Advances in Agronomy, Volume 172, the latest release in this leading reference on the topic, contains a variety of updates and highlights new advances in the field, with each chapter written by an international board of authors.

Lipids in Plants and Algae: From Fundamental Science to Industrial Applications, Volume 101 provides in-depth reviews on the most important aspects of the field. Topics in this volume encompass the most recent data about the physical properties of membrane lipids, lipid biosynthesis and metabolism (including glycerolipids, fatty acids, sterols, N-acylethanolamines, prostaglandins, phytoprostane), lipid storage, acyl flux, the dynamic and transport of glycerolipids, and the conversion of fatty acids into hydrocarbons. Lipid metabolism and lipidomics in plants and algae are one of the most challenging areas in biology, not only for fundamental research but also for the sustainable production of valuable molecules for green chemistry, including biofuel and health.

Cancer Vaccines as Immunotherapy of Cancer provides extensive and state-of-the-art information about the meaning, relevance and limitation of therapeutic cancer vaccines. It covers all the aspects involved in the vaccine research and development (identification of optimal target antigens, formulations, delivery strategies, adjuvants among others) as well as their use in combination with other immunomodulatory approaches. The book discusses topics such as identification of tumor associated and specific antigens, proteogenomic for identification of novel target tumor antigens, antigen-specific T cells, and Peptide and RNA based vaccines. Additionally, it covers oncolytic viruses for antigen delivery, cancer vaccine targeting viral antigens and combinatorial immunotherapy strategies. Written by leading experts worldwide, this is a valuable resource for cancer researchers, oncologists and members of biomedical field who wants to understand in depth the recent findings in the field of cancer vaccines.

The Vasculome: From Many, One introduces the fundamental bases of the "unity in diversity" of the Vasculome, from the coming together of various cell lineages during development, to its deceptively simple solution for architectural design: the efficient interplay of a few types of building blocks supporting key similar functions throughout the body and their highly specialized functional local variations. Specific examples are included to illustrate how the Vasculome is integral to the function and malfunction of different organs, such as the brain or the kidney. Each section is preceded by an introductory summary that will give a high level unified view of the key concepts illustrated in the various chapters in that section.

Deep Learning in Bioinformatics: Techniques and Applications in Practice introduces the topic in an easy-to-understand way, exploring how it can be utilized for addressing important problems in bioinformatics, including drug discovery, de novo molecular design, sequence analysis, protein structure prediction, gene expression regulation, protein classification, biomedical image processing and diagnosis, biomolecule interaction prediction, and in systems biology. The book also presents theoretical and practical successes of deep learning in bioinformatics, pointing out problems and suggesting future research directions. Dr. Izadkhah provides valuable insights and will help researchers use deep learning techniques in their biological and bioinformatics studies.

Viral Replication Enzymes and their Inhibitors, Part B, Volume 50 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics surrounding enzymes.

Advances in Agronomy, Volume 170, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field. Each chapter is written by an international board of authors.

Viral Replication Enzymes and their Inhibitors Part A, Volume 49, the latest release in the Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of related topics.

Biology of Cardiovascular and Metabolic Diseases combines physiology and pathophysiology of selected metabolic and cardiovascular diseases with health relevance. Written in a concise and easy to read manner, the book allows readers to gain an understanding on a number of topics, including cardiovascular physiology and pathophysiology and how it relates to the development of insulin resistance, diabetes and other metabolic diseases. The book also highlights the relevance of obesity in the development of cardiovascular and metabolic diseases and emphasizes the benefits of exercise as a preventative measure and way to treat underlying conditions.

