Dopamine is a small molecule traditionally regarded as a brain-derived neuronal modulator implicated in many neurological and psychiatric disorders. Outside the brain, dopamine fulfills all the criteria of a circulating hormone which affects normal and abnormal functions of multiple organs and regulatory systems and is also involved in many aspects of cancer formation and progression. This book provides a much needed systematic account of dopamine as an endocrine and autocrine/paracrine hormone and fills a major gap in the overall understanding of the production, distribution and actions of this very important molecule. Key Features: Explores the many different faces of dopamine as autocrine, paracrine and endocrine molecule Documents the adverse effects of antipsychotics on dopamine functions Reviews the many ways dopamine affects the cardiovascular, renal and reproductive systems Provides updates on receptor oligomerization and signaling Examines the role of dopamine in tumorigenesis Related Titles Jones, S. ed. Dopamine - Glutamate Interactions in the Basal Ganglia (ISBN 978-0-3673-8197-4) Luo, L. Principles of Neurobiology (ISBN 978-0-8153-4494-0) Sidhu, A. et al., eds. Dopamine Receptors and Transporters (ISBN 978-0-8247-0854-2)

Over the past few decades, cardiovascular disease and diabetes have emerged as major public health problems, both as distinct clinical entities and as comorbid conditions. As a result, the fields of vascular biology and endocrinology are working more closely now than ever before. With chapters by renowned experts, Cardiovascular Endocrinology: Shared Pathways and Clinical Crossroads emphasizes the considerable physiological interrelationships and clinical correlations between the specialties of cardiovascular medicine and endocrinology. Offering a wealth of information, Cardiovascular Endocrinology: Shared Pathways and Clinical Crossroads provides a range of insights, including a novel view of the hormonal regulation of the vascular system and the disruption of the nitric oxide signaling system. It also addresses the role of fatty acids and cytokines in the development of this problem. Importantly, this unique title also provides a state-of-the-art update on the importance of other hormones such as thyroid hormone and steroids, as well as the pathophysiology of cardiovascular disease and controversies surrounding the use of hormone replacement therapy. In all, Cardiovascular Endocrinology: Shared Pathways and Clinical Crossroads is a first-of-its-kind title that discusses and summarizes important clinical topics in cardiology and endocrinology. It offers clinicians and researchers an important resource for navigating the increasingly interrelated pathways of cardiovascular and endocrinologic disorders. The authors discuss a range of important issues from epidemiology to bench research to translation of this research to clinical practice.

In recent years, the development of new technologies capable of monitoring genome function has resulted in fewer hopeful estimates and increasingly solid depictions of genome output from individual samples. Genomics in Endocrinology focuses on exciting new advances in endocrinology resulting from DNA microarray studies and includes a comprehensive introduction to the use of DNA microarrays in endocrinology. The volume provides the basis for further understanding of the usefulness of microarray analyses in endocrinology research. Topics discussed are the methodology of DNA microarrays and general methods for the analysis of microarray data, as well as studies of a wide variety of normal and abnormal endocrine cells.

In the introductory chapter, the volumea (TM)s editors describe several issues in hypothesis formulation, experimental design, data analysis, and follow-up studies that may corroborate, validate, and extend hypotheses gained through microarray analyses. The contributed chapters span a variety of applications that we have divided into the areas of (1) genomic insights into molecular mechanisms responsible for hormone action, (2) genomic characterizations of endocrine producing tissues, and (3) genomic manifestations of diseases of hormonal systems.

A volume on the cutting-edge of technology, Genomics in Endocrinology will provide researchers with an authoritative volume on the most recent advances in monitoring genome function.

This issue of Physician Assistant Clinics, guest edited by CJ Chun, PA-C, is devoted to Endocrinology. Articles in this issue include: Diagnosing Diabetes Mellitus; Standards of Care and Treatments in Diabetes; Antihyperglycemic Medications: Overwhelmed with Too Many Options?; Special Considerations in Choosing Diabetes Therapy; Technology in Diabetes: Are You Tech-Savvy?; Unresolved Questions in Hypothyroidism; Thyrotoxicosis; Thyroid Nodules; Obesity: "Can the Battle Be Won?"; Pituitary: The Master Gland; Adrenal Disorders: Beyond The 'Flight or Fight' Response; Calcium, Parathyroid Disorder; and Male Hypogonadism.

