The Feynman Lectures on Gravitation are based on notes prepared during a course on gravitational physics that Richard Feynman taught at Caltech during the 1962-63 academic year. For several years prior to these lectures, Feynman thought long and hard about the fundamental problems in gravitational physics, yet he published very little. These lectures represent a useful record of his viewpoints and some of his insights into gravity and its application to cosmology, superstars, wormholes, and gravitational waves at that particular time. The lectures also contain a number of fascinating digressions and asides on the foundations of physics and other issues.Characteristically, Feynman took an untraditional non-geometric approach to gravitation and general relativity based on the underlying quantum aspects of gravity. Hence, these lectures contain a unique pedagogical account of the development of Einstein's general theory of relativity as the inevitable result of the demand for a self-consistent theory of a massless spin-2 field (the graviton) coupled to the energy-momentum tensor of matter. This approach also demonstrates the intimate and fundamental connection between gauge invariance and the principle of equivalence.

This volume details experimental protocols to study structure and function of hepatocytes in vivo and in vitro, and for characterizing heterogeneity and plasticity of hepatocytes in healthy and in injured liver. Chapters guide readers through separating hepatocyte subfractions, characterizing the heterogeneity, novel culture systems, hepatocyte-like cells from human pluripotent stem cells, analyzing drug metabolism, monitoring protein sorting, manipulating gene expression, and methods for expanding primary hepatoblastoma and identifying hepatocellular carcinoma subtypes. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Hepatocytes: Methods and Protocols aims to provide techniques to further understand molecular mechanisms involved in the regulating hepatocyte functions and underlying liver diseases.

Readers can install Quantum ESPRESSO on Windows 10, macOS, and Linux operating systems. Readers can download all input files of the book and learn each subject without making input files by themselves. Readers can learn the Wannier90 package for obtaining tight-binding parameters for theoretical modeling. Minimum information of density-functional theory and solid-state physics is included. All software except for the operating system is open software that readers can download without any cost.

Although many books have been written about Mathematica, very few of them cover the new functionality added to the most recent versions of the program. This thoroughly revised second edition of Mathematica Beyond Mathematics: The Wolfram Language in the Real World introduces the new features using real-world examples based on the experience of the author as a consultant and Wolfram certified instructor. The examples strike a balance between relevance and difficulty in terms of Mathematica syntax, allowing readers to incrementally build up their Mathematica skills as they go through the chapters While reading this book, you will also learn more about the Wolfram Language and how to use it to solve a wide variety of problems. The author raises questions from a wide range of topics and answers them by taking full advantage of Mathematica's latest features. For example: What sources of energy does the world really use? Are our cities getting warmer? Is the novel El Quixote written in Pi? Is it possible to reliably date the Earth using radioactive isotopes? How can we find planets outside our solar system? How can we model epidemics, earthquakes and other natural phenomena? What is the best way to compare organisms genetically? This new edition introduces the new capabilities added to the latest version of Mathematica (version 13), and discusses new topics related to machine learning, big data, finance economics, and physics. New to the Second Edition Separate sections containing carefully selected additional resources that can be accessed from either Mathematica or online Online Supplementary materials including code snippets used in the book and additional examples. Updated commands to take full advantage of Mathematica 13.

Biomass and Carbon Fuels in Metallurgy presents contemporary and new insights into the use of carbonaceous (Biomass) fuels in the metallurgical sector. The authors describe application of these fuels in different technological processes to produce pig iron, steel and ferroalloys. Emphasis is placed on biomass and its metallurgical utilization. Coverage includes the specification of fuels, their classification and the characteristics of their basic properties. The use of carbonaceous fuels in the production of various kinds of agglomerates (ferriferous, manganese and metalized) is also covered. Key Features: Provides a comprehensive view of carbonaceous fuels in various metallurgy processes Details experiments conducted on the use of traditional and alternative (biomass) carbonaceous fuels for the production of agglomerates. Demonstrates that the energy potential of biomass can also be successfully used in pyrometallurgical processes Describes applications of biomass-based fuels in different technological processes for the production of pig iron, steel and ferroalloys. Coverage includes the specification of fuels, their classification and the characteristics of their basic properties.

