Obesity: Oxidative Stress and Dietary Antioxidants cover the science of oxidative stress in obesity and associated conditions, including metabolic syndrome, bariatric surgery, and the potentially therapeutic usage of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are not described in isolation, but in concert with other processes, such as apoptosis, cell signaling and receptor mediated responses. This approach recognizes that diseases are often multifactorial and oxidative stress is but a single component. The book is designed for nutritionists, dietitians, food scientists, physicians and clinical workers, health care workers and research scientists.

Understanding endocrinology is central to understanding the key processes that affect normal reproductive function, while an understanding of normal endocrinology and the pathophysiology of endocrine disorders is important when dealing with reproductive disorders. This book provides a comprehensive background for all gynaecologists, covering: sexual differentiation and intersex disorders; adrenal disorders; normal puberty and adolescence; abnormal puberty; the menstrual cycle; disorders of menstruation; amenorrhoea; polycystic ovary syndrome; anovulatory fertility and ovulation induction; lactation and lactational amenorrhoea; hyperprolactinaemia; thyroid disease; diabetes; lipid metabolism and lipoprotein transport; premature ovarian failure; and calcium metabolism and its disorders. The book is primarily designed to provide a comprehensive summary for candidates preparing for the Part 2 MRCOG examination, and as such covers the RCOG curriculum for reproductive endocrinology. It is also a valuable guide for all healthcare professionals working in the field, including trainees, consultants and any health professional coming into contact with women.

The Handbook of Lymphoma is an in-depth and comprehensive guide to the diagnosis, staging, treatment, and management of patients with the disease. The Handbook aims to provide healthcare professionals with an informative and up-to-date guide to the latest developments in the treatment of patients with both Hodgkin and non-Hodgkin lymphoma. Lymphoma is a cancer of the lymphatic system and, as with other cancers, is a disease of the body's cells. Usually, cells divide in the body in an orderly and controlled manner, however when this process gets out of control and the cells carry on dividing in an abnormal manner a tumor can form known as lymphoma in one or more groups of lymph nodes. This field has seen increasing development in the available options for treating patients with lymphoma particularly in the recent emergence and approval of targeted therapies. In this clinically focused Handbook, the authors address these advances by looking at treatment recommendations for both Hodgkin and non-Hodgkin lymphoma, and also making suggestions on the future outlook for patients with this disease. This Handbook is an invaluable and educational source of topical information for all medical and healthcare professionals with an interest in lymphoma.

Endocrine and Hormonal Toxicology Edited by Philip W. Harvey, Kevin C. Rush and Andrew Cockburn AgrEvo UK Ltd, Saffron Walden, UK This is the first book to consider the integrated role of the classical endocrine system and hormones (including those from tissues outside the classical endocrine system) in toxicological responses. Although focusing on the latest knowledge on endocrine glands as target organs and the mechanistic and molecular basis for toxicity in these organs, Endocrine and Hormonal Toxicology has been written to cover toxicological responses at the whole body level mediated by endocrine or hormonal mechanisms. This whole body, multi--organ approach significantly broadens the relevance of this volume to toxicologists. Following an introductory section on the types of endocrine toxicity including primary, secondary and indirect mechanisms, the next section deals with endocrine organs as toxicological targets. International contributions focus on the pituitary, thyroid and parathyroids, adrenals, testes, ovaries and the pancreas, and comparative endocrine carcinogenesis. A third section of the book develops the whole body approach, in which chapters are devoted to hormonal mechanisms of toxicity to the immune, nervous, cardiovascular, gastrointestinal and reproductive systems, as well as to the liver, kidney and skin. The final section covers human and environmental health perspectives discussing endocrine disrupting chemicals, hormonal mechanisms in breast cancer and current regulatory trends in endocrine and hormonal toxicology. The comprehensive nature of Endocrine and Hormonal Toxicology makes it accessible to both specialist and general toxicologists, and to those within the fields of endocrinology, pharmacology and pathology.

