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Books > Medicine > Clinical & internal medicine > Endocrinology > General

Visceral and Ectopic Fat - Risk Factors for Type 2 Diabetes, Atherosclerosis, and Cardiovascular Disease (Paperback): Hildo J.... Visceral and Ectopic Fat - Risk Factors for Type 2 Diabetes, Atherosclerosis, and Cardiovascular Disease (Paperback)
Hildo J. Lamb
R3,545 Discovery Miles 35 450 Ships in 12 - 17 working days

While the health consequences and mechanisms by which visceral fat causes disease are well-studied, relatively less is known about ectopic fat, its patterns of deposition and its effects on the pathoetiology of type 2 diabetes, atherosclerosis, and cardiovascular disease. Visceral and Ectopic Fat: Risk Factors for Type 2 Diabetes, Atherosclerosis, and Cardiovascular Disease covers the wealth of literature that has been amassed over the past decade on this topic. This reference brings all the research and clinical data together in one volume and helps clinicians and academic researchers understand more thoroughly the underlying mechanisms and interrelation between fat depots and ectopic fat stores in relation to health and disease. It showcases some of the recent developments in adipose tissue biology, particularly on the impact of interventional strategies - bariatric surgery, liposuction, physical and dietary intervention - of which information is desired among health specialists and policy makers.

Inflammation and Obesity - A New and Novel Approach to Manage Obesity and its Consequences (Paperback): Raman Mehrzad Inflammation and Obesity - A New and Novel Approach to Manage Obesity and its Consequences (Paperback)
Raman Mehrzad
R3,341 Discovery Miles 33 410 Ships in 12 - 17 working days

Inflammation and Obesity: A New and Novel Approach to Manage Obesity and its Consequences is a comprehensive and up-to-date exploration of the correlation between obesity and inflammation. From the pathophysiology of obesity and inflammation, to the molecular mechanisms of obesity induced chronic inflammation, the book discusses how obesity and inflammation interact with other diseases. It highlights the hidden risk factors of obesity induced chronic inflammation, provides specific patient management guidelines regarding the higher inflammatory response in patients, and concludes with new therapeutic strategies to address inflammation in obese patients.

Male Sexual Dysfunction - Pathophysiology and Treatment (Paperback): Fouad R. Kandeel Male Sexual Dysfunction - Pathophysiology and Treatment (Paperback)
Fouad R. Kandeel
R1,901 Discovery Miles 19 010 Ships in 12 - 17 working days

Although impotence may be the most widely recognized manifestation of male sexual dysfunction, many other forms of sexual disorders do not involve the erectile mechanism, from deficiencies of desire to disturbances in ejaculatory function to the failure of detumescence. With such a myriad-and often co-existing-number of disorders, the successful treatment of male sexual dysfunction requires not only a thorough understanding of the underlying physiology and pathophysiology, but also the coordinated efforts of multiple specialties, including endocrinology, andrology, urology, radiology, sex therapy, and even sometimes psychiatry, cardiology, or oncology. Male Sexual Dysfunction: Pathophysiology and Treatment presents the collective expertise of more than 60 international authorities in a single landmark text. From foundations in the anatomy of the male genital tract to the latest neuroimaging data, readers will appreciate the comprehensive information detailing the tremendous advances made in the delineation of sexual function and its disorders as well as the expert descriptions of practical and cost-effective medical, surgical, and psychological strategies for the treatment of all forms of male sexual dysfunction.

Disorders of Emotion in Neurologic Disease, Volume 183 (Hardcover): Kenneth M. Heilman, Stephen E. E Nadeau Disorders of Emotion in Neurologic Disease, Volume 183 (Hardcover)
Kenneth M. Heilman, Stephen E. E Nadeau
R5,638 Discovery Miles 56 380 Ships in 12 - 17 working days

Disorders of Emotion in Neurologic Disease, Volume 183 in the Handbook of Clinical Neurology Series, informs clinicians on which neurologic diseases are likely to have a secondary effect on emotion, what to look for in diagnosis, and best practices for treatment. The book begins with an understanding of the neurological basis for emotions in order to better understand what goes awry in neurological disease. It then discusses specific neurologic diseases and disorders affecting emotion.

Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging (Paperback): Sandeep Kumar Singh, Chih Li Lin, Shailendra Kumar... Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging (Paperback)
Sandeep Kumar Singh, Chih Li Lin, Shailendra Kumar Mishra
R3,345 Discovery Miles 33 450 Ships in 12 - 17 working days

Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging is a comprehensive and timely book on all aspects of anti-aging strategies. The book provides comprehensive, foundational knowledge on the mechanisms of aging and current anti-aging strategies and approaches developed. Aging research has experienced an unprecedented advance over recent years with the discovery that the rate of aging is determined, at least to some extent, mainly by our genetics and modulated by environmental factors. The hallmarks of aging describe the molecular and cellular processes that govern biological aging and their variation in individuals.

Radiopharmaceuticals for Therapy (Hardcover, 1st ed. 2016): F. F. (Russ) Knapp, Ashutosh Dash Radiopharmaceuticals for Therapy (Hardcover, 1st ed. 2016)
F. F. (Russ) Knapp, Ashutosh Dash
R4,932 Discovery Miles 49 320 Ships in 12 - 17 working days

This book provides detailed information on therapeutic radiopharmaceuticals and discusses emerging technologies which have potential for broad clinical implementation. Recent advances in molecular biology, radiopharmaceutical chemistry and radioisotope production have stimulated a new era for the use of radiopharmaceuticals for targeted radionuclide therapy (TRT). Emerging clinical trials include use of peptides and monoclonal antibodies radiolabeled with therapeutic radionuclides for cancer therapy. In addition, small molecules are used for the treatment of chronic diseases such as metastatic bone pain palliation and radiation synovectomy of inflammatory joints. In the interventional arena, therapy of primary and metastatic liver cancer and arterial restenosis following angioplasty of both the coronary and peripheral arteries are being explored. Reactor and accelerator production of therapeutic radioisotopes is also integrated into these discussions. The development and use of radiopharmaceutical targeting characteristics required for treatment of specific disease processes and how these are implemented for radiopharmaceutical design strategies are also described. Radiopharmaceuticals for Therapy will benefit audiences in nuclear medicine and radionuclide therapy and will thus prove an invaluable source of up-to-date information for students, radiopharmaceutical scientists and professionals working in the radiopharmacy and nuclear medicine specialties.

Polycystic Kidney Disease (Hardcover): Jinghua Hu, Yong Yu Polycystic Kidney Disease (Hardcover)
Jinghua Hu, Yong Yu
R3,197 Discovery Miles 31 970 Ships in 12 - 17 working days

This volume focuses on the investigatory methods applied to autosomal dominant polycystic kidney disease (ADPKD), one of the most common human genetic diseases. ADPKD is caused by mutations in PKD1 and TRPP2, two integral membrane proteins that function as receptor/ion channels in primary cilia of tubular epithelial cells. Thus, ADPKD belongs to ciliopathies, a group of disorders caused by abnormal cilia formation or function. This proposed book will cover the state-of-the-art methods ranging from molecular biology, biochemistry, electrophysiology, to tools in model animal studies. Key Features Explores the role of cilia in polycystic kidney disease Focuses on myriad state-of-the-art methods and techniques Reviews specific mutations integral to this autosomal genetic disease Includes discussions of model systems

Hormones and Epigenetics, Volume 122 (Hardcover): Gerald Litwack Hormones and Epigenetics, Volume 122 (Hardcover)
Gerald Litwack
R4,651 Discovery Miles 46 510 Ships in 12 - 17 working days

Hormones and Epigenetics, Volume 122, the latest release in the Vitamins and Hormones series, highlights new advances in the field, with this new volume presenting timely, interesting chapters written by an international board of authors.

Aphasia, Volume 185 (Hardcover): Argye Elizabeth Hillis, Julius Fridriksson Aphasia, Volume 185 (Hardcover)
Argye Elizabeth Hillis, Julius Fridriksson
R5,627 Discovery Miles 56 270 Ships in 12 - 17 working days

Aphasia, Volume 185 covers important advances in our understanding of how language is processed in the brain and how lesions or degeneration in the left hemisphere affect language processing. This new release reviews research regarding how language recovers from brain injury, along with new interventions developed to enhance recovery, including language rehabilitation, noninvasive brain stimulation and medications. Sections cover neuroanatomy and neurophysiology of language networks, focus on mechanisms of recovery (and decline) of language, and include chapters on intervention, including recently developed behavioral therapies, brain stimulation, medications, and a review of studies of treatment for both post-stroke aphasia and primary progressive aphasia.

