Provides exclusive material on refractories Discusses detailed descriptions of different shaped and unshaped refractories Uses phase diagrams for better understanding of concepts Explores details on testing and specifications including thermochemical and corrosion behaviour Includes a separate chapter on trends of refractories and other issues

Image synthesis across and within medical imaging modalities is an active area of research with broad applications in radiology and radiation oncology. This book covers the principles and methods of medical image synthesis, along with state-of-the-art research. First, various traditional non-learning-based, traditional machine-learning-based, and recent deep-learning-based medical image synthesis methods are reviewed. Second, specific applications of different inter- and intra-modality image synthesis tasks and of synthetic image-aided segmentation and registration are introduced and summarized, listing and highlighting the proposed methods, study designs, and reported performances with the related clinical applications of representative studies. Third, the clinical usages of medical image synthesis, such as treatment planning and image-guided adaptive radiotherapy, are discussed. Last, the limitations and current challenges of various medical synthesis applications are explored, along with future trends and potential solutions to solve these difficulties. The benefits of medical image synthesis have sparked growing interest in a number of advanced clinical applications, such as magnetic resonance imaging (MRI)-only radiation therapy treatment planning and positron emission tomography (PET)/MRI scanning. This book will be a comprehensive and exciting resource for undergraduates, graduates, researchers, and practitioners.

Autophagy and Metabolism: Potential Target for Cancer Therapy presents updates on autophagy in cancer metabolism and how it can be used to develop new, more efficient treatments. Written by experts in the field, the book presents recent research and explains how to translate it to the clinical setting. Sections discuss tumor cell metabolism and autophagy as therapeutic targets, autophagy regulation in cancer, signaling pathways in metabolic dysregulation in solid tumors, metabolic stress and cell death pathways, and the role of the tumor microenvironment. In addition, topics cover combined targeting autophagy, metabolism for cancer therapy, and the autophagy effect on immune cell metabolism. This will be a valuable resource for researchers, oncologists, graduate students, and members of the biomedical field who are interested in learning more about the interaction between autophagy and cancer metabolism.

Get Insight on the Function of Supercomplexes in Biological Systems Redox Proteins in Supercomplexes and Signalosomes is one of the first books to explore the key role played by redox proteins and their interaction network in a wide range of essential cellular processes in all domains of life. The book explains how the mitochondrial respiratory chain is dynamically organized in supercomplexes even under physiological conditions. It also addresses the impact of supercomplex assembly on mitochondrial morphology, physiology, and biogenesis to shed light on the molecular mechanisms of pathological situations, including aging. Discover the Connection between Bioenergetic Supercomplexes and Signalosomes Compiling state-of-the-art research from leading practitioners in the field, this book gives you guidance on dealing with these biological systems in your investigations. The book shows that supercomplexes and signalosomes provide the link between reductive and systems biology, which enables us to understand how the molecular properties of individual macromolecular components trigger cellular function.

Describes landmark experiments in cell biology and biochemistry Discusses the "How" and "Why" of historically important experiments Includes primary, original data and graphs Emphasizes biological techniques, which helps understand how many of the experiments performed were possible. Documents, chronologically, how each result fed into the next experiments.

Features • Presents an accessible introduction to the topic in addition to more advanced material for specialists in the field. • Covers a broad spectrum of topics this new field. • Contains exciting case studies and examples, such as quantum dots, bionanomaterials, and future perspectives.

Reports on waste valorization in the winemaking industry and converting the waste into more useful products including oils, antioxidants and other valuable materials. Explores research which contributes to environmental sustainability and circular economy in the winemaking industry. Describes other ways to reduce the ecological footprint of the wine industry such as using less fertilizer, more benign pesticides and reduction of water footprint. Proposes options for a potential wine waste biorefining. Reviews alternative uses of agro-industrial wine wastes as sources of additives for the food, cosmetic and pharmaceutical industries.

