Medicinal Chemistry: A Look at How Drugs Are Discovered is written for those who are interested in learning how drugs are discovered. Compared to other books on the market, this text takes a different approach by presenting the subject on chemical reaction mechanism terms, which ideally makes the subject matter more interesting and easier to comprehend. The authors describe the drug discovery process, from advancing an initial lead to the approval process, and include drug discovery sources. Additional features: Explains medicinal chemistry on chemical mechanism terms, allowing for a more interesting and easier to comprehend text Includes valuable insights toward the various pathways taken at pharmaceutical industries in drug discoveries Improved by including questions raised and suggestions made from students in the authors' medicinal chemistry classes This book will benefit both upper level undergraduates and graduates studying in the fields of medicinal chemistry and drug discovery, as well as scientists working in the pharmaceutical industry.

Provides background for design and development of metamaterial structures using novel unit cells. Gives in-depth performance study of miniaturization of microstrip antennas. Discusses design and development of both transmission and reflection types metasurfaces and their practical applications. Verifies a variety of Metamaterial structures and Metasurfaces experimentally

Presents a clear path to developing quantitative multi-phase and multi-component phase field models for solidification and other phase transformation kinetics based on practical grand potential functional Derives explicitly and discusses the quantitative nature of the model formulations through matched interface asymptotic analysis Explores a framework for quantitative treatment of rapid solidification to control solute trapping and solute drag dynamics

• Familiarizes the reader with the basic terminology applied to toxicology • Explains how the exposure to a chemical is critically important when estimating the human health risk • Provides a balanced approach, neither spotlighting sensational findings nor downplaying potential real risks

Revised, updated and expanded to continue to provide the most accurate, compact and practical source on fluoropolymers. Explores breakthroughs in understanding property-structure relationships, new polymerization techniques and the chemistry underlying polymers. Fluoropolymers are high up on the specialty polymers group and due to their unique properties, are naturally part of the solution to industrial sustainability challenges. Describes the technology of fluoropolymers, including thermoplastic and elastomeric products. Expands upon critical environmental aspects of fluoropolymers and recycling of these special polymers

Offers transferrable problem-solving ideas and skills applicable for other disciplines and future careers. Provides new students with support and inspiration for their college experience. Includes guidance for successful interactions with professors, peers, professionals, and others. Encourages thoughtful determination of desired outcomes from the college experience and shaping ones actions toward accomplishing those objectives.

High-k Materials in Multi-Gate FET Devices focuses on high-k materials for advanced FET devices. It discusses emerging challenges in the engineering and applications and considers issues with associated technologies. It covers the various way of utilizing high-k dielectrics in multi-gate FETs for enhancing their performance at the device as well as circuit level. Provides basic knowledge about FET devices Presents the motivation behind multi-gate FETs, including current and future trends in transistor technologies Discusses fabrication and characterization of high-k materials Contains a comprehensive analysis of the impact of high-k dielectrics utilized in the gate-oxide and the gate-sidewall spacers on the GIDL of emerging multi-gate FET architectures Offers detailed application of high-k materials for advanced FET devices Considers future research directions This book is of value to researchers in materials science, electronics engineering, semiconductor device modeling, IT, and related disciplines studying nanodevices such as FinFET and Tunnel FET and device-circuit codesign issues.

As one of the most extensive and important protein post-translational modifications, glycosylation plays a vital role in regulating organisms and is associated with various physiological and pathological processes. Recently, researchers have focused on the need to characterize protein glycosylation sites, structures, and their degree of modification, to better understand their biological functions while also looking for potential biomarkers for diagnosis and treatment of disease. Mass spectrometry (MS) is one of the most powerful tools used to study biomolecules including glycoproteins and glycans. With the continuous development of glycoproteomics and glycomics based on MS analysis, more techniques have evolved and contribute to understanding the structure and function of glycoproteins and glycans. This book reviews advancements achieved in MS-based glycoproteomic analysis, including a wide range of analytical methodologies and strategies involved in selective enrichment; as well as qualitative, quantitative, and data analysis, together with their clinical applications. Significant examples are discussed to illustrate the principles, laboratory protocols, and advice for key implementation to ensure successful results. Mass Spectrometry-Based Glycoproteomics and Its Clinic Application will serve as a valuable resource to elucidate new techniques and their applications for students, postdocs, and researchers working in proteomics, glycoscience, analytical chemistry, biochemistry, and clinical medicine. Editor: Haojie Lu is a professor at Fudan University, specializing in proteomics based on mass spectrometry with particular emphasis on novel technologies for separation and identification of low-abundant proteins and post-translationally modified proteins (including glycosylation), as well as relative and absolute quantification methods for proteomics.

