This book addresses how to estimate substance use and thereby evaluate policies intended to reduce the harms caused by drugs and other substances. Wastewater analysis (WWA) can provide efficient, affordable, fine-grained and objective data on population substance use trends on a very large scale. The authors discuss the potential implications of WWA as a new method for understanding substance use in a variety of settings and ignite a discourse with policy makers, criminologists, epidemiologists and other disciplines about the need for collaboration with WWA scientists. The book also features an explanation of the costs and harms of substance use with academic literature from criminological and epidemiological sources and reports from lead agencies. Additional features include: Details on the origin of wastewater analysis in environmental science Description of analytical chemistry methods for tracing a wide variety of substances, including illicit drugs, alcohol, tobacco and other chemicals Exploration of the major empirical problems in estimating population consumption of alcohol, tobacco and drugs at the international and national level Examination of the principles of human research ethics and their application to wastewater analysis Wastewater Analysis for Substance Abuse Monitoring and Policy Development is a valuable tool for analytical chemists, wastewater scientists and criminologists, as well as researchers and policy makers across disciplines who work in drug sectors.

The book fills a void as a textbook with hands-on laboratory exercises designed for biomedical engineering undergraduates in their senior year or the first year of graduate studies specializing in electrical aspects of bioinstrumentation. Each laboratory exercise concentrates on measuring a biophysical or biomedical entity, such as force, blood pressure, temperature, heart rate, respiratory rate, etc., and guides students though all the way from sensor level to data acquisition and analysis on the computer. The book distinguishes itself from others by providing electrical circuits and other measurement setups that have been tested by the authors while teaching undergraduate classes at their home institute over many years. Key Features: * Hands-on laboratory exercises on measurements of biophysical and biomedical variables * Each laboratory exercise is complete by itself and they can be covered in any sequence desired by the instructor during the semester * Electronic equipment and supplies required are typical for biomedical engineering departments * Data collected by undergraduate students and data analysis results are provided as samples * Additional information and references are included for preparing a report or further reading at the end of each chapter Students using this book are expected to have basic knowledge of electrical circuits and troubleshooting. Practical information on circuit components, basic laboratory equipment, and circuit troubleshooting is also provided in the first chapter of the book.

Intellectually Impaired People: The Ongoing Battle addresses challenges against the background of history, changing societal environments, and current intellectual approaches and attitudes toward persons with disabilities. The book discusses national and international conventions, societal attitudes, sheltered workshops, the right of intellectually impaired persons for self-responsibility and its limitations, and the place of mentally impaired persons in the public image. Additionally, the book attempts to capture the forces that drive the changes of our conceptual frameworks. The US Tuskegee study which withheld antibiotics from black men with syphilis was not ended by scientific criticism but by a courageous man, press reports, and a changed social perception. The non-hiding of handicapped children is not the result of government orders, there are many non-resolvable dilemmas and tension between supporting, understanding, and patronizing a complex situation with many potential future avenues.

Fundamental Causation addresses issues in the metaphysics of deterministic singular causation, the metaphysics of events, property instances, facts, preventions, and omissions, as well as the debate between causal reductionists and causal anti-reductionists. The book also pays special attention to causation and causal structure in physics. Weaver argues that causation is a multigrade obtaining relation that is transitive, irreflexive, and asymmetric. When causation is singular, deterministic and such that it relates purely contingent events, the relation is also universal, intrinsic, and well-founded. He shows that proper causal relata are events understood as states of substances at ontological indices. He then proves that causation cannot be reduced to some non-causal base, and that the best account of that relation should be unashamedly primitivist about the dependence relation that underwrites its very nature. The book demonstrates a distinctive realist and anti-reductionist account of causation by detailing precisely how the account outperforms reductionist and competing anti-reductionist accounts in that it handles all of the difficult cases while overcoming all of the general objections to anti-reductionism upon which other anti-reductionist accounts falter. This book offers an original and interesting view of causation and will appeal to scholars and advanced students in the areas of metaphysics, philosophy of science, and philosophy of physics.

