Responding to a renewed interest in the growing problem of iodine deficiency worldwide, Drs. Charles Oxnard and Peter Obendorf, along with experienced translator and anatomist John Dennison, take a fresh look at the classic text, Der endemische Kretinismus, published in 1936 by Springer. Translated here for the first time into English, this landmark text will be a welcome resource for researchers confronting the problem of iodine deficiency. Oxnard and Obendorf point out that there is very little detailed knowledge or numerical data on cretinism available in the English-speaking world. In addition, highly-renowned Professor Basil S. Hetzel, recently-retired World Health Organization Chairman of the International Council for Control of Iodine Deficiency Disorders, published in 2009 with Dr Chen Zu-pei on the resurgence of iodine deficiency in China. Indeed, throughout the entire developing world there may be as many as two billion people at risk to iodine deficiency; perhaps three quarters of a billion have goiter, and ten million may be cretins. Even in developed countries, iodine deficiency is re-emerging (as in New South Wales in 19% of children) with the result of significantly reduced numbers of gifted children (though this is not cretinism per se). Certain to be of significant interest to a wide range of researchers, health providers and professionals, including government health administrators, this English translation of Endemic Cretinism is a major contribution to the literature.

2022 Endocrine Case Management: Meet The Professor Reference Edition is your source for the latest updates in the diagnosis and management of a wide range of endocrine disorders. This valuable resource allows you to evaluate your knowledge and gain insight into the strategies used by clinical experts. Updated annually.

Regulation of Insulin Secretion.- Impaired Glucose-Induced Insulin Secretion: Studies in Animal Models with Spontaneous NIDDM.- Perturbation of Islet Metabolism and Insulin Release in NIDDM.- Regulation of Cytoplasmic Free Ca2+ in Insulin-Secreting Cells.- The ss-Cell Sulfonylurea Receptor.- Insulin, Insulin Receptors and Glucose Transporters.- Regulation of Glucose Transporters and the Na/K-ATPase by Insulin in Skeletal Muscle.- Insulin Receptor: Aspects of Its Structure and function.- The Diabetogenes Concept of NIDDM.- Molecular Genetics of NIDDM and the Genes for Insulin and Insulin Receptor.- Autoregulation of Glucose Transport: Effects of Glucose on Glucose Transporter Expression and Cellular Location in Muscle.- Insulin Action in NIDDM.- Insulin Resistance and the Pathogenesis of Non-Insulin Dependent Diabetes Mellitus: Cellular and Molecular Mechanisms.- Indirect Effects of Insulin in Regulating Glucose Fluxes.- The Insulin-Antagonistic Effect of the Counterregulatory Hormones - Clinical and Mechanistic Aspects.- On Insulin Action in Vivo: The Single Gateway Hypothesis.- Gluconeogenesis.- Acute Hormonal Regulation of Gluconeogenesis in the Conscious Dog.- Estimating Gluconeogenic Rates in NIDDM.- Glucose Metabolism during Physical Exercise in Patients with Noninsulin-Dependent (Type II) Diabetes.- Substrates and the Regulation of Hepatic Glycogen Metabolism.- Gluconeogenesis in Type 2 Diabetes.- Obesity, Lipoproteins, Atherogenesis, and NIDDM.- Regulation of Adipose Tissue Lipolysis, Importance for the Metabolic Syndrome.- Cellular and Molecular Factors in Adipose Tissue Growth and Obesity.- Regional Obesity and NIDDM.- Hyperinsulinemia and VLDL Kinetics.- Hyperinsulinism and Dyslipidemias as Coronary Heart Disease Risk Factors in NIDDM.- Potential Impact of New Concepts In NIDDM on Delivery of Care to Diabetic Populations.- A Paradigm to Link Clinical Research to Clinical Practice: The Challenge in Non-Insulin Dependent Diabetes Mellitus.