The book sets out to inform a broad range of professionals working in medicine and healthcare about how creative thinking and design concepts can be used to innovate in providing an enhanced patient experience. It outlines these concepts as a primary means to identify, clarify and resolve some of the process improvement and enhancement challenges in healthcare delivery. It demonstrates by example how such challenges can be addressed, drawing on case examples from healthcare and other industries, and from the authors’ own experiences as innovators and educators. It emphasizes the value of learning in action. For the reader who already has a leaning towards novel approaches to addressing healthcare delivery challenges, it provides guidance on harnessing team inputs and engaging with a network of contributors. It is an ideal resource for all working in medicine and healthcare, from managers, nurses, doctors, administrators, executives, and allied health professionals to medical engineers, medical physicists, medical scientists and medical product developers. Features Provides a unique framework to conceptualise innovation in healthcare and medicine. Authored by an award-winning medical scientist and an established business school Professor who have proven track-records with innovation, in education settings and as entrepreneurs. Presents a clear interdisciplinary approach, complemented with practical case studies set in the context of the challenges facing healthcare delivery in the 21st century. Dr. Barry McMahon has a national and international reputation as an Academic Medical Physicist in the fields of novel physiological measurement and medical device innovation and design. He is the co- inventor of the Functional Lumen Imaging Probe (FLIP) technique later commercialised as EndoFLIP™. He was the Director of the Innovation Academy at Trinity College Dublin from 2012 to 2017. Since 2020 he is advising Children’s Health Ireland on innovation practice. In 2021, he retired as Chief Physicist/Clinical Engineer at Tallaght Hospital, Ireland and currently runs his own innovation-consulting group Electric Mindset Ltd. Dr. Paul Coughlan is Professor in Operations Management and Co-Director of Faculty at Trinity Business School, Trinity College Dublin. His research explores collaborative strategic improvement of operations through network action learning. He was the Director of the Innovation Academy at Trinity College Dublin from 2010 to 2012. He is a founding director of a research-based spin-out venture, Easy Hydro Ltd.

This book investigates in detail the emerging deep learning (DL) technique in computational physics, assessing its promising potential to substitute conventional numerical solvers for calculating the fields in real-time. After good training, the proposed architecture can resolve both the forward computing and the inverse retrieve problems. Pursuing a holistic perspective, the book includes the following areas. The first chapter discusses the basic DL frameworks. Then, the steady heat conduction problem is solved by the classical U-net in Chapter 2, involving both the passive and active cases. Afterwards, the sophisticated heat flux on a curved surface is reconstructed by the presented Conv-LSTM, exhibiting high accuracy and efficiency. Besides, the electromagnetic parameters of complex medium such as the permittivity and conductivity are retrieved by a cascaded framework in Chapter 4. Additionally, a physics-informed DL structure along with a nonlinear mapping module are employed to obtain the space/temperature/time-related thermal conductivity via the transient temperature in Chapter 5. Finally, in Chapter 6, a series of the latest advanced frameworks and the corresponding physics applications are introduced. As deep learning techniques are experiencing vigorous development in computational physics, more people desire related reading materials. This book is intended for graduate students, professional practitioners, and researchers who are interested in DL for computational physics.

One of the fundamental principles of green chemistry is to design chemical products that minimize adverse consequences to human health and the environment. While chemists have been designing molecules for 200 years to have a limitless range of commercial applications, little or no attention has been given to developing commercial chemicals while avoiding hazards and toxicity. This book is the first to provide chemists with useful, practical guidance on how to minimize or avoid a wide range of hazards. Building on the insights gained from the pharmaceutical industry over the past 25 years on how to create desirable biological effects, the authors demonstrate how to avoid undesirable biological effects by design.

From the groundbreaking partnership of Macmillan Learning and Scientific American comes this one-of-a-kind introduction to the science of biology and its impact on the way we live. Available for the first time with Macmillan's new online learning tool, Achieve, Biology for a Changing World explores the core ideas of biology through chapters written and illustrated in the style of a Scientific American article. Chapters don't just feature compelling stories of real people-each chapter is a newsworthy story that serves as a context for covering the standard curriculum for the non-majors biology course. Achieve is Macmillan's new online learning platform that supports educators and students throughout the full range of instruction, including assets suitable for pre-class preparation, in-class active learning, and post-class study and assessment. The pairing of a powerful new platform with outstanding biology content provides an unrivaled learning experience.

Bioelectronics is emerging as a new area of research where electronics can selectively detect, record, and monitor physiological signals. This is a rapidly expanding area of medical research, that relies heavily on multidisciplinary technology development and cutting-edge research in chemical, biological, engineering, and physical science. This book provides extensive information on the (i) fundamental concepts of bioelectronics, (ii) materials for the developments of bioelectronics such as implantable electronics, self-powered devices, bioelectronic sensors, flexible bioelectronics, etc, and (iii) an overview of the trends and gathering of the latest bioelectronic progress. This book will broaden our knowledge about newer technologies and processes used in bioelectronics.

