This is the second of two "Annals" volume (see also Volume 1262) of papers by speakers at the 8th International Society for Neuroimmodulation Congress held in Dresden, Germany, October 2011. The papers focus on interactions among the immune, endocrine, and nervous systems that occur at multiple levels, from intracellular pathways by immune and neuro-endocrine mediators, to the exchange of information between the three systems that results in physiologic and adaptive effects. In certain instances, however, these interactions may be unbalanced or even disrupted, which can contribute to pathology, and aspects of such pathobiology are presented in some of the contributions. This volume aims focuses on translational science aspects of immune-neuro-endocrine interactions.

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This unique source of reference provides a comprehensive guide to the adverse side-effects of many commonly prescribed drugs on fertility and sexual health. More than 150 drugs are listed in this compilation, and the evidence linking them with infertility and sexual dysfunction is carefully reviewed. The volume is designed to provide a rapid source of reference to alert doctors and pharmacists to these hazardous side-effects. The volume also includes an introductory account of the reproductive process and a review of the mechanisms by which these drugs can interfere or inhibit reproduction. Another important theme of the volume is the effect of social and recreational drugs and environmental agents on reproductive health.

Addressing controversial and topical issues in the field of salivary gland disease and surgical management of salivary gland disease, this new edition integrates the newest clinical findings with the historical pathological records, and attempts to resolve any conflicts between the two. Fully-illustrated and updated since the first edition in 2002, it is particuarly useful for trainees sitting their final exam, because it deals with new controversial subjects which are topical at all the conferences and exam vivas.

This color atlas is a detailed guide on how to perform open, endoscopic, and robotic thyroidectomy techniques safely and effectively. Each chapter offers step-by-step descriptions of essential surgical procedures and techniques. Relevant information is included on surgical anatomy, and clear guidance is provided on preoperative set-up, draping, instrumentation, and complications and their treatment. The description of endoscopic thyroidectomy techniques focuses on the bilateral axillo-breast approach (BABA), while in the case of robotic thyroidectomy both BABA and the bilateral axillo-postauricular approach are described. In each case, the evidence supporting the technique is carefully examined. In the closing chapter, the role of new energy sources in thyroid surgery is discussed. The lucid text is supported by more than 200 full-color illustrations clarifying surgical anatomy, instrumentation, and procedures, and surgical video clips are also available to readers via a website. This atlas will be invaluable in enabling surgeons to achieve optimal outcomes when performing thyroid surgery.

Diabetes mellitus is one of the leading causes of blindness worldwide, with diabetic retinopathy (DR) remaining the most common cause of eye disease for people with diabetes. Current guidelines state that all patients with diabetes should be screened for retinal problems. Diabetic Retinopathy, second edition, offers a practical, clinically focused guide to DR. Featuring 20 concise chapters this resource covers the basics of diabetes mellitus and ocular anatomy, why screening is required, the epidemiology and nature of diabetic retinopathy, as well as associated ocular diseases. It has been fully updated to include the latest trial data and newest developments in the management of diabetic retinopathy, as well as three new chapters covering patients of concern, imaging techniques in diabetic retinopathy, and an overview of treatment strategies for diabetic eye disease. Part of the Oxford Diabetes Library series, this pocketbook is a concise companion for professionals involved in screening and treating diabetic retinopathy.

In a field where even experts may find that years have elapsed since they last encountered a child with a given disorder, it is essential for the clinician to have a comprehensive source of practical and highly illustrated information covering the whole spectrum of metabolic disease to refer to. The content is divided into sections of related disorders, including disorders of amino acid metabolism, lipid storage disorders, and mitochondrial diseases for ease of reference, with an introductory outline where appropriate summarizing the biochemical features and general management issues. Within the sections, each chapter deals with an individual disease, opening with a useful summary of major phenotypic expression including clear and helpful biochemical pathways, identifying for the reader exactly where the defect occurs. Throughout the book, plentiful photographs, often showing extremely rare disorders, are an invaluable aid to diagnosis. Key Features * Fully updated to incorporate all new developments in the field * Brand new chapters cover methylmalonic aciduria of ACSF3 deficiency, branched chain keto acid dehydrogenase deficiency, serine deficiencies, purine nucleoside phosphorylase deficiency, antiquitin deficiency, and others * Excellent and detailed clinical descriptions, with numerous valuable hints and suggestions for management * Helpful explanatory algorithms and decision trees, and high-quality illustrative material including biochemical pathways and an unrivaled photographic collection, which enhance clinical applicability The fourth edition of this highly regarded book, authored by two of the foremost authorities in pediatric metabolic medicine, continues to provide incomparable insight into the problems associated with metabolic diseases and remains invaluable to pediatricians, geneticists, and general clinicians worldwide.

