This volume is the second part of the thematic on Ion Channels as Therapeutic Targets. The popular Advances in Protein Chemistry and Structural Biology series, an essential resource for protein chemists, brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics.

Antimicrobial Food Packaging takes an interdisciplinary approach to provide a complete and robust understanding of packaging from some of the most well-known international experts. This practical reference provides basic information and practical applications for the potential uses of various films in food packaging, describes the different types of microbial targets (fungal, bacteria, etc.), and focuses on the applicability of techniques to industry. Tactics on the monitoring of microbial activity that use antimicrobial packaging detection of food borne pathogens, the use of biosensors, and testing antimicrobial susceptibility are also included, along with food safety and good manufacturing practices. The book aims to curtail the development of microbiological contamination of food through anti-microbial packaging to improve the safety in the food supply chain.

Single-Port Robotic Surgery in Urology: The New Beginning After the Advent of Dedicated Platforms describes the novel field of robotic single-port urologic surgery. Recent advances in surgical robotics combined with the pursuit to reduce the invasiveness of laparoscopic surgery have led to the development of novel robotic platforms specifically designed for single-port surgery. This reference summarizes the state-of-the-art of robotic single-port urologic surgery. Coverage takes a three-part approach, providing a description of the technological evolution which led to the advent of novel platforms specifically designed for single-port surgery, describing the urological procedures that can be performed, and outcomes and potential drawbacks.

Advances in Clinical Chemistry, Volume 74, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians, and research scientists. This serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry and is the benchmark for novel analytical approaches in the clinical laboratory.

Ensuring National Biosecurity: Institutional Biosafety Committees reviews the various responsibilities and associated challenges Institutional Biosafety Committees (IBCs) face and proposes changes that may help improve this system and increase national biosecurity and worker safety. In recent years IBCs in academic and other institutions have been tasked with increasing levels of responsibility, overseeing work with recombinant genetic material and hazardous agents. IBC members often lack the training to effectively ensure that the work performed is truly safe for scientists and the general community, and so increasingly rely upon the expertise of the researchers themselves. With the proposed US dual-use research policies soon to be implemented, this strain may increase. This book provides readers with the necessary information to be able to enhance national biosecurity within the US, EU, Australia, New Zealand, Japan and more. Ensuring National Biosecurity is as an invaluable reference for biosafety professionals or for researchers who need to understand the regulatory landscape that impacts their research.

New Insights on the Development of the Vascular System examines the most recent literature and data on the development of the vascular system, along with advice on new laboratory techniques and approaches to data analysis. This volume is a comprehensive handbook to the state-of-the-art in vascular system development. Several genetic and epigenetic mechanisms are involved in the early development of the vascular system, and there is extensive literature on the genetic background and molecular mechanisms responsible for blood vessel formation. Yet new data and techniques have been developed in recent years. Although scientific literature covers the descriptive aspects of embryonic vascular system development, modern techniques such as the technology of cell fusion, cell sorting and image analysis give new insight into the mechanisms by which vessels form and regress and how blood flow changes directions in the same vessels.

Molecular Aspects of Exercise Biology and Exercise Genomics, the latest volume in the Progress in Molecular Biology and Translational Science series includes a comprehensive summary of the evidence accumulated thus far on the molecular and cellular regulation of the various adaptations taking place in response to exercise. Changes in the cellular machinery are described for multiple tissues and organs in terms of signaling pathways, gene expression, and protein abundance. Adaptations to acute exercise as well as exposure to regular exercise are also discussed and considered.

Regulatory T Cells in Health and Disease focuses on the mechanism by which T cells become regulatory T cells, the processes which control the number of regulatory T cells in the blood and tissue, and the ways in which regulatory T cell prevent autoimmune disease and interact with infections and cancer.

Sugarcane: Agricultural Production, Bioenergy and Ethanol explores this vital source for "green" biofuel from the breeding and care of the plant all the way through to its effective and efficient transformation into bioenergy. The book explores sugarcane's 40 year history as a fuel for cars, along with its impressive leaps in production and productivity that have created a robust global market. In addition, new prospects for the future are discussed as promising applications in agroenergy, whether for biofuels or bioelectricity, or for bagasse pellets as an alternative to firewood for home heating purposes are explored. Experts from around the world address these topics in this timely book as global warming continues to represent a major concern for both crop and green energy production.

