The field of inflammatory bowel disease has evolved in many ways. The first has been the revolution in medical therapy for the disease. With the advent of biologic therapy, the aspirational goal of therapy has become mucosal healing. These medications have also made it possible to avoid or delay surgery for ulcerative colitis and Crohn's disease. Although non-invasive strategies such as MR or CT enterography or stool-based assays are helpful, they have not been able to replace the prognostic information provided by endoscopy. Simultaneously, the quality and spectrum of tools available to perform endoscopy has widened. High resolution endoscopes are now the norm and are nearly as good as chromoendoscopy for identifying dysplasia in ulcerative colitis patients. Most gastroenterologists also perform dilations but do not generally do this for patients with IBD. Finally, newer devices such as enteroscopes, endoscopic ultrasound, and endomicroscopes are being incorporated into the algorithms to diagnose and treat complications of IBD. This issue highlights all of these advances by the experts in their fields.

Searching for an objective and specific in vivo biomarker for normal physiology and early disease diagnosis has always been a major goal, but also one of the most challenging aspects in brain research. Possible earlier identification of the key pathological signature of diseases (for instance, Alzheimers disease (AD)) is critical for efficient treatment and disease prevention. The concept of combined imaging features is based on the recent accumulating evidence that neither PET nor MRI alone is enough for characterising the earliest AD pathology. The results of this book will, for the first time, highlight in vivo the possibility to describe the early detection and multiple biomarkers based on combined imaging features using PET-MRI, which is the most ideal model for such studies. The newly-developed hybrid imaging technology combining PET and MRI (PET/MRI) for the past few years is emerging, and has drawn much attention in technical developments and clinical applications. PET-MRI opens new horizons in multi-parametric neuroimaging for clinical research that allows simultaneous imaging of multiple parametric changes, such as blood flow and metabolism at the same time. This integration significantly decreases the potential errors in image registration, the difficulty of interpreting underlying coexisting pathophysiological events, and most importantly, patient discomfort. This book will provide the most up-to-date and current status of multiple neuroimaging techniques. The most intriguing application of multi-modality neuroimaging lies in simultaneous interpretation and unique information that each modality can offer. Therefore, this book will present some forefront and interesting examples for the first time in this field of research. This will hopefully trigger the interest of colleagues in this challenging field and help facilitate the applications of the neuroimaging techniques described.

Dieses Buch fasst therapieorientiert die modernen Moeglichkeiten und neuesten Erkenntnisse auf dem Gebiet der Gefassdiagnostik zusammen. Es schlagt weiterhin die Brucke von der sonographischen Gefassdiagnostik zur Therapie. Ultraschall in der Gefassdiagnostik fuhrt den Anfanger vom rationalen Untersuchungsablauf zur sicheren Befunderhebung. Erfahrene Nutzer profitieren von Tipps und Tricks zur zeiteffizienten Diagnostik, der Beschreibung seltener Gefasserkrankungen und der Darstellung der therapeutischen Konsequenz aus den Ultraschallbefunden. In der Neuauflage ist besonders berucksichtigt: - Die Duplexsonographie als Moeglichkeit zur Visualisierung der normalen und pathologischen Hamodynamik zu verstehen, ist ein besonderes Anliegen des Buches ("Lernen, Dopplerspektren richtig zu lesen"). - Konzepte zur zeiteffizienten Untersuchung zum Teil vom Autor selbst entwickelt - Methodenkritische Diskussion von Diskrepanzen in Ultraschallstudien sowie in Vergleichsstudien mit radiologischen Verfahren. - Methodische Neuerungen wie die Kontrastmittelsonographie werden vorgestellt und die diagnostischen Moeglichkeiten im klinischen Alltag detailliert gefassbezogen diskutiert. - Neue wissenschaftliche Erkenntnisse werden methodenkritisch reflektiert, auf Ihre Wertigkeit in Diagnostik und Therapie planung uberpruft und Kontroversen diskutiert. - Ultraschall in der Stufendiagnostik rational bis zu Therapie einsetzen

From "AB systems" to "Zipper artefact" - even for the experienced practitioner in MRI, the plethora of technical terms and acronyms can be daunting and bewildering. This concise but comprehensive guide provides an effective and practical introduction to the full range of this terminology. It will be an invaluable source of reference for all students, trainees and medical professionals working with MRI. More than 800 terms commonly encountered in MR Imaging and Spectroscopy are clearly defined, explained and cross-referenced. Illustrations are used to enhance and explain many of the definitions, and references to further reading will point the reader to more in-depth coverage. As well as being a compendium of terms from A to Z, the volume concludes with a useful collection of appendices, which tabulate many of the key constants, properties and equations of relevance.

