Providing the most comprehensive, up-to-date coverage of this exciting biomedical field, Handbook of Photomedicine gathers together a large team of international experts to give you a complete account of the application of light in healthcare and medical science. The book progresses logically from the history and fundamentals of photomedicine to diverse therapeutic applications of light, known collectively as phototherapies. It facilitates your understanding of human diseases caused by light, the rationale for photoprotection, and major applications of phototherapy in clinical practice. The handbook begins with a series of historical vignettes of pioneers from the last two centuries. It also presents the fundamentals of physics and biology as applied to photomedicine. It next examines conditions and diseases caused by light, including skin cancer, dermatoses, and immunosuppression. The remainder of the book focuses on the most important clinical therapeutic applications of different kinds of light that vary in both wavelength and intensity. The book discusses ultraviolet phototherapy for skin diseases and infections and presents the basic science of photodynamic therapy and its use in cancer therapy and other medical specialties. It then covers mechanistic studies and clinical applications of low-level laser (light) therapy as well as the use of high power or surgical laser therapy in specialties, such as dentistry and dermatology. The book concludes with a collection of miscellaneous types of phototherapy.

The model-based investigation of motions of anthropomorphic systems is an important interdisciplinary research topic involving specialists from many fields such as Robotics, Biomechanics, Physiology, Orthopedics, Psychology, Neurosciences, Sports, Computer Graphics and Applied Mathematics. This book presents a study of basic locomotion forms such as walking and running is of particular interest due to the high demand on dynamic coordination, actuator efficiency and balance control. Mathematical models and numerical simulation and optimization techniques are explained, in combination with experimental data, which can help to better understand the basic underlying mechanisms of these motions and to improve them. Example topics treated in this book are * Modeling techniques for anthropomorphic bipedal walking systems * Optimized walking motions for different objective functions * Identification of objective functions from measurements * Simulation and optimization approaches for humanoid robots * Biologically inspired control algorithms for bipedal walking * Generation and deformation of natural walking in computer graphics * Imitation of human motions on humanoids * Emotional body language during walking * Simulation of biologically inspired actuators for bipedal walking machines * Modeling and simulation techniques for the development of prostheses * Functional electrical stimulation of walking.

This book develops methods using mathematical kinetic theory to describe the evolution of several socio-biological systems. Specifically, the authors deal with modeling and simulations of biological systems constituted by large populations of interacting cells, whose dynamics follow the rules of mechanics as well as their own ability to organize movement and biological functions. It proposes a new biological model focused on the analysis of competition between cells of an aggressive host and cells of the immune system. Modeling in kinetic theory may represent a way to understand phenomena of non equilibrium statistical mechanics that is not described by the traditional macroscopic approach. The authors of this work focus on models that refer to the Boltzmann equation (generalized Boltzmann models) with the dynamics of populations of several interacting individuals (kinetic population models). The book follows the classical research line applied to modeling real systems, linking the phenomenological observation of systems to modeling and simulations. used to identify the prediction ability of specific models. The book will be a valuable resource for applied mathematicians as well as researchers in the field of biological sciences. It may also be used for advanced graduate courses in biological systems modeling with applications to collective social behavior, immunology, and epidemiology.

The risks of shortages for some crucial metals and uncertainty about the land-based reserves of several others justify the search to diversify our sources of supply and investigate their potential. Mineral resources in the deep sea are attracting increasing interest with the progressive discovery of various forms of ores. France possesses large areas of deep seafloor in the three oceans as well as world-class human and technological resources and know-how, resulting from over 40 years of experience. This study takes stock of knowledge about mineralisations and associated metals, technologies for exploring and exploiting them, biodiversity and the potential impact of exploitation on the deep environment and the partnerships which are vital for France and Europe. This information will be useful for decision-makers in drawing up strategies, defining research and development programmes and in enhancing and developing commercial utilizations for these high-potential resources.