Sperm DNA damage is common and has been associated with reduced rates of conception, impaired embryonic development and increased risk of miscarriage. Although the exact causes of sperm DNA damage are unknown, it is clear that infertile men possess substantially higher levels of sperm DNA damage than do fertile men. Written by leading, internationally renowned clinicians and basic scientists with expertise in sperm DNA, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction provides readers with a thoughtful and comprehensive review of the biological and clinical significance of sperm DNA damage. The work covers the fundamental principles of sperm chromatin architecture and function, the proposed modes of DNA damage and repair, the tests of sperm DNA damage, the clinical aspects of DNA damage and the impact of DNA damage on reproductive outcome. Unlike any other title on the topic, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction is an invaluable addition to the literature and will serve as an indispensable resource for basic scientists with an interest in sperm biology and for urologists, gynecologists, reproductive endocrinologists, and embryologists working in the field of infertility.

This practice-oriented book provides a comprehensive and up-to-date review of the history, surgical anatomy, etiology, pathogenesis, clinical presentation and treatment of primary, secondary, and tertiary hyperparathyroidism. The coverage is wide ranging, encompassing, for example, innovations in both medical and surgical treatment, current indications for parathyroidectomy, the role and performance of minimally invasive surgery, the value of intraoperative parathyroid hormone monitoring and guidance on reoperations. Individual chapters are devoted to particular conditions and disease settings, including multiple endocrine neoplasia types 1 and 2 and parathyroid carcinoma, with provision of information on genetic testing, clinical manifestations and therapy. All aspects of secondary hyperparathyroidism in predialysis and dialysis patients are discussed. The book is endorsed by the Italian Society of Surgery. It will be of great value for endocrine surgeons and endocrinologists and will also be of interest to specialists in internal medicine, nephrologists, urologists, gynecologists and radiologists.

Historically the field of endocrine research has always been at the forefront of scientific endeavors. The investigators of these important breakthroughs in research have been rewarded by numerous Nobel awards. In the field of diabetes alone, Nobel prizes have been awarded to researchers who discovered insulin, characterized the protein and invented radioimmunoassays using insulin as a paradigm. Not surprisingly, biomedical researchers have always been attracted by the endocrine system and other similar systems of intercellular communication.
Over the past two decades, endocrine research has developed rapidly and adapted modern molecular and cellular biology techniques for its specific use. These changes have allowed researchers in the field to maintain their edge. Thus, endocrine disease-related genes have been characterized and mutations in these genes have helped explain common and
less common endocrine disorders. Our understanding of the regulation of gene expression has been greatly enhanced by molecular techniques.
In an attempt to bring investigators up to date with the recent advances in this exploding field we have decided to publish a series entitled Advances in Molecular and Cellular Endocrinology. Internationally famous investigators have agreed to participate and their contributions are appreciated.
Volume 1 has focused on aspects of the hypothalamic-pituitary axis including GnRH and GH gene regulation, molecular aspects of insulin, insulin-like growth factors and glucagon. In addition, reviews on the recently cloned calcium receptor and steroid receptor interactions with DNA are presented.

In this fascinating book, Jacques Balthazart presents a simple description of the biological mechanisms that are involved in the determination of sexual orientation in animals and also presumably in humans. Using scientific studies published over the last few decades, he argues that sexual orientation, both homosexual and heterosexual, is under the control of embryonic endocrine and genetic phenomena in which there is little room for individual choice. The author begins with animal studies of the hormonal and neural mechanisms that control the so-called instinctive behaviors and analyzes how this animal work may potentially apply to humans. The book does not focus exclusively on homosexuality, however. Instead, the book acts as a broader guide to the biological basis of sexual orientation, and also discusses important gender differences that may influence sexual orientation. While firmly grounded in the scientific literature, this text is developed for a broader audience and will be of interest to psychologists, researchers, students, and anyone interested in the biological factors that determine our sexuality.