The first accessible text on the topic of animals as environmental predictors, bringing together the literature from as far back as 18th century through to the present day. - Covers wider terrain than other titles in a relatively unexplored subject area. The text discusses climate change (highly topical) and how animals may be able to be used to predict future weather and climatic events. There is international potential as the climate challenge is global, and the examples span worldwide case studies. The sources used include myths, anecdotes, news articles and stories backed up by relevant scientific literature in international peer-reviewed journals. Each chapter starts with a short fictitious story to set the scene and anecdotes from indigenous cultures are especially interesting. The author draws on his vast expertise in biochemistry and cell biology. The science does not impede the less technical reader, due to the engaging mix of stories, anecdotes, personal observations and scientific underpinnings.

As transgender and gender non-binary individuals are a growing demographic, the number of patients seeking gender confirmation surgery is increasing. Atlas of Operative Techniques in Gender Affirmation Surgery is a highly illustrated and practical guide to the different types of gender affirmation surgery. Top and bottom surgeries are illustrated include facial feminization, mastectomy, techniques in phalloplasty, metoidioplasty, different approaches to vaginoplasty, management of complications of gender affirming surgery, and more. This comprehensive textbook is a must-have guide for individuals interested in gender affirmation surgery to master the complex operative procedures that this field demands and to refine their techniques.

Understanding the underlying principles of statistical techniques and effectively applying statistical methods can be challenging for researchers at all stages of their career. This concise, practical guide uses a simple, engaging approach to take scientists and clinicians working in laboratory-based life science and medical research through the steps of choosing and implementing appropriate statistical methods to analyse results. The author draws on her extensive experience of advising students and researchers over the past 30 years, breaking down complex concepts into easy-to-understand units. Practical examples using free online statistical tools are included throughout, with illustrations and diagrams employed to keep jargon to a minimum. Sample size calculations and considerations are covered in depth, and the book refers to types of data from experiments that clinicians and lab-based scientists are likely to encounter. Straightforward, accessible and encouraging throughout, this is a go-to reference for researchers who want to achieve statistical autonomy.

This unique volume provides an insight into bioactive compounds of tea from studies of both chemical structures and pharmacological aspects. Examples of the beneficial health effects of tea compounds in managing health problems and diseases are presented, with an emphasis on viral diseases such as COVID-19. Vaccines are not always available in many countries, thus simple and inexpensive measures which are easily available to help mitigate for example, the COVID-19 pandemic, are urgently needed. Dietary bioactive compounds could be alternative nutritional approaches in combating infection in addition to existing therapies and also upcoming vaccines and drugs, by enhancing their efficacy. Features : Emphasizes the antiviral activity of the tea compounds and the latest findings against Coronavirus and SARS-Cov-2. Provides a general overview of tea constituents, chemical structures of these compounds and their potential health benefits. Tea is one of the most commonly used beverages around the world and people with different backgrounds will be interested in reading about its health benefits. Correlating the therapeutic effect of tea components with COVID-19 is extremely beneficial for health care team members and general population. Assists the reader in understanding the therapeutic value of using tea to tackle COVID-19 symptoms, offering simple, inexpensive tips to help mitigate the virus.

Adds three new chapters (constructed wetlands, stream sediments, and rice production systems) and is updated throughout Examines the adaptation of wetland plants to varying anaerobic soil conditions Provides the basic concepts involved in biogeochemical cycling of nutrients and contaminants in wetlands as related to environmental significance and ecological functions Examines the role of microbial processes in sulfate reduction, denitrification, and methane production Provides case studies for key biogeochemical processes governing wetland function in freshwater wetlands

Key features: Organised and centred around analysis techniques, not traditional Mechanics and E&M. Presents a unified approach, in a different order, meaning that the same laboratories, equipment, and demonstrations can be used when teaching the course. Demonstrates to students that the analysis and concepts they are learning are critical to the understanding of biological systems.

This book provides an introduction to the significant role of physics in evolution, based on the ideas of matter and energy resource flow, organism self-copying, and ecological change. The text employs these ideas to create quantitative models for important evolutionary processes. Many fields of science and engineering have come up against the problem of complex design-when details become so numerous that computer power alone cannot make progress. Nature solved the complex-design problem using evolution, yet how it did so has been a mystery. Both laboratory experiments and computer-simulation attempts eventually stopped evolving. Something more than Darwin's ideas of heredity, variation, and selection was needed. The solution is that there is a fourth element to evolution: ecological change. When a new variation is selected, this can change the ecology, and the new ecology can create new opportunities for even more new variations to be selected. Through this endless cycle, complexity can grow automatically. This book uses the physics of resource flow to describe this process in detail, developing quantitative models for many evolutionary processes, including selection, multicellularity, coevolution, sexual reproduction, and the Serengeti Rules. The text demonstrates that these models are in conceptual agreement with numerous examples of biological phenomena, and reveals, through physics, how complex design can arise naturally. This will serve as a key text on the part physics plays in evolution, and will be of great interest to students at the university level and above studying biophysics, physics, systems biology, and related fields.

