Proposed topics for this issue include: Molecular markers in thyroid neoplasms; Surgical management of primary hyperparathyroidism; Surgical management of well-differentiated thyroid cancer; Surgical management of carcinoid tumors; Recurrent laryngeal nerve monitoring; Surgical management of Zollinger-Ellison syndrome; Management of adrenal cancer; Sporadic and familial medullary thyroid cancer; Insulinoma; Adrenal incidentaloma; Secondary and tertiary hyperparathyroidism; Aldosteronomas; Surgical Management of MEN 1, and 2; Surgical Management of non-M.E.N. endocrinopathies.

This two-part issue of the Endocrinology and Metabolism Clinics of North America brings the practicing endocrinologist up to date on the most important topics in pediatric endocrinology. Part I covers genomics: genetic disorders and new techniques; newborn screening; hormones in the premature infant; congenital disorders of the thyroid: hyper/hypo; glucose in the PIC setting; diabetes prevention; obesity: etiology, prevention, and treatment; metabolic syndrome in pediatrics; complementary and alternative medicine in pediatric endocrinology; imaging in pediatric endocrine dosoirders; U/S gonads; and global epidemiology of Type 1 diabetes.

This issue of the Endocrinology and Metabolism Clinics of North America, devoted to the topic of lipids, provides the most essential updates and new treatments in the field. The following subject matter is addressed: assessment of the effectiveness of advanced lipoprotein testing; rosk scores for prediction of cardiovascular outcomes; lifestyle and dietary approaches to lowering LDC-cholesterol and triglycerides, and raising HDL-cholesterol; comparative efficacy and safety of statins, ezetimibe, bile acide binders, and combinations for lowering LDL-C; alternative therapies for reducing LDL-C, including intestinal bypass, and new medications such as squalene synthase inhibitors, ApoB antisense oligonucleotides, small interfering RNA's of Apo B and proprotein convertase subtilism kexin 9 (PCSK9); myopathic problems of statins; pharmacologic management of hypertriglyceridemia, including fibric acids, niacin, and fish oils; new treatments for raising LDL cholesterol, lipid management in special patient populations, including pediatric, geriatric, and patients with HIV; lipid management in renal failure, hemodialysis, and transplantation.

Autoimmune disorders are amongst the most frequently encountered conditions in endocrine practice. The evidence-based approach to therapeutics and detailed evaluation of the outcome of existing treatment regimens have led to some advances in care delivery. Pragmatic reviews by leading international experts outline the clinical state of the art in several chapters of this issue of the Endocrinology and Metabolism Clinics of North America devoted to autoimmune disorders. Topics covered include the following: regulatory T cells as key players in tolerance and autoimmunity; immunology lessons from monogenic conditions such as AIRE; immunogenetics of T1D and AITD; advances in T1D therapeutics, including islet cell replacement and salvage; updates on TSHR structure, function, and monoclonal human TSHR antibodies; animal models of Grave's disease; evidence-based and emerging modalities of treatment of Graves' hyperthyroidism; patient selection and treatment of thyroid-associated ophthalmopathy; antibodies to steroidogenic tissues: Addison's and POF; diagnosis and management of polyendocrinopathy syndromes; autoimmune parathyroid disease; and autoimmune hypophysitis.