Biotribology includes tribological phenomena of natural and implant surface interactions under relative motion in the human body. Biotribology: Emerging Technologies and Applications disseminates ideas and research trends in biotribology and presents pioneering recent research advances impacting the field, focusing on the roles of mathematics, chemistry, physics, materials, and mechanical engineering. Discusses lubrication of joint replacements, computational modeling of biotribology and multibody biomechanical models Describes metal-organic frameworks, medical friction pairs, and electrochemical techniques to tribocorrosion tests Covers state of the art and future technological developments and applications, as well as challenges and opportunities Biotribology is an important and growing field, and the topics covered in this book will be of great interest to the international tribology community, appealing to readers working in the fields of materials science, biomedical engineering, biotechnology, mechanical engineering, and related areas.

* Covers material testing and development using computational intelligence * Highlights the technologies to integrate computational intelligence and materials sciences * Discusses how computational tools can generate new materials with advanced applications * Details case studies and detailed applications * Investigates challenges in developing and using computational intelligence in materials science * Analyzes historic changes that are taking place in designing of materials

This is the first all-encompassing textbook designed to support trainee clinical scientists in medical physics as they start work in a hospital setting whilst undertaking an academic master's course. Developed by practising physicists and experienced academics using their experience of teaching trainee medical physicists, this book provides an accessible introduction to the daily tasks that clinical scientists perform in the course of their work. It bridges the gap between theory and practice, making the book also suitable for advanced undergraduate and graduate students in other disciplines studying modules on medical physics, including those who are considering a career in medical physics through applying to the NHS Scientist Training Programme (STP). Features: Provides an accessible introduction to practical medical physics within a hospital environment Maps to the course content of the Scientist Training Programme in the NHS Acts as a complement to the academic books often recommended for medical physics courses

Blood microcirculation is essential to our bodies for the successful supply of nutrients, waste removal, oxygen delivery, homeostasis, controlling temperature, wound healing, and active immune surveillance. This book provides a physical introduction to the subject and explores how researchers can successfully describe, understand, and predict behaviours of blood flow and blood cells that are directly linked to these important physiological functions. Using practical examples, this book explains how the key concepts of physics are related to blood microcirculation and underlie the dynamic behavior of red blood cells, leukocytes, and platelets. This interdisciplinary book will be a valuable reference for researchers and graduate students in biomechanics, fluid mechanics, biomedical engineering, biological physics, and medicine. Features: The first book to provide a physical perspective of blood microcirculation Draws attention to the potential of this physical approach for novel applications in medicine Edited by specialists in this field, with chapter contributions from subject area specialists

Design of new processes that avoid the use of toxic reagents has been the focus of intense research of late. Catalysis by metals and non-metals offers diverse opportunities for the development of new organic reactions with promising range of selectivities-chemoselectivity, regioselectivity, diastereoselectivity, and enantioselectivity. Furthermore, these transformations frequently occur under mild conditions, tolerate a broad array of functional groups, and proceed with high stereoselectivity. The area of catalysis is sometimes referred to as a 'foundational pillar' of green chemistry. Catalytic reactions often reduce energy requirements and decrease separations because of increased selectivity; they are also capable of permitting the use of renewable feedstocks of less toxic reagents or minimizing the quantities of reagents needed. New catalytic organic synthesis methodologies have, thus, offered several possibilities for considerable improvement in the eco-compatibility of fine chemical production. Hence, these catalytic methodologies have emerged as powerful tools for the efficient and chemoselective synthesis of heterocyclic molecules. Key Features: Presents the synthesis of different five-membered heterocycles. Contains the most up-to-date information in this fast-moving field. Covers novel catalytic approaches used in the study and application of catalysts in synthetic organic reactions. Presents new methodologies for the synthesis of heterocycles.

