Endocrine Board Review (EBR) 10th Edition, Reference Edition 2018 is a board examination preparation book designed for endocrine fellows who have completed or are nearing completion of their fellowship and are preparing to sit for the board certification exam, and for practicing endocrinologists in search of a comprehensive self-assessment of endocrinology, either to prepare for recertification or to update their practice. EBR consists of approximately 240 case-based, American Board of Internal Medicine (ABIM) style, multiple-choice questions. Each section follows the ABIM Endocrinology, Diabetes, and Metabolism Certification Examination blueprint, covering the breadth and depth of the certification and recertification examinations. Each case is discussed in detail with detailed answer explanations and references provided. EBR is updated annually with new questions. Customers are advised that this book is a reference edition and the questions in it are designed for self-study and reference. The content is the same as the non-reference edition, but CME and MOC credits are not available upon completion of the material. Anyone with questions about CME and/or MOC credits should consult www.endocrine.org/store for further information.

This book provides the first comprehensive overview of the emerging field of interdisciplinary salivary bioscience. It serves as a foundational reference guide to the collection, analysis, and interpretation of salivary data, as well as its myriad applications in medicine, surveillance and public health. The ease and non-invasive nature of saliva collection makes it highly useful in diverse fields such as pediatrics, dentistry, neuroscience, psychology, animal welfare and precision medicine. This book introduces students and scientists alike to the vast potential of salivary bioscience in both research and practice.

This book provides an overview of the latest knowledge of the psychological aspects of polycystic ovary syndrome (PCOS), and paves the way for advances in this rapidly evolving field. Taking an evidence-based approach, the book elucidates the ways in which PCOS causes anxiety and depression, impacts Quality of Life (QoL), and is associated with other psychological issues. The psychological impact of key features of PCOS are explored too, with a special focus on insulin resistance / diabetes, and fertility issues. The book concludes with a chapter on practical recommendations on how best to help with anxiety and depression in PCOS. An important feature of this book is its identification of the ways in which testosterone, a defining characteristic of PCOS, impacts psychology. In doing so it fills a lacunae in current research and offers evidence that maps out the complex ways in which biology impacts psychology in PCOS, and also how psychology can be harnessed to impact biology in a positive way. It will appeal in particular to scholars and clinicians in the fields of health psychology and women's health.

In this definitive new text, the major medicines, devices and vaccines used by women worldwide are brought together for the first time in a single volume. Written and edited by international experts with an evidence-based approach, the book offers a comprehensive summary of all the key areas of women's medicines. In the first part, issues relating to female drug exposure and considerations for prescribing for subgroups of women - for example during pregnancy and lactation - are presented in the context of contemporary clinical practice. In the second part, specific groups of pharmaceutical products are reviewed, including oral contraceptives, emergency contraception, treatment of chronic pelvic pain, hormone replacement therapy, bisphosphonates, herbal medicines for women, contraceptive devices and human papilloma virus (HPV) vaccines. Every chapter reviews and summarises the efficacy and safety of each group of products and concludes with a useful set of clinical take home messages. In the third part, broader perspectives are presented - from a primary care overview of prescribing for women, through to regulatory, political and religious aspects, including issues with women's medicines in developing countries. The final two chapters focus on risk communication and conclude that women themselves should be placed at the centre of all discussions about their medicines. The book is aimed at prescribers, other healthcare professionals and students in the field of women's health throughout the world. It is an extremely valuable resource for all in clinical practice, for students of medicine, nursing, pharmacy and related sciences, and also for those in medicines regulation, pharmacovigilance and the pharmaceutical industry.

355 articles arranged under the following sections: B and T Cells of the Mucosal Immune System: Trafficking and Cytokine Regulation. Nonlymphoid Cells of the Mucosal Immune System: Epithelial Cells, APC, and Other Cell Types. Development of Mucosal Immunity: Reproductive Tract, Ontogeny, Phylogeny, and Immunodeficiency. Gnotobiology, Environmental, Nutritional, and Intrinsic Factors in Mucosal Immunology. Structure, Proteolysis, and Function of Mucosal Immunoglobulins: Cellular Receptors. Clinical Immunology, Immunopathology, Immunodeficiency, and Allergology. Microbial, Parasite, and HIV Mucosal Infections. Immunology of the Liver. Oral Immunology and Immunopathology. Autoimmunity, Oral Tolerance, and Aging. Chronic Inflammation, Inflammatory Bowel Diseases and Celiac Disease. Induction of Mucosal Immune Responses and Vaccine Delivery Systems. Index.