This book provides a complete review of multiple metabolic disorders and the use of phytochemicals for their prevention and treatment. When describing each metabolic disorder, all authors describe the main health alterations, providing the most current figures and statistics worldwide; medicinal plants used in traditional medicine for its treatment and scientific information related to their potential to prevent or treat each condition. Authors also include a complete scientific background check, comprehensive analysis of all phytochemicals recommended for each disorder, a description of the mechanism(s) of action and in vivo and/or in vitro studies. Within this volume, a series of 7 plant species, recommended to treat or prevent the previously described disorders, are presented with their botanical information, traditional use in different cultures and countries, and the available scientific information validating their health benefits. Besides, six main metabolic disorders are described, providing a full scientific background for its general understanding, and three study cases are presented, where metabolic disorders are analyzed and approached from different medical and pharmaceutical angles. Chapter 1 a Soybean contains a great nutritional value, which makes it an excellent food for the human diet. It has large amounts of protein and lipids and also provides fiber, calcium, iron, zinc, and several vitamins. For these reasons, the possible benefits of soy consumption for human health have been studied. Although the results obtained to date have not been conclusive, thanks to its high content of isoflavones (phytochemicals with estrogenic activity), soy is attributed with anti-inflammatory, antioxidants and antifungals properties. Moreover, soybeans could provide significant benefits to patients with cardiovascular diseases, cancer, or diabetes. Chapter 2 a Oil, proteins, vitamins, fibers, and phytochemicals present in the avocado plant have shown the excellent capability of not only addressing the prevalence of these metabolic diseases but also being safe and having minimal side effects. The general objective of this book chapter is to review the bioactive compounds and their action to promote health benefits in the prevention and management of metabolic disorders. Chapter 3 a Heliopsis longipes roots, which contain affinin, has been used in traditional cuisine as a spice for its pungent. Due to its tingling and numbing properties, it is frequently applied to heal diverse pains such as toothache, earache, and headache. Within this chapter, its applications on anti-inflammatory activity, local anesthetic, analgesic, anti-mutagenic, and antioxidant activity, will be reviewed. Chapter 4 a The species Opuntia ficus-indica (L.) Mill., represents a good source of nutrients and antioxidants in the diet of consumers. This chapter aims to offer a simple and economical alternative formulation of artisan conserves prepared with nopal, in which the antioxidant activity was evaluated. Chapter 5 a Metabolic syndrome is known as a group of metabolic abnormalities that increase the risk of developing cardiovascular diseases and type 2 diabetes. The cost of health for companies is very high for workers who have obesity or metabolic syndrome compared to healthy workers. Metabolic syndrome is closely related to obesity, and this, in turn, is associated with a poor diet (high intake of carbohydrates and fats). This chapter explains the decrement of risk factors in workers of Young Living Ecuador Farm based on the Health Belief Model. Chapter 6 a The objective of this chapter book was to analyze the evidence obtained by clinical studies reported by scientific literature. Clinical studies have employed different components or products of grapes, such as pulp, freeze-dried grape, extracts, wine, and a distinct dose of resveratrol, to demonstrate their biological properties against diabetes mellitus, hypertension, and obesity. Chapter 7 a The main purpose of this chapter is to describe the analysis of whether glycated hemoglobin values could be used as a limit marker for earlier diagnosis of type 2 DM in overweight patients. This was a nonexperimental, analytical, retrospective, longitudinal study of 100 overweight patients diagnosed with type 2 DM. The study was carried out in 2014 at Teodoro Maldonado Carbo Hospital, Guayaquil, Ecuador. Chapter 8 a Rosemary is classified not only as spice or ornamental but also as a medicinal plant. It is an important source of volatile and non-volatile compounds. The proportion of them varies in function of diverse factors as a region of growth, environment, extraction treatment, and others. Thanks to its composition, rosemary owners several properties such as anti-obesity, anti-diabetes, anti-cancer, among others, thus the importance of this plant over metabolic diseases is presented in this chapter. Chapter 9 a Agave has been used in traditional medicine as an anesthetic, anticonvulsant, antipyretic, urinary antiseptic, cathartic, cicatricial, and regenerative, diuretic, emmenagogue, and eupeptic. Agave extracts and derived agave products have been used to prevent several metabolic diseases, such as diabetes and cancer. However, more studies are needed to support these effects.

This book is one of the first to evaluate the role of Steroids in autoimmune rheumatic diseases from the basic mechanisms to the clinical involvements and focuses on the importance of steroidal hormones in the pathogenesis and therapeutic management of the autoimmune rheumatic diseases. In particular, the chapters analyze the mechanisms of action and the involvement of adrenal steroids (glucocorticoids) in the neuroendocrine immune system, including effects on the elderly.
The perturbations of the HPA axis as a source of altered steroidal synthesis will be discussed and related to some interesting pathological conditions that commonly complicate the autoimmune rheumatic diseases such as psychosis or fibromyalgia. Concerning the role of gonadal steroids (sex hormones), several chapters will discuss clinical and epidemiological evidences of their role, as well as their effects as risk factors in autoimmune rheumatic diseases, including a section on pediatrics.
*The premier issue evaluating the role of steroids in autoimmune rheumatic diseases from the basic mechanisms to the clinical involvements
*Documents the latest research and indicate recent and coming new therapeutic-biological approaches to the therapy
*The book will present therapeutic perspectives concerning the new glucocorticoids, and the effects of biological drugs on their synthesis

Congenital Adrenal Hyperplasia: A Comprehensive Guide addresses how hydrocortisone works, what can go wrong, and how to correct it, also explaining why the timing of doses and measurement of cortisol from a dose is extremely important. The book provides an in-depth analysis of this disorder for pediatric endocrinologists and primary care providers, allowing them to help patients with an updated model of care and appropriate treatment. Patients and family members will benefit from the trend-forward information that will empower them to approach their healthcare providers with the expectation of receiving individualized care and treatment for this disorder.