Neuroendocrinology with its well defined functions, inputs, and outputs, is one of the most fertile grounds for computational modeling in neuroscience. But modeling is often seen as something of a dark art. This book aims to display the power of modeling approaches in neuroendocrinology, and to showcase its potential for understanding these complex systems. A recurring theme in neuroendocrinology is rhythms. How are rhythms generated, and what purpose do they serve? Are these two questions inextricably intertwined? This book is written for innocents, presuming no math beyond high school or computing beyond calculators. It seeks to lead the curious into the thinking of the modeler, providing the tools to the reader to understand models, and even develop their own, giving life to paper diagrams. The diverse chapters, from ion channels to networks, systems, and hormonal rhythms, each tell the story of a model serving to join the hard won dots of experimentation, mapping a new understanding, and revealing hidden knowledge. Written by a team of internationally renowned researchers Both print and enhanced e-book versions are available Illustrated in full colour throughout This is the fourth volume in a new Series Masterclass in Neuroendocrinology , a co- publication between Wiley and the INF (International Neuroendocrine Federation) that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology. Series Editors: John A. Russell, University of Edinburgh, UK and William E. Armstrong, The University of Tennessee, USA Written by a team of internationally renowned researchers Both print and enhanced e-book versions are available Illustrated in full colour throughout This is the fourth volume in a new Series Masterclass in Neuroendocrinology , a co- publication between Wiley and the INF (International Neuroendocrine Federation) that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology. Series Editors: John A. Russell, University of Edinburgh, UK and William E. Armstrong, The University of Tennessee, USA

It is no secret that the United States is facing an obesity epidemic with the obesity rates continuing to rise year after year. According to the Center for Disease Control, one third of Americans are now obese. It is no longer sufficient to simply point out the health risks of obesity to our patients as the reason to lose weight. Patients are seeking guidance in terms of what specific diet plan to follow and what foods should be eaten. There are thousands of diets on the market with new ones introduced daily. Not all diet plans have proven results, nor will they work for every patient. More importantly, not all diets marketed to the public are safe to follow for an extended timeframe. In fact, research shows us that diet composition is not the key to long term success, but compliance to a calorie deficient diet is the solution. So how does one choose which diet plan to recommend to patients? Finally, a book for clinicians is here to help answer this question. This book provides information to help patients understand several different research proven diets on the market today including: the Atkins diet, the DASH (Dietary Approaches to Stop Hypertension) diet, the I diet, the Mediterranean diet, Paleo Diets, South Beach, Vegetarian diets, Weight Watchers, and the Zone diet. Each diet is carefully and thoroughly reviewed in this book by some of America's top obesity medicine and weight management specialists to provide health practitioners a knowledge of the diet composition, current research evaluating the diet, typical weight loss results, the pros and cons of the diet as well as which patients would most benefit from each diet plan. This book provides the necessary tools for clinicians to feel comfortable discussing several of the more popular and scientifically researched diets with patients. This book offers solid information to advise patients, based on their specific health history, on which diet will afford the greatest chance for success.

The complex and fascinating subject of endocrinology can often seem rather daunting for non-specialists. For practising endocrinologists too, maintaining a broad overview of the subject can be a major task. Laboratory Animal Endocrinology has been written with both these audiences in mind. Focusing on the species regularly used in experimental studies (including rodents, dogs and monkeys), each chapter presents a wealth of information on hormone structure, synthesis, secretion, receptors, second messengers and their actions, and considers the various physiological and pharmacological processes which may be involved in hormonal regulation. Interspecies’ differences in hormonal structure, metabolism and interactions with drugs and other chemicals are particularly important to toxicologists and in drug safety evaluation. Laboratory Animal Endocrinology also explores these areas of research and provides much-needed support for the interpolation of endocrine data from one test species to another and to humans. The book is not intended exclusively for toxicologists however, but will prove indispensable for all those working with laboratory animals.

