The book reviews photosynthetic water oxidation and proton-coupled electron transfer in photosystem, focusing on the molecular vibrations of amino acid residues and water molecules. Photosynthetic water oxidation performed by plants and cyanobacteria is essential for the sustenance of life on Earth, not only as an electron source for synthesizing sugars from CO2, but also as an O2 source in the atmosphere. Water oxidation takes place at the Mn4CaO5 cluster in photosystem II, where a series of electron transfer reactions coupled with proton transfer occur using light energy. The author addresses the unresolved mechanisms of photosynthetic water oxidation and relevant proton-coupled electron transfer reactions using a combined approach of experimental and computational methods such as Fourier transform infrared difference spectroscopy and quantum chemical calculations. The results show that protonation and hydrogen-bond structures of water molecules and amino acid residues in the protein play important roles in regulation of the electron and proton transfer reactions. These findings and the methodology make a significant contribution to our understanding the molecular mechanism of photosynthetic water oxidation.

The book sets out to inform a broad range of professionals working in medicine and healthcare about how creative thinking and design concepts can be used to innovate in providing an enhanced patient experience. It outlines these concepts as a primary means to identify, clarify and resolve some of the process improvement and enhancement challenges in healthcare delivery. It demonstrates by example how such challenges can be addressed, drawing on case examples from healthcare and other industries, and from the authors’ own experiences as innovators and educators. It emphasizes the value of learning in action. For the reader who already has a leaning towards novel approaches to addressing healthcare delivery challenges, it provides guidance on harnessing team inputs and engaging with a network of contributors. It is an ideal resource for all working in medicine and healthcare, from managers, nurses, doctors, administrators, executives, and allied health professionals to medical engineers, medical physicists, medical scientists and medical product developers. Features Provides a unique framework to conceptualise innovation in healthcare and medicine. Authored by an award-winning medical scientist and an established business school Professor who have proven track-records with innovation, in education settings and as entrepreneurs. Presents a clear interdisciplinary approach, complemented with practical case studies set in the context of the challenges facing healthcare delivery in the 21st century. Dr. Barry McMahon has a national and international reputation as an Academic Medical Physicist in the fields of novel physiological measurement and medical device innovation and design. He is the co- inventor of the Functional Lumen Imaging Probe (FLIP) technique later commercialised as EndoFLIP™. He was the Director of the Innovation Academy at Trinity College Dublin from 2012 to 2017. Since 2020 he is advising Children’s Health Ireland on innovation practice. In 2021, he retired as Chief Physicist/Clinical Engineer at Tallaght Hospital, Ireland and currently runs his own innovation-consulting group Electric Mindset Ltd. Dr. Paul Coughlan is Professor in Operations Management and Co-Director of Faculty at Trinity Business School, Trinity College Dublin. His research explores collaborative strategic improvement of operations through network action learning. He was the Director of the Innovation Academy at Trinity College Dublin from 2010 to 2012. He is a founding director of a research-based spin-out venture, Easy Hydro Ltd.

Clearly presents the state of the art and future trends in the research of the biodegradable polymers in the context of circular economy Covers entire value chain and life cycle of biopolymers, considering different types of polymers Clarifies the life safety of (bio)degradable polymeric materials Presents novel opportunities and ideas for developing or improving technologies Determines the course of degradation during prediction study

This is the first textbook solely dedicated to the study of exocrine glands and cells throughout the human body. Students will gain a broad overview of the whole exocrine system, it's structural features and learn to understand it's integral parts in almost all bodily functions. Taking a systemic approach, the author guides readers through the different organ sites, shapes, methods of secretion and their secretory products. Starting with the glands of the integument, which is covering the outside of the body, the chapters proceed to also discuss the urinary tract, respiratory, digestive and reproductive systems. Various levels of complexity, from single goblet cells to the major organs, are thoroughly explained. A basic knowledge in histology is advantageous, for the numerous and rich illustrations. With its inviting writing style, this textbook is a perfect learning tool for students in Physiology and Medicine - particularly considering Dentistry, Dermatology, Gastroenterology and Pulmonology.

