This book explores the impact of nonlinearity on a broad range of areas, including time-honored fields such as biology, geometry, and topology, but also modern ones such as quantum mechanics, networks, metamaterials and artificial intelligence. The concept of nonlinearity is a universal feature in mathematics, physics, chemistry and biology, and is used to characterize systems whose behavior does not amount to a superposition of simple building blocks, but rather features complex and often chaotic patterns and phenomena. Each chapter of the book features a synopsis that not only recaps the recent progress in each field but also charts the challenges that lie ahead. This interdisciplinary book presents contributions from a diverse group of experts from various fields to provide an overview of each field's past, present and future. It will appeal to both beginners and seasoned researchers in nonlinear science, numerous areas of physics (optics, quantum physics, biophysics), and applied mathematics (ODEs, PDEs, dynamical systems, machine learning) as well as engineering.

Computational biology, mathematical biology, biology and biomedicine are currently undergoing spectacular progresses due to a synergy between technological advances and inputs from physics, chemistry, mathematics, statistics and computer science. The goal of this book is to evidence this synergy by describing selected developments in the following fields: bioinformatics, biomedicine and neuroscience. This work is unique in two respects - first, by the variety and scales of systems studied and second, by its presentation: Each chapter provides the biological or medical context, follows up with mathematical or algorithmic developments triggered by a specific problem and concludes with one or two success stories, namely new insights gained thanks to these methodological developments. It also highlights some unsolved and outstanding theoretical questions, with a potentially high impact on these disciplines. Two communities will be particularly interested in this book. The first one is the vast community of applied mathematicians and computer scientists, whose interests should be captured by the added value generated by the application of advanced concepts and algorithms to challenging biological or medical problems. The second is the equally vast community of biologists. Whether scientists or engineers, they will find in this book a clear and self-contained account of concepts and techniques from mathematics and computer science, together with success stories on their favorite systems. The variety of systems described represents a panoply of complementary conceptual tools. On a practical level, the resources listed at the end of each chapter (databases, software) offer invaluable support for getting started on a specific topic in the fields of biomedicine, bioinformatics and neuroscience.

This book relates to the analysis and the development of methods to for a nerve-machine interface. Peripheral nerves, both somatic and autonomic, carry signals related to control and the status of the organs. Nerves are made up of many fascicles, each surrounded by protective membranes. The goal is to provide a theoretical and experimental understanding of how one can recover neural signals from the various fascicles or selectively control the activation of these fascicles.

This book introduces advanced mathematical methods and techniques for analysis and simulation of models in mathematical epidemiology. Chronological age and class-age play an important role in the description of infectious diseases and this text provides the tools for the analysis of this type of partial differential equation models. This book presents general theoretical tools as well as large number of specific examples to guide the reader to develop their own tools that they may then apply to study structured models in mathematical epidemiology. The book will be a valuable addition to the arsenal of all researchers interested in developing theory or studying specific models with age structure.

This work presents the latest development in the field of computational intelligence to advance Big Data and Cloud Computing concerning applications in medical diagnosis. As forum for academia and professionals it covers state-of-the-art research challenges and issues in the digital information & knowledge management and the concerns along with the solutions adopted in these fields.

Mass spectrometry (MS) along with its hyphenated techniques is capable of high throughput, sensitivity, accuracy and selectivity for the analysis of structure and composition of almost any product. Like in electrophoresis, MS separates mo- cules based on the mass-to-charge ratio. In case of gel electrophoresis (SDS- PAGE), a well-known and efficient bioanalytical technique, proteins bear negative charges but have the same charge density, so proteins are separated according to their size. Similarly, in case of MS analysis, proteins carry the same charge, and are separated by their molecular weight. Unlike SDS-PAGE, however, modern ultra high resolution MS discerns very small mass differences and can resolve and completely identify in a single experiment species of the same nominal mass in complex biological mixtures. Consequently, MS can be used for the structural characterization, identification and sensitive detection of mixtures of biomolecules or for assessing the quality of isolated proteins (purity, integrity, or post-translational modifications, for example), carbohydrates, nucleic acids, drugs, metabolites, pollutants etc. In the post-genome era, MS is continuously developing as one of the most re- able analytical method for elucidating the structure of molecules originating from various biological matrices. The potential of MS for high-sensitive structural a- lyses became unsurpassable after the introduction of electrospray (ESI) and matrix assisted laser/desorption ionization (MALDI) methods, on one hand, and the pos- bility to deduce in detail unknown biopolymer structures by highly accurate mo- cular mass measurement followed by sequencing using dissociation techniques based on multiple stage MS, on the other.