Thyroid Diseases (Paperback): Fabrizio Monaco Thyroid Diseases (Paperback)
Fabrizio Monaco
R1,899 Discovery Miles 18 990 Ships in 12 - 17 working days

In recent years, the clinical evolution of thyroid diseases has been studied exhaustively as new discoveries have been made about thyroid malfunction and the effective management of patients. Thyroid Diseases presents a comprehensive exposition of a range of disorders caused by thyroid dysfunction. With contributions by well-known experts in the field, the book is the first compendium in several decades to assemble a vast amount of data and research into one volume. Following a methodological format, each chapter explores a different malady or condition. After defining the dysfunction or disease, the text presents the epidemiology, etiopathogenesis, clinical features, first and second level tests for diagnosis, first and second line therapies, prognosis, and recommendations for follow-up. Highlighted topics include: Transient forms of hyper- and hypothyroidism Subclinical hyper- and hypothyroidism Thyroid dysfunction during gestation and postpartum The influence of iodine on the thyroid during pregnancy The importance of drugs that modify thyroid function Thyroid disrupters that affect thyroid homeostasis The bimodal and/or transient development of some thyroid diseases The evolution of diagnosis, priorities of therapies, and lifelong monitoring of patients All of the contributors to this text pursued long periods of training in elite research laboratories. They are active investigators and well known in the international arena. The information presented in this volume is invaluable for practicing clinicians and those training in internal medicine, endocrinology, surgery, and other areas of medicine.

Management of Cerebrovascular Disorders - A Comprehensive, Multidisciplinary Approach (Hardcover, 1st ed. 2019): Alejandro M.... Management of Cerebrovascular Disorders - A Comprehensive, Multidisciplinary Approach (Hardcover, 1st ed. 2019)
Alejandro M. Spiotta, Raymond D. Turner, M. Imran Chaudry, Aquilla S. Turk
R5,301 R4,542 Discovery Miles 45 420 Save R759 (14%) Ships in 12 - 17 working days

This important title brings together a distinguished panel of thought-leaders, known for their insights into the development and application of minimally-invasive surgical and endovascular techniques, to provide a comprehensive and discerning compendium of our most current knowledge and state-of-the-art procedures in the management of cerebral vascular diseases. Written in a style that is accessible to students and experienced practitioners alike, the book covers all the important recent advances that have reshaped the field in dramatic ways. Emphasizing how surgical and endovascular techniques are complementary, the volume includes illuminating chapters on the nexus of endovascular and conventional "open" cerebrovascular surgery, including patient assessment and practice in a hybrid operating environment, utilizing the best methods to achieve optimal outcomes. A major addition to the clinical literature, Management of Cerebrovascular Disorders: A Comprehensive, Multidisciplinary Approach will be of significant interest to neurosurgeons, neurologists, neuroradiologists, neurointensivists, students, residents, fellows, and specialized attending physicians.

Gaucher Disease (Paperback): Anthony H. Futerman, Ari Zimran Gaucher Disease (Paperback)
Anthony H. Futerman, Ari Zimran
R1,899 Discovery Miles 18 990 Ships in 12 - 17 working days

In September of 2007 Gaucher Disease received a commendation in the Haematology category of the 2007 British Medical Association Medical Book Competition! Although rare in the general population, Gaucher disease is the most prevalent of the lysosomal storage disorders, making research into this particular orphan disorder an invaluable prototype for the diagnosis, research, and treatment of others. Like many rare conditions, Gaucher disease has benefited from the explosion of medical research in the last decade, the amount of new information on this disease is staggering and the rate of new discoveries has left previous books on the subject unable to provide useful, up-to-date information. The most current, fully comprehensive reference to date, Gaucher Disease provides valuable information for academic and industry scientists, and clinicians. Outlining the latest research on the biochemical mechanisms and pathology of lysosomal storage disorders, this book covers diverse topics including animal models, crystallography, imaging and radionuclide evaluation. It not only addresses the developmental basis for current treatments like the now widely available enzyme replacement therapy, but also includes chapters introducing new therapies on the horizon. With contributions from world-renowned experts in substrate reduction therapy, pharmaceutical chaperone therapy, hematopoietic stem cell transplantation and gene therapy, as well as chapters on a second generation of enzyme replacement therapy, this book explores the full spectrum of possibilities offered by the most recent advances in medicine. Some of the most interesting aspects of the book include the discussions on patient management, those touching on the ethics of research, and the societal aspects of treating rare diseases with expensive therapy.