The use of neuroimaging studies in psychiatry is exploding -- and offers tremendous potential for practicing clinicians. Yet if you're like many psychiatrists, you're sometimes uncertain about which studies to use in specific situations. Until now, you've had to sort through the only information available -- technical reviews in the literature -- for guidance. But no more.

Essentials of Neuroimaging for Clinical Practice is an all-in-one resource that explains how to use these powerful techniques to improve outcomes. It demystifies neuroimaging with clear, concise, and practical advice on using today's most advanced applications in the diagnostic workup of patients.

This practical clinical guide will help you achieve a solid understanding of the full range of neuroimaging modalities: - Structural techniques such as computed tomography (CT) and magnetic resonance imaging (MRI) - Functional techniques such as positron emission tomography (PET), single photon emission computed tomography (SPECT), functional magnetic resonance imaging (fMRI), and magnetic resonance spectroscopy (MRS)- Other techniques such as electroencephalography (EEG) -- including quantitative EEG and event-related potentials -- and magnetoencephalography.

For each modality, you'll find: - A basic review of the technique -- trace the development of each modality, and become familiar with its underlying technology.- Guidance on when to use it -- learn which techniques are best to use in specific clinical situations. - Tips for ordering studies -- discover how to write up orders to obtain the most accurate and detailed information from each study, including when to use contrast and how to determine the best acquisition parameters.- A look at its future potential in practice and research -- explore the current capabilities of each modality and the most promising strategies for improving diagnostic results.

Filled with examples of real-life imaging studies, Essentials of Neuroimaging for Clinical Practice is a must-have tool for all practicing psychiatrists and psychologists. In addition, it will serve as an excellent clinical guide for residents -- and an outstanding text for courses in clinical neuroimaging for psychiatrists.

Ideal for classroom use and self-study, this book explains the implementation of the most effective modern methods in image analysis, covering segmentation, registration and visualisation, and focusing on the key theories, algorithms and applications that have emerged from recent progress in computer vision, imaging and computational biomedical science. Structured around five core building blocks - signals, systems, image formation and modality; stochastic models; computational geometry; level set methods; and tools and CAD models - it provides a solid overview of the field. Mathematical and statistical topics are presented in a straightforward manner, enabling the reader to gain a deep understanding of the subject without becoming entangled in mathematical complexities. Theory is connected to practical examples in x-ray, ultrasound, nuclear medicine, MRI and CT imaging, removing the abstract nature of the models and assisting reader understanding, whilst computer simulations, online course slides and a solution manual provide a complete instructor package.

Based on hospital clinical trials examining the use of signal and image processing techniques, Surface Imaging for Biomedical Applications bridges the gap between engineers and clinicians. This text offers a thorough analysis of biomedical surface imaging to medical practitioners as it relates to the diagnosis, detection, and monitoring of skin conditions and disease. Written from an engineer s perspective, the book discusses image acquisition methods, image processing, and pattern recognition techniques. It focuses on a variety of techniques used in recent years for image processing and pattern recognition (principal component analysis, independent component analysis, singular value decomposition, texture modeling, inverse model analysis, polynomial surface fitting, and classification techniques), and considers interventional and non-invasive procedures used to diagnose skin-related disease.

It examines the biological causation of four skin disorders (psoriasis, vitiligo, ulcer, and acne), provides basic terminologies in surface imaging, and details the outcome of various clinical observations and other research. It also details numerous measurement parameters related to surface imaging (body surface, skin color, tissue characteristic, thickness, roughness, volume of skin, and retinal changes).

• Discusses the development of a psoriasis severity measurement tool
• Provides material on assessing segmented repigmentation areas in vitiligo patients via VT-Scan
• Introduces a volume ulcer assessment using non-invasive 3D imaging
• Presents an automated system for acne grading that is based on capturing the images of various body parts using the DSLR camera
• Includes the MATLAB(r) codes for various pattern recognition techniques applied during the assessment/measurement at the end of each chapter

This interdisciplinary reference highlights the importance of disease diagnosis and monitoring, and is suitable for medical practitioners, biomedical engineers, and core image processing researchers."