Tens of thousands of different animal species live on this planet, having survived for millions of years through adaptation and evolution, which has given them a vast variety of structures and functions. Biomechanical studies of animals swimming and flying can aid understanding of the mechanisms that enable them to move effectively and efficiently in fluids . Based on such understandings and analyses, we can aim to develop environmentally friendly machines that emulate these natu ral movements. The Earth Summit in Rio de Janeiro in 1992 agreed major treaties on biological diversity, addressing the comb ined issues of environmental protection and fair and equitable economic development. With regard to coastal environments, increasing biological diversity has begun to play an important role in reestablishing stable and sustainable ecosystems. This approach has begun to influence research into the behavior of aquatic species, as an understanding of the history of an individual aquatic species is indispensable in constructing an environmental assessment mod el that includes the physical, chemical, and biological effects of that species . From an engineering viewpoint, studying nature's biological diversity is an opportunity to reconsider mechanical systems that were systematically constructed in the wake of the Industrial Revolution. We have been accumulating knowledge of the sys tems inherent in biological creatures and using that knowledge to create new, envi ronmentally friendly technologies.

This book reviews the relationship between receptors, carbohydrate moieties, and pathogenic surfaces and lectins' pathophysiology of immune responses and examines the mechanisms of action of the molecules for the treatment potentials. Increasing evidence has suggested that lectin-carbohydrate interactions perform important roles in various regulations of immune responses, but much remains to be learned about these crucial properties and their interplay with other molecules. In addition, a better understanding of the structural and functional properties of lectin and the activated immune response will be of critical importance for the development of new diagnostic tools and therapeutic strategies. These key areas are the focus of this book, which documents the latest research findings in the field. Evidence is provided for the various lectin types from animal and plant as well as microbial or marine lectins, and this wide range of molecular knowledge directs us to various diseases, including infectious diseases and cancer. In presenting state-of-the-art knowledge on the interactions between lectin and its interactions,the book will help to pave the way for the development of novel targets for the prevention and treatment of many disorders.

This detailed volume presents an updated collection of state-of-the-art protocols in cardiac tissue engineering. These protocols demonstrate advancements in cell sourcing, assembly, and use of engineered cardiac tissues, imaging and diagnostics, as well as therapeutic applications. New animal models, biomaterials, and quantitative analyses are described for broad adoption. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cardiac Tissue Engineering: Methods and Protocols, Second Edition serves as an ideal resource for inspiring the advancement of cardiotoxicity assessment, drug discovery, and heart repair and regeneration in order to accelerate heart health improvement around the globe.

This book discusses prospective alternative approaches to fight bacterial infections to minimize the indiscriminate use of conventional antibiotics. It offers the current knowledge on research and development of alternative antibacterial agents such as probiotics, nanobiotics etc. while it also discusses newly emerging trends such as phage therapy, antibody therapy etc. The book highlights on the phytochemicals with potent antibacterial activities as alternatives to conventional antibiotics. Chemical modification to develop next generation antibiotics with enhanced efficacy has also been included. Such modifications are reported to overcome the inherent resistance of the parent antibiotics. Phage therapy and targeted antibodies are considered as potential alternative approaches to treat bacterial ailments and represent areas of cutting-edge research and have therefore been discussed with sufficient care. Mainly, the book highlights various approaches other than conventional antibiotics in treating bacterial infections. The scientific advancements in these areas will strengthen the 'One Health' approach benefiting human beings, animals and environment as well. This book is a comprehensive resource to cater researchers, biological scientists, herbalists and clinical practitioners with up-to-date information on antibacterials other than antibiotics.

Proteomics is a well-established area of Science; yet with a strong area in constant evolution, namely sample treatment. There few books that currently cover the field of emerging sample treatments in proteomics, this new volume will be the first to cover all emerging and existing studies. This unique book presents the latest advances in the field focusing on emerging trends linked to high-resolution mass spectrometry, technology addressed to treat samples faster and to attempts to simplify the proteome for the reader.

