This book covers liquid chromatography, gas chromatography and capillary electrophoresis, the three main separation techniques lately available, applied to key omic sciences, such as genomics, proteomics, metabolomics and foodomics. The fundamentals of each technique are not covered herein. Instead, the recent advances in such techniques are presented focusing on the application to omics analyses and unique aspects in each case. This volume intends to offer wide ranging options available to researchers on omics sciences, and how to integrate them in order to achieve the comprehension of a biological system as a whole. Omic sciences have been of ultimate importance to comprehend the complex biochemical reactions and related events that occurs upon a biological system. The classical central dogma of molecular biology, which states that genetic information flows unidirectionally from DNA to RNA and then to proteins, has been gradually replaced by the systems biology approach. This book presents a multidisciplinary approach that explains the biological system as a whole, where the entire organism is influenced by a variety of internal events as well as by the environment, showing that each level of the biological information flux may influence the previous or the subsequent one.

This book is the first comprehensive overview of the emerging field of cuffless blood pressure monitoring. Increasing clinical evidence proves that longitudinal measurements of blood pressure allow for earlier detection and better management of multiple medical conditions and for superior prediction of cardiovascular events. Unfortunately, today's clinical and industry standards for blood pressure monitoring still require the inflation of a pneumatic cuff around a limb each time a measurement is taken. Over the last decades clinicians, scientists and device manufacturers have explored the feasibility of technologies that reduce or even completely eliminate the need of cuffs, initiating the era of cuffless blood pressure monitoring. Among the existing literature, this book is intended to be a practical guide to navigate across this emerging field. The chapters of the handbook have been elaborated by experts and key opinion leaders in the domain, and will guide the reader along the clinical, scientific, technical, and regulatory aspects of cuffless blood pressure monitoring.

Tumor Vascularization discusses the different types of growth of tumor blood vessels and their implications on research and healthcare. The book is divided into three parts: the first one, General Mechanisms, discusses different vessel growth mechanisms, such as sprouting angiogenesis, non-angiogenesis dependent growth, intussusceptive microvascular growth, vascular co-option and vasculogenic mimicry. The second and third parts, entitled Clinical Implications and Therapeutic Implications are dedicated to translating recent findings in this field to patient treatment and healthcare. This book is a valuable source for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in tumor progression and blood vessels.

Translational Sports Medicine covers the principles of evidence-based medicine and applies these principles to the design of translational investigations. This title is an indispensable tool in grant writing and funding efforts with its practical, straightforward approach that will help aspiring investigators navigate challenging considerations in study design and implementation. It provides valuable discussions of the critical appraisal of published studies in translational sports medicine, allowing the reader to learn how to evaluate the quality of such studies with respect to measuring outcomes and to make effective use of all types of evidence in patient care. In short, this practical guidebook will be of interest to every medical researcher or sports medicine clinician who has ever had a good clinical idea but not the knowledge of how to test it. Readers will come to fully understand important concepts, including case-control study, prospective cohort study, randomized trial and reliability study. Medical researchers will benefit from greater confidence in their ability to initiate and execute their own investigations, avoid common pitfalls in translational sports medicine, and know what is needed in collaboration.

The novel coronavirus 2019 (COVID-19) has caused a serious global pandemic in just eight months. Nearly every country and territory in the world has been affected by the virus. The virulence and infection rate of the virus are profound, and has required extreme social distancing measures across the globe in order to prevent overwhelming the healthcare services and hospitals. COVID-19 appears to have the greatest effects on elderly individuals and those who have co-morbid diseases, such as heart disease, asthma, and diabetes. As the peak begins to slow in many countries, the death rates remain high amidst justified fears of a second wave. A rapid worldwide mobilization has begun to identify effective treatments and develop vaccines. This new volume will increase readers' understanding of the ongoing COVID-19 pandemic through a series of chapters that address these concerns. Leading experts will discuss the effects of the virus in cases of co-morbidities, new treatment approaches, mental health aspects of the pandemic, and convey the results of survey studies. The book will be an excellent resource for researchers studying virology, metabolic diseases, respiratory disorders, and clinical scientists, physicians, drug companies, and healthcare services and workers.