Biomedical Literature Mining, discusses the multiple facets of modern biomedical literature mining and its many applications in genomics and systems biology. The volume is divided into three sections focusing on information retrieval, integrated text-mining approaches, and domain-specific mining methods. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Biomedical Literature Mining is designed as a useful bioinformatics resource in biomedical literature text mining for both those long experienced in, or entirely new to, the field.

When Kai Zuber's pioneering text on neutrinos was published in 2003, the author correctly predicted that the field would see tremendous growth in the immediate future. In that book, Professor Zuber provided a comprehensive self-contained examination of neutrinos, covering their research history and theory, as well as their application to particle physics, astrophysics, nuclear physics, and the broad reach of cosmology; but now to be truly comprehensive and accurate, the field's seminal reference needs to be revised and expanded to include the latest research, conclusions, and implications. Revised as needed to be equal to the research of today, Neutrino Physics, Third Edition delves into neutrino cross-sections, mass measurements, double beta decay, solar neutrinos, neutrinos from supernovae, and high-energy neutrinos, as well as entirely new experimental results in the context of theoretical models. Written to be accessible to graduate students and readers from diverse backgrounds, this edition, like the first, provides both an introduction to the field as well as the information needed by those looking to make their own contributions to it. And like the second edition, it whets the researcher's appetite, going beyond certainty to pose those questions that still need answers. Features Presents the only single-author comprehensive text on neutrino physics Includes experimental and theoretical particle physics and examines solar neutrinos and astroparticle implications Offers details on new developments and recent experiments

This detailed volume presents an updated collection of state-of-the-art protocols in cardiac tissue engineering. These protocols demonstrate advancements in cell sourcing, assembly, and use of engineered cardiac tissues, imaging and diagnostics, as well as therapeutic applications. New animal models, biomaterials, and quantitative analyses are described for broad adoption. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cardiac Tissue Engineering: Methods and Protocols, Second Edition serves as an ideal resource for inspiring the advancement of cardiotoxicity assessment, drug discovery, and heart repair and regeneration in order to accelerate heart health improvement around the globe.

Provides a practical, experimentally-driven introduction to the materials science of surfaces and thin films Connects the essential concepts with the variables controlled in a laboratory setting, to aid in understanding experimental design and results Takes a visual approach with many illustrations of experimental deposition and characterization techniques to highlight what happens at the atomic level on surfaces and thin films Includes worked examples and problems at the end of each chapter Gives conceptually clear, mathematically simple explanations

The papers in this volume comprise the refereed proceedings of the Second IFIP International Conference on Computer and Computing Technologies in Agriculture (CCTA2008), in Beijing, China, 2008. The conference on the Second IFIP International Conference on Computer and Computing Technologies in Agriculture (CCTA 2008) is cooperatively sponsored and organized by the China Agricultural University (CAU), the National Engineering Research Center for Information Technology in Agriculture (NERCITA), the Chinese Society of Agricultural Engineering (CSAE) , International Federation for Information Processing (IFIP), Beijing Society for Information Technology in Agriculture, China and Beijing Research Center for Agro-products Test and Farmland Inspection, China. The related departments of China's central government bodies like: Ministry of Science and Technology, Ministry of Industry and Information Technology, Ministry of Education and the Beijing Municipal Natural Science Foundation, Beijing Academy of Agricultural and Forestry Sciences, etc. have greatly contributed and supported to this event. The conference is as good platform to bring together scientists and researchers, agronomists and information engineers, extension servers and entrepreneurs from a range of disciplines concerned with impact of Information technology for sustainable agriculture and rural development. The representatives of all the supporting organizations, a group of invited speakers, experts and researchers from more than 15 countries, such as: the Netherlands, Spain, Portugal, Mexico, Germany, Greece, Australia, Estonia, Japan, Korea, India, Iran, Nigeria, Brazil, China, etc.

This book provides a comprehensive and critical overview of carbon materials in terms of molecular structure, intermolecular relationships, bulk and surface properties, and their behavior in current and emerging applications. It also presents advances in carbon research and development.