Studienarbeit aus dem Jahr 2014 im Fachbereich Medizin - Radiologie, Nuklearmedizin, Note: 1,0, DIPLOMA Fachhochschule Nordhessen; Zentrale, Sprache: Deutsch, Abstract: Diese Arbeit versteht sich als komprimierter Versuch, ein wenig Licht in das Fachgebiet der Radiologie, mit all seinen Facetten zu bringen. Aufgezeigt werden soll, in welchen Bereichen des taglichen Arbeitens die Radiologie zur Anwendung kommt und welche unverzichtbare Rolle sie in der Medizin einnimmt. Sie dient als eine Art Informationsbroschure fur all jene im Gesundheitssektor tatigen Personen. Die Idee liegt in der Anregung an eine engere interdisziplinare Zusammenarbeit. Im ersten und umfangreicheren Teil dieser Arbeit werde ich auf die geschichtliche Entwicklung und die allgemeinen theoretischen Grundlagen des Fachbereiches Radiologie mit all ihrer Komplexitat eingehen. Der Theoretische Teil dieser Arbeit enthalt einige dennoch sehr vereinfachte physikalische Grundlagen, die aber zum besseren Gesamtverstandnis beitragen sollen. Erst im zweiten Teil fuhre ich auf, welche Auswirkung und welchen Stellenwert sie in der interdisziplinaren Zusammenarbeit im medizinischen Alltag hat. Mit dieser Arbeit stelle in Aussicht was sie uns zukunftig noch bringen wird.

Second-harmonic generation (SHG) microscopy has shown great promise for imaging live cells and tissues, with applications in basic science, medical research, and tissue engineering. Second Harmonic Generation Imaging offers a complete guide to this optical modality, from basic principles, instrumentation, methods, and image analysis to biomedical applications. The book features contributions by experts in second-harmonic imaging, including many pioneering researchers in the field. Written for researchers at all levels, it takes an in-depth look at the current state of the art and possibilities of SHG microscopy.

Organized into three sections, the book:

• Provides an introduction to the physics of the process, step-by-step instructions on how to build an SHG microscope, and comparisons with related imaging techniques
• Gives an overview of the capabilities of SHG microscopy for imaging tissues and cells including cell membranes, muscle, collagen in tissues, and microtubules in live cells by summarizing experimental and analytical methods
• Highlights representative biomedical and medical applications in imaging cancer, fibroses, autoimmune diseases, connective tissue disorders, eye pathologies, and cardiovascular disease

Historically, clinical imaging at the cellular and tissue level has been performed by pathologists on ex vivo biopsies removed by the surgeon. While histology remains the "gold standard" for pathologists, its interpretation remains highly subjective. Much of SHG research has focused on developing more quantitative, objective metrics. A tutorial for newcomers and an up-to-date review for experts, this book explores how SHG may be used to more precisely image a wide range of pathological conditions and diseases."

The imaging of small cellular components requires powerful instruments, and an entire family of equipment and techniques based on the confocal principle has been developed over the past 30 years. Such methods are commonly used by neuroscience researchers, but the majority of these users do not have a microscopy or a cell biology backgrounds and do can encounter difficulties in obtaining and interpreting results. This volume brings experts in high-resolution optical microscopy applications in neuroscience and cell biology together to document the state of the art. Outlining what is currently possible, the volume also discusses promising developments for the future and aids readers in selecting the most scientifically meaningful approach to solve their questions. Each chapter discusses instrumentation and technology in relationship to application in research. All of the common and cutting edge trends are covered - fluorescence / laser electron / nonlinear microscopy, infrared fluorescence, multiphoton imaging, tomography, FRAP, live imaging, STED, PALM/STORM, etc.
* Single and multiphoton confocal microscopy, and 4-pi confocal microscopy
* Obtaining nanoresolution via photoactivation localization microscopy (PALM)
* Several procedures that correlate observations in optical fluorescence microscopy and electron microscopy
* Study of morphology and function via high-resolution fluorescence procedures
* Additional high-resolution microscopic techniques

Achieve the most accurate imaging diagnosis for pediatric radiology.

"Differential Diagnosis in Pediatric Imaging"offers the most up-to-date knowledge of pediatric imaging diagnostic techniques. It provides imagers, clinicians and their trainees with simple methods to evaluate both frequently and rarely seen diseases and disorders, and suggests differential diagnoses fully taking into account clinical findings. In addition, the text provides how-to tips for identifying normal images - saving time and helping to avoid common misinterpretations.

Readers are guided through a comprehensive, easy-to-navigate radiological library of pediatric disorders, which are divided by organ system. Sections include the head and neck, chest, musculoskeletal, urogenital and the digestive tract, and are complemented by a thorough review of normal values. Each chapter discusses the imaging findings and different diagnostic possibilities, while mirroring clinical situations encountered in daily practice.

Features: Easy-to-read tables highlight important findings and clinical clues to help identify diagnoses at a glance 1,500 high-quality images cover all major childhood disordersA comprehensive chapter on normal values and measurements

Written by an international group of expert authors, this text is the foremost guide to the expanding specialty of pediatric radiology. Radiologists and residents in radiology can use this text as reference for daily practice and in preparation for exams.