This volume provides computational methods and reviews various aspects of computational studies of protein aggregation. Chapters discuss the relationship between protein misfolding and protein aggregation, methods of prediction of aggregation propensities of protein, peptides, protein structure, results of computer simulations of aggregation, and computational simulations focused on specific diseases such as Alzheimer's, Parkinson's, and preeclampsia. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Computer Simulations of Aggregation of Proteins and Peptides aims to ensure successful results in the further study of this vital field.

Is designed to serve as a comprehensive and up-to-date manual for process, device, layout, and design engineers Covers topics that designers as well as layout and process engineers deal with every day, such as front-end-of-line (FEOL) and back-end-of-line BEOL DRs, coverage DRs, stressors DRs, and modeling, foundry reliability, and advance (20 nm) step-by-step process flow Can be used by those studying semiconductors and microelectronics as well as students and researchers in the fields of electrical engineering, physics, materials engineering, and chemical engineering

This book presents a range of current research topics in biological network modeling, as well as its application in studies on human hosts, pathogens, and diseases. Systems biology is a rapidly expanding field that involves the study of biological systems through the mathematical modeling and analysis of large volumes of biological data. Gathering contributions from renowned experts in the field, some of the topics discussed in depth here include networks in systems biology, the computational modeling of multidrug-resistant bacteria, and systems biology of cancer. Given its scope, the book is intended for researchers, advanced students, and practitioners of systems biology. The chapters are research-oriented, and present some of the latest findings on their respective topics.

This book provides a powerful diagnosis of why the global governance of science struggles in the face of emerging powers. Through unpacking critical events in China and India over the past twenty years, it demonstrates that the 'subversiveness' assumed in the two countries' rise in the life sciences reflects many of the regulatory challenges that are shared worldwide. It points to a decolonial imperative for science governance to be responsive and effective in a cosmopolitan world. By highlighting epistemic injustice within contemporary science, the book extends theories of decolonisation. -- .

Data fusion problems arise frequently in many different fields. This book provides a specific introduction to data fusion problems using support vector machines. In the first part, this book begins with a brief survey of additive models and Rayleigh quotient objectives in machine learning, and then introduces kernel fusion as the additive expansion of support vector machines in the dual problem. The second part presents several novel kernel fusion algorithms and some real applications in supervised and unsupervised learning. The last part of the book substantiates the value of the proposed theories and algorithms in MerKator, an open software to identify disease relevant genes based on the integration of heterogeneous genomic data sources in multiple species. The topics presented in this book are meant for researchers or students who use support vector machines. Several topics addressed in the book may also be interesting to computational biologists who want to tackle data fusion challenges in real applications. The background required of the reader is a good knowledge of data mining, machine learning and linear algebra.

This new book, Carbon Nanotubes for Energy and Environmental Applications, covers the timely issue of green applications of carbon nanotubes. It covers the diverse usages of carbon nanotubes for the sensing of environmentally hazardous chemicals, for water purification, for the protection of the environment, and for new energy applications. The development of highly sensitive CNT-based gas sensors for air pollution monitoring, for green synthesis of carbon nanotubes, and for green energy applications are discussed in this volume. The diverse topics in the volume include nanodiamonds for energy storage, new lubricant additives that enhance energy efficiency, how carbon nanotubes can be applied in the food and agricultural sectors, the use of CNTs in water purification and desalination, carbon nanotubes-based electrochemical sensors for environmentally hazardous chemicals, and much more. This timely book addresses a need of the hour and will provide valuable for environmentally conscious industry professionals, faculty and students, and researchers in materials science, engineering, physics, and chemistry with interest in nanomaterials.

