This text provides a comprehensive review of the cytology of disease processes of the mediastinum and mediastinal lymph nodes with emphasis in lung and gut nodal cancer staging in specimens obtained by EUS-FNA. This book also reviews the cytology of intramural masses of the gastrointestinal tract using a pattern-based diagnostic approach. The cytomorphology of lesions obtained by EUS-FNA is peculiar by the common presence in the obtained sample of normal luminal gastrointestinal contents, and the cytopathologist should be familiar with this pattern not often seen when the sampling is done by percutaneous approach. Technical considerations pertaining to the operator performing the procedure as well as to the cytopathologist, with emphasis on rapid on-site interpretation are also covered. Most lesions described in the book also have endoscopic US image correlation. Cytology of the Mediastinum and Gut is a useful and practical guide for cytological interpretation and differential diagnosis of lesions obtained by EUS-FNA of mediastinum and gut. All chapters are written by experts with many years of experience in the field and contain the cytology, immuno-profile, molecular profile, and ultrasound features of the masses described.

Now in a fully revised and updated fourth edition, this book remains the most comprehensive resource on Prader-Willi syndrome (PWS) available on the market. There have been significant changes in the diagnosis, clinical care and treatment of PWS since the previous edition was published in 2006, and more thorough information on understanding the cause and diagnosis of the condition, along with clinical presentation and findings with natural history data now available. The book is divided into three thematic sections. Part One discusses the genetics, diagnosis, research and overview of PWS, including current laboratory testing. The medical physiology and treatment of PWS comprise Part Two, covering the GI system, obesity as well as the use of growth hormone. Part Three, the largest section, presents a wide-ranging, multidisciplinary management approach to PWS, attending to the many manifestations of the condition. Topics here include neurodevelopmental aspects, speech and language disorders, motor issues, psychological and behavioral management, educational and transitional considerations, vocational training and residential care, and advocacy for both school discipline and sexuality. Syndrome-specific growth charts, benefits eligibility information and additional resources are included in helpful appendices. Timely and well-crafted, this latest edition of Management of Prader-Willi Syndrome remains the gold standard for clinicians and health care providers working with patients diagnosed with this rare obesity-related genetic disorder.

In the last decades, major advances have been made in assisted reproductive technologies (ART) and the public demand for these procedures has increased globally. All ART clinics, from those just starting out to the well established, must employ the latest equipment and implement the best practices, while ensuring that their resources are effectively engaged to optimize patient outcomes. This is a tenet of the fiduciary role of physicians and it is increasingly recognized as a quantifiable goal regulated by formal certifications and accreditations. Quality management protocols such as those proposed by the International Organization for Standardization (ISO) are being rapidly adopted as standards of measure. Quality Management in ART Clinics: A Practical Guide provides easily adoptable ways to implement and improve formalized quality management systems. Essential to any clinic to achieve best practices and maintenance of formal regulatory certifications, this book brings together the know-how of experienced opinion leaders operating in key areas worldwide. The book offers an overview of primary regulations in the ART field, with attention to quality management demands, and links specific requirements to practical steps for implementation. Filled with process and procedure examples, flow diagrams and administrative form templates, this book is the first of its kind, gathering the necessary elements for optimizing practice, management, and quality assurance.

Ovulation induction and controlled ovarian stimulation lie at the very heart of treatment for infertility, but have been subject to a bewildering variety of variations and improvements over recent years. The Second Edition of this highly successful book updates the reader on the progress and developments in this area. Furthermore, it provides the busy clinician with a reliable overview of the principles involved and the management needed. As with the previous edition, the emphasis throughout this book is on logical evidence and evidence-based solutions supplemented with Professor Homburg's extensive clinical experience gleaned from more than forty years working in the field. A number of highly useful algorithms and explanatory tables reinforce this approach, ensuring that the reader is presented with easy-to-grasp, well-presented information that maximizes clarity and understanding. This book offers a concise, no-nonsense, practical guide to ovulation induction and controlled ovarian stimulation and will be an essential resource for the general gynaecologists, fertility specialists and trainees, health workers and students.