1) Provides analytical solutions based on a three-phase model for composites of various structures 2) Identifies computational models to solve problems within all applications of composite materials 3) Constructs higher approximations of the Maxwell formula 4) Proposes efficient analytical algorithms ensuring reliable computational analysis

Biodiversity and Biomedicine: Our Future provides a new outlook on Earth's animal, plant, and fungi species as vital sources for human health treatments. While there are over 10 million various species on the planet, only 2 million have been discovered and named. This book identifies modern ways to incorporate Earth's species into biomedical practices and emphasizes the need for biodiversity conservation. Written by leading biodiversity and biomedical experts, the book begins with new insights on the benefits of biologically active compounds found in fungi and plants, including a chapter on the use of wild fruits as a treatment option. The book goes on to discuss the roles of animals, such as amphibians and reptiles, and how the threatened presence of these species must be reversed to conserve biodiversity. It also discusses marine organisms, including plants, animals, and microbes, as essential in contributing to human health. Biodiversity and Biomedicine: Our Future is a vital source for researchers and practitioners specializing in biodiversity and conservation studies. Students in natural medicine and biological conservation will also find this useful to learn of the world's most bio-rich communities and the molecular diversity of various species.

National Science Foundation (NSF) is a unique federal agency because it supports scientific research financially, but does not engage in scientific work itself. Its history is known only in part because the NSF is a vibrant, expanding, and living entity that makes the final telling of its story impossible. Much can be learned from its beginning as well as its component parts. If the founding of the NSF in 1950 was couched in an era of physics, especially atomic physics, certainly by the end of the 20th century and the beginning of the 21st, biology was, and remains, the queen of sciences for the predictable future. This book highlights the elite status of America's biological sciences as they were funded, affected, and, to a very real degree, interactively guided by the NSF. It examines important events in the earlier history of the Foundation because they play strongly upon the development of the various biology directorates. Issues such as education, applied research, medical science, the National Institutes of Health, the beginnings of biotechnology, and other matters are also discussed.

Bioimaging is a sophisticated non-invasive and non-destructive technique for direct visualization of biological processes. Highly luminescent quantum dots combined with magnetic nanoparticles or ions form an exciting class of new materials for bioimaging. These materials can be prepared in cost-effective ways and show unique optical behaviours. Magnetic Quantum Dots for Bioimaging explores leading research in the fabrication, characterization, properties, and application of magnetic quantum dots in bioimaging. * Covers synthesis, properties, and bioimaging techniques. * Discusses modern manufacturing technologies and purification of magnetic quantum dots. * Explores thoroughly the properties and extent of magnetization to various imaging techniques. * Describes the biocompatibility, suitability, and toxic effects of magnetic quantum dots. * Reviews recent innovations, applications, opportunities, and future directions in magnetic quantum dots and their surface decorated nanomaterials. This comprehensive reference offers a roadmap of the use of these innovative materials for researchers, academics, technologists, and advanced students working in materials engineering and sensor technology.

Discusses digital fashion design and e-prototyping, including 2D/3D CAD, fashion simulation, fit analysis, digital pattern cutting, marker making, and the zero-waste concept Covers digital human modelling and VR/AR technology Details digital fashion business and promotion, including application of e-tools for supply chain, e-commerce, block chain technologies, big data, and AI

This engaging volume sheds light on the central role the turn to the body plays in the philosophies of Spinoza and Nietzsche, providing an ideal starting point for understanding their work. Ioan explores their critiques of traditional morality, as well as their accounts of ethics, freedom and politics, arguing that we can best compare their respective philosophical physiologies, and their broader philosophical positions, through their shared interest in the notion of power. In spite of significant differences, Ioan shows the ways in which the two thinkers share remarkable similarities, delving into their emphatic appeal to the body as the key to solving fundamental philosophical problems, both theoretical and practical.

Revised, updated and expanded to continue to provide the most accurate, compact and practical source on fluoropolymers. Explores breakthroughs in understanding property-structure relationships, new polymerization techniques and the chemistry underlying polymers. Fluoropolymers are high up on the specialty polymers group and due to their unique properties, are naturally part of the solution to industrial sustainability challenges. Describes the technology of fluoropolymers, including thermoplastic and elastomeric products. Expands upon critical environmental aspects of fluoropolymers and recycling of these special polymers

Presents sensor specification, theory of operation, sensor design, and application criteria Provides background plus specific information for practicing engineers who want to understand sensors Includes a complete chapter on industrial sensor communication protocols Explains temperature sensitivity, how to determine, and how to avoid Discusses how to understand and utilize sensor specifications

Features • Presents an accessible introduction to the topic in addition to more advanced material for specialists in the field. • Covers a broad spectrum of topics this new field. • Contains exciting case studies and examples, such as quantum dots, bionanomaterials, and future perspectives.