Pancreatic Disease: Basic Science and Clinical Management summarises the state of the art in basic science and clinical management of pancreatic disease. This book provides a clear and up-to-date review of the advancing areas in clinical pancreatology and clinical research related to the pancreas. Written by leading experts in the field, this comprehensive review directs the interested reader towards important and current published source material.

Covering all aspects of pancreatic disease, contributions are included from pancreatic surgeons and medical pancreatologists on pancreatic cancer, acute pancreatitis and chronic pancreatitis. Special features include a systematic review of the evidence for the use of gemcitabine in pancreatic cancer prepared for the National Institute of Clinical Excellence (NICE), the UK body charged with evaluating new drug treatment. Gemcitabine has FDA approval. There are several contributions dealing with the management of pancreatic neuroendocrine tumours.

This book will be useful to gastroenterologists, internists and surgeons, and specialist clinicians with an interest in pancreatic disease. Trainees in medical and surgical pancreatology will find it a companion to supplement standard textbooks.

This book contains a comprehensive series of reviews on the calcitonin gene-related peptide (CGRP) family of peptides. This family of peptide hormones has a diverse and constantly expanding range of important physiologic functions, including regulation of blood calcium, vascular tension, feeding behavior and pain recognition.

This volume includes chapters on:

• The adrenomedullin peptides and signalling
• Ligand binding and activation of the CGRP receptor
• Understanding amylin receptors
• The CGRP-receptor component protein
• The calcitonin peptide family
• Genetic regulation of CGRP
• Vascular actions of CGRP and adrenomedullin
• Intermedin/adrenomedullin 2 function
• CGRP and adrenomedullin as pain-related peptides
• Amylinergic control of ingestive behaviour
• Calcitonin receptors

This book discusses their receptors, physiological and pathophysiological functions and potential as clinical targets. It will appeal to researchers who study any of these peptides and those with an interest in migraine therapy due to the involvement of CGRP in this disorder. The book is unique because it brings together research on the whole peptide family for the first time in several years. It will be a useful reference volume for researchers in this area. This book will also appeal to researchers in the broader field of bioactive peptides.

Adrenal disorders are often difficult to diagnose due to common symptoms, and challenging to treat due to common comorbidities. Adrenal Disorders: 100 Cases from the Adrenal Clinic provides a comprehensive, case-based approach to the evaluation and treatment of both common and uncommon adrenal disorders, offering practical, real-world guidance highlighted by ultrasound scans, biopsy images, and tables. Features 100 two-page cases covering a wide range of common and uncommon adrenal disorders. Includes case report, investigations, treatment, and outcome for each case, plus a case overview with expert advice, take-home points, and references. Organizes comprehensive content by type of disorder, including adrenal masses (benign and malignant), primary aldosteronism, ACTH-independent Cushing syndrome, ACTH-dependent Cushing syndrome, adrenal carcinoma, pheochromocytoma, adrenal and ovarian hyperandrogenism, and adrenal disorders in pregnancy. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Growth Hormone and the Heart endeavors to bring together knowledge that has been accumulated in the area of GH and the heart, from basic to clinical studies, by research groups working on this topic throughout the world. Lessons from different experimental models and from several human diseases (acromegaly, adult GH deficiency, heart failure) suggest to endocrinologists and cardiologists that GH may not only have a role in the physiology and pathophysiology of heart function, but that GH itself may have a place in the treatment of primary heart diseases (such as dilated cardiomyopathy) or of cardiac complications of hypopituitarism. Growth Hormone and the Heart will be a useful update of the research produced in the field of cardiovascular endocrinology. The Editors also hope that this book will serve as the primary step in the recognition of the wide physiological and clinical significance of GH and heart interactions.

In Adrenal Disorders, a panel of distinguished physicians and researchers select the most relevant new findings and integrate them into the existing body of clinical knowledge on adrenal pathologies. The book includes important reviews of disturbances in cortisol homeostasis, and new concepts regarding adrenal tumors and hereditary adrenal diseases. Also discussed are mineralocorticoids and the syndromes of mineralocortoid excess and aldosterone synthase deficiency. Authoritative and insightful, Adrenal Disorders provides physicians and scientists with a comprehensive, state-of-the-art practical guide to the devastating diseases of the adrenals that are so often difficult to diagnose and treat.