Many wetlands around the world act as sinks for pollutants, in particular for trace elements. In comparison to terrestrial environments, wetlands are still far less studied. A collaborative effort among world experts, this book brings the current knowledge concerning trace elements in temporary waterlogged soils and sediments together. It discusses factors controlling the dynamics and release kinetics of trace elements and their underlying biogeochemical processes. It also discusses current technologies for remediating sites contaminated with trace metals, and the role of bioavailability in risk assessment and regulatory decision making. This book is intended for professionals around the world in disciplines related to contaminant bioavailability in aquatic organisms, contaminant fate and transport, remediation technologies, and risk assessment of aquatic and wetland ecosystems.

Organic chemistry research has moved rapidly toward synthesis and medicinal application of nitrogen-containing compounds such as triazenes, triazines, and hydroxytriazenes due to their excellent biological activities. Many of them are presently in clinical trials. Triazene compounds have excellent medicinal properties and limited toxicity. Hydroxytriazenes are excellent chelating agents for transition metals. Newer studies show very promising biological and medicinal applications of these classes of compounds. Hydroxytriazenes and Triazenes: The Versatile Framework, Synthesis, and Medicinal Applications highlights synthetic methods, recent advances, and potential applications of triazines, triazenes, and hydroxytriazenes. This book includes holistic information on synthetic methods for novel compounds based on this moiety, up-to-date information on the how and why of their diverse or even multitargeted medicinal application, and future state of the art of both aspects. Other features include: Highlights recent advances and diverse possible applications of biological functions Covers the chemistry of triazine, triazene, and hydroxytriazene systems On the basis of in silico predictions, the book highlights synthetic methods and their applications A valuable source of information for those actively engaged in medicinal chemistry, drug discovery, and synthetic organic chemistry

Provides clear instructions and step-by-step exercises to make learning the material easier for students. Emphasizes fundamental laboratory skills which prepare a student for the industry. Builds students' skills through an organized and systematic presentation of materials, procedures, and tasks. Updates reflect recent innovations and regulatory requirements to ensure students stay up to date. Supplies skills suitable for careers in forensic, clinical, quality control, environmental, and other testing laboratories.

This book is based on three undergraduate and postgraduate courses taught by the author on Matrix theory, Probability theory and Antenna theory over the past several years. It discusses Matrix theory, Probability theory and Antenna theory with solved problems. It will be useful to undergraduate and postgraduate students of Electronics and Communications Engineering. Print edition not for sale in South Asia (India, Sri Lanka, Nepal, Bangladesh, Pakistan and Bhutan).

Activities and biological relationships of terpenes. An accurate assessment of where and what terpenes can lead to. Discusses how microbes, in particular the actinomycetales, have well over 400 different gene clusters that produce terpenes. Arranged by biological activities and usage. Provides information on eukaryotic enzymes that have been shown to be a source of "ethnobotanical" terpenes

In the recent decades, the emerging new molecular measurement techniques and their subsequent availability in chemical database has allowed easier retrieval of the associated data by the chemical analyst. Before the data revolution, most books focused either on mathematical modeling of chemical processes or exploratory chemometrics. Computational and Statistical Methods for Chemical Engineering aims to combine these two approaches and provide aspiring chemical engineers a single, comprehensive account of computational and statistical methods. The book consists of four parts: Part I discusses the necessary calculus, linear algebra, and probability background that the student may or may not have encountered before. Part II provides an overview on standard computational methods and approximation techniques useful for chemical engineering systems. Part III covers the most important statistical models, starting from simple measurement models, via linear models all the way to multivariate, non-linear stochiometric models. Part IV focuses on the importance of designed experiments and robust analyses. Each chapter is accompanied by an extensive selection of theoretical and practical exercises. The book can be used in combination with any modern computational environment, such as R, Python and MATLAB. Given its easy and free availability, the book includes a bonus chapter giving a simple introduction to R programming. This book is particularly suited for undergraduate students in Chemical Engineering who require a semester course in computational and statistical methods. The background chapters on calculus, linear algebra and probability make the book entirely self-contained. The book takes its examples from the field of chemistry and chemical engineering. In this way, it motivates the student to engage actively with the material and to master the techniques that have become crucial for the modern chemical engineer.