An extensive list of print and nonprint resources is provided to facilitate further research. With the world's attention now focused on this vital issue, this volume will prove indispensable to school, public, and academic libraries. Includes biographical sketches of individuals and organizations committed to saving endangered species Provides an extensive list of print and nonprint resources to facilitate further research

Describes extensively the design and microfabrication of nanosensors based on nanotechnological tools. Provides a wide range of bioplatforms based on e.g., carbon nanostructures and Describes extensively a large number of application as a part of Nanomaterial based biosensors.

This unique volume provides an insight into bioactive compounds of tea from studies of both chemical structures and pharmacological aspects. Examples of the beneficial health effects of tea compounds in managing health problems and diseases are presented, with an emphasis on viral diseases such as COVID-19. Vaccines are not always available in many countries, thus simple and inexpensive measures which are easily available to help mitigate for example, the COVID-19 pandemic, are urgently needed. Dietary bioactive compounds could be alternative nutritional approaches in combating infection in addition to existing therapies and also upcoming vaccines and drugs, by enhancing their efficacy. Features : Emphasizes the antiviral activity of the tea compounds and the latest findings against Coronavirus and SARS-Cov-2. Provides a general overview of tea constituents, chemical structures of these compounds and their potential health benefits. Tea is one of the most commonly used beverages around the world and people with different backgrounds will be interested in reading about its health benefits. Correlating the therapeutic effect of tea components with COVID-19 is extremely beneficial for health care team members and general population. Assists the reader in understanding the therapeutic value of using tea to tackle COVID-19 symptoms, offering simple, inexpensive tips to help mitigate the virus.

Highlights the performance of epoxy-based biocomposites with reinforced with various natural fibres and plant resources. Investigates the behavior of hybrid biocomposites and biocomposites reinforced with various nanofillers. Evaluates the response of epoxy-based biocomposites exposed to moisture absorption, accelerated weathering, and hygrothermal aging. Discusses the static and dynamic properties, such as creep, fatigue, and free vibration properties. Chapters are written by global experts to cover a diverse scope of industry applications for fiber-reinforced polymer composites.

Highlights the utilization of nanofillers. Investigates the moisture absorption and ageing on the physio-chemical, mechanical, thermal properties of the vinyl ester-based composites. Considers the influence of hybridization, fibre architecture, and fibre-ply orientation on the mechanical and thermal properties of vinyl ester-based biocomposites. Discusses the effects of the alkali treatment. Chapters are written by global experts to cover a diverse scope of industry applications for fibre-reinforced polymer composites.

This comprehensive Monograph examines all peripheral and central mechanisms of regulating the secretion of milk from the lactating breast. The author reviews the complete female breast development, starting with the early childhood, up to pregnancy and lactation. Structural and ultrastructural data on the alveolar-ductal system, together with details of breast innervation, are used to investigate the physiological process of lactation. Readers will appreciate the special focus on reflexes, both in the child and the mother, that help to regulate maternal milk production and secretion. Following this, the author sheds a light on the composition and dynamics of milk components during the different periods of lactation. The final section of this volume focusses on practical aspects of modern breastfeeding, like the use of breast pumps or galactogogues, to influence the productivity of milk production. These fundamental principles and structural details will be particularly useful for physiologists and clinicians working in gynecology and pediatrics.

This book presents the proceedings of the 39th annual Midwest Biopharmaceutical Statistics Workshop (MBSW), held in Muncie, Indiana on May 16-18, 2016. It consists of selected peer- reviewed and revised papers on topics ranging from statistical applications in drug discovery and CMC to biomarkers, clinical trials, and statistical programming. All contributions feature original research, and together they cover the full spectrum of pharmaceutical R&D - with a special focus on emergent topics such as biosimilarity, bioequivalence, clinical trial design, and subgroup identification. Founded in 1978, the MBSW has provided a forum for statisticians to share knowledge, research, and applications on key statistical topics in pharmaceutical R&D for almost forty years, with the 2016 conference theme being "The Power and 3 I's of Statistics: Innovation, Impact and Integrity." The papers gathered here will be of interest to all researchers whose work involves the quantitative aspects of pharmaceutical research and development, including pharmaceutical statisticians who want to keep up-to-date with the latest trends, as well as academic statistics researchers looking for areas of application.