Sex-Steroid Interactions with Growth Hormone presents the proceedings of an international symposium held from October 22-25 in Naples, Florida. The proceedings provide new insights and concepts gained by molecular, cellular and neuroendocrine research into mechanistic interactions of the reproductive and somatotrophic axes. Chapters include discussions of the impact of sex steroids on growth hormone secretion in both children and adults; sex steroids, growth hormone releasing factor, and somatostatin; how sex steroids modulate growth hormone action on target issues; and differential effects of growth hormone secretagogues in men and women. This volume is designed for physicians, scientists and other health professionals interested or trained in clinical and basic endocrinology, growth or reproduction.

The obesity epidemic has generated immense interest in recent years due to the wide-ranging and significant adverse health and economic consequences that surround the problem. Much attention has been focused on behaviors that lead to obesity, in particular to over consumption of energy-dense food and to sedentary lifestyle. However, obesity is an extremely complex condition with poorly defined pathogenesis. Thanks to greatly enhanced research in the area, the discovery of pathways in the brain and peripheral organs that mediate energy homeostasis has provided a framework for understanding the biological basis of obesity. Metabolic Basis of Obesity adds an important new dimension to the growing literature on obesity by offering a comprehensive review of specifically how metabolic imbalance culminates in obesity. Developed by a team of expert authors, this important title discusses the principles of energy balance, genetics of body weight regulation, hormones and adipokines, and metabolic pathways in the brain, liver, muscle and fat, to name just several of the areas covered. The book also examines the connection between obesity and diabetes, cardiovascular disease and other complications. Current and future diagnostic and treatment strategies are also reviewed. Comprehensive and timely, Metabolic Basis of Obesity is an essential reference for understanding the burgeoning problem of obesity.

This book is the first to focus on the range of innovations that have been critical to the emergence of modern endocrine surgery. It provides a state-of-the art review of these developments, providing surgeons a single resource to better understand them. The text is broken into five parts. The first two parts cover the diagnosis and preoperative work-up of thyroid disease and parathyroid disease. Part three and four cover surgical adjuncts and surgical techniques. Finally, part five covers post-operative management and reviews developments that have allowed for ambulatory management to become a standard aspect of endocrine surgery. The book is written by experts that have been the primary proponents of the individual innovations. Chapters discuss the challenges and issues that the innovation address, its current state or use, and potential short- and long-term future directions/advances. Equipped with the knowledge provided by this text, surgeons can assess their own practice and choose to integrate innovations that may improve their patients' outcomes. Innovations in Modern Endocrine Surgery serves as a valuable resource for all physicians and trainees interested in the how and why of performing modern thyroid and parathyroid surgery. It also allows surgeons to measure the state of their current practice against the most progressive techniques and determine if opportunities exist to update their approach.

This book provides a unique ethnographic account of women living with polycystic ovary syndrome (PCOS) in India. It examines how contaminated environments and political-economic changes render urban middle-class women in India vulnerable to PCOS, a condition which has the potential to disrupt conventional, normative feminine biographies of marriage and childbearing. The volume revolves around two main themes: how toxic landscapes, the endocrine disrupting chemicals suffusing them, and the political-economic environments related to them are linked to endocrine disorders such as PCOS; and how the biosocial disruptions caused by PCOS are both affecting women and reflective of changes in contemporary urban India. The author draws on anthropological fieldwork to investigate these connections through a fresh approach, combining a political ecological framework with perspectives from the anthropology of toxic exposures and health-environment systems. The first of its kind, this volume will be indispensable to students and researchers of anthropology, particularly medical anthropology, medical sociology, human geography, science and technology studies, medical humanities, health-environment systems, endocrine disorders, public health, and South Asian studies.

Endocrinology, as a discipline, was a late arrival in the corpus of established subjects. Its growth in recent years has been prodigious, extending from mor phology to molecular levels. Most of the major endocrine glands were noted by the early anatomists, although the adrenal glands were not described until 1563 by Bartholomaeus Eustachius (1520-1574). On the other hand, elucidation of the function of these glands was extremely slow. Key work by A. A. Berthold (1849), although overlooked at the time, showed that comb atrophy in castrated fowl was prevented by testis transplantation. The idea that glands produced substances reach ing the bloodstream directly and not via excretory ducts stemmed from Claude Bernard, who first used the term internal secretion in 1855. The clinical observa tions of Thomas Addison at Guy's Hospital-published as a monograph in 1855 entitled The Constitutional and Local Effects of Disease of the Suprarenal Capsules -were seminal. However, the stimulus of this early research did not bring imme diate widespread further investigations. Upon the discovery of secretin in 1902, Bayliss and Starling considered the term "internal secretion" to be clumsy, and the term "hormone" was coined (from OQ UW-1 excite or arouse) and it was first used by Starling in his Croonian of 1905."