For more than 30 years, the highly regarded Secrets Series (R) has provided students and practitioners in all areas of health care with concise, focused, and engaging resources for quick reference and exam review. Endocrine Secrets, 7th Edition, features the Secrets' popular question-and-answer format that also includes lists, tables, pearls, memory aids, and an easy-to-read style - making inquiry, reference, and review quick, easy, and enjoyable. The proven Secrets Series (R) format gives you the most return for your time - succinct, easy to read, engaging, and highly effective. Fully revised and updated throughout, including protocols and guidelines that are continuously evolving and that increasingly dictate best practices. Top 100 Secrets and Key Points boxes provide a fast overview of the secrets you must know for success in practice and on exams. Features bulleted lists, mnemonics, practical tips from prominent endocrinologists - all providing a concise overview of important board-relevant content. Keeps you up to date with new techniques and technologies, as well as changing treatment options and drug information. Equips you for effective practice with coverage of the most current developments in obesity management, weight loss drugs, and bariatric surgery; type 2 diabetes mellitus; insulin therapy; thyroid cancer; osteoporosis therapies; and much more. Portable size makes it easy to carry with you for quick reference or review anywhere, anytime. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Vassopressin, Volume 111, the latest release in the Vitamins and Hormones series, first published in 1943, covers the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms, with this release focusing on topics relating to hepcidin, bacterial infection, and iron overload, the role of heparan sulfates in hepcidin regulation, hepcidin CDNA and human gene sex hormones, growth factors and hepcidin, HFE gene polymorphisms and hereditary hemochromatosis, hepcidin and il-1beta, hepcidin-ferroportin axis, cardiomyocyte hepcidin, adipocyte iron, leptin and hepcidin, regulators of hepcidin expression, and much more.

Medical emergencies due to disorders of the endocrine system represent a unique category of clinical care. Hypotension, fever, palpitations, confusion, and electrolyte abnormalities are all signs of disparate endocrine emergencies that require immediate diagnoses and treatment. Recognition of endocrine emergencies will frequently lead to rapid improvement and stabilization of the patient. Now in a revised and expanded second edition including the latest clinical guidelines and protocols, Endocrine Emergencies serves as a handy single reference for any endocrinologist, internist, hospitalist, and emergency medicine physician to rapidly identify and initiate treatment. Topics covered include acute adrenal insufficiency, diabetic ketoacidosis, thyroid storm, hyponatremia, and myxedema coma, among many others. Each chapter opens with a precis that provides, in a single page, a presentation of symptoms, workup, and therapy. This serves as a rapid, "off the shelf" cue to immediately begin a differential diagnoses and therapy plan. The remainder of each chapter is an in-depth review of the pathophysiology, diagnoses, and management of the disease process. Book chapters are written by experts in the field and reflect the consensus and standard of care for specific endocrine emergencies. Updated with the latest clinical evidence and treatment options, Endocrine Emergencies remains a valuable resource for practitioners in endocrinology and internal medicine, as well as emergency room physicians, hospital support staff, fellows and residents.