The second edition of this work continues to address the intimate pathophysiologic relationship between hypertension and stroke. The editors and authors clearly and concisely synthesize our developing knowledge of this relationship and place epidemiologic and physiologic information into a practical clinical context. Comprehensive chapters present the evidence supporting strategies for stroke prevention and care, including blood pressure lowering therapies, anti-coagulation, and management of other cerebrovascular risk factors. In addition to prescriptive measures for first stroke prevention, the book illuminates current regimens for care immediately after acute stroke and for the prevention of recurrent stroke. This latest edition also features extensively updated chapters from the previous edition, as well as new chapters on the effects of hypertension and stroke on the cerebral vasculature, blood pressure management in subarachnoid hemorrhage, and blood pressure variability, antihypertensive therapy, and stroke risk. Written by experts in the field, Hypertension and Stroke: Pathophysiology and Management, Second Edition is of great utility for specialists in neurology and cardiovascular medicine and a valuable practical resource for all physicians caring for older adults and hypertensive patients.

The American Cancer Society recently estimated that about 45,000 new cases of thyroid cancer will be diagnosed in the United States, with three-quarters occurring in women. The overall 5-year survival rate is about 97%, making it one of the least lethal cancers. We are experiencing an epidemic of well-differentiated thyroid cancer, in part due to the widespread use of imaging modalities that detect thyroid nodules and microcarcinomas. Concurrently, there have been a number of recent advances in surgical treatment, as well as diagnostic modalities that allow us to detect small amounts of residual local and metastatic disease. Additionally, a reexamination of past treatment regimens has led to new recommendations regarding the use of radioactive iodine, and to new therapeutic options, such as targeted therapy which have supplanted the use of more toxic chemotherapy for metastatic cancer. Multiple academic organizations have developed consensus guidelines for the management of thyroid cancer, occasionally with conflicting recommendations. In Thyroid Cancer, a renowned group of authors presents a broad overview of the pathology, pathophysiology, diagnosis, and management of thyroid cancer, with an emphasis on recent evidence-based information. State-of-the-art and a significant contribution to the literature, Thyroid Cancer is an invaluable reference for endocrinologists, oncologists, nuclear medicine physicians, radiation oncologists, primary care physicians, and surgeons who deal with head and neck cancer.

The mature T and NK cell lymphomas are rare, comprising approximately 10% of all malignant lymphomas. The incidence of T- cell lymphoma is variable around the world, with a higher incidence compared to B-cell lymphomas in the Asian basin. While the overall incidence of B-cell lymphomas has begun to decline in the United States, the incidence of T-cell lymphomas continues to rise. Over the last decade, a number of novel agents have been developed which target T-cell lymphomas and studies have identified novel genes and pathways associated with lymphomagenesis in T-cells. This comprehensive volume examines the clinical and biological aspects of the T-cell lymphoproliferative disorders in adults and children. The book includes an overview of both the cutaneous and the systemic T-cell malignancies and addresses the classification of T-cell lymphomas, the clinical features of each subtype, and the relevant molecular and genetic studies. Clinical outcomes and treatment strategies are discussed with an emphasis on the development of novel biological and targeted therapies. An outstanding resource for hematologists and oncologists, this book gathers insights from experts in the field and provides the most up-to-date information on all of the T-cell lymphoma subgroups and current and emerging therapies.

Jacques Barzun, the noted Columbia University historian of ideas and culture, once described the feeling that some people experience when they come upon a new reference book. He wrote: "Hand over to one of us a new Dictionary, "Companion," or Guide, and our eyes first light up and then turn dreamy: we have seized the volume and are off, arm in arm with the guide i or companion. ..." The book now in your hands made my eyes light up. Thyroid Disorders with Cutaneous Manifestations is that kind of book. Heymann, who has been fascinated by this sometimes controversial subject for decades, has brought not only his own expertise, but that of many experts from the fields of the skin and the thyroid gland. Steven Jay Gould wrote about overlapping and nonoverlapping magisteria-this book demonstrates just how much important overlap there is. But it also covers the basics in such a way that dermatologists can find what they need to know about the thyroid and thyroidologists can find what they need to know about the skin. Thyroid Disorders with Cutaneous Manifestations falls neatly into the tra- tion of medical monographs that become standards. They fulfill the roles of gathering, digesting, and synthesizing current knowledge, and they do so in a way that review articles cannot approach and that the scientific literature is not designed to accomplish.