When reconstructing the past, the archaeologist needs to take into account all kinds of relevant information. Where no written evidence is available, the natural sciences play an indispensable role. Troia is a remarkable site in this respect. The present Troia project, under the directorship of Manfred Korfmann, integrates various disciplines including geoarchaeology, archaeobotany, zooarchaeology, anthropology, geophysical prospection as well as chemical and technological studies of metal, stone and pottery. Hardly any other archaeological project is supported so intensely and on such a broad scale by archaeometric investigations as the international research group in Troia. In April 2001 an International Symposium was held in Heidelberg, Germany, with the aim of promoting scientific interaction and providing synopses of the various disciplines engaged in Troia. This volume contains most of the contributions presented at the symposium.

Although many books have been written about Mathematica, very few of them cover the new functionality added to the most recent versions of the program. This thoroughly revised second edition of Mathematica Beyond Mathematics: The Wolfram Language in the Real World introduces the new features using real-world examples based on the experience of the author as a consultant and Wolfram certified instructor. The examples strike a balance between relevance and difficulty in terms of Mathematica syntax, allowing readers to incrementally build up their Mathematica skills as they go through the chapters While reading this book, you will also learn more about the Wolfram Language and how to use it to solve a wide variety of problems. The author raises questions from a wide range of topics and answers them by taking full advantage of Mathematica's latest features. For example: What sources of energy does the world really use? Are our cities getting warmer? Is the novel El Quixote written in Pi? Is it possible to reliably date the Earth using radioactive isotopes? How can we find planets outside our solar system? How can we model epidemics, earthquakes and other natural phenomena? What is the best way to compare organisms genetically? This new edition introduces the new capabilities added to the latest version of Mathematica (version 13), and discusses new topics related to machine learning, big data, finance economics, and physics. New to the Second Edition Separate sections containing carefully selected additional resources that can be accessed from either Mathematica or online Online Supplementary materials including code snippets used in the book and additional examples. Updated commands to take full advantage of Mathematica 13.

This book offers an overview of the statistical methods used in clinical and observational vaccine studies. Pursuing a practical rather than theoretical approach, it presents a range of real-world examples with SAS codes, making the application of the methods straightforward. This revised edition has been significantly expanded to reflect the current interest in this area. It opens with two introductory chapters on the immunology of vaccines to provide readers with the necessary background knowledge. It then continues with an in-depth exploration of the analysis of immunogenicity data. Discussed are, amongst others, maximum likelihood estimation for censored antibody titers, ANCOVA for antibody values, analysis of data of equivalence, and non-inferiority immunogenicity studies. Other topics covered include fitting protection curves to data from vaccine efficacy studies, and the analysis of vaccine safety data. In addition, the book features four new chapters on vaccine field studies: an introductory one, one on randomized vaccine efficacy studies, one on observational vaccine effectiveness studies, and one on the meta-analysis of vaccine efficacy studies. The book offers useful insights for statisticians and epidemiologists working in the pharmaceutical industry or at vaccines institutes, as well as graduate students interested in pharmaceutical statistics.

This volume details current and new computational methodologies to study peptides. Chapters guide readers through antimicrobial peptides, foldability, amyloid sheet formation, membrane-active peptides, organized peptide assemblies, protein-peptide interfaces, prediction of peptide-MHC complexes, advanced free energy simulations for peptide binding, and methods for high throughput peptide or miniprotein design. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials, software, and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Computational Peptides Science: Methods and Protocols aims to provide concepts, methods, and guidelines to help both novices and experienced workers benefit from today's new opportunities and challenges.

In the lung, more recent data have been accumulated on lung stem cell biology/function and the potential applications of stem cells in pulmonary diseases that are facilitated by the recent development of a broad range of cutting edge in vitro and in vivo research tools and approaches, including mouse and human organoid cultures, genetic editing in vitro and in vivo, human induced pluripotent cell (iPS cell) models of disease, haploid cells for genetic as well as compound screening paradigms, genetically engineered mice, and stem cell transplantation to cure diseases. Stem Cell Innovation in Health and Disease: Volume 2: The Lung, contains two major sections describing cutting edge research for understanding stem cell functions in the lung and respiratory system, and for developing methods to bring stem cells from bench to bedside; respectively. Each section includes insights ranging from using mouse and human organoid cultures, genetic editing in vitro and in vivo, and human induced pluripotent cells (iPSCs) to study stem cell functions and model lung diseases, through the cutting-edge research aiming to bring stem cells from bench to bedside, including the potential application of iPSCs, ESCs and blood stem cells (stem cell transplants) in the treatment of lung diseases/disorders. This book, therefore, discusses the fact-based promise of stem cells and regenerative medicine in the lung in the real world.