Apart from diabetes mellitus, endocrine diseases requiring surgical treatment are relatively uncommon. However, when they do occur, they frequently present major clinical anaesthestic problems that require extensive knowledge of the pathophysiology of the condition, and considerable anaesthetic expertise. This book provides the anaesthetist with a comprehensive examination of each of the endocrine conditions, covering underlying pathophysiological problems, and guidance on optimal anaesthetic care. It will be of use to trainee and consultant anaesthetists working in both specialist endocrine wards and general surgery wards where a patient with endocrine disease might present.

Developed by a renowned group of international authors, this engaging, case-based title once again offers readers a wide range of thought-provoking case studies that reflect contemporary, challenging, hands-on clinical care. Expanded and fully updated, Endocrinology and Diabetes: A Problem Oriented Approach, 2nd Edition addresses the complete range of endocrinologic problems found in patient care, offering the reader a convenient and pointed way to solve clinical problems in a timely manner. Due to its comprehensive coverage and practical focus, this title has developed a special place in the field of endocrinology and will again be of great interest to endocrinologists, diabetologists, internal medicine physicians, family physicians, fellows, and residents. The enthusiastic reception and warm welcome of the first edition of this book was overwhelming and gratifying. Despite many standard texts that cover physiology and clinical aspects of endocrinology, this book found a special place because it focused on patient care and practical aspects of endocrine practice. In the current volume we were fortunate to again have the honor of collaboration by international authors who pride themselves foremost as clinical endocrinologists. We hope our readers will find this updated, improved edition worthwhile, and use it for the benefit of their patients.

Whether you are a student of biomedicine or medicine, trainee, resident, or endocrinology fellow, Clinical Endocrinology provides you with the core information you need to understand this notoriously complex subject. The book describes the biochemistry, physiology, and anatomy that underpin clinical practice and then integrates genuine clinical cases to show the application of this basic science in diagnosis and treatment. Key features include: a flowing narrative that leads you through the basic science boxes that provide core reference information advanced boxes that provide additional material suitable for residents and fellows case studies that link with the text and describe the presentation, diagnosis, and management of real patients further clinical material that builds on the basic science and describes the causes of endocrine disorders, their clinical features, and treatment options coverage of the latest advances and discoveries self-assessment questions to test understanding The book is lavishly illustrated throughout with line drawings and clinical photographs. The authors, one a scientist and the other a clinician, guide you through the complexities of physiology and biochemistry so that you can understand the nature and management of endocrine pathologies. At all times they relate basic science to clinical medicine in a clear and lucid style that is both practical and clinically relevant. From reviews: "Clinical Endocrinology is very well written and beautifully illustrated." Lancet Diabetes Endocrinology, January 2013 "All in all this is an excellent, essential textbook which does the job admirably in terms of synthesising the essence of human physiology and excreting a patient-centred approach to addressing the clinical manifestations of endocrine hypo- and hyper-function." The Endocrinologist, December 2013 "This book would appeal particularly to medical students or endocrinologists in training... [It] provides a useful review of endocrinology in a comprehensive manner starting from basic science principles and ending with clinical applications." Doody's Notes, May 2013 About the authors: Professor Saffron Whitehead is Professor of Endocrine Physiology at St George's Medical School, University of London Dr John Miell is a Consultant Endocrinologist at University Hospital Lewisham, London