With the discovery of internal secretions from the sex glands, later named the hormones testosterone and estrogen, physicians and the public thought these new products would point the way to rejuvenating an aging body and providing a longer, disease-free life. But the discovery and use of these sex gland products did not progress in an orderly manner, but in a somewhat erratic, bizarre course. In the late nineteenth and early twentieth century, attempts to capture and utilize the sex gland secretions resulted in pills composed of sex gland material, injections of an emulsion of the glands, and even transplants (grafts) of testicular or ovarian tissue, all of which proved to be worthless. But this was not obvious at the time. The results of treating men, in particular, with these products produced enthusiastic reports of regaining lost manhood. It was not until the actual discovery of testosterone and estrogen that the seemingly miraculous results of this ""organotherapy"" were proved to be only an illusion. Today, with the ability to diagnose and treat hormonal deficiencies, a patient may expect a favorable response to their complaints.

LA WRENCE G. RAISZ, MD Division of Endocrinology and Metabolism, University of Connecticut Health Center. Farmington. CT The rapid transfer of new knowledge concerning the pathogenesis, diagnosis, preven tion, and treatment of disease into clinical practice has always been a major challenge in medicine. This challenge is particularly difficult to meet in osteoporosis, not only because has been so much new knowledge generated in recent years, but also because this there disorder has not caught the attention of many practicing physicians. The goal of this volume is to help primary care physicians develop a better understanding of osteoporosis and a more effective approach to diagnosis, prevention, and treatment. As primary care physicians become more and more responsible for the maintenance of health and the prevention of disease, osteoporosis must become one of their important concerns. The magnitude of the problem of osteoporosis has been widely publicized. Within the next 30 years, the cost of hip fractures alone is expected to exceed $40 billion a year in the United States and will be a major cause ofincreased mortality. In addition, vertebral crush fractures will cripple more and more of our elderly population, both men and women. This enormous toll is not inevitable. Current methods of identifying individuals at risk and applying preventive programs could reduce the incidence offractures by 50% or more. This should be the minimum goal of clinicians."

Oxford Desk Reference: Endocrinology provides easy access to evidence-based materials for quick consultation but also provides an in-depth expert reference for clinical practice. It covers the process of diagnosis, investigation, and management, as well as information for patients. Internationally-renowned experts have brought together evidence, guidelines and their clinical expertise to put trustworthy support at your fingertips. The vast spectrum of endocrine disorders are clearly laid out in self-contained topics for easy reference. Chapters build bridges between pathogenesis, clinical presentation, differential diagnosis and investigation to aid understanding. Careful consideration is given to establishing a diagnosis including the recognition, investigation and management of the rarer diagnoses. The practical treatment of everyday endocrine disorders and the management of life-long conditions are outlined in clear protocols. Chapters are organised by endocrine glands, disorders and syndromes and there are sections on the involvement of hormones in other specialities including endocrine oncology. The continuity from childhood to adolescent and adult endocrinology as well as the needs of older patients is explored in specific sections. Dedicated chapters cover the important roles endocrine specialist nurses play in patient management, and dietetic advice. The editors have included a wealth of practical resources including: * A speedy reference section, which provides summaries and quick direction * A patient advice and reference section, which supports face-to-face discussion with patients * A medicolegal chapter, which outlines risk and DVLA regulations Oxford Desk Reference: Endocrinology is the ideal companion for consultants, registrars associate specialists and clinical assistants as well as those from other disciplines who share endocrine clinics including endocrine surgeons, oncologists, gynaecologists and paediatricians.