Biomarkers of Inborn Errors in Metabolism: Clinical Aspects and Laboratory Determination is structured around the new reality that laboratory testing and biomarkers are an integral part in the diagnosis and treatment of inherited metabolic diseases. The book covers currently used biomarkers as well as markers that are in development. Because biomarkers used in the initial diagnosis of disease may be different than the follow-up markers, the book also covers biomarkers used in both the prognosis and treatment of inherited metabolic disorders. With the introduction of expanded new-born screening for inborn metabolic diseases, an increasing numbers of laboratories are involved in follow-up confirmatory testing. The book provides guidance on laboratory test selection and interpreting results in patients with suspected inherited metabolic diseases. The book provides comprehensive guidance on patient diagnosis and follow-up through its illustrative material on metabolic pathways, genetics and pathogenesis, treatment and prognosis of inherited metabolic diseases, along with essential information on clinical presentation. Each chapter is organized with a uniform, easy-to-follow format: a brief description of the disorder and pathway; a description of treatment; biomarkers for diagnosis; biomarkers followed for treatment efficacy; biomarkers followed for disease progression; confounding conditions that can either: affect biomarker expression or mimic IEMs; other biomarkers: less established, future.

This issue of Endocrinology and Metabolism Clinics, edited by Dr. Robert Rapaport, is devoted to Pediatric Endocrinology. Articles in this issue include: Thyroid Cancer in Pediatrics; Gender and Sex Assignment; CAH Prenatal Diagnosis; Diabetes; Polycystic Ovarian Disease; Newborn Screening for X-linked ALD; Growth in Patients w/ Skeletal Dysplasia; Thyroid Imaging in Infants; Bariatric Surgery in Youth; Pituitary Imaging in Pediatrics; and Cardiac and Metabolic Features of GH Deficiency.

This issue of Hematology/Oncology Clinics of North America is devoted to Neuroendocrine tumors. Articles in this issue include: Pathology Classification of Neuroendocrine Tumors; Clinical Presentation and Diagnosis of Neuroendocrine Tumors; Surgical Management of Gastrointestinal Carcinoid Tumors; Systemic Therapies for Advanced Gastrointestinal Carcinoid Tumors; Thymic and Bronchial Carcinoid Tumors; Surgical Management of Pancreatic Neuroendocrine Tumors; Systemic Therapies for Advanced Pancreatic Neuroendocrine Tumors; Pheochromocytoma and Paraganglioma; Poorly Differentiated Neuroendocrine Tumors; Role of Somatostatin Analogs in the Treatment of Neuroendocrine Tumors; Peptide Receptor Radiotherapy in the Treatment of Neuiroendocrine Tumors; Hepatic-Directed Therapies in Patients with Neuroendocrine Tumors; and Neuroendocrine Tumor Clinical Trial Interpretation and Design.

This issue of Surgical Oncology Clinics of North America, guest edited by Dr. Douglas L. Fraker, is devoted to Endocrine Tumors. Dr. Fraker has assembled expert authors to review the following topics: Management of thyroid nodular disease: Current cytopathology classifications and genetic testing; Surgical management of lymph node compartments in papillary thyroid cancer; Current guidelines for post-operative treatment and follow-up of well differentiated thyroid cancer; Outpatient thyroid surgery - is it safe?; Asymptomatic hyperparathyroidism- diagnostic pitfalls and surgical intervention; Intra-operative PTH monitoring: optimal utilization; Minimally invasive parathyroidectomy vs bilateral neck exploration for primary hyperparathyroidism; Pheochromocytoma and paraganglioma: Diagnosis, genetics, and treatment; Minimally invasive adrenalectomy; Treatment of adrenocortical cancinoma: benefits of aggressive surgery; Biochemical diagnosis and pre-operative imaging of gastro-intestinal neuroendocrine tumors; Minimally invasive techniques for resection of pancreatic neuroendocrine tumors; and Treatment of metastatic neuroendocrine tumors to the liver.

Providing experimental methods and protocols for performing pheromone research in a variety of organisms ranging from invertebrates to vertebrates, Pheromone Signaling: Methods and Protocols covers a wide spectrum of experimental approaches necessary for handling pheromone molecules, measuring receptor response and neural activation, and analyzing behavioral output. A great deal of progress has been made in understanding the molecular mechanisms underlying pheromone action, largely due to the discovery of receptor genes, the advancement of imaging techniques, and key multi-disciplinary approaches including aspects of organic chemistry, biochemistry, molecular biology, electrophysiology, and behavioral science. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips for troubleshooting and avoiding known pitfalls. Authoritative and practical, Pheromone Signaling: Methods and Protocols details the key methodologies utilized in laboratories all over the world, making them accessible to those who want to begin investigation in the area of pheromone research.