Oncofertility is a specialty that bridges the disciplines of reproductive endocrinology and infertility and oncology, with the goal of expanding the reproductive options of cancer patients. Given fertility risks associated with specific cancer treatments, as well as the improved long-term survival made possible by these therapies, there has been growing interest in expanding reproductive options for cancer patients. Indeed, both cancer survivors and the medical community have acknowledged the importance of patient counseling and the pursuit of fertility preservation options prior to starting cancer treatment. Oncofertility Medical Practice: Clinical Issues and Implementation is the third in a series of timely and indispensable books on fertility preservation for cancer patients-the first one focused on advances in basic science research and the second one offered ethical, legal, and social perspectives on the theme. This book elucidates the latest practices and emerging treatments in oncofertility and provides necessary information on the successes, risks, and limitations of fertility preserving technologies. Authoritative and insightful, written by an impressive multi-disciplinary cadre of specialists, this book is a valuable up-to-date resource for all those practicing in this demanding field. "This excellent text is an invaluable resource and a "must read" for clinicians and researchers interested in Oncofertility. The editors and authors need to be congratulated for their fine work." Roger A. Lobo, MD, Professor of Obstetrics and Gynecology, Columbia University and Past President of the American Society for Reproductive Medicine

A number of studies, mostly focusing on estrogen replacement therapy in women, have reported beneficial actions of these hormones on various neurobiological and neuropathological parameters in health and disease. Recent research has focused on gender differences and there is increasing evidence that estrogens exert protective effects in schizophrenia. Hormonal fluctuations or lack of estrogen may increase the risk of depression among vulnerable women. Treatment of depression with estrogen may stabilize and restore disrupted homeostasis - as during post-partum, premenstrual, or perimenopausal conditions - and act as a psychomodulator to offset vulnerability to dysphoric mood when estrogen levels are significantly decreased, as in the case of postmenopausal women. Studies on the effect of estrogens on Alzheimer's Disease are still rather controversial, they do, however, facilitate the hypothesis that estrogens may have a modifying effect on the onset and course of AD, at least in subgroups of patients.

Often, information in review books can raise as many questions as it answers. This interferes with the study process, because the learner must either look up additional information or skip ahead without truly comprehending what he or she has read. As an alternative, Pediatric Genetics and Inborn Errors of Metabolism: A Practically Painless Review presents bite-size chunks of information that can be read and processed rapidly, helping learners to stay active while studying and to pick up new information the first time they read it. This book's question and answer format allows for self-testing or study with a partner or a group. The format also facilitates dipping into the book during a few minutes of downtime at the hospital or office. Pediatric Genetics and Inborn Errors of Metabolism: A Practically Painless Review is a quick and easy way to master these tricky topics and is suitable for those studying for the pediatric board exam, practicing physicians brushing up their skills, and any busy clinician who wants to learn more about these topics while on the go.

The pituitary gland is often referred to as the master gland, coordinating hormonal signals from the hypothalamus and peripheral circulation to maintain homeostasis in the body. Patients with pituitary dysfunction are faced with challenges unique to each stage of their life cycle. For example, the goals of management for a hypopituitary adolescent transitioning to adulthood would be to optimize growth and sexual development. In early adulthood, approaches that optimize of fertility in men and women can be a priority, and the management approach will be very different from that of older adults requiring sex hormone replacement. This case-based guide will provide practical clinical guidance on approaches to the management of pituitary disorders organized by time of life, from childhood and fertile years through to older age. Sensibly divided into sections, various pituitary disorders and conditions are described and relevant treatment strategies are outlined. Sections included discussions of the unique considerations for the pituitary gland in childhood and adolescents, patients desiring fertility and pregnant patients, health optimization and non-tumoral diagnoses in adults, and management of disorders of the hypothalamic-pituitary axis in the elderly. Each chapter presents a clinical case vignette as an introduction to the concepts and a framework for the discussion of the diagnosis, management and unique consideration of each pituitary pathology. Practical and user-friendly, Pituitary Disorders throughout the Life Cycle is an excellent resource for practicing clinical endocrinologists (pediatric, transitional care, adult) and reproductive endocrinologists as well as specialty residents and trainees.