Presents technical perspectives on emerging wastes in developing economies. Discusses the issues of e-waste which is growing three times faster than general municipal waste globally. Covers the spectrum of nanowaste to upcycling in the market. Discusses management of marine plastic debris and microplastics. Diverse audience including those in solid waste management, electrical and electronic technology, and the medical industry

Reflecting the fast pace of research in the field, the Second Edition of Bulk Metallic Glasses has been thoroughly updated and remains essential reading on the subject. It incorporates major advances in glass forming ability, corrosion behavior, and mechanical properties. Several of the newly proposed criteria to predict the glass-forming ability of alloys have been discussed. All other areas covered in this book have been updated, with special emphasis on topics where significant advances have occurred. These include processing of hierarchical surface structures and synthesis of nanophase composites using the chemical behavior of bulk metallic glasses and the development of novel bulk metallic glasses with high-strength and high-ductility and superelastic behavior. New topics such as high-entropy bulk metallic glasses, nanoporous alloys, novel nanocrystalline alloys, and soft magnetic glassy alloys with high saturation magnetization have also been discussed. Novel applications, such as metallic glassy screw bolts, surface coatings, hyperthermia glasses, ultra-thin mirrors and pressure sensors, mobile phone casing, and degradable biomedical materials, are described. Authored by the world's foremost experts on bulk metallic glasses, this new edition endures as an indispensable reference and continues to be a one-stop resource on all aspects of bulk metallic glasses.

This book provides a systematic presentation of the mathematical foundation of modern physics with applications particularly within classical mechanics and the theory of relativity. Written to be self-contained, this book provides complete and rigorous proofs of all the results presented within. Among the themes illustrated in the book are differentiable manifolds, differential forms, fiber bundles and differential geometry with non-trivial applications especially within the general theory of relativity. The emphasis is upon a systematic and logical construction of the mathematical foundations. It can be used as a textbook for a pure mathematics course in differential geometry, assuming the reader has a good understanding of basic analysis, linear algebra and point set topology. The book will also appeal to students of theoretical physics interested in the mathematical foundation of the theories.

Interaction of Radiation with Matter focuses on the physics of the interactions of ionizing radiation in living matter and the Monte Carlo simulation of radiation tracks. Clearly progressing from an elementary level to the state of the art, the text explores the classical physics of track description as well as modern aspects based on condensed matter physics. The first section of the book discusses the fundamentals of the radiation field. In the second section, the authors describe the cross sections for electrons and heavy ions-the most important information needed for simulating radiation track at the molecular level. The third section details the inelastic scattering and energy loss of charged particles in condensed media, particularly liquid water. The final section contains a large number of questions and problems to reinforce learning. Designed for radiation interaction courses, this textbook is the ideal platform for teaching students in medical/health physics and nuclear engineering. It gives students a solid grounding in the physical understanding of radiation track structure in living matter, enabling them to pursue further work in radiological physics and radiation dosimetry.

The role of metal ions in protein folding and structure is a critical topic to a range of scientists in numerous fields, particularly those working in structural biology and bioinorganic chemistry, those studying protein folding and disease, and those involved in the molecular and cellular aspects of metals in biological systems. Protein Folding and Metal Ions: Mechanisms, Biology and Disease presents the contributions of a cadre of international experts who offer a comprehensive exploration of this timely subject at the forefront of current research. Divided into four sections, this volume: Provides case study examples of protein folding and stability studies in particular systems or proteins that comprise different metal ions of co-factors Reviews the proteins that shuttle metal ions in the cell to a particular target metalloprotein Illustrates how metal binding can be connected to pathological protein conformations in unrelated diseases, from cancer to protein deposition disorders such as Parkinson's disease Addresses protein redesign of metal-containing proteins by computational methods, folding simulation studies, and work on model peptides - dissecting the relative energetic contribution of metals sites to protein folding and stability Together, the 13 chapters in this text cogently describe the state of the science today, illuminate current challenges, propose future possibilities, and encourage further study in this area that offers much promise especially with regard to novel approaches to the treatment of some of the most challenging and tragic diseases.

A dangerous byproduct of industrial progress is often an increase of pollutants discharged into the environment. These pollutants are often harmful to plants and animals, including humans. They also damage buildings and architectural and cultural monuments. This handbook describes many of the important physico-chemical properties of inorganic and organic substances found in industrial wastes and describes their toxic effects on humans.