Students and researchers in the health sciences are faced with greater opportunity and challenge than ever before. The opportunity stems from the explosion in publicly available data that simultaneously informs and inspires new avenues of investigation. The challenge is that the analytic tools required go far beyond the standard methods and models of basic statistics. This textbook aims to equip health care researchers with the most important elements of a modern health analytics toolkit, drawing from the fields of statistics, health econometrics, and data science. This textbook is designed to overcome students' anxiety about data and statistics and to help them to become confident users of appropriate analytic methods for health care research studies. Methods are presented organically, with new material building naturally on what has come before. Each technique is motivated by a topical research question, explained in non-technical terms, and accompanied by engaging explanations and examples. In this way, the authors cultivate a deep ("organic") understanding of a range of analytic techniques, their assumptions and data requirements, and their advantages and limitations. They illustrate all lessons via analyses of real data from a variety of publicly available databases, addressing relevant research questions and comparing findings to those of published studies. Ultimately, this textbook is designed to cultivate health services researchers that are thoughtful and well informed about health data science, rather than data analysts. This textbook differs from the competition in its unique blend of methods and its determination to ensure that readers gain an understanding of how, when, and why to apply them. It provides the public health researcher with a way to think analytically about scientific questions, and it offers well-founded guidance for pairing data with methods for valid analysis. Readers should feel emboldened to tackle analysis of real public datasets using traditional statistical models, health econometrics methods, and even predictive algorithms. Accompanying code and data sets are provided in an author site: https://roman-gulati.github.io/statistics-for-health-data-science/

Features Combines all topics into one comprehensive introduction. Explores practical applications of theory to healthcare. Can be used to accompany the NHS Modernising Scientific Careers syllabus.

Ecdysone is the steroidal prohormone of the major insect moulting hormone 20-hydroxyecdysone. It groups with its homologues the steroidal molting hormones in arthropods, but they also occur in other phyla where they can play different roles. Besides ecdysteroids appear in many plants mostly as protection agents (toxins or antifeedants) against herbivorous insects.

The important developments and achievements in modern ecdysone science since the first edition in 1989 by J. Koolman have led to this new revised, expanded and retitled reference work. New chapters in this edition include RNA interference, the ecdysone receptor crystal structures and structure activity relationships, etc. Each article may also be read independently, as a review of that particular subject.

Complete up-to-date coverage of many important topics - the book is divisible into five conceptual areas: (1) Distribution and diversity of ecdysteroids in the two kingdoms is still basis, (2) In the post-genomic era, ecdysteroid genetic hierarchies in insect growth and reproduction, (3) Role of cross talk of genes and growth factors in ecdysteroid titers and signaling, (4) Ecdysteroids function through nuclear and membrane receptors, and (5) Ecdysteroids in modern agriculture, medicine, doping and ecotoxicology. Each of the 23 chapters is written by scientists active in the reviewed research area and a truly distinguished international team of contributors has been chosen.

Ecdysone, Structures and Functions will be of immense use and contains essential information for scientists, students, and professionals alike in entomology, endocrinology, physiology, chemistry, and agricultural, plant, biomedicine and environmental sciences.

This book shares the experimental findings and views in current multidisciplinary medical science combining both basic and applied research aimed at resolving problematic health issues. The key topics address contagious diseases, in particular the epidemiology, clinical presentation, and management of influenza and influenza-like infections as well as brain tuberculosis. Pulmonary medicine is represented by articles addressing a range of practical issues, including the diagnosis, symptoms, comorbidities, and treatment of obstructive sleep apnea, a syndrome whose incidence shows a persistent upward trend worldwide. Other articles address the pathogenesis of air pollution toxicity and allergy and sensory irritation in toxic exposure studies. An intriguing relation of atopic dermatitis to depression and serotoninergic system is debated. The book attempts to integrate research into clinical work and to implement findings to improve care and to decrease suffering from diseases. It is dedicated to the practicing professionals, researchers, and all engaged in health care.