Investigations into the mechanisms of spennatogenesis, sperm matura tion and fertilization provide the basis of our understanding of male re productive physiology. Since in recent years molecular and cellular en docrinology has provided particularly important contributions to our knowledge, the European Workshops on Molecular and Celluar Endo crinology of the Testis, held regularly during even years since 1980, have become a prominent forum for researchers in the field to discuss recent findings and exchange new ideas. The most recent of these Testis Workshops, the 7th, was held on May 5 - 10, 1992 at Castle Elmau in the Bavarian Alps. The main lectures of this Workshops form the core of this book. In order to provide a broader view of the current status of male re production research, this volume also contains the proceedings of the Schering Foundation Workshop on "Basic Mechanisms of Reproduc tion and Male Fertility Control" which was held in Berlin on October 31 to November 2, 1991. The topics of the two meetings were planned to complement each other. By combining the proceedings of both workshops, it became possible to produce a book that covers a wide spectrum of current highlights in male reproduction research and pro vides the reader with an up-to-date review of the field. The timeliness of the book is emphasized by the fact that it was al ready available when the 7th European Testis Workshop took place.

Since 1948, hydrocortisone (cortisol), the principal glucocorticoid (GC) of the human adrenal cortex has been successfully used at phar- macological concentrations for the suppression of clinical manifesta- tions of rheumatoid arthritis. Numerous compounds with GC activity have also been developed and used. Fifty years after their initial clinical use, GCs are still the most im- portant and frequently prescribed class of anti-inflammatory drugs for various inflammatory disorders. They are administered either orally, parenterally (intravenous, intramuscular, intrathecal), or topically (cu- taneous, intranasal, pulmonic, rectal). Despite the many beneficial ef- fects of GCs, they also have their limitations and disadvantages that occur with varying prevalence on different organs and after different durations of therapy. These side-effects can range in severity from cos- metic (e.g. telangiectasias, hypertrichosis) to seriously disabling (e.g. induction of glaucoma, diabetes, osteoporosis) or even life-threatening disorders (e.g. gastric haemorrhage). These adverse effects of GCs se- riously handicap their successful use as anti-inflammatory agents. There is therefore a strong need for the development of substances with the anti-inflammatory potency of classical GCs but with reduced side-effects.

New research has shown that neuroendocrine tumors are more common than previously thought. Progress in our understanding of the molecular pathogenesis of these not-so-rare cancers has resulted in renewed interest in developinginnovative therapeutic options. In particular, novel molecular targeted agents have been shown to have significant anti-tumor activity, and integration of these therapies has led to critical advances in management.

In this volume, an outstanding group of the world s leaders in the field have assembled to convey their knowledge of the epidemiology, biology, and management of allthemajor types of neuroendocrine tumors. The book takes a multi-modality approach to understanding disease processes and therapeutics, including chapters on medical and surgical treatment as well as a chapter devoted to imaging. Throughout, the authors emphasize recent advances in our understanding of molecular biology and the subsequent emerging therapeutic options."