The best way to become acquainted with a subject is to write a book about it. BenjaminDisraeli Cryobiologyisatruemultidisciplinaryscienceinvolvingconceptsfrombiology, medicine, and physics. Its ?eld comprises the study of any biologicalobject or system (e. g. , proteins, cells, tissues, organs, or organisms) under the temp- atures below the normal (ranging from hypothermic conditions to cryogenic temperatures): cold-adaptation of organisms; cryoconservation of biological objects; conservation of organs under hypothermic conditions; lyophilization; cryosurgery. Origins of cryobiology could be traced down to ancient Eg- tians; probably the ?rst scienti?c account of this science is the monograph by Sir Robert Boyle "New Experiments and Observations Touching Cold" (London, 1683). Twentieth century witnessed a rapid development of cryo- ologyrelatedtotheprogressofthecryogenicequipment(closedsystemsbased on liquid nitrogen, Joule-Tohomson cooling with mixed gases, etc. ), devel- ments of monitoring techniques, extension of the list of diseases that have been successfully treated by cryomedicine, and consolidation of research by foundation (simultaneously in 1964) of two major scienti?c societies in this ? eld - The Society for Cryobiology and The Society for Low Temperature Biology. There are a lot of good books on cryobiologythat can be divided into two groups: (1) the ones that treat the whole ?eld of cryobiology - these ones are somewhatout-of-dateand(2)thebooksonspeci?capplicationsofcryobiology such as cryosurgery or cryoconservation.

This review series covers trends in modern biotechnology, including all aspects of this interdisciplinary technology, requiring knowledge, methods, and expertise from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science.

In "Emergence, Mind, and Consciousness," author Gary A. Lucas does something that many consider impossible: he bridges the gap between a bottom-up description of brain mechanisms and the top-down emergence of mental processes. The result is a comprehensive yet readily understandable explanation of how consciousness emerges.

Lucas, however, strives to do more. He seeks to design an artificial agent with all the essential properties of the human mind- consciousness, declarative memory, a sense of self, reasoning skills, language, and social identity. His account is mechanistic, and yet, as the bio-inspired networks are linked to emergent mental properties, we come to understand that we can truly construct a conscious agent. We have a model for how to build one.

If you're interested in the emergent properties of mind, consciousness, cognition, self-awareness, social belongingness, or the possibility of constructing a robotic agent with such properties, then this is essential reading. It is conscious mind explained on a level that even a robot will understand it.

Computational Biomechanics for Medicine: Solid and fluid mechanics for the benefit of patients contributions and papers from the MICCAI Computational Biomechanics for Medicine Workshop help in conjunction with Medical Image Computing and Computer Assisted Intervention conference (MICCAI 2019) in Shenzhen, China. The content is dedicated to research in the field of methods and applications of computational biomechanics to medical image analysis, image-guided surgery, surgical simulation, surgical intervention planning, disease prognosis and diagnostics, analysis of injury mechanisms, implant and prostheses design, as well as artificial organ design and medical robotics. These proceedings appeal to researchers, students and professionals in the field.

The book describes the significant multidisciplinary research findings at the Universita Politecnica delle Marche and the expected future advances. It addresses some of the most dramatic challenges posed by today's fast-growing, global society and the changes it has caused. It also discusses solutions to improve the wellbeing of human beings. The book covers the main research achievements in the various disciplines of the life sciences, and includes chapters that highlight mechanisms relevant to all aspects of human diseases, the molecular, cellular, and functional basis of therapy, and its translation into the management of people's health needs. It also describes research on traditional and innovative foods to enhance quality, safety and functionality, and to develop bioactive/nutraceutical compounds. Further chapters address conservation and management of various environments, from the forests to the oceans, describing the studies on countermeasures against climate changes and terrestrial/aquatic pollutants, and on terrestrial/marine biodiversity, ecosystems and landscapes, erosion of genetic biodiversity, innovative aquaculture feed, sustainable crop production and management of forests. Lastly, the book reports the findings of research work on different classes of biomolecules, and on the molecular basis of antibiotic resistances and their diffusion.

The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. Volume 5 is devoted to cells, tissues, and organs of the cardiovascular and ventilatory systems with an emphasis on mechanotransduction-based regulation of flow. The blood vessel wall is a living tissue that quickly reacts to loads applied on it by the flowing blood. In any segment of a blood vessel, the endothelial and smooth muscle cells can sense unusual time variations in small-magnitude wall shear stress and large-amplitude wall stretch generated by abnormal hemodynamic stresses. These cells respond with a short-time scale (from seconds to hours) to adapt the vessel caliber. Since such adaptive cell activities can be described using mathematical models, a key objective of this volume is to identify the mesoscopic agents and nanoscopic mediators required to derive adequate mathematical models. The resulting biomathematical models and corresponding simulation software can be incorporated into platforms developed in virtual physiology for improved understanding and training.