This book explores the original discovery of lithium and its development from a mineral to various applications that culminate in its present use in the electromotive industry

This book introduces advanced mathematical methods and techniques for analysis and simulation of models in mathematical epidemiology. Chronological age and class-age play an important role in the description of infectious diseases and this text provides the tools for the analysis of this type of partial differential equation models. This book presents general theoretical tools as well as large number of specific examples to guide the reader to develop their own tools that they may then apply to study structured models in mathematical epidemiology. The book will be a valuable addition to the arsenal of all researchers interested in developing theory or studying specific models with age structure.

This book discusses prospective alternative approaches to fight bacterial infections to minimize the indiscriminate use of conventional antibiotics. It offers the current knowledge on research and development of alternative antibacterial agents such as probiotics, nanobiotics etc. while it also discusses newly emerging trends such as phage therapy, antibody therapy etc. The book highlights on the phytochemicals with potent antibacterial activities as alternatives to conventional antibiotics. Chemical modification to develop next generation antibiotics with enhanced efficacy has also been included. Such modifications are reported to overcome the inherent resistance of the parent antibiotics. Phage therapy and targeted antibodies are considered as potential alternative approaches to treat bacterial ailments and represent areas of cutting-edge research and have therefore been discussed with sufficient care. Mainly, the book highlights various approaches other than conventional antibiotics in treating bacterial infections. The scientific advancements in these areas will strengthen the 'One Health' approach benefiting human beings, animals and environment as well. This book is a comprehensive resource to cater researchers, biological scientists, herbalists and clinical practitioners with up-to-date information on antibacterials other than antibiotics.

Current demand in biomedical sciences emphasizes the understanding of basic mechanisms and problem solving rather than rigid empiricism and factual recall. Knowledge of the basic laws of mass and momentum transport as well as model development and validation, biomedical signal processing, biomechanics, and capstone design have indispensable roles in the engineering analysis of physiological processes. To this end, an introductory, multidisciplinary text is a must to provide the necessary foundation for beginning biomedical students. Assuming no more than a passing acquaintance with molecular biology, physiology, biochemistry, and signal processing, Biomedical Engineering Principles, Second Edition provides just such a solid, accessible grounding to this rapidly advancing field. Acknowledging the vast range of backgrounds and prior education from which the biomedical field draws, the organization of this book lends itself to a tailored course specific to the experience and interests of the student. Divided into four sections, the book begins with systems physiology, transport processes, cell physiology, and the cardiovascular system. Part I covers systems analysis, biological data, and modeling and simulation in experimental design, applying concepts of diffusion, and facilitated and active transport. Part II presents biomedical signal processing, reviewing frequency, periodic functions, and Fourier series as well as signal acquisition and processing techniques. Part III presents the practical applications of biomechanics, focusing on the mechanical and structural properties of bone, musculoskeletal, and connective tissue with respect to joint range, load bearing capacity, and electrical stimulation. The final part highlights capstone design, discussing design perspectives for living and nonliving systems, the role of the FDA, and the project timeline from inception to proof of concept. Cutting across many disciplines, Biomedical Engineering Principles, Second Edition offers illustrative examples as well as problems and discussion questions designed specifically for this book to provide a readily accessible, widely applicable introductory text.

This book explains physical principles, unique benefits, broad categories, implementation aspects, and performance criteria of distributed optical fiber sensors (DOFS). For each kind of sensor, the book highlights industrial applications, which range from oil and gas production to power line monitoring, plant and process engineering, environmental monitoring, industrial fire and leakage detection, and so on. The text also includes a discussion of such key areas as backscattering, launched power limitations, and receiver sensitivity, as well as a concise historical account of the field's development.

Includes over 250 solved problems to supplement graduate-level courses in fluid mechanics and turbomachinery. Enables students to practice applying key concepts of fluid mechanics and the governing conservation laws to solve real-world problems. Uses the physics-first approach, allowing for a good understanding of the problem physics and the results obtained. Covers problems on flowpath aerodynamics design. Covers problems on secondary air systems modeling of gas turbines.