Describes various electrochemical processes related to the renewable compounds, including hydrogen evolution, oxygen evolution, oxygen reduction, carbon dioxide reduction, nitrogen reduction, methanol oxidation, urea oxidation and ammonia oxidation. Highlights fundamental aspects, catalysts designing principles and measurement criteria of different electrochemical transformations. Covers the important electrocatalysts, including transition metal phosphide-based electrocatalysts, earth-abundant electrocatalysts, graphene-supported nanomaterials, self-supported nanoarrays, single-atom catalysts and MOFs derived electrocatalysts. Explores the strategies and mechanisms for improving the electrocatalytic performance of various electrocatalysts. Discusses future development of renewable compounds produced by electrochemical transformation.

Key features: * Builds an integrated perspective of photovoltaics by highlighting the essential role of nanotechnology in each type of solar cell. * Performs simplified mathematical analysis of operational mechanisms of nanostructured solar cells supplemented with solved examples. * Enhances learning with clear explanations of technological advances and illustrative diagrams without sacrificing scientific rigor.

Highlights nanotechnology applications in smart buildings. Reviews nano-enhanced glass and phase change materials for energy saving and energy storage. Discusses nanomaterials used in air purification applications as well as sustainable pigments. Covers latest developments in polymers, glasses, coatings, paints, and insulating materials.

This timely book provides a succinct summary of methods for the synthesis of bioactive heterocycles using a multicomponent reaction (MCR) approach. The majority of pharmaceuticals and biologically active agrochemicals are heterocycles while countless additives and modifiers used in industrial applications are heterocyclic in nature. With the recent introduction of high-throughput biological evaluation, the importance of MCRs for drug discovery has been recognized and considerable efforts have been focused especially on the design and development of multi-component procedures for the generation of various bioactive heterocycles due to their significant therapeutic potential.

Provides a broad introduction to nanophysics and nanotechnologies, and the importance of low-dimensional and surface physics is discussed indepth. Chapters in Volume 1 covers the large range of physical preparation techniques available for the production of nanomaterials and nanostructuring.

Nanotechnologies represent a fast-growing market and this unique volume highlights the current studies in applied sciences on sustainability of green science and technology. The chapters include modelling, machine learning, nanotechnology, nanofluids, nanosystems, smart materials and applications and solar and fuel cells technology. The authors cover simulation, additive manufacturing, machine learning and the autonomous system. Various aspects of green science as well as trans-disciplinary topics between fundamental science and engineering are presented.The book is suitable for all postgraduates and researchers working in this rapid growing research area. Features Presenting latest research on green materials and sustainability. Provide in depth discussion on modeling and simulation using latest techniques. Technical exposure for the readers on additive manufacturing principles. Numerous examples on nanofluids and nano technology are presented. Discusses computer modeling, superconductivity, nanotubes and related structures such as graphene.

Features Edited by established authorities in the field, with chapter contributions from subject area specialists. Provides a comprehensive review of the field. Up to date with the latest developments and cutting-edge research.

This book focuses on flame retardants (FR) for textile materials. It discusses basics of flame retardancy and flammability and covers various types of flame retardants and materials, including natural FRs, halogen, phosphorous, and nanomaterial-based FRs. This book also discusses methods of applications of FRs and discusses FRs and the environment. Covers a variety of interdisciplinary applications in the textile industry Emphasizes environmental aspects Reports on a large number of FR compounds studied globally Discusses in detail recent developments in halogen-free eco-friendly flame retardants Extensively describes basic aspects of flame retardancy and their measurements Aimed at the practitioner and textile engineering professional this work aims to ensure development of safe textile materials for various uses, including apparel, protective wear, floor coverings, upholstery, drapery, and others.

Finite Element Analysis of Weld Thermal Cycles Using ANSYS aims at educating a young researcher on the transient analysis of welding thermal cycles using ANSYS. It essentially deals with the methods of calculation of the arc heat in a welded component when the analysis is simplified into either a cross sectional analysis or an in-plane analysis. The book covers five different cases involving different welding processes, component geometry, size of the element and dissimilar material properties. A detailed step by step calculation is presented followed by APDL program listing and output charts from ANSYS. Features: Provides useful background information on welding processes, thermal cycles and finite element method Presents calculation procedure for determining the arc heat input in a cross sectional analysis and an in-plane analysis Enables visualization of the arc heat in a FEM model for various positions of the arc Discusses analysis of advanced cases like dissimilar welding and circumferential welding Includes step by step procedure for running the analysis with typical input APDL program listing and output charts from ANSYS.