The intestine is among the leading organs, in which several cutting edge in vitro and in vivo research tools and approaches have recently been developed and used to investigate stem cell biology/function, and the potential applications of stem cells in the treatment of intestinal diseases. These cutting-edge research tools and approaches involve human and murine organoid cultures, genetic editing in vitro and in vivo, human induced pluripotent cell (iPS cell) models of disease, haploid cells for genetic as well as compound screening paradigms, genetically engineered mice, and stem cell transplantation to cure diseases. Stem Cell Innovation in Health and Disease: Volume 1: The Intestine contains two major sections describing cutting edge research for understanding stem cell functions in the intestine, and for developing methods to bring stem cells from bench to bedside; respectively. Each section includes insights ranging from using mouse and human organoid cultures, genetic editing in vitro and in vivo, and human induced pluripotent cells (iPSCs) to study stem cell functions and model intestinal diseases, through the cutting-edge research, including the potential application of iPSCs, ESCs and blood stem cells (stem cell transplants) in the treatment of intestinal diseases/disorders. This volume, therefore, discusses the fact-based promise of stem cells and regenerative medicine in the intestine in the real world.

This proceedings volume highlights the latest research and developments in psychometrics and statistics. It represents selected and peer-reviewed presentations given at the 85th Annual International Meeting of the Psychometric Society (IMPS), held virtually on July 13-17, 2020. The IMPS is one of the largest international meetings on quantitative measurement in education, psychology and the social sciences. It draws approximately 500 participants from around the world, featuring paper and poster presentations, symposiums, workshops, keynotes, and invited presentations. Leading experts and promising young researchers have written the included chapters. The chapters address a wide variety of topics including but not limited to item response theory, adaptive testing, Bayesian estimation, propensity scores, and cognitive diagnostic models. This volume is the 9th in a series of recent works to cover research presented at the IMPS.

This book reviews recent advances in the emerging field of computational network biology with special emphasis on comparative network analysis and network module detection. The chapters in this volume are contributed by leading international researchers in computational network biology and offer in-depth insight on the latest techniques in network alignment, network clustering, and network module detection. Chapters discuss the advantages of the respective techniques and present the current challenges and open problems in the field. Recent Advances in Biological Network Analysis: Comparative Network Analysis and Network Module Detection will serve as a great resource for graduate students, academics, and researchers who are currently working in areas relevant to computational network biology or wish to learn more about the field. Data scientists whose work involves the analysis of graphs, networks, and other types of data with topological structure or relations can also benefit from the book's insights.

The papers in this volume comprise the refereed proceedings of the Second IFIP International Conference on Computer and Computing Technologies in Agriculture (CCTA2008), in Beijing, China, 2008. The conference on the Second IFIP International Conference on Computer and Computing Technologies in Agriculture (CCTA 2008) is cooperatively sponsored and organized by the China Agricultural University (CAU), the National Engineering Research Center for Information Technology in Agriculture (NERCITA), the Chinese Society of Agricultural Engineering (CSAE) , International Federation for Information Processing (IFIP), Beijing Society for Information Technology in Agriculture, China and Beijing Research Center for Agro-products Test and Farmland Inspection, China. The related departments of China's central government bodies like: Ministry of Science and Technology, Ministry of Industry and Information Technology, Ministry of Education and the Beijing Municipal Natural Science Foundation, Beijing Academy of Agricultural and Forestry Sciences, etc. have greatly contributed and supported to this event. The conference is as good platform to bring together scientists and researchers, agronomists and information engineers, extension servers and entrepreneurs from a range of disciplines concerned with impact of Information technology for sustainable agriculture and rural development. The representatives of all the supporting organizations, a group of invited speakers, experts and researchers from more than 15 countries, such as: the Netherlands, Spain, Portugal, Mexico, Germany, Greece, Australia, Estonia, Japan, Korea, India, Iran, Nigeria, Brazil, China, etc.