Although acute inflammation is a healthy physiological response indicative of wound healing, chronic inflammation has been directly implicated in a wide range of degenerative human health disorders encompassing almost all present day non-communicable diseases including autoimmune diseases, obesity, diabetes and atherosclerosis. Chronic Inflammation: Molecular Pathophysiology, Nutritional and Therapeutic Interventions provides an exposition of the process of chronic inflammation in three parts: Systems Biology of Inflammation and Regulatory Mechanisms describes the process of chronic inflammation including initiation, progression, and resolution. Pathologies Associated with Inflammation gives a rigorous and critical treatment of specific human health disorders where chronic inflammation plays a major role. Nutrition & Therapeutics for Inflammatory Diseases details the protective abilities of structurally diverse antioxidants, phytochemicals, anti-inflammatory diets, omega-3 fatty acids, NSAIDs, disease modifying anti-rheumatic drugs, and novel regimens. Designed for scientists as well as clinicians, Chronic Inflammation provides critical understanding of the key checkpoints that regulate chronic inflammation. Going beyond the epidemiology of chronic inflammation, the text covers regulatory mechanisms controlling inflammation initiation, progression, and resolution. The authors address pathologies associated with inflammation and provide various nutritional and therapeutic interventions for inflammatory diseases.

The popular narrative of "globesity" posits that the adoption of Western diets is intensifying obesity and diabetes in the Global South and that disordered metabolisms are the embodied consequence of globalization and excess. In Metabolic Living Harris Solomon recasts these narratives by examining how people in Mumbai, India, experience the porosity between food, fat, the body, and the city. Solomon contends that obesity and diabetes pose a problem of absorption between body and environment. Drawing on ethnographic fieldwork carried out in Mumbai's home kitchens, metabolic disorder clinics, food companies, markets, and social services, he details the absorption of everything from snack foods and mangoes to insulin, stress, and pollutants. As these substances pass between the city and the body and blur the two domains, the onset and treatment of metabolic illness raise questions about who has the power to decide what goes into bodies and when food means life. Evoking metabolism as a condition of contemporary urban life and a vital political analytic, Solomon illuminates the lived predicaments of obesity and diabetes, and reorients our understanding of chronic illness in India and beyond.

This is the first textbook on surgery for Diabetic Foot in the world. It is written as a practical surgery manual for residents and young surgeons performing surgical procedures for patients with diabetic foot problems. Such a guide will be useful not only to residents and surgeons in Singapore but also to our neighbouring countries including, Malaysia, Indonesia, Hong Kong, India, Sri Lanka etc. Each surgical procedure is written in a systematic fashion covering indications, pre-operative preparation, anaesthesia, patient positioning, operative technique (in step by step fashion and illustrations) and post-operative care.The scope covers all aspects of surgery for diabetic foot from surgical debridement, split skin grafting, surgery for osteomyelitis, minor amputations including ray, transmetatarsal, Lisfranc, Chopart and Modified Pirogoff amputation to major amputations such as below knee, through knee and above knee amputation. It also includes assessment for revascularisation and revascularisation procedures.This book will serve as a useful practical guide for training surgical residents and for surgeons aspiring to do diabetic foot surgery.

Genetic Diagnosis of Endocrine Disorders, Second Edition provides users with a comprehensive reference that is organized by endocrine grouping (i.e., thyroid, pancreas, parathyroid, pituitary, adrenal, and reproductive and bone), discussing the genetic and molecular basis for the diagnosis of various disorders. The book emphasizes the practical nature of diagnosing a disease, including which tests should be done for the diagnosis of diabetes mellitus in adults and children, which genes should be evaluated for subjects with congenital hypothyroidism, which genetic tests should be ordered in obese patients or for those with parathyroid carcinoma, and the rationale behind testing for multiple endocrine neoplasias.

Respiratory Neurobiology: Physiology and Clinical Disorders, Part One, Volume 188 is one of two volumes on the neurology of breathing. This volume focuses on the neurophysiology of breathing, while the second volume focuses on pathologies attributable to abnormalities of the neural control of breathing, breathing problems that may occur in neurological diseases, and the neurological complications of respiratory diseases.

Diabetes is a complex disease and is also one of the most common. It is very difficult to reach an accurate estimate for the global prevalence of diabetes since the standards and methods of data collection vary widely in different parts of the world. In addition, many potential sufferers are not included in the count because according to an estimate about 50% of cases remain undiagnosed for up to 10 years. However, according to an estimate for 2010, globally, there are about 285 million people (amounting to 6.4% of the adult population) suffering from this disease. This number is estimated to increase to 439 million by 2030 if no cure is found. The general increase in life expectancy, leading to an ageing population, and the global rise in obesity are two main reasons for the increase.