The difficulty in achieving effective translation of basic mechanistic biomedical knowledge into effective therapeutics, is the greatest challenge in biomedical research. Nowhere is this more apparent than in the reductionist approaches to understanding and manipulating the acute inflammatory response in the settings of sepsis, trauma/hemorrhage, wound healing, and related processes. This book discusses complex systems and computational biology methods and approaches that have advanced sufficiently to allow for knowledge generation, knowledge integration, and clinical translation in the settings of complex diseases related to the inflammatory response. Well-regulated, self-resolving inflammation is necessary for the appropriate communication and resolution of infection and trauma, and for maintenance of proper physiology and homeostasis. In contrast, self-sustaining inflammation drives the pathobiology of the aforementioned diseases. It is now increasingly recognized that controlling and reprogramming inflammation in order to reap the benefits of this evolutionarily-conserved process is preferred to simply abolishing indiscriminately.

This book provides a reference for people working in the design, development, and manufacturing of medical devices. ​While there are no statistical methods specifically intended for medical devices, there are methods that are commonly applied to various problems in the design, manufacturing, and quality control of medical devices. The aim of this book is not to turn everyone working in the medical device industries into mathematical statisticians; rather, the goal is to provide some help in thinking statistically, and knowing where to go to answer some fundamental questions, such as justifying a method used to qualify/validate equipment, or what information is necessary to support the choice of sample sizes. While, there are no statistical methods specifically designed for analysis of medical device data, there are some methods that seem to appear regularly in relation to medical devices. For example, the assessment of receiver operating characteristic curves is fundamental to development of diagnostic tests, and accelerated life testing is often critical for assessing the shelf life of medical device products. Another example is sensitivity/specificity computations are necessary for in-vitro diagnostics, and Taguchi methods can be very useful for designing devices. Even notions of equivalence and noninferiority have different interpretations in the medical device field compared to pharmacokinetics. It contains topics such as dynamic modeling, machine learning methods, equivalence testing, and experimental design, for example. This book is for those with no statistical experience, as well as those with statistical knowledgeable—with the hope to provide some insight into what methods are likely to help provide rationale for choices relating to data gathering and analysis activities for medical devices.

"Systems Biology of Apoptosis" summarizes all current achievements in this emerging field. Apoptosis is a process common to all multicellular organisms. Apoptosis leads to the elimination of cells via a complex but highly defined cellular programme. Defects in the regulation of apoptosis result in serious diseases such as cancer, autoimmunity, AIDS and neurodegeneration. Recently, a substantial step forward in understanding the complex apoptotic pathways has been made by utilising systems biology approaches. Systems biology combines rigorous mathematical modelling with experimental approaches in a closed loop cycle for advancing our knowledge about complex biological processes. In this book, the editor describes the contemporary systems biology studies devoted to apoptotic signaling and focuses on the question how systems biology helps to understand life/death decisions made in the cell and to develop new approaches to rational treatment strategies.

The papers in this volume comprise the refereed proceedings of the Second IFIP International Conference on Computer and Computing Technologies in Agriculture (CCTA2008), in Beijing, China, 2008. The conference on the Second IFIP International Conference on Computer and Computing Technologies in Agriculture (CCTA 2008) is cooperatively sponsored and organized by the China Agricultural University (CAU), the National Engineering Research Center for Information Technology in Agriculture (NERCITA), the Chinese Society of Agricultural Engineering (CSAE) , International Federation for Information Processing (IFIP), Beijing Society for Information Technology in Agriculture, China and Beijing Research Center for Agro-products Test and Farmland Inspection, China. The related departments of China's central government bodies like: Ministry of Science and Technology, Ministry of Industry and Information Technology, Ministry of Education and the Beijing Municipal Natural Science Foundation, Beijing Academy of Agricultural and Forestry Sciences, etc. have greatly contributed and supported to this event. The conference is as good platform to bring together scientists and researchers, agronomists and information engineers, extension servers and entrepreneurs from a range of disciplines concerned with impact of Information technology for sustainable agriculture and rural development. The representatives of all the supporting organizations, a group of invited speakers, experts and researchers from more than 15 countries, such as: the Netherlands, Spain, Portugal, Mexico, Germany, Greece, Australia, Estonia, Japan, Korea, India, Iran, Nigeria, Brazil, China, etc.