Features Surveys of the systems approach to analysing and understanding multifaceted, complex problems in astrobiology, written by two scientists who also have engineering backgrounds. Systems applications to areas important to astrobiology, such as chemical evolution, prebiotic chemistry, geochemical/geophysical settings conducive to emergence of life, robotic space exploration, and much more. Wide appeal for all readers interested in the origin and occurrence of life in our Solar System and beyond.

Features Introduces the physics of accelerators, lasers, and plasma in tandem with the industrial methodology of inventiveness. Outlines a path from idea to practical implementation of scientific and technological innovation. Contains more than 380 illustrations and numerous end-of-chapter exercises.

Developed from the author's course on advanced mechanics of composite materials, Finite Element Analysis of Composite Materials with Abaqus (R) shows how powerful finite element tools tackle practical problems in the structural analysis of composites. This Second Edition includes two new chapters on "Fatigue" and "Abaqus Programmable Features" as well as a major update of chapter 10 "Delaminations" and significant updates throughout the remaining chapters. Furthermore, it updates all examples, sample code, and problems to Abaqus 2020. Unlike other texts, this one takes theory to a hands-on level by actually solving problems. It explains the concepts involved in the detailed analysis of composites, the mechanics needed to translate those concepts into a mathematical representation of the physical reality, and the solution of the resulting boundary value problems using Abaqus. The reader can follow a process to recreate every example using Abaqus graphical user interface (CAE) by following step-by-step directions in the form of pseudo-code or watching the solutions on YouTube. The first seven chapters provide material ideal for a one-semester course. Along with offering an introduction to finite element analysis for readers without prior knowledge of the finite element method (FEM), these chapters cover the elasticity and strength of laminates, buckling analysis, free edge stresses, computational micromechanics, and viscoelastic models for composites. Emphasizing hereditary phenomena, the book goes on to discuss continuum and discrete damage mechanics as well as delaminations and fatigue. The text also shows readers how to extend the capabilities of Abaqus via "user subroutines" and Python scripting. Aimed at advanced students and professional engineers, this textbook features 62 fully developed examples interspersed with the theory, 82 end-of-chapter exercises, and 50+ separate pieces of Abaqus pseudo-code that illustrate the solution of example problems. The author's website offers the relevant Abaqus and MATLAB model files available for download, enabling readers to easily reproduce the examples and complete the exercises. Video recording of solutions to examples are available on YouTube with multilingual captions.

This book bridges the gap between theoretical concepts and their implementations, especially for the high-performance structures/components related to advanced composite materials. This work focuses on the prediction of various structural responses such as deformations, natural frequencies etc. of advanced composites under complex environments and/or loading conditions. In addition, it discusses micro-mechanical material modeling of various advanced composite materials that involve different structures ranging from basic to advanced, such as beams, flat and curved panels, shells, skewed, corrugated, and other materials, as well as various solution techniques via analytical, semi-analytical, and numerical approaches. This book: Covers micro-mechanical material modeling of advanced composite materials Describes constitutive models of different composite materials and kinematic models of different structural configuration Discusses pertinent analytical, semi-analytical, and numerical techniques Focusses on structural responses relating to deformations, natural frequencies, and critical loads under complex environments Presents actual demonstrations of theoretical concepts as applied to real examples using Ansys APDL scripts This book is aimed at researchers, professionals, and graduate students in mechanical engineering, material science, material engineering, structural engineering, aerospace engineering, and composite materials.

The evolution of a classic The new 12th edition of Introduction to Genetic Analysis takes this cornerstone textbook to the next level. The hallmark focuses on genetic analysis, quantitative problem solving, and experimentation continue in this new edition while incorporating robust updates to the science. Introduction to Genetic Analysis is now supported in Achieve, Macmillan's new online learning platform. Achieve is the culmination of years of development work put toward creating the most powerful online learning tool for biology students. It houses all of our renowned assessments, multimedia assets, e-books, and instructor resources in a powerful new platform.

Details all recently developed methods for palladium and platinum determination using spectrophotometry in a single source. Organized so that given so that anyone interested in a particular method using a specific reagent can go directly to those details. Facilitates the development of better methods for specific conditions of a sample.