With the basic platform set, Editor presents his views and advice tothe readers, especially to diabetic patients suffering from T2DM, on the basis ofhis observations and information collected from other diabetics.

The 4th International Symposium on Women's Health and Menopause, organized by the Giovanni Lorenzini Medical Foundation (Milan, Italy and Houston, Texas) focused on the new strategies to improve the quality of life of post-menopausal women. This volume illustrates the findings of this conference and includes information on the age-related degenerative processes occurring after menopause including cardiovascular disease, cancer, fractures and dementia.

The (printed) 'Updated Edition' now comes with added value access to the complete, downloadable eBook version via Student Consult. Search, read and revise whilst on the move and use the interactive self-assessment to test your understanding. Crash Course - a more flexible, practical learning package than ever before. Crash Course - your effective every day study companion PLUS the perfect antidote for exam stress! Save time and be assured you have all the core information you need in one place to excel on your course and achieve exam success. A winning formula now for over 15 years, each series volume has been fine tuned and fully updated, with an improved layout tailored to make your life easier. Especially written by senior medical students or recent graduates - those who have just been in the exam situation - with all information thoroughly checked and quality assured by expert faculty advisers, the result are books which exactly meet your needs and you know you can trust. Each provides an integrated approach to the subject by linking together topics such as anatomy, development, histology, physiology and pharmacology. Diseases and complaints, clerking, clinical assessment and examination, common skills and further investigations are also covered. Commencing with clear 'Learning Objectives', every chapter guides you succinctly through the topic, giving full coverage of the curriculum whilst avoiding unnecessary and often confusing detail. A fully revised self-assessment section matching the latest exam formats is also included.In this edition, Crash Course Endocrinology has been carefully revised to further reflect the requirements today's medical curriculum, including enhanced coverage of the essential area of diabetes. More than 130 illustrations present clinical, diagnostic and practical information in an easy-to-follow manner Friendly and accessible approach to the subject makes learning especially easy Written by students for students - authors who understand exam pressures Contains 'Hints and Tips' boxes, and other useful aide-memoires Succinct coverage of the subject enables 'sharp focus' and efficient use of time during exam preparation Contains a fully updated self-assessment section - ideal for honing exam skills and self-testing Self-assessment section fully updated to reflect current exam requirements Contains 'common exam pitfalls' as advised by faculty Crash Courses also available electronically! Online self-assessment bank also available - content edited by Dan Horton-Szar! The (printed) 'Updated Edition' now comes with added value access to the complete, downloadable eBook version via Student Consult. Search, read and revise whilst on the move and use the interactive self-assessment to test your understanding. Crash Course - a more flexible, practical learning package than ever before. Now celebrating over 10 years of success - Crash Course has been specially devised to help you get through your exams with ease. Completely revised throughout, the new edition of Crash Course is perfectly tailored to meet your needs by providing everything you need to know in one place. Clearly presented in a tried and trusted, easy-to-use, format, each book in the series gives complete coverage of the subject in a no-nonsense, user-friendly fashion. Commencing with 'Learning Objectives', each chapter guides you succinctly through the topic, giving full coverage of the curriculum whilst avoiding unnecessary and often confusing detail. Each chapter is also supported by a full artwork programme, and features the ever popular 'Hints and Tips' boxes as well as other useful aide-memoires. All volumes contain an up-to-date self-assessment section which allows you to test your knowledge and hone your exam skills. Authored by students or junior doctors - working under close faculty supervision - each volume has been prepared by someone who has recently been in the exam situation and so relates closely to your needs. So whether you need to get out of a fix or aim for distinction Crash Course is for you!!

From the tissue culture dish to genetically modified mice, this volume explores the long recognized role of steroid hormones in regulating cell proliferation and differentiation. Many striking effects of steroid hormones are apparent during development and neoplasia and these topics are covered extensively. Several chapters address the pharmacological uses of steroid and related hormones, their analogs and antagonists in controlling growth of endocrine cancers. This book also highlights the complex role of cross talk between steroid hormones and signals initiated at the cell surface in the regulation of cell cycle in hormone responsive tissues.