Molecular Mechanisms of Nutritional Interventions and Supplements for the Management of Sexual Disfunction and Benign Prostatic Hyperplasia presents the epidemiologic data linking diet with BPH and ED, along with a deep explanation on why nutritional approaches and different macronutrients may modify the pathogenesis of the disease. Coverage includes the relevance/epidemiology of the disease, pathophysiological events causing the disease, available therapeutic options, molecular mechanisms of action of available treatments, epidemiological and intervention studies suggesting the benefit of diet as therapeutic option for BPH and ED, and potential mechanisms of action of nutritional based approaches as treatment for BPH and ED. By combining medicine, diet and lifestyle options, this title provides a truly multidisciplinary approach to BPH and ED, making it a unique resource for those treating BPH and an irreplaceable reference guide for those in research.

Advances in Agronomy, Volume 169, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field. Each chapter is written by an international board of authors.

Advances in Agronomy, Volume 168, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field. Each chapter is written by an international board of authors.

Advances in Botanical Research: Past, Current and Future Topics, Volume 100 in the Advances in Botanical Research series, celebrates a remarkable achievement as 100 volumes have now been published, with several others being prepared. New chapters in this monumental release include Editorial activities for Advances in Botanical Research, Revisiting ABR editing in the period 2006-2012: An exciting experience with Jean-Claude Kader, A tribute to the scientific contributions of Pierre Gadal and his laboratory, Evolution of Bacterial Phototrophy, Algae for Global Sustainability, Genomics of cyanobacteria: New insights and lessons for shaping our future, An overview of the root-knot-nematode compatible interaction, and more.

Wood Degradation and Ligninolytic Fungi, Volume 99 summarizes current knowledge on wood degradation by fungi. Chapters in this new release include Intracellular detoxification strategies of lignolytic fungi, Cell signaling during wood degradation, Evolution of ligninolytic systems in fungi, Diversity and distribution of lignolytic fungi, Fungal catalysts for lignin valorization: applied aspects, Expression of fungal lignocellulolytic genes in the environment, Wood degradation in grapevine disease, Imaging wood degradation, Lignin degradation by ascomycetes, and more. The increasing interest for wood decaying fungi over the past few years has sparked great potential for their use in biomass valorization, their important function in global carbon cycle, and for the damages they can cause on wood materials, hence this new release includes updates on these and related topics.

Inoculating Cities: Case Studies of Urban Pandemic Preparedness begins with a brief historical description of infectious disease outbreaks in cities as well as an overview of infectious disease outbreaks since 2000 that hold profound implications for cities and urban environments - such as severe acute respiratory syndrome (SARS) in 2003, H1N1 influenza in 2009, Ebola virus in 2014, Zika virus in 2015, and more recently, COVID-19 in 2020. Each of these outbreaks affected different geographies of the world and underscored the importance of urban pandemic preparedness or urban health security as a means of mitigating the threats posed by infectious diseases. This book describes several of the characteristics of cities that make them uniquely vulnerable to infectious disease threats which include, but are not limited to, their population density, population diversity, internal and external population movements, and inequalities in cities. Finally, the book discusses frameworks and capacities that are essential for preparing cities to prevent, detect, and respond to infectious disease outbreaks. With contributions from experts and researchers with first-hand experiences with infectious disease outbreaks, their impact on the management of disease, and pandemic preparedness in progressively urban societies, Inoculating Cities addresses the unique threats infectious diseases pose to urban environments and surveys innovative models that cities are using to combat these threats.

Blood gas tests are a group of tests that are widely used and essential for the evaluation and management of a patient's ventilation, oxygenation, and acid-base balance, often in emergent situations, and along with blood gases are other critical care analytes measured on blood: calcium, magnesium, phosphate, and lactate. Blood Gases and Critical Care Testing: Clinical Interpretations and Laboratory Applications, Third Edition, serves as your single most important reference for understanding blood gases and critical care testing and interpretation. The third edition of this classic book is a complete revision and provides the fundamentals of blood gas (pH, pCO2, pO2) and other critical care tests (calcium, magnesium, phosphate, and lactate), including the history, the definitions, the physiology, and practical information on sample handling, quality control and reference intervals. Case examples with clear clinical interpretations of critical care tests have been included to all chapters. This book will serve as a valuable and convenient resource for clinical laboratory scientists in understanding the physiology and clinical use of these critical care tests and for providing practical guidelines for successful routine testing and quality monitoring of these tests.