Handbook of Essential Oils: Science, Technology, and Applications presents the development, use and marketing of essential oils. Exciting new topics include insecticidal applications, but there is a continued focus on the chemistry, pharmacology and biological activities of essential oils. The third edition unveils new chapters including the insect repellent and insecticidal activities of essential oils, the synergistic activity with antibiotics against resistant microorganisms, essential oil applications in agriculture, plant-insect interactions, and pheromones and contaminants in essential oils. Features Presents a wide range of topics including sources, production, analysis, storage, transport, chemistry, aromatherapy, pharmacology, toxicology, metabolism, technology, biotransformation, application, utilization, and trade Includes discussions of biological activity testing, results of antimicrobial and antioxidant tests, and penetration enhancing activities useful in drug delivery Covers up-to-date regulations and legislative procedures, together with the use of essential oils in perfumes, cosmetics, feed, food, beverages, and pharmaceutical industries Unveils new chapters including the insect repellent and insecticidal activities of essential oils, the synergistic activity with antibiotics against resistant microorganisms, essential oil applications in agriculture, plant-insect interactions, and pheromones and contaminants in essential oils The American Botanical Council (ABC) named the second edition as the recipient of the 2016 ABC James A. Duke Excellence in Botanical Literature Award and recognized that essential oils are one of the fastest growing segments of the herbal product market

This book reviews all important aspects of dietary research associated with cancer with the aim of shedding new light on these conditions through combined understanding of traditional and new paradigms. The book is divided into 17 chapters, the first portion reinterprets healthy diets for cancer based on up-to-date evidence from a network science perspective, examining the dietary patterns, outcome of diet related clinical trials, emerging framework of molecular mechanisms and interactions of dietary interventions and their applications in personalized diet, ground realities of benefits and regulatory frame work for functional foods, nutraceuticals and supplements in cancer prevention and upcoming future prospectus in diet-cancer research.. The later part of the book discusses recent advances in understanding of the elaborative discourse on cancer and fasting, covering, for example, calorie restriction and fasting mimicking diet. Finally, different Dietary research and approaches are considered in the context of novel intervention for cancer research. Dietary Research in Cancer will be of interest for all researchers, nutritionists, students and clinicians in the field.

This book offers a historical account of the development of the On-X carbon mechanical heart valve, discussing the steps involved in developing the materials, and describes how the design of the valve has evolved over the years. It explores both the scientific and corporate problems researchers have encountered over the years in the journey of making a mechanical heart valve. The chapters provide a detailed description of the design of the mechanical leaflet-based prosthetic valve, with a particular focus on blood flow characteristics. This book includes an overview of the state-of-the-art in the chemistry and physics of carbon, and compiles the advances in carbon-based technology and its applications in cardiac and thoracic surgery. This is an ideal book for bioengineers working on the chemistry and physics of carbon, and other professionals involved with cardiac and thoracic surgery.

"Examines all known industrial processes using shape selective zeolites. Second Edition contains new, up-to-date information on the specific features that make zeolites shape selective, the role shape selective catalysis can play providing environmentally clean fuels, 12-membered oxygen ring systems, mesopore systems, and more."

Features: • Provides an accessible introduction to the subject. • Up to date with the latest advances in emerging technologies and procedures. • Provides a historical overview of CT technology.

This book allows readers to gain an in-depth understanding of the role of real-world data in pharmacoepidemiology, and highlights the strengths and limitations of the respective databases with regard to pharmacoepidemiological research. Over the past decade, the increasing use of real-world data in pharmacoepidemiological research has been accompanied by a growing recognition of the value of real-world evidence in clinical and regulatory decision-making. Electronic healthcare databases allow analyses of drug and vaccine utilization in routine care after approval, as well as investigations of their comparative effectiveness and safety. They are especially useful for the identification of rare risks and rare drug exposures over long periods of time, and as such sustainably extend the basis for drug safety research. This book provides an introduction to the role of real-world data in pharmacoepidemiological research and the main developments in the last 15 years. It also offers a comprehensive overview of the general classification characteristics of databases, together with their strengths and limitations, and a detailed description of 21 individual databases, written by professionals who work with or maintain them.