This issue of Endocrinology and Metabolism Clinics, guest edited by Dr. Paul Hruz, is devoted to HIV and Endocrine Disorders. Articles in this issue include: Dyslipidemia and cardiovascular risk in HIV infection; Changes in nutritional concerns in HIV/AIDS; HIV Lipodystrophy: Lessons learned about adipose tissue and metabolic disorders; Hypogonadism in the HIV infected male; Gonadal function and reproductive health in women with HIV; Osteopenia, osteoporosis, and fracture risk with HIV infection and treatment; HIV-associated calcium and vitamin D abnormalities; Alterations in pancreatic islet function in HIV; Insulin resistance, glucose intolerance, and diabetes in HIV; Thyroid abnormalities in HIV; HPA axis/adrenal pathology in HIV; and Endocrinopathies in HIV-infected children.

This work, Essential Endocrinology: A Primer for Nonspecialists, is written with dual purposes in mind: first, to provide a framework of basic endocrinology and diabetology to the medical student, and second, to provide a quick, con cise, and handy "guide" to the junior residents in their early years of training who wish to obtain a working knowledge about endocrine disorders that affect their patients. One of the outstanding advantages of being a teacher of en docrinology to students and junior residents is that it bestows a perspective from a unique vantage point. Books written for the junior members of our profession have suffered from extremes of caliber, ranging from excellence beyond their comprehension to insufferable mediocrity. Textbooks in en docrinology that are simple enough to cover the principles of that speciality and yet comprehensive enough without treading into controversial quicksand are few and far between. This book is aimed at filling that gap and is written with no other criterion than simplifying a complex subject matter. From this touchstone, the work has never really departed. A decade of experience as a teacher and physician in the field of endo crinologyhas impressed on me that the process of "simplification" rests on four basic principles: an understanding of endocrine concepts, the application of these concepts to the understanding of diseases, the transference of knowl edge to clinical situations, and the integration of the patient with the labo ratory, the ultimate testing ground where clinical diagnoses stand or fall."

The 3rd edition of Hormones offers a comprehensive treatment of the hormones of humans all viewed from the context of current theories of their action in the framework of our current understanding their physiological actions as well as their molecular structures, and those of their receptors. This new edition of Hormones is intended to be used by advanced undergraduates and graduate students in the biological sciences. It will also provide useful background information for first year medical students as they engage in studies which are increasingly problem-based rather than discipline-focused. As the field of endocrinology itself has expanded so much in the past two decades, the up-to-date presentation of the basics presented in this book will be a solid foundation on which more specialized considerations can be based. New to this Edition: Coverage, for the first time of the following hormones; ghrelin, oxyntomodulin, kisspeptin, adrenomedullin, FGF23, erythropoietin, VIP and extended coverage of NO. Coverage of the hypothalamus has been integrated with the anterior pituitary because of the intimate functional and relationship between the two. The chapter on the thymus has been eliminated as more properly belonging in a book on immunology. Consideration of the role of hormones in cancer has been integrated into the chapters on the relevant hormones. Each of these areas occupies a unique niche in our understanding of the biological world and is part of the universality of signaling systems and how they govern biological systems.
New full color format includes over 600 full color, completely redrawn imagesCompanion web site will host all images from the book as PPT slides and .jpeg filesAll chapters have been completely updated and revitalized. Coverage of the hypothalamus has been integrated into the anterior pituitary chapter and coverage of the thymus has been eliminated and left to immunology textbooks

Psychoneuroendocrinology is the study of the interaction between hormones, the brain and human behaviour. This is the first book to examine psychoneuroendocrinology in the context of sport and exercise, offering a comprehensive review of current research and assessment techniques and highlighting directions for future research.

The book explores the links between hormones and behaviour, and draws important conclusions for how their study will aid in the understanding of the bidirectional link between sport and behaviour, central to the psychology of sport and exercise. It presents the key hormones that underpin behaviour in a sporting context, including the description of their physiologic mechanisms and behavioural effects. The book reports benchmark standards for the assessment and analysis of hormonal influences of behaviour in sport, and examines practical issues and contexts such as emotional state, overtraining and stress.