Hashimoto's Protocol - A 90-Day Plan for Reversing Thyroid Symptoms and Getting Your Life Back (Hardcover): Izabella Wentz Hashimoto's Protocol - A 90-Day Plan for Reversing Thyroid Symptoms and Getting Your Life Back (Hardcover)
Izabella Wentz 6
R835 R461 Discovery Miles 4 610 Save R374 (45%) Ships in 12 - 17 working days

Instant #1 New York Times Bestseller Dr. Izabella Wentz, the author of the phenomenal New York Times bestseller Hashimoto's Thyroiditis, returns with a long-awaited, groundbreaking prescription to reverse the symptoms of this serious autoimmune condition that is becoming one of the country's fastest growing diseases. More than thirty-five million Americans currently suffer from Hashimoto's-an autoimmune disease that affects the thyroid gland and causes the body to attack its own cells. To alleviate the symptoms of this debilitating condition-including chronic cough, acid reflux, IBS, allergies, chronic pain, hair loss, brain fog, and forgetfulness-patients are often prescribed synthetic hormones that have numerous life-altering side effects. But there is a better way. Diagnosed with Hashimoto's at twenty-seven, pharmacist Dr. Izabella Wentz knows first-hand the effects of the disease, as well as the value-and limitations-of medication. The key to improved health, she argues, involves lifestyle interventions. In Hashimoto's Protocol, she outlines a proven treatment that has helped thousands heal and many others feel better-in as fast as ninety days. Drawing on her own personal experience as well as her work consulting with thousands of patients, Hashimoto's Protocol offers a practical pathway for healing and reversing the autoimmune damage at the root of the disease. The first step is a quick-start two-week detox that includes foods to eat and inflammatory foods to avoid, advice on supplements to support the liver, and an adrenal recovery plan. Next, readers create a personalized plan with foods, supplements, and other lifestyle interventions tailored to their body's own unique Hashimoto's triggers, which they can identify using self-tests included in the book. Hashimoto's Protocol also features original recipes. Grounded in the latest science, Hashimoto's Protocol is the first book to offer a proven protocol by an acknowledged expert in the field to treat this condition and help sufferers reclaim their lives.

Chesley's Hypertensive Disorders in Pregnancy (Paperback, 5th edition): Robert N Taylor, Kirk P. Conrad, Sandra T.... Chesley's Hypertensive Disorders in Pregnancy (Paperback, 5th edition)
Robert N Taylor, Kirk P. Conrad, Sandra T. Davidge, Anne Cathrine Staff, James M. Roberts
R4,661 Discovery Miles 46 610 Ships in 12 - 17 working days

Leon Chesley's Hypertensive Disorders in Pregnancy was initially published in 1978. Four decades later, hypertension complications in pregnancy are still a major cause of fetal and maternal morbidity and death, especially in less developed nations. It is also a leading cause of preterm birth now known to be a risk factor in remote cardiovascular disease. Despite this, hypertensive disorders remain marginally studied and management is often controversial. Chesley's Hypertensive Disorders in Pregnancy, Fifth Edition continues its tradition as one of the beacons to guide the field of preeclampsia research, recognized for its uniqueness and utility. This revision focuses on prediction, prevention, and management for clinicians, and is an essential reference text for clinical and basic investigators alike. It provides a superb analysis of the multiple topics that relate to hypertension in pregnancy, especially of preeclampsia.