Translational Bioinformatics in Healthcare and Medicine offers an overview of main principles of bioinformatics, biological databases, clinical informatics, health informatics, viroinformatics and real-case applications of translational bioinformatics in healthcare. Written by experts from both technology and clinical sides, the content brings together essential knowledge to make the best of recent advancements of the field. The book discusses topics such as next generation sequence analysis, genomics in clinical care, IoT applications, blockchain technology, patient centered interoperability of EHR, health data mining, and translational bioinformatics methods for drug discovery and drug repurposing. In addition, it discusses the role of bioinformatics in cancer research and viroinformatics approaches to counter viral diseases through informatics. This is a valuable resource for bioinformaticians, clinicians, healthcare professionals, graduate students and several members of biomedical field who are interested in learning more about how bioinformatics can impact in their research and practice.

Advances in Agronomy, Volume 167, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field. Each chapter is written by an international board of authors.

Handbook of Gastrointestinal Motility and Disorders of Gut and Brain Interactions, Second Edition fills the void in GI literature for a short and concise go-to book for GI motility and gut and brain interactions disorders. This exceptionally illustrated reference contains all the information needed for a quick reference of GI motility and disorders of the gut and brain interactions, as well as adolescent and pediatric disorders and disorders which affect the entire GI system, each systematically arranged by disorder and gut anatomy for easy reference. Each chapter also includes extensive color pictures and illustrations of each test involved as well as descriptions of how to perform and interpret the motility tests that are incorporated into patient care decisions. The current advances in the field have led the way for new updates to existing content as well as a new section for the book dedicated to systemic disorders and special topics including neurology of the gut, cannabis and the gut, eating disorders, pediatric and adolescent disorders, nutritional therapies, and psychological evaluation and treatment. This is the perfect reference for those who encounter the common problems of dysphagia, heartburn, nausea, vomiting, abdominal pain, irritable bowel syndrome, constipation, and fecal incontinence in daily practice including practicing physicians, gastroenterologists, motility laboratory personnel, surgeons, and internists.

Stem Cells and Aging covers what is known about the effect of time and age on the basic units of life, which are the corresponding tissue-specific or adult stem cells. Even though the concept of stem cells was introduced nearly a century ago by Alexander Maximow, modern stem-cell research began in 1963 when James Till, Ernest McCullough and Lou Siminovitch established assays to detect hematopoietic stem cells. In fact, given the importance of the aging-associated diseases, scientists have developed a keen interest in understanding the aging process as they attempt to define the role of dysfunctional stem cells in the aging process. With an aging population worldwide, understanding these age-related stem cell changes at a basic biology level and at the level of their influences for regenerative medicine is of interest and importance. There is increasing evidence that the aging process can have much adverse effects on stem cells. In the modern era, one of the emerging fields in treating human diseases is stem cell research, as stem cells have the remarkable potential to treat a wide range of diseases. Nevertheless, understanding the molecular mechanism involved in aging and deterioration of stem cell function is crucial in developing effective new therapies for aging.

In the lung, more recent data have been accumulated on lung stem cell biology/function and the potential applications of stem cells in pulmonary diseases that are facilitated by the recent development of a broad range of cutting edge in vitro and in vivo research tools and approaches, including mouse and human organoid cultures, genetic editing in vitro and in vivo, human induced pluripotent cell (iPS cell) models of disease, haploid cells for genetic as well as compound screening paradigms, genetically engineered mice, and stem cell transplantation to cure diseases. Stem Cell Innovation in Health and Disease: Volume 2: The Lung, contains two major sections describing cutting edge research for understanding stem cell functions in the lung and respiratory system, and for developing methods to bring stem cells from bench to bedside; respectively. Each section includes insights ranging from using mouse and human organoid cultures, genetic editing in vitro and in vivo, and human induced pluripotent cells (iPSCs) to study stem cell functions and model lung diseases, through the cutting-edge research aiming to bring stem cells from bench to bedside, including the potential application of iPSCs, ESCs and blood stem cells (stem cell transplants) in the treatment of lung diseases/disorders. This book, therefore, discusses the fact-based promise of stem cells and regenerative medicine in the lung in the real world.