Tissue Engineering Strategies for Organ Regeneration addresses the existing and future trends of tissue engineering approaches for organ/tissue regeneration or repair. This book provides a comprehensive summary of the recent improvement of biomaterials used in scaffold-based tissue engineering, and the tools and different protocols needed to design tissues and organs. The chapters in this book provide the in-depth principles for many of the supporting and enabling technologies including the applications of BioMEMS devices in tissue engineering, and the combination of organoid formation and three dimensional (3D) bioprinting. The book also highlights the advances and strategies for regeneration of three-dimensional microtissues in microcapsules, tissue reconstruction techniques, and injectable composite scaffolds for bone tissue repair and augmentation. Key Features: Addresses the current obstacles to tissue engineering applications Provides the latest improvements in the field of integrated biomaterials and fabrication techniques for scaffold-based tissue engineering Shows the influence of microenvironment towards cell-biomaterials interactions Highlights significant and recent improvements of tissue engineering applications for the artificial organ and tissue generation Describes the applications of microelectronic devices in tissue engineering Describes different current bioprinting technologies

This intriguing and accessible book examines the experiments on neutrino oscillations. It argues that this history gives us good reason to believe in the existence of neutrinos, a particle that interacts so weakly with matter that its interaction length is measured in light years of lead. Yet, the scientific process has provided evidence of the elusive neutrino. Written in a style accessible to any reader with a college education in physics, Are There Really Neutrinos? is of interest to students and researchers alike. This second edition contains a new epilogue highlighting the new developments in neutrino physics over the past 20 years.

Published in 1974: The CRC Handbook of Materials Science provides a current and readily accessible guide to the physical properties of solid state and structural materials.

This book covers the entire span of quantum mechanics whose developments have taken place during the early part of the twentieth century up till the present day. We start with the Rutherford-Bohr model of the atom followed by Schrodinger's wave mechanics with its application to the solution of calculating the energy spectrum of a particle in a box, the harmonic oscillator and finally the hydrogen atom. Heisenberg's matrix mechanics and its duality with Schrodinger's wave mechanics, quantum mechanics in the interaction picture. Dirac's relativistic theory of the electron exhibiting the spin of the electron as a relativistic effect when it interacts with an external electromagnetic field. Feynman's path integral approach to non-relativistic quantum mechanics with is a marvellous intuitive interpretation as a sum over paths and how classical mechanics is obtained from its limit as Planck' constant tends to zero, methods for computing the spectra of the Dirac Hamiltonian in a radial potential, quantum field theory as developed by Feynman, Schwinger, Tomonaga and Dyson for describing the interaction between electrons, positrons, and photons via propagators using both the operator theoretic expansions and Feynman's path integral. We also introduce time independent and time dependent perturbation theory in quantum mechanics with applications to quantum gate design for quantum computers forming a major part of the research conducted by the author's research group, Quantum noise introduced into the Schrodinger and Dirac's equation based on the Hudson-Parthasarathy quantum stochastic calculus in Boson Fock space, scattering theory and wave operators with applications to quantum gate design, some aspects of second quantization like the interpretation of Boson Fock space in terms of harmonic oscillator algebras and the BCS theory of superconductivity, Wigner-Mackey-Frobenius theory of induced representations of a group with applications to Wigner's theory of particle classification, Dirac's equation in a gravitational field and Yang-Mills non-Abelian gauge theories with application to the construction of unified quantum field theories and finally, the more recent theory of super-symmetry which is a Boson-Fermion unification theory. We have discussed the statistics of Boson's, Fermions and Maxwell-Boltzmann based on entropy maximization. The book is written in problem-solution format and it would be of use to physicists and engineers interested respectively in developing unified field theories and in the design of quantum gates. Note: T&F does not sell or distribute the Hardback in India, Pakistan, Nepal, Bhutan, Bangladesh and Sri Lanka.

Provides practical solutions for the treatment and recycling of distillery waste illustrated by specific case studies. Focuses on recent industry practices and preferences, along with newer approaches for wastewater treatment. An instructive compilation of treatment approaches, including advanced physicochemical and integrated/sequential methods. Covers biocomposting of sludge and effluent and biodiesel production from distillery waste for recycling and sustainable development. Emphasizing the relationship of metagenomics with organometallic compounds of distillery waste. Discusses the role of ligninolytic enzymes and bioreactors in distillery wastewater treatment.