Extraskeletal Effects of Vitamin D - A Clinical Guide (Paperback, Softcover reprint of the original 1st ed. 2018): Emilia... Extraskeletal Effects of Vitamin D - A Clinical Guide (Paperback, Softcover reprint of the original 1st ed. 2018)
Emilia Pauline Liao
R2,660 Discovery Miles 26 600 Ships in 10 - 15 working days

While the skeletal effects of vitamin D are well-documented, the role and importance of vitamin D outside of bone health has not been well-established. Vitamin D receptors are located in nearly every tissue of the body, and low levels of vitamin D are associated with a range of various diseases. This book provides an in-depth examination of these extraskeletal effects of vitamin D and the associations between vitamin D deficiency and various disease states. Beginning with a review of the biochemistry and physiology of vitamin D, subsequent chapters investigate its relationship to autoimmune and infectious diseases, various forms of cancer, endocrine issues such as diabetes, obesity and reproductive function, cardiovascular disease and muscle weakness. Concluding chapters discuss the role of vitamin D in neurological disorders, including Alzheimer's Disease, and cognitive function. Focusing on extraskeletal effects only across a range of conditions, Extraskeletal Effects of Vitamin D will be an important resource for clinical endocrinologists and primary care physicians.

A Clinician's Guide to Sperm DNA and Chromatin Damage (Paperback, Softcover reprint of the original 1st ed. 2018): Armand... A Clinician's Guide to Sperm DNA and Chromatin Damage (Paperback, Softcover reprint of the original 1st ed. 2018)
Armand Zini, Ashok Agarwal
R4,795 Discovery Miles 47 950 Ships in 10 - 15 working days

This comprehensive, up-to-date text, which brings together the key practical elements of the rapidly evolving field of sperm DNA and chromatin abnormalities, is divided thematically into five main sections. Part I discusses human sperm chromatin structure and nuclear architecture, while part II presents laboratory evaluation of sperm DNA damage, including SCSA, SCD, TUNEL and Comet assays, and cytochemical tests. Biological and clinical factors in the etiology of sperm DNA damage are discussed in part III, including oxidative stress, abortive apoptosis, cancer, and environmental and lifestyle factors. Part IV presents clinical studies on the utility of sperm DNA damage tests, both with natural and ART-assisted pregnancies, and debates the clinical utility of such tests. Finally, part V discusses current treatment options, such as antioxidant therapy, varicocelectomy, advanced sperm processing techniques and the use of testicular sperm. We are now beginning to better understand the unique organization of the sperm chromatin, as well as the nature and etiology of sperm DNA damage. Written and edited by worldwide experts in andrology, A Clinician's Guide to Sperm DNA and Chromatin Damage is an excellent resource for reproductive medicine and REI specialists, urologists, reproductive biologists and any professional working with the infertile male.

Bone Marrow Pathology Fifth Edition (Hardcover, 5th Edition): BJ Bain Bone Marrow Pathology Fifth Edition (Hardcover, 5th Edition)
BJ Bain
R5,040 R4,415 Discovery Miles 44 150 Save R625 (12%) Ships in 12 - 17 working days

Bone Marrow Pathology has been extensively revised to reflect the significant advances which have occurred in the application of cytogenetics and in particular, molecular genetics in the diagnosis, classification and understanding of haematological disorders. This comprehensive book not only provides information on all common disease entities, but also covers rare disorders in which bone marrow examination is useful. It is designed as a practical resource with "problems and pitfalls" highlighted throughout to aid laboratory diagnosis.

Aroused - The History of Hormones and How They Control Just About Everything (Paperback): Randi Hutter Epstein Aroused - The History of Hormones and How They Control Just About Everything (Paperback)
Randi Hutter Epstein
R382 Discovery Miles 3 820 Ships in 9 - 15 working days

Metabolism, behaviour, sleep, mood swings, the immune system, fighting, fleeing, puberty and sex: these are just a few of the things our bodies control with hormones. Armed with a healthy dose of wit and curiosity, medical journalist Randi Hutter Epstein takes us on a journey through the unusual history of these potent chemicals from a basement filled with jarred nineteenth-century brains to a twenty-first-century hormone clinic in Los Angeles. Brimming with fascinating anecdotes, illuminating new medical research and humorous details, Aroused introduces the leading scientists who made life-changing discoveries about the hormone imbalances that ail us, as well as the charlatans who used those discoveries to peddle false remedies.