This book presents recent methods for Systems Genetics (SG) data analysis, applying them to a suite of simulated SG benchmark datasets. Each of the chapter authors received the same datasets to evaluate the performance of their method to better understand which algorithms are most useful for obtaining reliable models from SG datasets. The knowledge gained from this benchmarking study will ultimately allow these algorithms to be used with confidence for SG studies e.g. of complex human diseases or food crop improvement. The book is primarily intended for researchers with a background in the life sciences, not for computer scientists or statisticians.

MATRIX is Australia's international and residential mathematical research institute. It facilitates new collaborations and mathematical advances through intensive residential research programs, each 1-4 weeks in duration. This book is a scientific record of the eight programs held at MATRIX in 2018: - Non-Equilibrium Systems and Special Functions - Algebraic Geometry, Approximation and Optimisation - On the Frontiers of High Dimensional Computation - Month of Mathematical Biology - Dynamics, Foliations, and Geometry In Dimension 3 - Recent Trends on Nonlinear PDEs of Elliptic and Parabolic Type - Functional Data Analysis and Beyond - Geometric and Categorical Representation Theory The articles are grouped into peer-reviewed contributions and other contributions. The peer-reviewed articles present original results or reviews on a topic related to the MATRIX program; the remaining contributions are predominantly lecture notes or short articles based on talks or activities at MATRIX.

The convergence of biology and computer science was initially motivated by the need to organize and process a growing number of biological observations resulting from rapid advances in experimental techniques. Today, however, close collaboration between biologists, biochemists, medical researchers, and computer scientists has also generated remarkable benefits for the field of computer science. Systemic Approaches in Bioinformatics and Computational Systems Biology: Recent Advances presents new techniques that have resulted from the application of computer science methods to the organization and interpretation of biological data. The book covers three subject areas: bioinformatics, computational biology, and computational systems biology. It focuses on recent, systemic approaches in computer science and mathematics that have been used to model, simulate, and more generally, experiment with biological phenomena at any scale.

Robert Rosen was not only a biologist, he was also a brilliant mathematician whose extraordinary contributions to theoretical biology were tremendous. Founding, with this book, the area of Anticipatory Systems Theory is a remarkable outcome of his work in theoretical biology. This second edition of his book Anticipatory Systems, has been carefully revised and edited, and includes an Introduction by Judith Rosen. It has also been expanded with a set of Prolegomena by Dr. Mihai Nadin, who offers an historical survey of this fast growing field since the original work was published. There is also some exciting new work, in the form of an additional chapter on the Ontology of Anticipation, by Dr. John Kineman. An addendum-- with autobiographical reminiscences by Robert Rosen, himself, and a short story by Judith Rosen about her father-- adds a personal touch. This work, now available again, serves as the guiding foundations for the growing field of Anticipatory Systems and, indeed, any area of science that deals with living organisms in some way, including the study of Life and Mind. It will also be of interest to graduate students and researchers in the field of Systems Science.

The primary purpose of this textbook is to introduce the reader to a wide variety of elementary permutation statistical methods. Permutation methods are optimal for small data sets and non-random samples, and are free of distributional assumptions. The book follows the conventional structure of most introductory books on statistical methods, and features chapters on central tendency and variability, one-sample tests, two-sample tests, matched-pairs tests, one-way fully-randomized analysis of variance, one-way randomized-blocks analysis of variance, simple regression and correlation, and the analysis of contingency tables. In addition, it introduces and describes a comparatively new permutation-based, chance-corrected measure of effect size. Because permutation tests and measures are distribution-free, do not assume normality, and do not rely on squared deviations among sample values, they are currently being applied in a wide variety of disciplines. This book presents permutation alternatives to existing classical statistics, and is intended as a textbook for undergraduate statistics courses or graduate courses in the natural, social, and physical sciences, while assuming only an elementary grasp of statistics.

This book provides the latest information on bioplastics and biodegradable plastics. The initial chapters introduce readers to the various sources and substrates for the synthesis of bioplastics and biodegradable plastics, and explain their general structure, physio-chemical properties and classification. In turn, the book discusses innovative methods for the production of bioplastics at the industrial level and for the microbial production of bioplastics. It highlights the processes that are involved in the conversion of agro-industrial waste into bioplastics, while also summarizing the mechanisms of biodegradation in bioplastics. The book addresses a range of biotechnological applications of bioplastics such as in agriculture, food packaging and pharmaceutical industry, as well as biomedical applications.

