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Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics
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Autoimmunity and the Pathogenesis of Diabetes (Paperback, Softcover reprint of the original 1st ed. 1990)
Loot Price: R1,527
Discovery Miles 15 270
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Autoimmunity and the Pathogenesis of Diabetes (Paperback, Softcover reprint of the original 1st ed. 1990)
Series: Endocrinology and Metabolism, 4
Expected to ship within 10 - 15 working days
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It has been a challenge for us to edit this volume of Endocrinology
and Metabo lism: Progress in Research and Clinical Practice. The
topic of the pathogenesis of insulin-dependent, type I diabetes
mellitus is particularly appropriate for this series, since
advances in this area have been made, to a large extent, by
applying state-of-the-art laboratory techniques to clinical
samples. Over the last several years, a number of lines of evidence
have been gathered, suggesting that classic type I diabetes
mellitus results from the autoimmune des truction of pancreatic
beta-cells in genetically susceptible individuals. This hypothesis
is particularly appealing because it offers a rational approach to
the prevention of diabetes by immunosuppression. We have tried to
present a balanced, authoritative summary of the information
currently available to support the autoimmune hypothesis for the
pathogenesis of human type I diabetes, to place this information in
historical perspective, to include relevant information from animal
models of type I diabetes in which more invasive experimentation is
ethical, and, finally, to update the reader on the current status
of attempts to intervene in the progression of diabetes with
immunosuppressive drugs. New York, New York Fredda Ginsberg-Fellner
Robert C. McEvoy Contents Preface.. . . .. .. .. . . . . . . . . .
. . . ... . . . . . . . . . . . .. . . . . . . .. . . . . v
Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . Xl . . . . . . . . . . . . . 1. The Autoimmune Hypothesis
of Insulin-Dependent Diabetes: 1965 to the Present . . . . . . . .
. . . . ..................... . . . . . .
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