Primary Care Nutrition - Writing the Nutrition Prescription (Hardcover): David Heber, Zhaoping Li Primary Care Nutrition - Writing the Nutrition Prescription (Hardcover)
David Heber, Zhaoping Li
R4,670 Discovery Miles 46 700 Ships in 12 - 17 working days

This book contains the necessary knowledge and tools to incorporate nutrition into primary care practice. As a practical matter, this effort is led by a dedicated primary care physician with the help of motivated registered dietitians, nurses, psychologists, physical therapists, and office staff whether within a known practice or by referral to the community. It is essential that the nutrition prescription provided by the physician be as efficient as possible. While many team members have superior knowledge in the areas of nutrition, exercise, and psychology, the health practitioner remains the focus of patient confidence in a therapy plan. Therefore, the endorsement of the plan rather than the implementation of the plan is the most important task of the physician. This book proposes a significant change in attitude of primary health care providers in terms of the power of nutrition in prevention and treatment of common disease. It features detailed and referenced information on the role of nutrition in the most common conditions encountered in primary care practice. In the past, treatment focused primarily on drugs and surgery for the treatment of disease with nutrition as an afterthought. Advanced technologies and drugs are effective for the treatment of acute disease, but many of the most common diseases such as heart disease, diabetes, and cancer are not preventable with drugs and surgery. While there is mention of prevention of heart disease, this largely relates to the use of statins with some modest discussion of a healthy diet. Similarly, prevention of type 2 diabetes is the early introduction of metformin or intensive insulin therapy.

Managing Treatment-Resistant Depression - Road to Novel Therapeutics (Paperback): Joao Luciano de Quevedo, Patricio Riva Posse,... Managing Treatment-Resistant Depression - Road to Novel Therapeutics (Paperback)
Joao Luciano de Quevedo, Patricio Riva Posse, William V. Bobo
R5,078 Discovery Miles 50 780 Ships in 12 - 17 working days

Managing Treatment-Resistant Depression: Road to Novel Therapeutics defines TRD for readers, discussing the clinical and epidemiological predictors, economic burden and neurobiological factors. In addition, staging methods for treatment resistance are fully covered in this book, including serotonin specific reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, other classes of antidepressants, including tricyclic antidepressants and monoamine oxidase inhibitors, augmentation strategies, and newer antidepressant treatments like ketamine and esketamine. In addition, evidence supporting the use of psychotherapies and neuromodulation strategies are also reviewed. Written by top experts in the field, this book is the first of its kind to review all methods of treatment for TRD.

Practical Stress Management - A Comprehensive Workbook (Paperback, 8th edition): John A Romas, Manoj Sharma Practical Stress Management - A Comprehensive Workbook (Paperback, 8th edition)
John A Romas, Manoj Sharma
R2,079 Discovery Miles 20 790 Ships in 12 - 17 working days

Practical Stress Management, Eighth Edition emphasizes a positive approach to stress management, covering topics such as relaxation techniques, coping with anxiety, managing anger, communication skills, exercise and nutrition. In this edition, the authors cover the latest advances in stress management, as well as stress related to the use of technology in education. The context of disasters, such as the COVID-19 pandemic, is also incorporated throughout. The workbook describes some of the surreptitious meditation techniques from India not described before in any text. Worksheets and Thoughts for Reflection boxes help users determine their own level of stress to apply effective stress management techniques.

Mammalian Endocrinology and Male Reproductive Biology (Paperback): Shio Kumar Singh Mammalian Endocrinology and Male Reproductive Biology (Paperback)
Shio Kumar Singh
R1,872 Discovery Miles 18 720 Ships in 12 - 17 working days

Mammalian Endocrinology and Male Reproductive Biology provides comprehensive and current coverage of the area of endocrinology and male reproductive biology, covering not just humans, but mammals in general. Written by international experts in their respective fields, this multi-author book also covers the latest developments in genomics of androgen action and male infertility. The book begins by covering sexual dimorphism in the central nervous system; structure, control of secretion and function of GnRH; and gonadotropins of pituitary origin and their role in gonadal functions. This is followed by an account of hormonal regulation of spermatogenesis, and the role of apoptosis in this process. Subsequent chapters center around epididymis, regulation of growth and function, and sperm motility regulation. The last chapters in the book discuss the structure and function of male accessory sex glands with associated pathologies as well as recent updates in male contraception, mechanism of androgen action, and genomics of male infertility. Wherever necessary, tables and figures have been added for a better understanding. Each chapter is appropriately referenced and contains current information on the latest developments in the field.