The Lymphatic System in Colorectal Cancer: Basic Concepts, Pathology, Imaging, and Treatment Perspectives provides an in-depth overview on the role of the lymphatic system in the pathogenesis and treatment of colorectal cancer. This is the first book to provide a comprehensive, multidisciplinary approach to the lymphatic system in colorectal cancer, with topics ranging from cancer biology and mathematical modeling to surgical approaches and novel imaging techniques. This book is valuable for cancer researchers, oncologists and anyone interested in the biology and treatment of colorectal cancer. Bringing together internationally renowned experts, the book's chapters encompass relevant content to help readers understand complex subjects. Lymphatic spread is one of the hallmarks of locally advanced colorectal cancer that adversely affects prognosis. Nevertheless, the molecular pathogenesis, dynamics and prognostic significance of lymphatic spread remain poorly understood. At the same time, novel surgical approaches such as complete mesocolic excision and sentinel node identification are being introduced, but their value remains uncertain.

Six Chemicals That Changed Agriculture is a scientific look at how the chemicals used in today's food production were developed, evaluated, and came to be in wide-spread use. From fertilizers to pest management, antibiotics to DNA, chemicals have transformed the way our food is grown, protected, and processed. Agriculture is the world's most important environment interaction, the essential human activity, and an increasingly controversial activity because of its use and presumed misuse of chemistry. The major characteristics of US agriculture for at least the last six decades have been rising productivity, declining number of mid-size farms, increasing farm size, an increasing percentage of farm production on fewer, large farms, increasing dependence of chemical technology and more developmental research being done by the agricultural chemical industry rather than by independent land-grant universities. Another equally important feature of modern agriculture is wide-spread suspicion of its technology by the public. The book will recount examples of this suspicion related to specific chemicals and present the essence of the suspicion and its results.

Current Topics in Membranes is targeted toward scientists and researchers in biochemistry and molecular and cellular biology, providing the necessary membrane research to assist them in discovering the current state of a particular field and in learning where that field is heading. This volume offers an up to date presentation of current knowledge in the field of Lipid Domains.

iPSCs - State of the Science, Volume Sixteen, the latest release in the Advances in Stem Cell Biology series, is an expansive collection of information and new discoveries in the field. This volume addresses the importance of induced pluripotent stems cells and how can they be derived from different sources. It addresses advances in research in induced pluripotent stem cells from alternate sources, such as spermatogonial stem cells, ovarian tissue, cancer cells, and many other sources. It is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation, and is contributed by world-renowned authors.

Data Mining for Bioinformatics Applications provides valuable information on the data mining methods have been widely used for solving real bioinformatics problems, including problem definition, data collection, data preprocessing, modeling, and validation. The text uses an example-based method to illustrate how to apply data mining techniques to solve real bioinformatics problems, containing 45 bioinformatics problems that have been investigated in recent research. For each example, the entire data mining process is described, ranging from data preprocessing to modeling and result validation.

The scope of this volume of Progress in Molecular Biology and Translational Science includes the molecular regulation of olfactory processes in vertebrates and insects including detailed discussion of olfactory proteins, signaling cascades and olfactory receptor modeling. In addition, because insect olfaction is an important and emerging field, it is also discussed in the context of key research questions such as disruption of host-finding by insect disease vectors, elucidation of the diverse range of compounds that are detected by insects, and the detection of pheromones by moths.

The Management of Scientific Integrity within Academic Medical Centers discusses the impact scientific misconduct has in eight complex case studies. Authors look at multifaceted mixtures of improper behavior, poor communication, cultural issues, adverse medical/health issues, interpersonal problems and misunderstandings to illustrate the challenge of identifying and managing what went wrong and how current policies have led to the establishment of quasi legal processes within academic institutions. The book reviews the current global regulations and concludes with a section authored by a US federal court judge who provides his perspective on the adequacy of current regulations and policies.