SocialBonding,aProductofEvolution: anIntroductiontotheVolume Mechanisms underlying reproductive and maternal functions or coping represent the initialstructuringforcebehindmanysocialbehaviors.Theyareaccompaniedbysel- tivehormonalenvironmentsaimedatfacilitatingor stabilizingthem.Sexandadrenal steroids are major players in the regulation of reproductive functions and coping challenges, but other hormones also participate in a variety of social behaviors (in particular,oxytocinandvasopressin,twophylogeneticallyveryoldmoietiesoriginally associated with maternal care and water balance) and are receiving increasing att- tion. Their role is highlighted in the present volume, which gathers contributions to theColloqueMedicineetRecherche"HormonesandSocialBehavior"organizedbythe FondationIPSENinDecember 2007. Whatisthekeytounderstandingtherationaleofhormonalsubstratesofbehavior? Evolution, of course. Higher manifestations of social behavior have evolved from - productivebehavior,characterizedbyErnstMayras"theleadingedgeofevolutionary change." As formulated by one contributor to thisvolume, however, "the evolutionary increase in neocortex seen in primates has induced a signi?cant emancipation of - havior from hormonal determinants, and in parallel, an increasing role for intelligent socialstrategies"(Keverne 2008). In so-called "lower" mammalian animals, many social behaviors are closely - pendent upon the olfactory system, a component of autonomous regulation of such importancethatitexpressesalargeproportionofallreceptorgenespresentinthebrain. Whenonelooksat"higher"mammalssuchasprimates,olfactorycontrolbecomesless stringent. Olfactory structures exhibit the same number of receptor genes, but a large number are transformed into non-coding "pseudogenes." In parallel, hormones i- tially targeted on physiological functions become increasingly associated with more diversi?edcognitivefunctions.

Cushings syndrome is a rare disorder that is associated with many co-morbidities such as systemic hypertension, diabetes, osteoporosis, impaired immune function, and psychiatric disease, all of which severely reduce quality of life and life expectancy. This book reviews the role of cortisol in the human body, focusing on the effects of excess cortisol due to Cushing's syndrome as well as the role of the HPA axis in metabolism, inflammation, and neuropsychiatric function. The volume will cover basic mechanistic data, clinical outcomes data, and novel therapies. Also discussed are everything from abnormalities of the HPA axis, to the role of the HPA axis in the development of neuropsychiatric disorders and metabolic disorders, to new definitions of Cushing's remission and recurrence. The Hypothalamic Pituitary Adrenal Axis in Health and Disease will provide a comprehensive and multi-disciplinary review of the pathophysiology and outcomes of excess cortisol in the human body and brain as well as the role of the HPA axis in other disease states.

Tamoxifen is a pioneering medicine for the treatment and prevention of breast cancer. It is the first drug targeted therapy in cancer to be successful. Tamoxifen targets the tumor estrogen receptor. The therapy is known to have saved the lives of millions of women over the past 40 years. This monograph, written by V. Craig Jordan - known as the "father of tamoxifen" - and his Tamoxifen Team at the Georgetown University Washington DC, illustrates the journey of this milestone in medicine. It includes a personal interview with V. Craig Jordan about his four decades of discovery in breast cancer research and treatment. V. Craig Jordan was there for the birth of tamoxifen as he is credited for reinventing a "failed morning after contraceptive" to become the "gold standard" for the treatment of breast cancer. He contributed to every aspect of tamoxifen application in therapeutics and all aspects of tamoxifen's pharmacology. He discovered the selective estrogen receptor modulators (SERMs) and explored the new biology of estrogen-induced apoptosis.