Biodiversity and Biomedicine: Our Future provides a new outlook on Earth's animal, plant, and fungi species as vital sources for human health treatments. While there are over 10 million various species on the planet, only 2 million have been discovered and named. This book identifies modern ways to incorporate Earth's species into biomedical practices and emphasizes the need for biodiversity conservation. Written by leading biodiversity and biomedical experts, the book begins with new insights on the benefits of biologically active compounds found in fungi and plants, including a chapter on the use of wild fruits as a treatment option. The book goes on to discuss the roles of animals, such as amphibians and reptiles, and how the threatened presence of these species must be reversed to conserve biodiversity. It also discusses marine organisms, including plants, animals, and microbes, as essential in contributing to human health. Biodiversity and Biomedicine: Our Future is a vital source for researchers and practitioners specializing in biodiversity and conservation studies. Students in natural medicine and biological conservation will also find this useful to learn of the world's most bio-rich communities and the molecular diversity of various species.

Clinical Chemistry, Immunology and Laboratory Quality Control: A Comprehensive Review for Board Preparation, Certification and Clinical Practice, Second Edition presents core topics and 70 case studies that illustrate the application of clinical chemistry knowledge to everyday patient care. This succinct reference offers practical examples of how things function in the pathology clinic with useful lists, key points, case studies and a bullet point format ideal for quick pre-board review. While larger textbooks in clinical chemistry provide highly detailed information regarding instrumentation and statistics, this book is designed to educate senior medical students, residents and fellows on how tests are performed. This second edition successfully helps pathology residents gain command of clinical chemistry, toxicology, immunology, and laboratory statistics in an effort to help them prepare for the American Board of Pathology examination. Clinical chemistry is a topic in which many senior medical students and pathology residents face challenges.

Biotechnological Strategies for the Treatment of Gluten Intolerance provides a comprehensive overview of a wide range of biotechnological approaches that will further research and upon implementation improve the quality of life of this population. Gluten intolerance is a heterogeneous condition with varying levels of sensitivity that have typically been treated with a gluten free diet, but this book provides new and exciting biotechnological approaches that affect diet as well as non-dietary approaches. The reference describes the varying levels of sensitivity and explores symptoms beyond the intestines for a complete overview of the spectrum of sensitivity. The impact of diversity of wheat species, gluten quality and the nutritional values of gluten free products are extensively discussed. This reference is perfect for researchers and clinicians that want to further treatment options for those suffering from gluten sensitivity.

Covers the State of the Art in Superfluidity and Superconductivity Superfluid States of Matter addresses the phenomenon of superfluidity/superconductivity through an emergent, topologically protected constant of motion and covers topics developed over the past 20 years. The approach is based on the idea of separating universal classical-field superfluid properties of matter from the underlying system's "quanta." The text begins by deriving the general physical principles behind superfluidity/superconductivity within the classical-field framework and provides a deep understanding of all key aspects in terms of the dynamics and statistics of a classical-field system. It proceeds by explaining how this framework emerges in realistic quantum systems, with examples that include liquid helium, high-temperature superconductors, ultra-cold atomic bosons and fermions, and nuclear matter. The book also offers several powerful modern approaches to the subject, such as functional and path integrals. Comprised of 15 chapters, this text: Establishes the fundamental macroscopic properties of superfluids and superconductors within the paradigm of the classical matter field Deals with a single-component neutral matter field Considers fundamentals and properties of superconductors Describes new physics of superfluidity and superconductivity that arises in multicomponent systems Presents the quantum-field perspective on the conditions under which classical-field description is relevant in bosonic and fermionic systems Introduces the path integral formalism Shows how Feynman path integrals can be efficiently simulated with the worm algorithm Explains why nonsuperfluid (insulating) ground states of regular and disordered bosons occur under appropriate conditions Explores superfluid solids (supersolids) Discusses the rich dynamics of vortices and various aspects of superfluid turbulence at T 0 Provides account of BCS theory for the weakly interacting Fermi gas Highlights and analyzes the most crucial developments that has led to the current understanding of superfluidity and superconductivity Reviews the variety of superfluid and superconducting systems available today in nature and the laboratory, as well as the states that experimental realization is currently actively pursuing

This volume presents state-of-the art design, analysis and integration approaches for biomedical data including novel statistical models for a comprehensive and powerful synthesis and assessment of scientific evidence. Chapters detail principles of systematic reviews, semi-automated tools for systematic searches, fixed- and random-effects meta-analytical models, living systematic reviews, meta-analysis of genetic studies, meta-analysis of pragmatic and explanatory trials, network meta-analysis, and other modern approaches for data synthesis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, the Meta- Research: Methods and Protocols book, written by global experts, will introduce the reader in a step-by-step process to the methods of the vital and highly promising field of evidence synthesis.