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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Genetics (non-medical) > DNA
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The Genetics of Obesity (Hardcover, 2014 ed.)
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The Genetics of Obesity (Hardcover, 2014 ed.)
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In the past four years, many genetic loci have been implicated for
BMI from the outcomes of genome-wide association studies (GWAS),
primarily in adults. Insulin-induced gene 2 (INSIG2) was the first
locus to be reported by this method to have a role in obesity but
replication attempts have yielded inconsistent outcomes. The
identification of the second locus, the fat mass- and
obesity-associated gene (FTO), h has been more robustly observed by
others. Studies from both FTO knock out and FTO overexpression
mouse model support the fact that FTO is directly involved in the
regulation of energy intake and metabolism in mice, where the lack
of FTO expression leads to leanness while enhanced expression of
FTO leads to obesity. Along with numerous other studies, a number
of genetic variants have been established robustly in the context
of obesity, giving us fresh insights into the pathogenesis of the
disease. This book will give a comprehensive overview of efforts
aimed at uncovering genetic variants associated with obesity, which
have been particularly successful in the past 5 years with the
advent of genome-wide association studies (GWAS). This book will
cover this state of the art technology and its application to
obesity in great detail. Topics covered will include genetics of
childhood obesity, genetics of syndromic obesity, copy number
variants and extreme obesity, co-morbidities of obesity genetics,
and functional follow-up of genetic variants. "
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