Section One - Regulation Of Cell Growth And Development.- The Role of Growth Hormone and Prolactin in Beta-Cell Growth and Regeneration.- The Insulin-Like Growth Factor Family of Peptides, Binding Proteins and Receptors: Their Potential Role in Tissue Regeneration.- The Effects of IGF-I and IGF-II on Cell Growth and Differentiation in the Central Nervous System.- Growth Factor Expression in Normal and Diabetic Rats During Peripheral Nerve Regeneration through Silicone Tubes.- Oncogenes and Cell Growth.- Interferon - A Candidate Mediator of Cell Growth.- Section Two - Models for the Study of Cell Regeneration.- Islet Beta-Cell Regeneration and Reg Genes.- Factors Regulating Islet Regeneration in the Post-Insulinoma NEDH Rat.- Regeneration of Pancreatic Endocrine Cells in Interferon Gamma Transgenic Mice.- Trophic Stimulation of the Ductular-Islet Cell Axis: A New Approach to the Treatment of Diabetes.- Section Three - Induction of Cell Growth and Mechanisms.- Expression of Insulin-Like Growth Factors (IGFs) and Their Binding Proteins (IGF BPs) During Pancreatic Development in Rat, and Modulation of IGF Actions on Rat Islet DNA Synthesis by IGF BPs.- The Partial Isolation and Characterization of Ilotropin, A Novel Islet-Specific Growth Factor.- Expression of Growth Factors in a Pancreatic Islet Regeneration Model.- Role of p21ras in Hormone Signalling and Cell Growth Transformation.- Phosphoinositides and Cell Growth.- The Physiological STOP Pathway: Target Regulation of Axonal Growth.- Cell Calcium Regulation of Myosin I - A Motor for Membrane Movement.- Section Four - Pathogenic and Therapeutic Ramifications.- Amylin Expression in the Pancreatic Beta-Cell.- Studies of Composite Grafts of Fetal Pancreas (FP) and Fetal Liver (FL) in the Streptozotocin-Induced Diabetic Rat.- Contributors.

Providing the latest evidence-based information on etiology, evaluation and treatment, this unique text provides an in-depth, comprehensive discussion of the epidemiology, genetic and endocrinologic factors and medical and surgical management of recurrent pregnancy loss (RPL). Taking a multidisciplinary approach including psychological treatment and patient perspectives, all aspects of current RPL prevention and treatment are elucidated. Detailed chapters provide real-world illustrative material and cover the set-up and management of RPL clinics and databases, containing practical tips. Recurrent Pregnancy Loss will be an excellent resource for OB-GYN specialists, general and reproductive endocrinologists, radiologists, hematologists, psychiatrists, psychologists, and any other investigators or clinicians treating patients confronted with this emotionally and physically trying condition.

1. The Role of Heat Shock Proteins in the Regulation of Steroid Receptor Function.- 2. Subcellular and Subnuclear Trafficking of Steroid Receptors.- 3. Structure and Function of the Steroid and Nuclear Receptor Ligand-Binding Domain.- 4. Structure and Function of the Steroid and Nuclear Receptor DNA Binding Domain.- 5. Modulation of Steroid/Nuclear Receptor Dimerization and DNA Binding by Ligands.- 6. Molecular Mechanisms of Nuclear-Receptor-Mediated Transcriptional Activation and Basal Repression.- 7. Transcriptional Cross-Talk by Steroid Hormone Receptors.- 8. Chromatin and Steroid-Receptor-Mediated Transcription.- 9. Regulation of Glucocorticoid and Estrogen Receptor Activity by Phosphorylation.- 10. Monomeric Nuclear Receptors.- 11. Orphan Nuclear Receptors and Their Ligands.

This volume, in discussing resistance to ibritumomab, will focus on the mechanism, hematological aspects, radiological and nuclear medicine aspects, and medical physics that deal with radiation dosimetry, and will outline future prospects for overcoming resistance and enhancing efficacy of ibritumomab.