Das massgebliche Referenzwerk zur Erkennung und Behandlung von akuten endokrinen und Stoffwechselerkrankungen Die Endokrinologie beschaftigt sich mit den haufigsten Krankheitsbildern und ernsthaften Erkrankungen, mit denen die heutige Medizin zu kampfen hat. Im klinischen Umfeld lassen sich Notfalle zum Grossteil auf Stoerungen des endokrinen Systems und des Stoffwechsels zuruckfuhren. Endocrine and Metabolic Medical Emergencies: A Clinician's Guide ist ein einzigartiges Referenzwerk, unterstutzt Endokrinologen, Notfall- und Allgemeinmediziner in Kliniken, Hospitalisten und Intensivmediziner und Allgemeinmediziner dabei, die Symptome endokriner Notfalle zu erkennen und die Patienten optimal und nach den hoechsten Standards zu versorgen. Die neue 2. Auflage dieses Buches, das bereits als das massgebliche Referenzwerk des Fachgebiets gilt, bietet bei bekannten und ungewoehnlichen endokrinen Notfallen Richtlinien fur die Akutversorgung, erlautert im Detail die Auswirkungen von akutmedizinischen und kritischen Erkrankungen auf den Stoffwechsel und das endokrine System und deren Einfluss auf Untersuchungen des endokrinen Systems, beschreibt besondere Patientenpopulationen, auch den Einfluss des Alterns, von Schwangerschaft, Transplantationen, Spatfolgen, von perioperativen Vorfallen, angeborenen Stoffwechselerkrankungen sowie von HIV/AIDS bei der Vorstellung und dem Management von Patienten. Weiterhin werden die mit dem jeweiligen System verbundenen Erkrankungen ausfuhrlich behandelt, ebenso stoffwechselbedingte Knochenerkrankungen, neuroendokrine Tumore u.v.a. Dieser Leitfaden enthalt unzahlige Fallstudien, Abbildungen und Kapitel, die von renommierten Autoren geschrieben wurden, und eignet sich zum schnellen Nachschlagen und fur das Studium. Behandelt werden Vorstellung, Diagnose, Management und Behandlung von Patienten mit Erkrankungen des endokrinen Systems und des Stoffwechsels auf Intensivstationen. Aktuelle Leitlinien befassen sich mit Themen wie klinische Lipidologie, Glukose, Natrium, Kalzium, Phosphat usw. Dieses unschatzbare Referenzwerk vereint die neuesten wissenschaftlichen Erkenntnisse mit Ratschlagen fur Klinik und Praxis. Kliniker erhalten alles aktuell Wissenswerte des Fachgebiets an die Hand sowie einen praxisorientierten klinischen Einblick, um Patienten optimal zu versorgen.

Originally published in 1935, this volume contains the text of the fifth Horsley Memorial Lecture, delivered by Sir Walter Langdon-Brown. This book will be of value to anyone with an interest in medical history, particularly the history of the discovery of the endocrine system.

There is a world-wide epidemic on obesity. This epidemic is driving the immense proportions of Type 2 diabetes across the globe. While there are numerous therapies for treating Type 2 diabetes, the most effective therapy is prevention. Prevention of Type 2 diabetes can be achieved properly by simultaneous prevention of obesity. Prediabetes, or metabolic syndrome, is the period between simple obesity and diabetes, and this critical period needs to be identified in a more consistent and systematic manner by clinicians worldwide. Clinical trials have indicated that diabetes prevention can be achieved by lifestyle changes and also by certain medications, though none are yet approved for use in prevention. On the other hand, there are funding agencies such as the NIH, CDC, and State Institutions that are interested in studying the prevention paradigms in different communities and ethnic minorities who are most prone to this epidemic. For these reasons, this title by renowned physician-scientist Derek LeRoith is both timely and vitally important for academic physicians, practitioners, allied health care providers, analysts, community activists, and all others interested in this increasing epidemic. This book provides a unique and comprehensive synthesis of the prevention and early diagnosis of Type 2 Diabetes, focusing on identifying risk factors and then moving into topics that address how to prevent their progression to full-blown diabetes. The difficult task of changing patients' behavior is given special emphasis. The chapters in this practical volume are written by a wide range of international experts, reflecting the editor's distinguished, internationally renowned career. The volume is organized in eight sections: an introduction to the overall issue of prevention, definitions of values based on ADA guidelines, pathophysiology, discussion of a range of interventional trials regarding prevention, and an overview of state-of-the-art clinical management approaches. Comprehensive and timely, Prevention of Type 2 Diabetes: From Science to Therapy is an essential reference for those treating and researching Type 2 Diabetes.