Pathology: Oxidative Stress and Dietary Antioxidants bridges the disciplinary knowledge gap to help advance medical sciences and provide preventative and treatment strategies for pathologists, health care workers, food scientists and nutritionists who have divergent skills. This is important as oxidative stress can be ameliorated with pharmacological, nutraceutical or natural agents. While pathologists and clinical workers understand the processes in disease, they are less conversant in the science of nutrition and dietetics. Conversely, nutritionists and dietitians are less conversant with the detailed clinical background and science of pathology. This book helps to fill those gaps.

Advances in Agronomy, Volume 161, continues to be recognized as a leading reference and first-rate source for the latest research in agronomy. Each volume contains an eclectic group of reviews by leading scientists throughout the world. As always, the subjects covered are rich, varied and exemplary of the abundant subject matter addressed by this long-running serial.

Metal-Air Batteries: Principles, Progress, and Perspectives covers the entire spectrum of metal-air batteries, their working principles, recent advancement, and future perspectives. Leading international researchers address materials design, electrochemistry, and architectural aspects. The fundamentals of metal-air materials for cathode and anode, their synthetic approaches, chemistries to modify their properties to provide high energy and power densities, along with long life and stable electrochemical characteristics are detailed. Key Features: Covers materials, chemistry, and technologies for metal-air batteries. Reviews state-of-the-art progress and challenges in metal-air batteries Provides fundamentals of the electrochemical behavior of various metal-air batteries. Offers insight into tuning the properties of materials to make them suitable for metal-air batteries. Provides new direction and a better understanding to scientists, researchers, and students working in diverse fields. This is a unique offering and a valuable resource for a wide range of readers including those in academia and industries worldwide.

This book highlights the recent advances of thermodynamics and biophysics in drug delivery nanosystems and in biomedical nanodevices. The up-to-date book provides an in-depth knowledge of bio-inspired nanotechnological systems for pharmaceutical applications. Biophysics and thermodynamics, supported by mathematics, are the locomotive by which the drug transportation and the targeting processes will be achieved under the light of the modern pharmacotherapy. They are considered as scientific tools that promote the understanding of physicochemical and thermotropic functionality and behavior of artificial cell membranes and structures like nanoparticulate systems. Therefore, this book focusses on new aspects of biophysics and thermodynamics as important elements for evaluating biomedical nanosystems, and it correlates their physicochemical, biophysical and thermodynamical behaviour with those of a living organism. In 2018, Prof. Demetzos was honored with an award by the Order of Sciences of the Academy of Athens for his scientific contribution in Pharmaceutical Nanotechnology.

This book commemorates the scientific contributions of distinguished statistician, Andrei Yakovlev. It reflects upon Dr. Yakovlev's many research interests including stochastic modeling and the analysis of micro-array data, and throughout the book it emphasizes applications of the theory in biology, medicine and public health. The contributions to this volume are divided into two parts. Part A consists of original research articles, which can be roughly grouped into four thematic areas: (i) branching processes, especially as models for cell kinetics, (ii) multiple testing issues as they arise in the analysis of biologic data, (iii) applications of mathematical models and of new inferential techniques in epidemiology, and (iv) contributions to statistical methodology, with an emphasis on the modeling and analysis of survival time data. Part B consists of methodological research reported as a short communication, ending with some personal reflections on research fields associated with Andrei and on his approach to science. The Appendix contains an abbreviated vitae and a list of Andrei's publications, complete as far as we know. The contributions in this book are written by Dr. Yakovlev's collaborators and notable statisticians including former presidents of the Institute of Mathematical Statistics and of the Statistics Section of the AAAS. Dr. Yakovlev's research appeared in four books and almost 200 scientific papers, in mathematics, statistics, biomathematics and biology journals. Ultimately this book offers a tribute to Dr. Yakovlev's work and recognizes the legacy of his contributions in the biostatistics community.