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product.The latest advances in vibrational spectroscopic biomedical imagingWritten by expert spectroscopists, Vibrational Spectroscopic Imaging for Biomedical Applications discusses recent progress in the field in areas such as instrumentation, detector technology, novel modes of data collection, data analysis, and various biomedical applications. This full-color volume covers various IR imaging techniques, including transmission reflection, transflection, and attenuated total reflection (ATR) imaging, and Raman imaging. The efficient use of vibrational spectroscopy in clinical applications is emphasized in this state-of-the-art guide. Coverage includes: Automated breast histopathology using mid-IR spectroscopic imaging Synchrotron-based FTIR spectromicroscopy and imaging of single algai cells and cartilage Preparation of tissues and cells for infrared and Raman spectroscopy and imaging Evanescent wave imaging sFTIR, Raman, and surface-enhanced Raman spectroscopic imaging of fungal cells Widefield Raman imaging of cells and tissues Resonance Raman imaging and quantification of carotenoid antioxidants in the human retina and skin Raman microscopy for biomedical applications--efficient diagnosis of tissues, cells, and bacteria The current sate of Raman imaging in clinical application Vibrational spectroscopic imaging of microscopic stress patterns in biomedical materials Tissue imaging with coherent anti-Stokes Raman scattering microscopy

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. 295 cases and more than 1700 illustrations teach you how to accurately interpret genitourinary tract images 4 STAR DOODY'S REVIEW! "The high-quality images and pithy discussions make this book very useful to radiologists, both in training and in practice....The book's best features are the excellent image quality, the inclusion of images of differential diagnostic considerations, and concise discussions of the cases. This is an excellent resource for radiologists in training and in practice. The case-based format is excellent for board preparation, and its concise prose provides all the necessary information while leaving out the excess."--Doody's Review Service Genitourinary Imaging Cases presents an efficient and systematic approach to examining images of the genitourinary system. You will find an unmatched collection of 295 cases ranging from normal anatomy to the full spectrum of disease -- including renal cystic masses, renal infection, renal vascular disease, and female pelvic abnormalities. Included with these cases are 1700+ high-quality images that are representative of what you would see on various imaging modalities. The book's easy-to-navigate organization is specifically designed for use at the workstation. The concise text, numerous images, and helpful icons speed access to essential information and simplify the learning process. Features: Each case includes findings, differential diagnosis, comment/discussion, and clinical pearls Icons, a grading system depicting the full spectrum of diseases, common to rare, and imaging findings, typical to unusual, along with the consistent chapter organization make this perfect for rapid at-the-bench consultation Strong focus on pathology Special emphasis on the latest diagnostic modalities that include both CT and MR images

Breast MRI has emerged as a valuable adjunct to the conventional imaging modalities in the detection of primary and recurrent breast cancer. Yet, most radiologists who rely on MRI do not have knowledge of the fundamentals so essential to achieving and maintaining high image quality. With a focus on the basic imaging principles of breast MRI rather than on mathematical equations, this book takes a practical approach to imaging protocols that helps radiologists increase their diagnostic effectiveness. The text walks the reader through the basics of MRI, making it especially accessible to beginners. From a detailed outline of equipment prerequisites for obtaining high quality breast MRI to instructions on how to optimize image quality, expanded discussions on how to obtain optimized dynamic information, and explanations of good and bad imaging techniques, the book covers the topics that are most relevant to performing breast MRI.

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. Essential light scattering theories, techniques, and practices Extend tissue characterization and analysis capabilities using cutting-edge biophotonics tools and technologies. This comprehensive resource details the principles, devices, and procedures necessary to fully employ light scattering in clinical and diagnostic applications. Biomedical Applications of Light Scattering explains how to work with biological scatterers and scattering codes, accurately model tissues and cells, build time-domain simulations, and resolve inverse scattering issues. Noninvasive biopsy procedures, precancer and disease screening methods, and fiber optic probe design techniques are also covered in this detailed volume. Analyze light scattering spectra from complex and continuous media Build high-resolution cellular models using FDTD and PSTD methods Work with confocal microscopic imaging and diffuse optical tomography Measure blood flow using laser Doppler, LSCI, and photon correlation Perform noninvasive optical biopsies using elastic scattering techniques Assess bulk tissue properties using differential pathlength spectroscopy Detect precancerous lesions using angle-resolved low-coherence interferometry Risk-stratify patients for colonoscopies using enhanced backscattering methods