The emerging, multi-disciplinary field of systems biology is devoted to the study of the relationships between various parts of a biological system, and computer modeling plays a vital role in the drive to understand the processes of life from an holistic viewpoint. Advancements in experimental technologies in biology and medicine have generated an enormous amount of biological data on the dependencies and interactions of many different molecular cell processes, fueling the development of numerous computational methods for exploring this data. The mathematical formalism of Petri net theory is able to encompass many of these techniques. This essential text/reference presents a comprehensive overview of cutting-edge research in applications of Petri nets in systems biology, with contributions from an international selection of experts. Those unfamiliar with the field are also provided with a general introduction to systems biology, the foundations of biochemistry, and the basics of Petri net theory. Further chapters address Petri net modeling techniques for building and analyzing biological models, as well as network prediction approaches, before reviewing the applications to networks of different biological classification. Topics and features: investigates the modular, qualitative modeling of regulatory networks using Petri nets, and examines an Hybrid Functional Petri net simulation case study; contains a glossary of the concepts and notation used in the book, in addition to exercises at the end of each chapter; covers the topological analysis of metabolic and regulatory networks, the analysis of models of signaling networks, and the prediction of network structure; provides a biological case study on the conversion of logical networks into Petri nets; discusses discrete modeling, stochastic modeling, fuzzy modeling, dynamic pathway modeling, genetic regulatory network modeling, and quantitative analysis techniques; includes a Foreword by Professor Jens Reich, Professor of Bioinformatics at Humboldt University and Max Delbruck Center for Molecular Medicine in Berlin. This unique guide to the modeling of biochemical systems using Petri net concepts will be of real utility to researchers and students of computational biology, systems biology, bioinformatics, computer science, and biochemistry."

This treasure of popular science by the Russian biophysicist Mikhail V. Volkenstein is at last, more than twenty years after its appearance in Russian, available in English translation.

As its title Entropy and Information suggests, the book deals with the thermodynamical concept of entropy and its interpretation in terms of information theory. The author shows how entropy is not to be considered a mere shadow of the central physical concept of energy, but more appropriately as a leading player in all of the major natural processes: physical, chemical, biological, evolutionary, and even cultural.

The theory of entropy is thoroughly developed from its beginnings in the foundational work of Sadi Carnot and Clausius in the context of heat engines, including expositions of much of the necessary physics and mathematics, and illustrations from everyday life of the importance of entropy.

The author then turns to Boltzmann's epoch-making formula relating the entropy of a system directly to the degree of disorder of the system, and to statistical physics as created by Boltzmann and Maxwell---and here again the necessary elements of probability and statistics are expounded. It is shown, in particular, that the temperature of an object is essentially just a measure of the mean square speed of its molecules.

Fluctuations" in a system are introduced and used to explain why the sky is blue, and how, perhaps, the universe came to be so ordered. Whether statistical physics reduces ultimately to pure mechanics, as Laplace's demon" would have it, is also discussed.

The final three chapters concentrate on open systems, that is, systems which exchange energy or matter with their surroundings---first linear systems close to equilibrium, and then non-linear systems far from equilibrium. Here entropy, as it figures in the theory of such systems developed by Prigogine and others, affords explanations of the mechanism of division of cells, the process of aging in organisms, and periodic chemical reactions, among other phenomena.

Finally, information theory is developed---again from first principles---and the entropy of a system characterized as absence of information about the system. In the final chapter, perhaps the piece de resistance of the work, the author examines the thermodynamics of living organisms in the context of biological evolution. Here the value of biological information" is discussed, linked to the concepts of complexity and irreplaceability. The chapter culminates in a fascinating discussion of the significance of these concepts, all centered on entropy, for human culture, with many references to particular writers and artists.

The book is recommended reading for all interested in physics, information theory, chemistry, biology, as well as literature and art."