A full-color guide to the entire field of clinical endocrinology and its scientific underpinnings - updated with the latest breakthroughs and developments Greenspan's Basic & Clinical Endocrinology delivers a succinct, leading-edge overview of the underlying molecular biology of the endocrine system and the latest perspectives on the diagnosis and treatment of specific diseases and disorders. Featuring an enhanced design that includes hundreds of full-color illustrations and clinical photographs, Greenspan's is a true must-have during traditional or integrated courses in endocrinology, endocrinology rotation, or exam prep in internal medicine and endocrinology and as reference for disease management. Greenspan's provides clinically relevant coverage of metabolic bone disease, pancreatic hormones and diabetes mellitus, hypoglycemia, obesity, geriatric endocrinology, and many other diseases and disorders. Supporting this essential material is a handy appendix of normal hormone reference ranges across the lifespan. Here's why Greenspan's is an essential tool for learning how to manage endocrine patients: * The Tenth Edition is enhanced by updated content throughout each chapter * NEW CHAPTERS on Transgender Endocrinology and Disorders of Sexual Determination and Differentiation * Important chapter on Evidence-Based Endocrinology and Clinical Epidemiology * Concise, balanced coverage of both scientific and clinical principles that guide patient management * The best source for current concepts in endocrine pathophysiology to aid clinical decision making * The most practical, current insights into diagnostic testing * More than 270 full-color illustrations and clinical photographs If you are in need of a well-illustrated, completely up-to-date guide to the entire field of clinical endocrinology, this trusted classic belongs on your desk or computer.

Early identification and diagnosis by type and stage is the key to high survival rates with thyroid cancer. To present the pathologist with current clinical information on diagnosis, differential diagnosis, staging, and prognosis of thyroid cancers, topics presented are: Poorly differentiated thyroid carcinoma; Paraganglimoa; Immunohistochemical markers for evaluation and prognosis in thyroid carcinoma; Familial endocrine syndromes; Parathyroid enoplasia; Inflammatory lesions of the thyroid associated with cancer; Assessing biological aggression in adrenal cortical neoplasia; Pituitary neoplasia; and Pancreatic endocrine neoplasia. Peter Sadow, whose clinical practice and research involve studying the mechanisms of endocrine carcinogenesis through translational studies involving the proteomics and genomics of endocrine neoplasms, primarily of the thyroid and adrenal glands, leads this issue.

Wide variety of pesticides and other synthetic chemicals may disrupt the normal function of the endocrine system, cause alteration and also attack the immune system of humans and wildlife at very low concentration levels. Chapter One of this book provides an overview of analytical methods, including sample preparation steps, chromatographic separation and detection of endocrine disrupting pesticides in a variety of food, environmental and biological matrices. Chapter Two studies endocrine disrupting compound (EDC) exposure from recycled wastewater compared to other water related risks in developed and developing nations. Chapter Three summarizes the role of EDCs on pregnancy and birth outcomes, included but not limited to fertility problems, premature birth, low birth weight, and miscarriage along with in-vitro, animal, and epidemiological studies. In the last chapter, the worst EDCs will be revealed and their related potential hazardous health risks to humans are discussed. Furthermore, suggestions to help the reader avoid such toxic chemicals are presented.

Mammalian Endocrinology and Male Reproductive Biology provides comprehensive and current coverage of the area of endocrinology and male reproductive biology, covering not just humans, but mammals in general. Written by international experts in their respective fields, this multi-author book also covers the latest developments in genomics of androgen action and male infertility. The book begins by covering sexual dimorphism in the central nervous system; structure, control of secretion and function of GnRH; and gonadotropins of pituitary origin and their role in gonadal functions. This is followed by an account of hormonal regulation of spermatogenesis, and the role of apoptosis in this process. Subsequent chapters center around epididymis, regulation of growth and function, and sperm motility regulation. The last chapters in the book discuss the structure and function of male accessory sex glands with associated pathologies as well as recent updates in male contraception, mechanism of androgen action, and genomics of male infertility. Wherever necessary, tables and figures have been added for a better understanding. Each chapter is appropriately referenced and contains current information on the latest developments in the field.