Psychoneuroendocrinology in Sport and Exercise is a breakthrough text that will be of interest to all advanced students and researchers working in the psychology and physiology of sport and exercise.

Richard B. Welbourn, a retired endocrine surgeon who has written two books on the subject, has compiled the definitive history of the new and advancing discipline of endocrine surgery. The book traces the history of endocrine surgery from its origins to the 1980s, detailing the stories behind the surgery of each gland. A valuable biographical index containing basic information as well as the ideas and achievements of great names in the field will prove an invaluable resource.

Topics include: Evolution of Endocrine Surgery; The Pituitary; The Thyroid; Thyroid Cancer; The Adrenal Glands; The Parathyroid Glands; The Endocrine Gut and Pancreas; Islet Cell Transplantation; Multiple Endocrine Adenopathy and Paraendocrine Syndromes; Cancer of the Breast and Prostate; Essential and Renal Hypertension; Surgical Stress. The book also includes more than 80 photos and diagrams. A chronological table shows the main events described in the text in their temporal context via milestones in general medicine, surgery and science, and selected major events in political and social history.

This book is designed to capture and clinically review the comprehensive database of clinical research articles that support and do not support the utilization of a variety of dietary supplements and other complementary medicines that physicians are exposed to in their daily practice. The growing list of CAM products that could interfere with surgery (anesthesia, bleeding, outcomes...) and/or conventional medicines is very large and is provided in each section of the book. Additionally, the list of dietary supplements that could be utilized to improve quality of life for breast cancer patients is also emphasized. The various sub-specialty groups in breast are adequately represented, which allows for a physician to rapidly and thoroughly investigate their topic of interest regardless of whether the topic is prevention, treatment, or a specific side effect of treatment. The practical nature of Integrative Medicine for Breast Cancer: An Evidence-Based Assessment cannot be overstated. Chapters include a general overview of the CAM agent, whether or not it has data in medicine and oncology, and a list of potential drug interactions and specific clinical scenarios where it can be utilized or discouraged in the specialty. Thus, this book will become the gold standard evidence based text for use in teaching, not only for the students interested in oncology and breast cancer, but for all current oncology health providers.

This volume presents the evolution of the authors' ideas about estrogen action and its modulation by a new group of drugs called SERMs (Selective Estrogen Receptor Modulators). The pioneering SERMs - tamoxifen and raloxifene - are known to have saved the lives of millions of women around the world and improved the health of millions more. Estrogen is the central hormone of women's health and reproduction. The book is a journey through 40 years of discovery and success in advancing women's health, with the prospect of improved innovation through medicinal chemistry for the future.

The Human Hypothalamus: Neuropsychiatric Disorders, Volume 181 in the Handbook of Clinical Neurology series, provides comprehensive summaries of recent research on the brain and nervous system as they relate to clinical neurology. This volume identifies the neurobiology and neurophysiology of disorders relating to the hypothalamus and provides treatment information for these disorders. Disorders covered include neuropsychiatric, neurodegenerative, periodic, and autoimmune disorders. Coverage includes Alzheimer's, Parkinson's, epilepsy, sleep, pain, depression, anxiety, OCD, PTSD, schizophrenia, autism, aggressions, addiction, and more.

The book aims to cover basic physiologic functions of melatonin, and its therapeutic applications in humans for a variety of clinically relevant disorders. This book contains chapters on the recent aspects of melatonin physiology, its receptors and their role in mitochondrial function, its immunomodulatory role and importance in seasonal dependent diseases, role in human reproduction, role in sleep, circadian rhythm and sleep disorders, role in neurologic disorders such as Parkinson's disease, Alzheimer's disease. Additionally, melatonin's therapeutic use in neurobehavioral disorders in children, migraine and tension headache is also covered in this book. Melatonin's antioxidant role in Duchenne's muscular dystrophy and in glaucoma have also been discussed in short chapters. Two major melatonin agonists, ramelteon and agomelatine are discussed extensively on their current clinical application and ongoing research. Two chapters on agomelatonin and its role in mood disorders, particularly depressive disorders, are an important feature of this book. The chapters are written by experts from the global academia recognized for their original research and published work in the field of melatonin science.