Alcoholism, the oldest addictive illness, remains a serious problem because of its major modifications of many physiological systems. The genetic and neurological origins and mechanisms are complex and only partly understood. However, it is clear that alcohol use modifies the production of most hormones, directly and indirectly modulating the systems that hormones regulate. Acute and chronic alcohol consumption affects virtually all cellular functions of tissues like brain, liver, immune system, and reproductive and endocrine organs. The latter have major regula tory roles, affecting many functions from development to repro duction. Although stress can further modify alcohol's effects on hormone production, it significantly causes most of alcohol's modi fications of the body to occur via changes in hormone production and secretion. Ronald R. Watson vii Contributors Michael L. Adams * Department of Psychiatry, Washington University School of Medicine, St. Louis, MO Robert A. Anderson, Jr .* Ob/Gyn Research, Rush-Presbyterian-St. Luke's Medical Center, Chicago,IL Kasibhatla Bhavani * Molecular Heptology Laboratory, Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA Theodore J. Cicero * Department of Psychiatry, Washington University School of Medicine, St.

A comprehensive, cutting-edge review of the complex interactions between maternal and fetal-placental tissues that control the establishment and maintenance of pregnancy, the proper development of the fetus, the birth process, and the behavioral aspects of bonding between mother and newborn. Expert researchers review the endocrine and physiological events that culminate in the delivery of offspring, and provide a solid base of comparative information on the menstrual cycle of primates, including humans. They also discuss the sources and functions of both steroid and protein hormones from the placenta and the details of their effects on uterine function, placental development, fetal growth and well-being, and maternal responses to pregnancy. This book will become the standard reference source not only for reproductive scientists, but also for those clinicians who want better to understand the complex factors that affect pregnancy-and their pregnant patients.

Biology of Menopause presents the proceedings of an international symposium held from September 10-13, 1998 in Newport Beach, CA. The proceedings review current knowledge and explores future research directions on the biologic changes of the hypothalamic-pituitary-ovarian axis across the menopausal transition and the associated changes in physiologic systems outside of the HPO axis, including the brain, the musculoskeletal and cardiovascular systems. Additionally, chapters present new methods of study and emerging areas of research.

Near the end of September 1980, the contributors to Hormonally Active Brain Pep tides: Structure and Function met to discuss their chapters for the monograph. This meeting was the eighth sponsored by the International Foundation for Biochemical Endocrinology and was held at the Hotel Plakir in Dubrovnik, Yugoslavia. Several months were allowed after the meeting for the contributors to revise their manuscripts and for editing. Professor Dr. Vladimir Pantie and the Serbian Academy of Sciences and Arts were in charge of the local arrangements and social activities. The Foundation is grateful for the splendid job that was done and for the out- standing scientific, cultural, and social activities. I thank the Serbian Acad- emy of Sciences and Arts and the Yugoslav Council of Academies for spon- soring my stay in Yugoslavia. I greatly enjoyed giving lectures, visiting laboratories, and discussing research projects in a number of centers in Yugoslavia. A diverse group of topics was presented in Dubrovnik concerning cer- tain brain peptides. The topics included "Structure, Function, and Confor- mation of Neuropeptides," "Distribution of Peptides in the Brain," "Reg- ulation of the Release of Peptide Hormones," "The Active Center of Gonadotropins," "In Vitro Synthesis of Hypothalamic Hormones," "Stud- ies on Gonadotropin-Releasing Hormone," "Studies on the Biosynthesis, Release, and Degradation of LH-RH," "Genesis and Properties of Pitu- itary ACTH, Prolactin, and Growth Hormone Producing Cells," "Precur- sors to Oligopeptide Hormones," and "Stress Effects on Peptide Hormone Synthesis.