A must-read for anyone working in electronics in the healthcare sector This one-of-a-kind book addresses state-of-the-art integrated circuit design in the context of medical imaging of the human body. It explores new opportunities in ultrasound, computed tomography (CT), magnetic resonance imaging (MRI), nuclear medicine (PET, SPECT), emerging detector technologies, circuit design techniques, new materials, and innovative system approaches. Divided into four clear parts and with contributions from a panel of international experts, Medical Imaging systematically covers: X-ray imaging and computed tomography-X-ray and CT imaging principles; Active Matrix Flat Panel Imagers (AMFPI) for diagnostic medical imaging applications; photon counting and integrating readout circuits; noise coupling in digital X-ray imaging Nuclear medicine-SPECT and PET imaging principles; low-noise electronics for radiation sensors Ultrasound imaging-Electronics for diagnostic ultrasonic imaging Magnetic resonance imaging-Magnetic resonance imaging principles; MRI technology

Prostate cancer is one of the most common malignancies in men in the Western world. Although a wide range of treatment regimens are available for this disease, there are few evidence-based guidelines for treatment selection. This volume describes the clinical value of imaging for improving not only staging and treatment selection, but also the diagnosis, treatment planning, and treatment follow-up for patients with prostate cancer.
A multidisciplinary disease management approach is critical in this disease. For the radiologist, understanding the pathophysiology, critical clinical issues, and advantages and limitations of different treatments is essential for meaningful interpretation of imaging studies. Similarly, for the practicing clinician, understanding the advantages and limitations of imaging modalities and the importance of optimal technique are crucial to the rational use of imaging. This volume serves as a valuable reference for radiologists, urologists, medical and radiation oncologists and all practitioners involved in the management of prostate cancer.

Doktorarbeit / Dissertation aus dem Jahr 2007 im Fachbereich Medizin - Radiologie, Nuklearmedizin, Note: magna cum laude, Universitat zu Koln (Klinik und Poliklinik fur Nuklearmedizin), 112 Quellen im Literaturverzeichnis, Sprache: Deutsch, Abstract: Nach Radioiodtherapie (RIT) stellt der Patient fur seine Umwelt (Angehorige, Personal auf Therapiestation und Unbeteiligte) eine Strahlenquelle dar. Die chemische Form des exhalierten Radioiods nach erfolgter RIT ist dabei ein wichtiger Faktor zur Beurteilung der zu erwartenden effektiven Dosis infolge von Inhalation. Die Bioverfugbarkeit wird in der Reihenfolge elementares Iod > aerosolische Iodformen > organisch gebundenes Iod jeweils um den Faktor 10 verringert. Somit ist aus Sicht des Strahlenschutzes eine Radioiodexhalation in moglichst vollstandig organisch gebundener Form wunschenswert. In der vorliegenden Arbeit wurde Ausmass und chemische Form der Radioiodexhalation in Tierexperimenten exogen moduliert und untersucht. Die Ergebnisse zeigen, dass Schilddrusenmedikamente einen Einfluss auf die Radioiodexhalation nach 131I]-Applikation haben. Bei unbeeinflusster Schilddruse wird das 131I] zum Grossteil in organisch gebundener Form abgeatmet. Bei der Kaliumiodid (KI) und Perchloratgruppe konnte gezeigt werden, dass der organisch gebundene Iodanteil mit steigender Blockierung der Schilddruse abnimmt. Der elementare Iodanteil vergrossert sich gegenlaufig. Es konnte ferner gezeigt werden, dass das Ausmass dieser Veranderung der prozentualen Verteilung der unterschiedlichen Radioiodformen im Exhalat von der Menge des praapplizierten Medikaments abhangig ist. Die KI und Perchlorat Gruppen lassen vermuten, dass mit steigender Blockade die Menge des exhalierten Iods ansteigt. Die Bestimmung des absoluten Anteils des durch Exhalation eliminierten Iods lieferte Werte zwischen 0,21 und 0,54 %. Diese Werte sind grossenordnungsmassig gut mit den bisher beim Menschen bestimmten Werten vergleichbar. Thyreostatika konnen fo

The new edition of Physics for Medical Imaging has been fully updated to reflect the latest advances in technology and legislation and the needs of today's radiology trainees. Invaluable reading, particularly for those sitting the primary and final examinations of the Royal College of Radiology, UK, the book will also be of value to radiographers and personnel interested in medical imaging. The concise text is also accompanied by clear line drawings and sample images to illustrate the principles discussed. Closely matches needs of FRCR examination candidates. Updated to reflect changes to FRCR examination. More medically orientated. Covers new legislation concerning radiological safety etc. 'Must-know' summaries at end of each chapter. Completely new design.