In the past decade, there has been increasing recognition of thyroid diseases as a common health problem. While there have been few major new advances in treatment, there is much greater understanding of why thyroid disorders occur and the long-term health effects of thyroid disease. As people with thyroid disease begin to know more about their disorder, they are able to co-operate better with treatment and their anxieties about the problem can be significantly reduced.
This fourth edition of Thyroid Disease: The Facts provides a reader-friendly source of information and reassurance for those people with thyroid disorders and their families. The book covers the wide range of conditions associated with thyroid dysfunction, from simple goitre to more complex disorders such as Graves' disease and Hashimoto's thyroiditis. This edition also includes several completely new chapters, including one specifically devoted to thyroid disorders in infants, children and adolescents. Each chapter concludes with a useful Question and Answer section.

This comprehensive book on Endocrine Surgery covers disorders of thyroid, parathyroid, adrenal glands along with neuroendocrine tumors of pancreas and gastrointestinal tract. It is a comprehensive, up-to-date treatise covering embryology, anatomy, etiology, clinical manifestations, diagnoses, and treatment modalities of surgical endocrine diseases. The authors explore the pertinent surgical endocrinology topics with a South Asian perspective. Color illustrations, flowcharts and tables make the topics lucid for professionals. This book provides the essential information surgeons require for evaluation and management of patients, both with straight forward, and complex endocrine problems. Key Features Focusses on concise yet comprehensive, up-to-date coverage of surgical endocrine diseases Discusses Robot Assisted Endocrine Surgery and explores its impact on healthcare finances Highlights the difference between practices used in western and resource limited countries by incorporating a South Asian perspective for region specific diseases.

This book covers the scope of cranial nerve monitoring of all cranial nerves that are of practical importance in head, neck, and thyroid surgery. It discussed enhanced patient outcomes in a wide array of surgical procedures in the head and neck that require the maintenance of complex regional functions by protecting cranial nerve integrity. Organized into four parts, the book begins with Part I offering historical perspectives on the subject while simultaneously reviewing various basic and advanced electrophysiology. Part II thoroughly reviews the extra-temporal bone facial nerve (CN VII), Glossopharyngeal Nerve (CN IX), Vagal/Recurrent Laryngeal Nerve (CN X), Spinal Accessory Nerve (CN XI), and Hypoglossal Nerve (CN XII). Subsequent chapters in Part III provide a complete and applied understanding of the neurophysiological principles that facilitate the surgeon's ability to monitor any nerve and intraoperative neural stimulation and nerve monitoring. The book presents various techniques as the standard of care to provide optimal neural detection, understand the neural functional real-time status during surgery and optimize specific surgical outcomes such as thyroid surgical outcomes. Closing chapters offer essential conversations regarding ethical considerations in nerve monitoring and medical malpractice. Filling a gap in the literature, Intraoperative Cranial Nerve Monitoring in Otolaryngology: Head and Neck Surgery provides a single source for surgeons who wish to optimize their outcomes in patient care and accelerate their learning curve to the level of more experienced surgeons.

Improving glycemic, lipid, and blood pressure outcomes is the essence of diabetes care. Maintaining consistently positive results is an ongoing challenge for every healthcare professional. After years of clinical practice, Mayer Davidson, MD, has developed a series of algorithmic techniques that can increase positive results. Based on the American Diabetes Association's Standards of care, this book offers detailed treatment algorithms that have been shown to be clinically effective in improving outcomes in people with diabetes.In this second edition, Davidson has revised and updated the algorithms to match the ever-changing ADA Standards of Care. Sections include: Laying the Groundwork: Background for Evidence-Based ADA Guidelines forStandards of Diabetes Care, Evidence-Based Principles of Dietary Therapy, Glycemia, Dyslipidemia, and Hypertension.