Clinics Collections: Obesity draws from Elsevier's robust Clinics Review Articles database to provide multidisciplinary teams, including general practitioners, endocrinologists, pediatricians, gastroenterologists, nurses, and other healthcare professionals, with practical clinical advice and insights on this highly prevalent disease and its comorbidities. Clinics Collections: Obesity guides readers on how to apply current primary research findings on obesity to everyday practice to help overcome challenges and complications, keep up with new and improved treatment methods, and improve patient outcomes. Areas of focus include obesity and secondary disorders, pediatric obesity, metabolic issues, dietary approaches, surgical options, and special considerations. Each article begins with keywords and key points for immediate access to the most critical information. Articles are presented in an easy-to-digest and concisely worded format. Elsevier Clinics Collections provide concise reviews of today's most prevalent conditions and significant medical developments. Other Clinics Collections titles available include Type II Diabetes Mellitus, Asthma, and Pain Management.

Beautifully presented, and now in full colour, the sixth edition of Essential Endocrinology and Diabetes is fully up-to-date with the latest knowledge and concepts on the workings of the endocrine system. It explains the key principles of endocrine physiology in an easy reading style popular with students, clinicians and scientists. The invaluable background on basic science and investigation, including new molecular techniques, provides the foundation for detailed discussion of the diagnosis and management of clinical endocrine disorders and diabetes. The teaching style and presentation has been strengthened throughout, and includes learning objectives and recap links at the beginning of each chapter that remind the reader of key findings and principles, while cross-referencing makes it easy to locate related information quickly and efficiently. There are also more case studies, with detailed answers applying theory to practice. Essential Endocrinology and Diabetes is the perfect resource for a course on endocrinology and diabetes, as part of USMLE teaching, and an on-going companion during postgraduate clinical and scientific study. It is accompanied by a FREE enhanced Wiley Desktop Edition - the interactive, digital version of the book - featuring downloadable text and images, highlighting and note taking facilities, book-marking, cross-referencing, in-text searching, and linking to references and glossary terms.

The human body's endocrine system includes eight major glands, which make hormones and travel through the bloodstream to tissues or organs. In this book, the authors' focus on the risk factors, genetics, diagnosis and management of gynecomastia (a benign condition characterized by enlargement of the male breast) and addresses the puzzling controversies surrounding menopausal hormone replacement therapy (HRT) and its health outcomes, which have been the subject of extensive investigation in recent years. The book concludes with a bibliography on recent titles published in the field that readers might find of interest.

Sarcoidosis is a multisystem granulomatous disease of unknown etiology. It can occur at all ages, with the incidence peaking at 20 to 40 years. This book reviews the epidemiology, etiology, pathology, clinical manifestations, diagnosis and management strategies of sarcoidosis, while highlighting recent studies that have provided new insights into this unique and debilitating disease. The authors also specifically point out the urological manifestations of sarcoidosis to avoid misdiagnoses and to provide early intervention.

The European Workshop on Molecular and Cellular Endocrinology of the Testis was organized for the first time at Geilo, Norway, 8-11 April 1980. Since then, these meetings have been held in Holland, France, Italy, England, Sweden/Finland (Aland), Germany, and Bel- gium. This year the circle has been closed: The 9th European Testis Workshop is back in the Norwegian mountains where it all started. The Scientific Committee of the First European Testis Workshop included Dr. H.J. van der Molen (Rotterdam), Dr. V. Hansson (Oslo), Dr. B. Cooke (London), Dr. V. Monesi (Rome), Dr. E.M. Ritzen (Stockholm), and Dr. J.M. Saez (Paris). Since then, two of the founders have left the Scientific Committee. Dr. Monesi died suddenly on 29 December 1979, 3 1/2 months before the first workshop took place. Thus, in spite of being one of the founders, he never experienced a Eu- ropean Testis Workshop. Dr. Mario Stefanini, from the same research institute in Rome, replaced Dr. Monesi on the Scientific Committee. Another founder of this workshop series, Dr. H.J. van der Molen (Rot- terdam), is one of the pioneers in research on molecular endocrinology of the testis in Europe. He left the Scientific Committee due to a change in his scientific career and was replaced by Dr. F.F.G. Rom- merts, whose lectures on "Testomania" have been a characteristic fea- ture of these meetings.