A contribution to the series on Natural Products Chemistry of Global Plants, Natural Products Chemistry of Botanical Medicines from Cameroon focuses on the sources and chemistry of natural products from plants in Cameroon, West Africa. The plants selected offer an opportunity to trace a route through history from ancient civilizations to the modern day, showing the important value to man of natural products in medicines and in foods. This book highlights how many of the extracts from Cameroon are today associated with important drugs, nutrition products, beverages, perfumes, cosmetics and pigments, as well as presenting their complex chemistry and structure. Key Features: Forms an important part of the series on Natural Products Chemistry of Global Plants, as Cameroon is a country with rich experience in the use of medicinal plants and with a wide diversity of botanical resources Addresses the current development of pharmacognosy research in Cameroon Provides readers with updated information on the chemistry and pharmacology of natural products with pharmaceutical potential Covers an extensive range of chemical, botanical and pharmacological diversities Xavier Siwe Noundou is a Scholar/Scientist based at Rhodes University in Grahamstown, South Africa. He has been a EU FP7 Marie Curie Fellow (2015-2016), Kaposvar University in Hungary (2015, 2016), Trakia Univesity in Bulgaria (2016), TWAS Fellow (2013), National Research Foundation South Africa Fellow (2014-2016). Dr Noundou works on Medicinal Chemistry focusing on Chemistry, Pharmacognosy and Nanotechnology. His main research interests include terrestrial natural products chemistry (from Cameroon and South Africa) and marine natural products chemistry (from the South African coastline): bioactive metabolites isolated as potential antiparasitic, antimicrobial, antiviral and antiproliferative candidates. He is author of more than forty scientific publications in his field of expertise.

This new volume presents various research studies that focus on the development of advanced nanomaterials and their composites and blends for different applications in sensing, electrical, biomedical, coating, industrial applications, etc. This book includes detailed discussions on the synthesis, properties, processing, and potential applications of nanomaterials and their blends and composites. Some chapters also explain the basic theoretical aspects of these nanostructured materials and systems, which help readers to develop a better understanding various application areas, including construction. Nanostructured Smart Materials: Synthesis, Characterization and Potential Applications responds to the need for advanced polymeric materials and nanostructured materials with ultimate performance and enhanced qualities and properties for varied applications. The chapters highlight information and research that will be valuable for development of new smart materials. This book will be a useful reference source for universities, colleges, researchers from R&D groups, scientists, postdoctoral fellows, industrialists, graduate and postgraduate students, and faculty.

Features Clearly illustrate the mathematical theories of nonlinear systems and its progress to both the non-expert and active researchers in this area Suitable for graduate students in Mathematics, Applied Mathematics and some of the Engineering sciences Written in a careful pedagogical manner by those experts who have been involved in the research themselves, and each contribution is reasonably self-contained

This book is an up-to-date review of the most important plasma-based techniques for material modification, from microelectronics to biological materials and from fusion plasmas to atmospheric ones. Each its technical chapters is written by long-experienced, internationally recognised researchers. The book provides a deep and comprehensive insight into plasma technology and its associated elemental processes and is illustrated throughout with excellent figures and references to complement each section. Although some of the topics covered can be traced back several decades, care has been taken to emphasize the most recent findings and expected evolution. The first time the word 'plasma' appeared in print in a scientific text related to the study of electrical discharges in gases was 1928, when Irving Langmuir published his article 'Oscillations in Ionized Gases'. It was the baptism of the predominant state of matter in the known universe (it is estimated that up to 99% of matter is plasma), although not on earth, where the conditions of pressure and temperature make normal the states of matter (solid, liquid, gas) which, in global terms, are exotic. It is enough to add energy to a solid (in the form of heat or electromagnetic radiation) to go into the liquid state, from which gas is obtained through an additional supply of energy. If we continue adding energy to the gas, we will partially or totally ionise it and reach a new state of matter, plasma, made up of free electrons, atoms and molecules (electrically neutral particles) and ions (endowed with a positive or a negative electric charge).

Explains the influence of InAs material in the performance of HEMTs and MOS-HEMTs Covers novel indium arsenide architectures for achieving terahertz frequencies Discusses impact of device parameters on frequency response Illustrates noise characterization of optimized indium arsenide HEMTs Introduces terahertz electronics including sources for terahertz applications

Contains the latest developments and technologies from astronomical observatories and telescope facilities on the ground and in space Accompanied by a companion website with examples, tutorials, Python scripts and resources Authored by an observational astronomer with over thirty years of observing and teaching experience

The first book on Ultrafine bubbles (UFBs). Reviews research done on UFBs. Helpful for readers and researchers interested in the fundamentals of this emerging field