Frank Nawroth thematisiert das Social Freezing und die zugehoerige Beratung, die nicht nur Chancen, sondern auch denkbare Komplikationen und Grenzen der Methode aufzeigen muss. Zum Beispiel haben die gesellschaftspolitisch nicht optimal geloeste Problematik des moeglichen Karriere-Nachteils einer berufstatigen Mutter oder die haufig bestehende Schwierigkeit, den geeigneten Partner zu finden, bei gleichzeitig verbesserten Kryokonservierungsmethoden dazu gefuhrt, dass Frauen ohne medizinische Indikation uber das Einfrieren ihrer Eizellen nachdenken. Die Technologie selbst ist seit Langerem Routine vor fertilitatsbeeintrachtigenden Therapien onkologischer Erkrankungen (Operation, Strahlen- und/oder Chemotherapie) im reproduktiven Alter.

Written primarily for 16-19 year old students, this primer aims to extend students' knowledge and inspire them to take their school-level learning further. It explores topics that are familiar from the curriculum and also introduces new ideas, giving students a first taste of the study of biology beyond school-level and demonstrating how concepts frequently encountered at school are relevant to and applied in current research. This is the ideal text to support students who are considering making the transition from studying biology at school to university. This primer introduces students to key elements of the endocrine system, including the structure and function of the major types of hormones. It explores the role of hormones in disease, in development, in reproduction and in behaviour. Although humans are its main focus, it draws on illuminating examples from a range of other species, including sex changes and aggression in fish, metamorphosis in amphibians, induction of ovulation in different species, and bonding behaviour in birds. The final section of the book looks at ways in which hormones can be used in medicine and agriculture, and can be abused to enhance sporting performance and weight loss. This primer will expand the breadth and depth of student understanding of the endocrine system, its variety, and its huge importance.

Das Standardwerk zur arteriellen Hypertonie, das keine noch so knifflige Frage auslasst! Die Klinik aller Hypertonieformen, die zeitgemasse Diagnostik und alle etablierten und neuen Therapieansatze sind von den jeweiligen Top-Spezialisten beschrieben. Ein besonderer Schwerpunkt liegt auf dem Umgang mit speziellen therapeutischen Problemen. Kein Arzt in Praxis und Klinik, der Patienten mit arterieller Hypertonie betreut, kann auf dieses Buch verzichten. Von der Hochdruckliga wird das Buch empfohlen.

Unter Mitarbeit zahlreicher Fachwissenschaftler

Diabetes in Medizin- und Kulturgeschichte behandelt die Geschichte der wissenschaftlichen Erforschung dieses Leidens von der Antike bis zur Entdeckung des Insulins (1921) unter gleichzeitiger Berucksichtigung der Geschichte des Patienten und kulturhistorischer Hintergrunde. Die abgedruckten medizinhistorischen Studien eroertern sowohl allgemeine Zusammenhange wie spezifische Details und besondere Forschungsleistungen der Vergangenheit. In der Bibliographie der Quellen werden die wesentlichen historischen Beitrage der Diabetesforschung und Diabetestherapie mit den Autoren und der Angabe der Druckorte zusammengestellt. Die Bibliographie der Sekundarliteratur vereinigt internationale Studien seit dem vergangenen Jahrhundert bis in die jungste Gegenwart uber die Geschichte der Theorien des Diabetes und der therapeutischen Ansatze. Abbildungen und literarische Texte dokumentieren kulturhistorische Zusammenhange. Ein Personen- und Sachregister erleichtert die Benutzung dieses Bandes, der insgesamt Mediziner, Medizinhistoriker, Medizinstudenten, Allgemeinhistoriker wie auch Diabetespatienten anregen moechte.

This book presents the latest insights into all the critical aspects of Klinefelter's Syndrome, in order to promote a more homogeneous a medical approach to this condition, leading to better and more "evidence-based" support, and improving patient satisfaction. It offers physicians and all health professionals involved in treating these patients (andrologists, pediatricians, endocrinologists, psychologists) a comprehensive overview and a useful tool for their daily clinical practice.