Digestive System Malignancies provides an up-to-date overview on the most relevant diagnostic techniques, staging of malignancies, and current therapeutic modalities for digestive system malignancies. With coverage from esophageal, gastric and pancreatic cancers, to colon, anal and peritoneal surface, this reference offers a wide-ranging guide to malignancies throughout the digestive system. The use of engaging infographics provides an "at-a-glace" perspective on the subject, allowing users to retain a large amount of information without scrolling through large text or complex algorithms. This is an important reference for clinicians, surgeons, medical students and scientists that need a quick reference on digestive system malignancies.

Virology is in a sense both one of the most important precursors and one of the most significant beneficiaries of structural and cellular molecular biology. Numerous breakthroughs in our understanding of the molecular interactions of viruses with host cells are ready for translation into medically important applications such as the prevention and treatment of viral infections. This book collects a wide variety of examples of frontline research into molecular aspects of viral infections from virological, immunological, cell- and molecular-biological, structural, and theoretical perspectives.

Antimicrobial Food Packaging, Second Edition continues to be an essential resource covering all aspects in the development and application of novel antimicrobial films to all types of packaged foods. The book is organized in six parts to include the main backgrounds and frameworks of the topic, types of packaging materials and packaging systems and the migration of packaging elements into food, the most relevant established and emerging technologies for microbial detection in food systems, the development and application of antimicrobial packaging strategies to specific food sectors, and the most promising combinational approaches, also including combinational edible antimicrobial coatings. Useful to a wide audience of researchers, scientists and students, the new edition brings six new chapters that include the latest information on smart packaging, algae biofilms for antimicrobial packaging applications, polylactic acid-tea polyphenol nanofibers, use in antimicrobial packaging, chitosan and proanthocyanidins, chitosan and e-polylysine bionanocomposite films, citrus essential oils, and also includes dairy products.

Xenobiotics in Chemical Carcinogenesis: Translational Aspects in Toxicology covers the translational toxicology of xenobiotics substances in carcinogenesis by explaining the toxicokinetic and toxicodynamic, toxicogenomic, biotransformation, and resistance mechanisms in the human body. The book begins with a historical review and link to future prospects for chemical carcinogenesis. It discusses major environmental xenobiotics and their risks in inducing cancer, along with content on toxic xenobiotics and their routes of exposure in humans, the role of xenobiotic metabolism in carcinogenesis, and the toxicokinetic and toxicodynamic of xenobiotics in cancer development. Lastly, the book explores current achievements such as using toxicogenomics for predicting the carcinogenicity of xenobiotic substances and the challenges posed by carcinogenic xenobiotic substances when examining preventive methods, diagnosis, and the development of anticancer drugs for specific toxicants.

New Frontiers and Applications of Synthetic Biology presents a collection of chapters from eminent synthetic biologists across the globe who have established experience and expertise working with synthetic biology. This book offers several important areas of synthetic biology which allow us to read and understand easily. It covers the introduction of synthetic biology and design of promoter, new DNA synthesis and sequencing technology, genome assembly, minimal cells, small synthetic RNA, directed evolution, protein engineering, computational tools, de novo synthesis, phage engineering, a sensor for microorganisms, next-generation diagnostic tools, CRISPR-Cas systems, and more. This book is a good source for not only researchers in designing synthetic biology, but also for researchers, students, synthetic biologists, metabolic engineers, genome engineers, clinicians, industrialists, stakeholders and policymakers interested in harnessing the potential of synthetic biology in many areas.

Neglected Tropical Diseases and other Infectious Diseases Affecting the Heart provides a comprehensive and systematic review on the literature surrounding Neglected Tropical Diseases and infectious diseases and how they affect the heart. Written by Emerging Leaders of the Interamerican Society of Cardiology (SIAC), the book includes the latest research findings, covering the cardiac involvement of a range of viral, bacterial and parasitic diseases, including COVID19, HIV, Zika, Lyme Disease, and more. Chapters cover epidemiology, the physiopathology of cardiovascular involvement, symptoms, diagnosis, and treatment options for each disease, making the book suitable to researchers, scientists, clinicians and physicians in the field.