Introduction to Modeling in Physiology and Medicine, Second Edition, develops a clear understanding of the fundamental principles of good modeling methodology. Sections show how to create valid mathematical models that are fit for a range of purposes. These models are supported by detailed explanation, extensive case studies, examples and applications. This updated edition includes clearer guidance on the mathematical prerequisites needed to achieve the maximum benefit from the material, a greater detail regarding basic approaches to modeling, and discussions on non-linear and stochastic modeling. The range of case study material has been substantially extended, with examples drawn from recent research experience. Key examples include a cellular model of insulin secretion and its extension to the whole-body level, a model of insulin action during a meal/oral glucose tolerance test, a large-scale simulation model of type 1 diabetes and its use in in silico clinical trials and drug trials.

Fundamentals of Nano-Textile Science provides a detailed overview of advanced nano-textiles methods, techniques, and treatments along with explanations of a wide range of applications. This book places emphasis on nanotechnology-based textile enhancements that provide high durability, better affinity, and more functionality in textile material and that overcomes the limitation of conventional processes in the textile industry. The first section of the book deals with the production method of nano-textile fibers. It elaborates how nano-techniques are used for producing textile fiber and discusses various pretreatment processes of textile materials using such methods as nano-scouring, nanobiophotoscouring, nano-bleaching, nano-softening, and nano-surface activation. The second section discusses the wide range of nanofinishing applications to make textile materials antimicrobial, flame retardant, UV-protected, etc. It also discusses different techniques and treatments applied on the surface of the finished product using plasma technology or layer-by-layer deposition techniques. This section also covers nano-based textile applications such as for sports clothing, military textiles, high-performance clothing, or smart wearable high-tech nano-textiles. In the last section, the book concludes with an overview of nanotechnological advancements being used for the management of textile effluents and for removing dyes from wastewater in textile processing, focusing on the health and safety perspective of nano-textiles. The book is written by highly experienced authors in this area and provides an immensely valuable resource for scientific researchers, academics, professionals, engineers, technologists and innovators working on designing and manufacturing textile materials. The volume will be an important resource for those who are looking for innovative production technologies or the latest nanotechnology developments in the design and manufacturing of nano-textile materials. Key features: Provides a detailed theoretical overview of nano-textiles along with novel advanced techniques, methods, treatments for enhanced properties and applications of textiles. Covers relevant techniques applied on the surface of the finished textile product using plasma technology or layer-by-layer deposition techniques Introduces various nanofinishes and applications including for sports clothing, military textiles, high performance clothing or smart wearable high-tech textiles Describes wearable smart nano-textile parameters, types of materials used, applications, and future innovations for prevention of hazards and pandemic diseases Explores innovative methods and treatments for management or removal of textile waste

Provides valuable information on standard protocols for the synthesis of green nanomaterials Promotes advanced technologies for applications of green and sustainable nanomaterials Demonstrates numerous characterization tools for working with sustainable nanomaterials Explores various application areas of the synthesized nanomaterials With the major goal of this volume to take a stock of sophistication in the development of a spectrum of recent nanomaterials that are eco-benign and sustainable, this volume will be a valuable addition to the libraries of faculty and scientists in green and sustainable chemistry and engineering.

Social pressure to minimize the use of animal testing, the ever-increasing concern on animal welfare, and the need for more human-relevant and more predictive toxicity tests are some of the drivers for new approaches to chemical screening. This book focuses on The Adverse Outcome Pathway, an analytical construct that describes a sequential chain of causally linked events at different levels of biological organization that lead to an adverse health or ecotoxicological effect. While past efforts have focused on toxicological pathway-based vision for human and ecological health assessment relying on in vitro systems and predictive models, The Adverse Outcome Pathway framework provides a simplified and structured way to organize toxicological information. Within the book, a systems biology approach supplies the tools to infer, link, and quantify the molecular initiating events and the key events and key event relationships leading to adverse outcomes. The advancement of these tools is crucial for the successful implementation of AOPs for regulatory purposes.