A succinct, single-authored text and atlas of bone marrow pathology, this book is based on over 10,000 bone marrow biopsies. Divided into seven sections, it covers indications and techniques for biopsy, normal findings, and bone marrow alterations in specific neoplastic and non-neoplastic disorders and other diseases. The author approaches the practical problems and pitfalls in making particular types of diagnoses. The volume is lavishly illustrated with over 300 full-color photographs. The emphasis has been placed on the histologic interpretation of the bone marrow core biopsy, but the histopathologic findings have been integrated with clinical and laboratory features, as well as with peripheral blood and bone marrow aspiration morphology.
Morphology is, in fact, accorded special attention in this book, since it remains the "gold standard" for many hematologic diagnoses and is the appropriate point of departure for more complex diagnostic investigations. More advanced immunologic and molecular techniques are not overlooked, however, and a discussion of these newer techniques is incorporated in the analysis throughout the text. Written as an introduction and guide to the interpretation of the bone marrow biopsy, this volume is intended primarily for pathologists and pathologists-in-training, but may also be used successfully by hematologists and oncologist who perform bone marrow biopsies.

Now in a revised and expanded second edition, this concise, straightforward and clearly written text presents the latest information on the evaluation and management of common issues and conditions in pediatric endocrinology. Endocrinologists, pediatricians, family physicians, residents, fellows and medical students will all benefit from the discussion of endocrine physiology and its application to common clinical practice. As in the original edition, the text presents the major signs and symptoms in the diagnosis and management of pediatric endocrine disorders, often allowing the practitioner to avoid an unnecessary consultation and preparing a provider for informed communication with parents of a child with an endocrine condition. The concepts covered in the text are designed to address the first 10 headings in the content outline of the Sub-board of Pediatric Endocrinology of The American Board of Pediatrics: disorders of the hypothalamic-pituitary axis, growth, calcium metabolism and bone, the thyroid gland, puberty, and the adrenal gland, among others. Concluding each chapter is a Suggested Reading section, directing the reader to outstanding larger and more detailed texts, manuscripts and websites that offer increased detail. Practical and user-friendly, Pediatric Endocrinology, Second Edition is not simply a checklist of everything that could be done but leads the reader toward a more specific goal of what should be done.

In diesem Praxisbuch finden Sie alle notwendigen Informationen, um Ihre Diabetespatienten kompetent rundum zu betreuen - von der Entscheidung fur die optimale Therapieform uber die Vor- und Nachsorge bei Operationen bis zur Behandlung von Spatkomplikationen. Die dritte Auflage wurde fast vollstandig neu verfasst, noch ubersichtlicher gestaltet und zum schnellen Erfassen der Inhalte um zahlreiche Tabellen, Aufzahlungen und UEbersichten erganzt. - Schwerpunkt der Neuauflage: Vorbeugung und Behandlung diabetesassoziierter Spatkomplikationen. ...ein sehr gelungenes Werk, das sicherlich rasch seinen festen Platz in der klinischen Diabetesliteratur finden wird. (Ernahrungs-Umschau)

Ein Screening auf angeborene endokrine und metabole Stoerungen ermoeglicht die Fruherkennung von Krankheiten wie Hypothyreose, AGS (adrenogenitales Syndrom), Phenylketonurie, Galaktosamie, Biotinidasemangel, Cystische Fibrose oder Homocystinurie. Je nach Land und politischen Bestimmungen unterscheiden sich jedoch die routinemassig durchgefuhrten Untersuchungen. Dieses Handbuch beschreibt praxisbezogen die biochemischen Grundlagen, die Grundsatze der Labor- und Bestatigungsdiagnostik sowie Therapiemoeglichkeiten zu insgesamt zwoelf Krankheiten. Daruber hinaus werden praanalytische Fragen, wie Zeitpunkt und Art der Blutentnahme oder moegliche Stoerfaktoren, umfassend behandelt. Der allgemeine Teil geht auf ethische und psychosoziale Aspekte des Screenings ein. Ein Verzeichnis der Screeningzentren und jener Labors, die fur die Bestatigungsdiagnostik Dienste anbieten, sowie ein Adressenverzeichnis von Elterngruppen und Informationsquellen im Internet komplettieren dieses Buch.