These comprehensive yet concise collections of articles by world experts survey the latest findings on the molecular biology of diabetes and insulin action and synthesize a coherent understanding of the subject. Topics include the etiology of type I and type II diabetes, molecular and cellular aspects of insulin action, and the mechanism of the insulin-stimulated glucose uptake.

The Frozen Section Library series provides concise, user-friendly, site specific handbooks that are well illustrated and highlight the pitfalls, artifacts and differential diagnosis issues that arise in the hurried frozen section scenario. Frozen Section Library: Lymph Nodes highlights the usefulness of techniques such as touch preparation cytology and fine needle aspiration (FNA) cytology, as well as FNA biopsy. This fascicle also suggests proper handling for subsequent ancillary studies, including flow cytometric, cytogenetic, and molecular studies. Special emphasis is given to the limitations of frozen section diagnosis in lymph node pathology. All chapters are written by experts in their fields and include the most up to date scientific information. This book serves as a very useful resource for physicians in the frozen section room and in intra-operative consultation situations dealing with, and interested in, this very complex field of diagnostic pathology. Frozen Section Library: Lymph Nodes is of great value to pathologists, residents, and fellows who diagnose pathologic processes involving lymph nodes. Cherie H. Dunphy, M.D. is Professor of Pathology and Laboratory Medicine, Executive Director of Hematopathology and Hematopathology Fellowship Department of Pathology and Laboratory Medicine University of North Carolina Chapel Hill, NC.

Maintaining the original goal of the first edition to integrate the basic science of endocrinology with its physiological and clinical principles, this new edition succinctly summarizes in 450 pages the latest findings on hormone secretion and hormone action, as well as all the most recent insights into the physiology and pathophysiology of hormonal disorders. Coverage extends across the entire spectrum of endocrinology-from mammalian cells, plants, and insects to animal models and human diseases-with much increased coverage of diabetes and metabolism. Highlights include cutting-edge discussions of appetite disorders, obesity, reproductive failure, control of thyroid function, hormone action in man and the lower species, and the mechanisms subserving hormone secretion.

are new to this edition. The authors provide not only the The second edition of Thyroid Cancer: A Comp- most current review of their respective areas, but also their hensive Guide to Clinical Management marks the pub- own recommendations and approach. The reader is fo- cation of a markedly updated and expanded volume that warned that in many cases these approaches, albeit rooted covers all aspects of the etiology, pathogenesis, diag- sis, initial treatment, and long-term management of all in available data, may be empiric rather than based varieties of thyroid cancer. Like the first edition, it will upon clear-cut results of well-controlled clinical t- als. Nevertheless, controversial issues are examined serve as a valuable reference source for pathologists, and evidence-based recommendations are presented endocrine surgeons, endocrinologists, nuclear medicine when available. physicians, and oncologists. However, the biggest There are updated chapters on our current state change is that the second edition is significantly enlarged and expanded to encompass important and extensive of knowledge of the molecular changes in thyroid treatments of more topics related to nuclear medicine. cancer, molecular markers, and how targeted the- pies are being developed. New therapeutic trials of Nuclear medicine physicians and procedures play a key redifferentiation agents to restore the sodium iodide role in the management of thyroid cancer patients and in symporter when lacking and more traditional che- retrospect, a comprehensive discussion of topics related therapies are discussed, with referral sources listed for to that field was somewhat lacking in the first edition.

This book provides a perspective on the current status of bioimaging technologies developed to assess the quality of musculoskeletal tissue with an emphasis on bone and cartilage. It offers evaluations of scaffold biomaterials developed for enhancing the repair of musculoskeletal tissues. These bioimaging techniques include micro-CT, nano-CT, pQCT/QCT, MRI, and ultrasound.