"An efficient yet comprehensive representation of cutting-edge developments become extremely crucial at this juncture of twenty-first century. From that point-of-view, the present book exactly fits in the requirement content-wise." -From the Foreword by Ajit Kumar Panda, PhD, IEEE Distinguished Lecturer of ED Society Providing cutting-edge research on nanoelectronics and photonic devices and its application in future integrated circuits, this state-of-the-art book tackles the challenges of the different detailed theoretical and analytical models of solving the problems of various nanodevices. The volume also explores from different angles the roles of material composition and choice of materials that now play the most critical role in determining outcomes of various low-dimensional nanoelectronic devices. The applications of those findings are extremely beneficial for the computing and telecommunication industries. Beginning with a solid theoretical background for every chapter, this volume covers the hottest areas of present-day electronic engineering. The continuous miniaturization of devices, components, and systems requires corresponding cutting-edge theoretical analysis supported by simulated findings before actual fabrication. That purpose is given maximum focus in this volume, which has interdisciplinary appeal, making it a comprehensive technological volume that deals with underlying aspects of physics, materials, structures in nano-regime, and the corresponding end-product in the form of device. The chapters provide up-to-the-minute theoretical and experimental works on nanoscale devices, with special emphasis on nano-MOSFET modeling and characterization and the latest pioneering research in the area of nanodevice fabrication. Equivalent circuit modeling is also analyzed for a few specific devices, leading to potential applications in various systems. The research provided in Low-Dimensional Nanoelectronic Devices: Theoretical Analysis and Cutting-Edge Research will help researchers and scientists in this area better address real-world problems and challenges in developing new low-dimensional nanoelectronic devices and will contribute toward building sustainable technology for the future.

Highlights the utilization of nanofillers. Investigates the moisture absorption and ageing on the physio-chemical, mechanical, thermal properties of the vinyl ester-based composites. Considers the influence of hybridization, fibre architecture, and fibre-ply orientation on the mechanical and thermal properties of vinyl ester-based biocomposites. Discusses the effects of the alkali treatment. Chapters are written by global experts to cover a diverse scope of industry applications for fibre-reinforced polymer composites.

Highlights the performance of epoxy-based biocomposites with reinforced with various natural fibres and plant resources. Investigates the behavior of hybrid biocomposites and biocomposites reinforced with various nanofillers. Evaluates the response of epoxy-based biocomposites exposed to moisture absorption, accelerated weathering, and hygrothermal aging. Discusses the static and dynamic properties, such as creep, fatigue, and free vibration properties. Chapters are written by global experts to cover a diverse scope of industry applications for fiber-reinforced polymer composites.

This book examines statistical methods and models used in the fields of global health and epidemiology. It includes methods such as innovative probability sampling, data harmonization and encryption, and advanced descriptive, analytical and monitory methods. Program codes using R are included as well as real data examples. Contemporary global health and epidemiology involves a myriad of medical and health challenges, including inequality of treatment, the HIV/AIDS epidemic and its subsequent control, the flu, cancer, tobacco control, drug use, and environmental pollution. In addition to its vast scales and telescopic perspective; addressing global health concerns often involves examining resource-limited populations with large geographic, socioeconomic diversities. Therefore, advancing global health requires new epidemiological design, new data, and new methods for sampling, data processing, and statistical analysis. This book provides global health researchers with methods that will enable access to and utilization of existing data. Featuring contributions from both epidemiological and biostatistical scholars, this book is a practical resource for researchers, practitioners, and students in solving global health problems in research, education, training, and consultation.