concerned. These devices, approved by the FDA only in 2015, have been used in Brazil since the 1990s, attesting to Brazilian expertise in the field. This book describes the various types of intragastric balloons used for the treatment of obesity, an alternative to bariatric surgery and other more invasive methods. It addresses their indications, procedures and outcomes, providing readers an overview of the therapeutic options available worldwide. It is divided into seven main sections: I - Introductory Issues; II - Devices; III - Technical Procedures and Related Issues; IV - Acute Complications and Treatment; V - Chronic Complications and Treatment; VI - Special Populations; and VII - Miscellaneous. This structure helps to promote a better knowledge construction and a reasonable flow of ideas throughout the book, guiding the reader from introductory topics to surgical procedures and complications. The book ultimately intends to offer an essential reference guide for all physicians and surgeons interested in the treatment of obese patients. It is intended for both experienced professionals looking for in-depth information and for trainees and residents seeking to broaden their perspectives concerning the treatment of obesity.

The much-anticipated new edition of this standard textbook compiles current information on the various integrated areas of endocrinology, physiology, and biology of reproduction in one diverse volume. The text provides a physiological foundation for clinical training and encourages further research by including an extensive listing of references at the end of each chapter. Coverage includes the seven domestic species as well as llamas, alpacas, and vicunas.

Revised and improved, the fifth edition contains:
Cutting-edge information--500rovided by new contributors
A new chapter on South American camelids
Concise text which has been filtered to eliminate redundancy
Upgraded illustrations, including additional color plates and over 100 new figures.

"McDonald's Veterinary Endocrinology and Reproduction" is widely used in veterinary schools throughout the United States and Canada, with the Spanish translation used in Latin America and Spain. This mainstay is an essential part of veterinary and agricultural education.

The Systems of the Body series has established itself as a highly valuable resource for medical and other health science students following today's systems-based courses. Now thoroughly revised and updated in this third edition, each volume presents the core knowledge of basic science and clinical conditions that medical students need, providing a concise, fully integrated view of each major body system that can be hard to find in more traditionally arranged textbooks or other resources. Multiple case studies help relate key principles to current practice, with links to clinical skills, clinical investigation and therapeutics made clear throughout. Each (print) volume also now comes with access to the complete, enhanced eBook version, offering easy anytime, anywhere access - as well as self-assessment material to check your understanding and aid exam preparation. The Endocrine System provides highly accessible coverage of the core basic science principles in the context of clinical case histories, giving the reader a fully integrated understanding of the system and its major diseases. Introduction Receptors and Hormone Action The Hypothalamus and Pituitary Part I: The Hypothalamus and Posterior Pituitary4 The Hypothalamus and Pituitary Part II: The Anterior Pituitary The Adrenal Glands Part I: The Adrenal Medulla The Adrenal Glands Part II: The Adrenal Cortex The Thyroid Gland Hormonal Control of Reproduction Part I: Male Reproductive System Hormonal Control of Reproduction Part II: Female Reproductive System Hormonal Control of Reproduction Part III: Development and Fertility Insulin and the Regulation of Plasma Glucose Hormonal Regulation of Plasma Calcium and Calcium Metabolism Miscellaneous Hormones Systems of the Body Series: The Renal System The Musculoskeletal System The Nervous System The Digestive System The Endocrine System The Respiratory System The Cardiovascular System

Goodman's Basic Medical Endocrinology, Fifth Edition, has been student tested and approved for decades. This essential textbook provides up-to-date coverage of rapidly unfolding advances in the understanding of hormones involved in regulating most aspects of bodily functions. It is richly illustrated in full color with both descriptive schematic diagrams and laboratory findings obtained in clinical studies. This is a classic reference for moving forward into advanced study.

Despite the gains of the women s movement, women are still judged by what they look like--and men, by what they do. Fat--A Fate Worse Than Death? offers hardy resistance to the narrow, random, and irrational appearance standards set for American women through an approach that is personal, eclectic, courageous, and funny. If you are interested in giving up your diet, throwing out your scales, and concentrating on who you are on a deeper level, this book will show you how to accept, appreciate, and even love your body Using statistics, research, anecdotes, and personal experiences, Fat--A Fate Worse Than Death? explores how appearance standards have built a prison for women. With the book s helpful advice, reading suggestions, and list of more than 100 ways to fight looksism, sexism, ageism, and racism, you will learn to express your rights and needs, regardless of your shape or size, and tear down those prison walls. Designed to transcend the boundaries between the personal and the political, Fat--A Fate Worse Than Death? discusses: examples of how weight and size constitute the last socially accepted prejudice the national "War on Fat" counteracting societal influences that support weight preoccupation connection between appearance standards for older women and large women nurturing your body resisting male-defined standards of beauty for women the myth of diets and dieting how the body resists weight loss how women are disempowered by concentration on weight and appearance how concentrating on appearance leaves real-life issues unaddressed how feeling bad about yourself can turn you into a willing consumerFeminists, faculty and students of women s studies programs, aging women, women of radical politics, and other concerned women and men will find that Fat--A Fate Worse Than Death? states explicitly how women are kept powerless by subscribing to cultural and social edicts on physical appearance. Don t live silently in a society that degrades and discounts women because of their physical stature and don t let obsession with thinness keep you passive, docile, and unable to give your energy to things that really need your passion and intelligence. Read this book and learn to not only value yourself for who you are, but also to counteract American culture s equality-denying prejudices and practices."