The book is organized so as to address in separate sections first the preparatory topics of medicine (clinical and epidemiological), science in general, and statistics (mathematical); then topics of epidemiological research proper; and, finally, topics of 'meta-epidemiological' clinical research. In those two main sections, a further grouping is based on the distraction between objects and methods of study. In this framework, the particular topics are addressed both descriptively and quasi-prescriptively, commonly with a number of explicatory annotations. This book is intended to serve as a handbook for whomever is, in whatever way, concerned with epidemiological or 'meta-epidemiological' clinical research. But besides this, it is also intended to serve as a textbook for students in introductory courses on 'epidemiological' research - to which end there is a suggested hierarchy of the concepts that might reasonably be covered.

Environmental variation plays an important role in many biological and ecological dynamical systems. This monograph focuses on the study of oscillation and the stability of delay models occurring in biology. The book presents recent research results on the qualitative behavior of mathematical models under different physical and environmental conditions, covering dynamics including the distribution and consumption of food. Researchers in the fields of mathematical modeling, mathematical biology, and population dynamics will be particularly interested in this material.

NOTE: Before purchasing, check with your instructor to ensure you select the correct ISBN. This ISBN is for the paperback PhysioEx Lab Manual and does NOT include access to the PhysioEx 10.0 website. The Lab Manual for PhysioEx (TM) 10.0 Laboratory Simulations in Physiology features 12 Exercises that contain 63 easy-to-use laboratory simulation activities to complement or replace wet labs, including those that are expensive or time-consuming to perform in class. PhysioEx allows students to repeat labs as often as they like, perform experiments without harming live animals, and conduct experiments that are difficult to perform in a wet lab environment because of time, cost, or safety concerns. 3 ways students can access the PhysioEx 10.0 website: By purchasing a Mastering A&P title that includes PhysioEx 10.0 -- the most common way students access the PhysioEx 10.0 website. By purchasing instant online access to PhysioEx 10.0 Premium Website (ISBN: 9780136447672 / 0136447678) at www.physioex.com. By purchasing the PhysioEx 10 Lab Manual package (ISBN: 9780136643746 / 0136643744) that includes an access code to the PhysioEx 10.0 website.

This volume presents the latest developments in the highly active and rapidly growing field of diffusion MRI. The reader will find numerous contributions covering a broad range of topics, from the mathematical foundations of the diffusion process and signal generation, to new computational methods and estimation techniques for the in-vivo recovery of microstructural and connectivity features, as well as frontline applications in neuroscience research and clinical practice. These proceedings contain the papers presented at the 2017 MICCAI Workshop on Computational Diffusion MRI (CDMRI'17) held in Quebec, Canada on September 10, 2017, sharing new perspectives on the most recent research challenges for those currently working in the field, but also offering a valuable starting point for anyone interested in learning computational techniques in diffusion MRI. This book includes rigorous mathematical derivations, a large number of rich, full-colour visualisations and clinically relevant results. As such, it will be of interest to researchers and practitioners in the fields of computer science, MRI physics and applied mathematics.

"Metallomics and the Cell" provides in an authoritative and timely manner in 16 stimulating chapters, written by 37 internationally recognized experts from 9 nations, and supported by more than 3000 references, several tables, and 110 illustrations, mostly in color, a most up-to-date view of the "metallomes" which, as defined in the "omics" world, describe the entire set of biomolecules that interact with or are affected by each metal ion. The most relevant tools for visualizing metal ions in the cell and the most suitable bioinformatic tools for browsing genomes to identify metal-binding proteins are also presented. Thus, MILS-12 is of relevance for structural and systems biology, inorganic biological chemistry, genetics, medicine, diagnostics, as well as teaching, etc.

Sustainable agriculture is a rapidly growing field aiming at producing food and energy in a sustainable way for humans and their children. Sustainable agriculture is a discipline that addresses current issues such as climate change, increasing food and fuel prices, poor-nation starvation, rich-nation obesity, water pollution, soil erosion, fertility loss, pest control, and biodiversity depletion. Novel solutions are proposed based on integrated knowledge from sciences as diverse as agronomy, soil science, molecular biology, chemistry, toxicology, ecology, economy, philosophy and social sciences. Because actual society issues are now intertwined, global, and fast-developing, sustainable agriculture will bring solutions to build a safer world. This book series gathers review articles that analyze current agricultural issues and knowledge, then propose alternative solutions. It will therefore help all scientists, decision-makers, professors, farmers and politicians who wish to build a safe agriculture, energy and food system for future generations.