Recurrent Implantation Failure - Etiologies and Clinical Management (Paperback, Softcover reprint of the original 1st ed.... Recurrent Implantation Failure - Etiologies and Clinical Management (Paperback, Softcover reprint of the original 1st ed. 2018)
Jason M. Franasiak, Richard T. Scott Jr.
R2,645 Discovery Miles 26 450 Ships in 10 - 15 working days

This unique text discusses the wide range of causes and pathophysiologic conditions contributing to recurrent implantation failure (RIF) and the current treatment approaches to best approach this challenging patient population. Beginning with a presentation of the mechanism of normal implantation, the physiologic synchrony between embryo and endometrium, and the roles of both gametes and embryos in RIF, the book then examines the various genetic, immune and environmental factors involved. Abnormalities of the hematologic and endocrine system, as well as those of the anatomy and microbiome, are described in detail. Last but no less important, the psychological stress and treatment of patients experiencing RIF is discussed. Assisted reproductive technology (ART) success has increased substantially over the past three decades. However, despite these advances, recurrent implantation failure is still a common issue confronting patients and clinicians, and RIF represents one of the greatest challenges in ART and remains a source of frustration and disappointment for patients, clinicians, and researchers involved in the process. Providing an in-depth investigation into the pathophysiology and biological mechanisms of RIF and its clinical management, this will be an excellent resource for reproductive endocrinologists and infertility specialists.

Male Hypogonadism - Basic, Clinical and Therapeutic Principles (Hardcover, 2nd ed. 2017): Stephen J. Winters, Ilpo T. Huhtaniemi Male Hypogonadism - Basic, Clinical and Therapeutic Principles (Hardcover, 2nd ed. 2017)
Stephen J. Winters, Ilpo T. Huhtaniemi
R4,325 Discovery Miles 43 250 Ships in 10 - 15 working days

Now in a revised second edition, this comprehensive text covers all aspects of male hypogonadism from the basic science to clinical management, comprehensively explaining and applying new insights to the treatment of hypogonadal men. Chapters covering neuroendocrine control of testicular function, Leydig cell function, spermatogenesis, and normal and delayed puberty open the book. The focus then turns to the pathophysiology and treatment of hypogonadism and other forms of testicular dysfunction, such as Klinefelter syndrome, cryptorchidism, and disorders of the pituitary, as well as reproductive and endocrine consequences of cancer treatment, environmental factors, obesity and aging. Next are chapters that describe the available options for androgen replacement therapy, and the outcomes when men with hypogonadism of various causes are treated with testosterone, as well as a chapter devoted to current approaches to stimulating spermatogenesis in gonadotropin-deficient men. Highly practical and updated with the latest available data, this second edition of Male Hypogonadism: Basic, Clinical and Therapeutic Principles cogently presents a large body of scientific information on male reproductive endocrinology to provide a thorough understanding of the pathophysiology, clinical characteristics, and treatments for disorders that adversely affect testicular function.

Metabolic Living - Food, Fat, and the Absorption of Illness in India (Hardcover): Harris Solomon Metabolic Living - Food, Fat, and the Absorption of Illness in India (Hardcover)
Harris Solomon
R2,500 Discovery Miles 25 000 Ships in 12 - 17 working days

The popular narrative of "globesity" posits that the adoption of Western diets is intensifying obesity and diabetes in the Global South and that disordered metabolisms are the embodied consequence of globalization and excess. In Metabolic Living Harris Solomon recasts these narratives by examining how people in Mumbai, India, experience the porosity between food, fat, the body, and the city. Solomon contends that obesity and diabetes pose a problem of absorption between body and environment. Drawing on ethnographic fieldwork carried out in Mumbai's home kitchens, metabolic disorder clinics, food companies, markets, and social services, he details the absorption of everything from snack foods and mangoes to insulin, stress, and pollutants. As these substances pass between the city and the body and blur the two domains, the onset and treatment of metabolic illness raise questions about who has the power to decide what goes into bodies and when food means life. Evoking metabolism as a condition of contemporary urban life and a vital political analytic, Solomon illuminates the lived predicaments of obesity and diabetes, and reorients our understanding of chronic illness in India and beyond.

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