Das massgebliche Referenzwerk zur Erkennung und Behandlung von akuten endokrinen und Stoffwechselerkrankungen Die Endokrinologie beschaftigt sich mit den haufigsten Krankheitsbildern und ernsthaften Erkrankungen, mit denen die heutige Medizin zu kampfen hat. Im klinischen Umfeld lassen sich Notfalle zum Grossteil auf Stoerungen des endokrinen Systems und des Stoffwechsels zuruckfuhren. Endocrine and Metabolic Medical Emergencies: A Clinician's Guide ist ein einzigartiges Referenzwerk, unterstutzt Endokrinologen, Notfall- und Allgemeinmediziner in Kliniken, Hospitalisten und Intensivmediziner und Allgemeinmediziner dabei, die Symptome endokriner Notfalle zu erkennen und die Patienten optimal und nach den hoechsten Standards zu versorgen. Die neue 2. Auflage dieses Buches, das bereits als das massgebliche Referenzwerk des Fachgebiets gilt, bietet bei bekannten und ungewoehnlichen endokrinen Notfallen Richtlinien fur die Akutversorgung, erlautert im Detail die Auswirkungen von akutmedizinischen und kritischen Erkrankungen auf den Stoffwechsel und das endokrine System und deren Einfluss auf Untersuchungen des endokrinen Systems, beschreibt besondere Patientenpopulationen, auch den Einfluss des Alterns, von Schwangerschaft, Transplantationen, Spatfolgen, von perioperativen Vorfallen, angeborenen Stoffwechselerkrankungen sowie von HIV/AIDS bei der Vorstellung und dem Management von Patienten. Weiterhin werden die mit dem jeweiligen System verbundenen Erkrankungen ausfuhrlich behandelt, ebenso stoffwechselbedingte Knochenerkrankungen, neuroendokrine Tumore u.v.a. Dieser Leitfaden enthalt unzahlige Fallstudien, Abbildungen und Kapitel, die von renommierten Autoren geschrieben wurden, und eignet sich zum schnellen Nachschlagen und fur das Studium. Behandelt werden Vorstellung, Diagnose, Management und Behandlung von Patienten mit Erkrankungen des endokrinen Systems und des Stoffwechsels auf Intensivstationen. Aktuelle Leitlinien befassen sich mit Themen wie klinische Lipidologie, Glukose, Natrium, Kalzium, Phosphat usw. Dieses unschatzbare Referenzwerk vereint die neuesten wissenschaftlichen Erkenntnisse mit Ratschlagen fur Klinik und Praxis. Kliniker erhalten alles aktuell Wissenswerte des Fachgebiets an die Hand sowie einen praxisorientierten klinischen Einblick, um Patienten optimal zu versorgen.

The articles comprising this volume were first presented at the World Congress on Neurohypophysial Hormones held in Bordeaux, France on September 8-12, 2001. This conference brought together more than 170 scientists from 18 countries who belong to the different fields of interest representing research in the hypothalamo-neurohypophysial system.

Two neurohypophysial neurohormones, oxytocin and vasopressin, exert a variety of central and peripheral actions and thus involve different scientific domains, which too often, even today, do not always find the appropriate occasion to interact. This volume is composed of chapters dealing with topics varying from basic and clinical neurosciences and neuroendocrinology, to reproductive, renal, cardiovascular physiology and pathology. It encompasses all areas of current neurohypophysial research and should be of vital interest as an integrative reference volume to specialized investigators and as an excellent introductory text to students, scientists and clinicians not yet closely familiar with the field. To ensure novelty and to make sure that all topics of current importance were covered, plenary and symposium speakers as well as poster presentations concentrated on recent advances made in the last few years.

This book presents the latest insights into all the critical aspects of Klinefelter's Syndrome, in order to promote a more homogeneous a medical approach to this condition, leading to better and more "evidence-based" support, and improving patient satisfaction. It offers physicians and all health professionals involved in treating these patients (andrologists, pediatricians, endocrinologists, psychologists) a comprehensive overview and a useful tool for their daily clinical practice.

The use of model organisms together with the power of genetics has profoundly affected our understanding of the physiology of one organ, the skeleton, in two distinct but complementary ways. Thisis the first translational reference to focus on these major conceptual advances in bone biology and their development in the clinic. Several advances have already been translated into therapies and others are being tested for diseases as different as osteoporosis, type-2 diabetes, and hypo-fertility. This book is a timely reference for both basic and clinical researchers in bone biology and endocrinology.
Summarizes the latest research and translational applications of how the varied growth and development of bone affects appetite, metabolism, reproduction, and a wide range of endocrine functions Provides a common language for bone biologists, endocrinologists, osteologists, and other researchers, such as neuroscientists, who study appetite, fuel metabolism and diabetes, to discuss the development of translational research and new therapeutic strategies for bone, metabolic, and neuro-endocrine diseases.

Saves researchers and clinicians time in quickly accessing the very latest details on a broad range of bone research and therapeutics, as opposed to searching through thousands of journal articles "

This practical book focuses on the most recent advances in natural cycle and minimal stimulation in vitro fertilization (IVF). The volume presents the steps that need to be followed to successfully perform these techniques and covers all aspects and competences involved. The book provides information on physiology of folliculogenesis, ovulation, oocytes and luteal phase and based on this information on clinical practice of stimulation, ovulation induction and inhibition, follicle aspiration and luteal phase support in natural cycle and minimal stimulation IVF. In addition costs, risks, success rates and several treatment protocols are provided. An overview of large European, Japanese and American programs and the discussion of clinical cases will complete the coverage of the topic. This practical and easy-to-use guide is a valuable resource for all clinicians performing any kind of IVF techniques.