Sex matters! Are there differences between the sexes when it comes to brain function and the behaviours that result? This volume attempts to answer this fundamental question. If the answer is 'yes' then this should impact upon our approach to treating mental illness in humans, and to modelling it in animals, as we look for aetiological and pharmacological solutions.

This book provides easy-to-understand, scientifically backed answers to readers' questions about hormones, helping them understand the many important roles they play, particularly during adolescence. Especially during the teenage years, people are quick to blame raging hormones for everything from acne to rebellious behavior. But hormones play vital and varied roles throughout our lives, driving such basic processes as growth and metabolism and orchestrating sexual maturation and reproduction. But for many, hormones are mysterious and misunderstood. How much do you really know about hormones, how they affect our health, and how what we do can affect them? Books in Greenwood's Q&A Health Guides series follow a reader-friendly question-and-answer format that anticipates readers' needs and concerns. Prevalent myths and misconceptions are identified and dispelled, and a collection of case studies illustrate key concepts and issues through relatable stories and insightful recommendations. Each book also includes a section on health literacy, equipping teens and young adults with practical tools and strategies for finding, evaluating, and using credible sources of health information both on and off the internet—important skills that contribute to a lifetime of healthy decision making.

This volume starts with an elementary introduction covering stem cell methodologies used to produce specific types of neurons, possibilities for their therapeutic use, and warnings of technical problems. In addition the authors report successes in achieving the derivation of a specific type of neuron. The dopamine neuron offers an important example and is discussed in more detail. Additional chapters cover problems obviously approachable with cells derived from stem cells, including their need in surgeries for pituitary cancers. The last chapter provides an overview of this particular field of research and presents a vision for its future directions.

Medical and Surgical Treatment of Parathyroid Diseases is an accessible and user-friendly guide, addressing the key points of parathyroid diseases using case studies, as well as hundreds of high quality images and illustrations. Written and edited by respected leaders in the field of parathyroid surgery, this book aids in the comprehension of innovative concepts and focuses on the latest in clinical research. Written for otolaryngologists and oncologists at various stages of experience, Medical and Surgical Treatment of Parathyroid Diseases includes chapters dedicated to parathyroid anatomy, physiology, and embryology, medical therapy for parathyroid disease (indications and pharmacotherapy), diagnostic imaging, surgical treatments, and special topics such as health services and healthcare economics related to parathyroid surgery.

Clinical Urologic Endocrinology: Principles for Men's Health provides an organized, accessible reference on men's endocrinological health. Over 30 million men in the US alone suffer from erectile dysfunction and over 13 million men in the US suffer from hypogonadism (low testosterone). One out of seven couples also suffer from subfertility of which 50-60% have male factor involvement. More and more men are coming forward to seek treatment for such issues, which in the past were considered taboo and there is a strong need for a book which provides guidance for practitioners who support men in their reproductive and sexual concerns. This book covers in depth the key issues in male reproductive health in one easy-to-use resource. Clinical Urologic Endocrinology: Principles for Men's Health is a valuable reference for urologists, endocrinologists, internal medicine physicians, family medicine physicians, sex therapists, and allied health professionals providing care for men in the areas of sexual health, fertility, and men's endocrinological health.

Precision Medicine in Neurodegenerative Disorders, Part One, Volume 192 deals with the "Why" in the approach to slow the progression of those suffering from diseases of accelerated brain aging. Matching a biology-correcting therapy with those biologically suitable to benefit from such therapy represents the vision and mission of precision medicine, the highest level of personalized medicine. This first Handbook of Clinical Neurology volume is intended to provide a scholarly background on the framework, basic science, and conceptual pitfalls related to disease-modifying efforts in Parkinson, Alzheimer, and other neurodegenerative disorders. Among the topics covered are the different models of precision medicine, the lumping-versus-splitting tension in biomarker development and therapeutics, and the rationale for replacing the convergence of the prevailing autopsy-based nosology of neurodegenerative diseases with the divergence of a systems biology approach to human diseases. Specific chapters are dedicated to the promise of genetic subtypes and the lessons in disease modification offered by the fields of oncology and cystic fibrosis that can be adapted to the field of neurodegeneration.