The intestine is among the leading organs, in which several cutting edge in vitro and in vivo research tools and approaches have recently been developed and used to investigate stem cell biology/function, and the potential applications of stem cells in the treatment of intestinal diseases. These cutting-edge research tools and approaches involve human and murine organoid cultures, genetic editing in vitro and in vivo, human induced pluripotent cell (iPS cell) models of disease, haploid cells for genetic as well as compound screening paradigms, genetically engineered mice, and stem cell transplantation to cure diseases. Stem Cell Innovation in Health and Disease: Volume 1: The Intestine contains two major sections describing cutting edge research for understanding stem cell functions in the intestine, and for developing methods to bring stem cells from bench to bedside; respectively. Each section includes insights ranging from using mouse and human organoid cultures, genetic editing in vitro and in vivo, and human induced pluripotent cells (iPSCs) to study stem cell functions and model intestinal diseases, through the cutting-edge research, including the potential application of iPSCs, ESCs and blood stem cells (stem cell transplants) in the treatment of intestinal diseases/disorders. This volume, therefore, discusses the fact-based promise of stem cells and regenerative medicine in the intestine in the real world.

Clinical Chemistry, Immunology and Laboratory Quality Control: A Comprehensive Review for Board Preparation, Certification and Clinical Practice, Second Edition presents core topics and 70 case studies that illustrate the application of clinical chemistry knowledge to everyday patient care. This succinct reference offers practical examples of how things function in the pathology clinic with useful lists, key points, case studies and a bullet point format ideal for quick pre-board review. While larger textbooks in clinical chemistry provide highly detailed information regarding instrumentation and statistics, this book is designed to educate senior medical students, residents and fellows on how tests are performed. This second edition successfully helps pathology residents gain command of clinical chemistry, toxicology, immunology, and laboratory statistics in an effort to help them prepare for the American Board of Pathology examination. Clinical chemistry is a topic in which many senior medical students and pathology residents face challenges.

Biotechnological Strategies for the Treatment of Gluten Intolerance provides a comprehensive overview of a wide range of biotechnological approaches that will further research and upon implementation improve the quality of life of this population. Gluten intolerance is a heterogeneous condition with varying levels of sensitivity that have typically been treated with a gluten free diet, but this book provides new and exciting biotechnological approaches that affect diet as well as non-dietary approaches. The reference describes the varying levels of sensitivity and explores symptoms beyond the intestines for a complete overview of the spectrum of sensitivity. The impact of diversity of wheat species, gluten quality and the nutritional values of gluten free products are extensively discussed. This reference is perfect for researchers and clinicians that want to further treatment options for those suffering from gluten sensitivity.

Pragmatic Randomized Clinical Trials Using Primary Data Collection and Electronic Health Records addresses the practical aspects and challenges of the design, implementation, and dissemination of pragmatic randomized trials, also sometimes referred to as practical or hybrid randomized trials. While less restrictive and more generalizable than traditional randomized controlled trials, such trials have specific challenges which are addressed in this book. The book contains chapters encompassing common designs along with advantages and limitations of such designs, analytic aspects in planning trials and estimating sample size, and how to use patient partners to help design and operationalize pragmatic randomized trials. Pragmatic trials conducted using primary data collection and trials embedded in electronic health records - including electronic medical records and administrative insurance claims - are addressed. This comprehensive resource is valuable not only for pharmacoepidemiologists, biostatisticians and clinical researchers, but also across the biomedical field for those who are interested in applying pragmatic randomized clinical trials in their research.