Clinics Collections: Type II Diabetes Mellitus draws from Elsevier's robust Clinics Review Articles database to provide multidisciplinary teams, including general practitioners, endocrinologists, and other healthcare professionals, with practical clinical insights on the evaluation and management of patients with this disease and other co-morbidities. Clinics Collections: Type II Diabetes Mellitus guides readers on how to apply current primary research findings on type II diabetes to everyday practice to help overcome management challenges, keep up with new and improved treatments, and improve patient outcomes. Areas of focus include diabetic complications associated with the foot, cardiovascular system, renal system, gastrointestinal system, ophthalmologic disorders, dermatologic disorders, neurologic and psychological disorders, special considerations, and more! Each article begins with keywords and key points for immediate access to the most critical information. Articles are presented in an easy-to-digest and concisely worded format. Elsevier Clinics Collections provide concise reviews of today's most prevalent conditions and significant medical developments.

"The Protective Arm of the RAS: Functional Aspects and Therapeutic Implications" is the first comprehensive publication to signal the protective role of the renin angiotensin system (RAS) providing readers with early insight into a system which will become of major medical importance. It is extensively demonstrated that the RAS, when over activated, represents a disease-promoting and disease-sustaining system. But recently the protective role of the RAS has emerged supported by a large number of experimental studies. In fact, specific components of the RAS, namely angiotensin AT2 receptors (AT2R), the angiotensin (1 7) peptide with its receptor Mas, and the enzyme ACE 2 exert significant beneficial actions by counter-balancing the well-known harmful side of the RAS.
Provides a complete understanding of the protective, beneficial role of the Renin Angiotensin System (RAS).Combines the knowledge of editors who pioneered research on protective renin angiotensin system including Dr. Robson Santos who discovered angiotensins-(1-7) and its receptor Mas; and Dr. U. Muscha Steckelings and Dr. Thomas Unger who made contributions to AT2 receptor research and were the first to use a novel specific AT2-antagonist in preclinical studies.Shows the protective RAS axes are able to ameliorate the course of several cardiovascular, renal and neurological diseases.
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Studies have shown that low quality of life is a risk factor for increased hospitalization, diminished adherence to treatment, and increased morbidity and mortality. Recently, quality of life has been an area of interest in endocrinology. Studies have demonstrated that it is reduced in disturbances such as diabetes mellitus, obesity, thyroid diseases, Cushing's disease, and pituitary tumors. This book aims at reviewing recently published data on quality of life in endocrine diseases. It presents the available data on quality of life in non-functioning pituitary tumors, prolactinomas, acromegaly, GH deficiency, Cushing's syndrome, hypo- and hyperthyroidism, hypogonadism, diabetes mellitus, and obesity.

Model Animals in Neuroendocrinology: From Worm to Mouse to Man offers a masterclass on the opportunities that different model animals offer to the basic understanding of neuroendocrine functions and mechanisms of action and the implications of this understanding. The authors review recent advances in the field emanating from studies involving a variety of animal models, molecular genetics, imaging technologies, and behavior assays. These studies helped unravel mechanisms underlying the development and function of neuroendocrine systems. The book highlights how studies in a variety of model animals, including, invertebrates, fish, birds, rodents and mammals has contributed to our understanding of neuroendocrinology. Model Animals in Neuroendocrinology provides students, scientists and practitioners with a contemporary account of what can be learnt about the functions of neuroendocrine systems from studies across animal taxonomy. This is the seventh volume in the Masterclass in Neuroendocrinology Series, a co-publication between Wiley and the INF (International Neuroendocrine Federation) that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology.