Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers provides a comprehensive introduction to collagen and structural proteins. Type I collagen is one of the most abundant molecules in the body, playing essential roles in different tissues, particularly bone and skin. A key aspect of type I collagen is its post-translational modifications which are essential for correct synthesis and structural integrity of collagens, for tissue-specific functionality, as well as for application as biomarkers of different pathologies. This volume summarizes current data on key structural proteins (collagens, laminins and elastin), reviews how these molecules affect pathologies, and describes selected modifications of proteins that result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the ECM harbor cryptic signaling functions that may be viewed as endocrine functions. Additionally, it highlights how this knowledge can be exploited to modulate fibrotic disease.

Understanding of the interactions of milk proteins in complex food systems continues to progress, resulting in specialized milk-protein based applications in functional foods, and in protein ingredients for specific health applications. Milk Proteins is the first and only presentation of the entire dairy food chain - from the source to the nutritional aspects affecting the consumer. With focus on the molecular structures and interactions of milk proteins in various processing methods, Milk Proteins presents a comprehensive overview of the biology and chemistry of milk, as well as featuring the latest science and developments. Significant insight into the use of milk proteins from an industry viewpoint provides valuable application-based information. Those working with food and nutritional research and product development will find this book useful.

This highly informative and carefully presented book comprises select proceedings of Foundation for Molecular Modelling and Simulation (FOMMS 2018). The contents are written by invited speakers centered on the theme Innovation for Complex Systems. It showcases new developments and applications of computational quantum chemistry, statistical mechanics, molecular simulation and theory, and continuum and engineering process simulation. This volume will serve as a useful reference to researchers, academicians and practitioners alike.

* A new approach that breaks new ground using psychophysics and mathematics in order to investigate human interaction * Identifies the critical direction of change, and the means to achieve it, in order to maintain a stable social environment that is going to require testable and provable theories that apply to our social space and the various cultures and groups that exist within it * An important text for graduate and advanced undergraduate students or classes, along with private and government analysts all operating within the areas of political theory, detection theory, social psychology, organizational behavior, psychophysics, and applied mathematics in the social and information sciences

Demonstrates the conditions under which a 2D-LC method should be considered as an alternative to a 1D-LC method. Establishes a sound fundamental basis of the principles of the technique, followed by guidelines for method optimization. Provides a single source for technical knowledge advances and practical guidance described in recent literature. Assists with the initial decision to develop a 2D-LC method. Guides the reader in developing a high-quality method that meets the needs of their application.

Covers all aspects of gold nanorods along with selected protocols Focuses on synthetic chemistry, optical property, and fictionalization approach of colloidal gold nanorods Describes standard synthetic methods and advantage of gold nanorods in biomedical applications Includes authentic and reproducible experimental procedures Discusses applications like redox catalyst, catalyst promoter, delivery carrier, solar cell material, and so forth

Mathematics and Music: Composition, Perception, and Performance, Second Edition includes many new sections and more consistent expectations of a student's experience. The new edition of this popular text is more accessible for students with limited musical backgrounds and only high school mathematics is required. The new edition includes more illustrations than the previous one and the added sections deal with the XronoMorph rhythm generator, musical composition, and analyzing personal performance. The text teaches the basics of reading music, explaining how various patterns in music can be described with mathematics, providing mathematical explanations for musical scales, harmony, and rhythm. The book gives students a deeper appreciation showing how music is informed by both its mathematical and aesthetic structures. Highlights of the Second Edition: Now updated for more consistent expectations of students' backgrounds More accessible for students with limited musical backgrounds Full-color presentation Includes more thorough coverage of spectrograms for analyzing recorded music Provides a basic introduction to reading music Features new coverage of building and evaluating rhythms

Introduction to Biological Membranes: Composition, Structure and Function, Second Edition is a greatly expanded revision of the first edition that integrates many aspects of complex biological membrane functions with their composition and structure. A single membrane is composed of hundreds of proteins and thousands of lipids, all in constant flux. Every aspect of membrane structural studies involves parameters that are very small and fast. Both size and time ranges are so vast that multiple instrumentations must be employed, often simultaneously. As a result, a variety of highly specialized and esoteric biochemical and biophysical methodologies are often utilized. This book addresses the salient features of membranes at the molecular level, offering cohesive, foundational information for advanced undergraduate students, graduate students, biochemists, and membranologists who seek a broad overview of membrane science.

Quorum sensing (QS) describes a chemical communication behavior that is nearly universal among bacteria. Individual cells release a diffusible small molecule (an autoinducer) into their environment. A high concentration of this autoinducer serves as a signal of high population density, triggering new patterns of gene expression throughout the population. However QS is often much more complex than this simple census-taking behavior. Many QS bacteria produce and detect multiple autoinducers, which generate quorum signal cross talk with each other and with other bacterial species. QS gene regulatory networks respond to a range of physiological and environmental inputs in addition to autoinducer signals. While a host of individual QS systems have been characterized in great molecular and chemical detail, quorum communication raises many fundamental quantitative problems which are increasingly attracting the attention of physical scientists and mathematicians. Key questions include: What kinds of information can a bacterium gather about its environment through QS? What physical principles ultimately constrain the efficacy of diffusion-based communication? How do QS regulatory networks maximize information throughput while minimizing undesirable noise and cross talk? How does QS function in complex, spatially structured environments such as biofilms? Previous books and reviews have focused on the microbiology and biochemistry of QS. With contributions by leading scientists and mathematicians working in the field of physical biology, this volume examines the interplay of diffusion and signaling, collective and coupled dynamics of gene regulation, and spatiotemporal QS phenomena. Chapters will describe experimental studies of QS in natural and engineered or microfabricated bacterial environments, as well as modeling of QS on length scales spanning from the molecular to macroscopic. The book aims to educate physical scientists and quantitative-oriented biologists on the application of physics-based experiment and analysis, together with appropriate modeling, in the understanding and interpretation of the pervasive phenomenon of microbial quorum communication."

Introduces a new way of looking at various important and fundamental phenomena in condensed matter from the perspective of microscopic theory Explores a new interface of quantum condensed matter physics and molecular biophysics, highlighting research potentialities Addresses the crucial questions surrounding these phenomena when they are mutually coexisting or competing in real condensed matter systems or materials, from both theoretical and experimental angles Deals with biological molecules and some of their properties and processes and discusses the modeling of these with the help of condensed matter physics and statistical physics Emphasizes fundamental concepts, particularly in condensed matter physics and making proper use of them

This book provides an overview of the emerging topics in biostatistical theories and methods through their applications to evidence-based global health research and decision-making. It brings together some of the top scholars engaged in biostatistical method development on global health to highlight and describe recent advances in evidence-based global health applications. The volume is composed of five main parts: data harmonization and analysis; systematic review and statistical meta-analysis; spatial-temporal modeling and disease mapping; Bayesian statistical modeling; and statistical methods for longitudinal data or survival data. It is designed to be illuminating and valuable to both expert biostatisticians and to health researchers engaged in methodological applications in evidence-based global health research. It is particularly relevant to countries where global health research is being rigorously conducted.

The importance of protecting the environment against pollution is an objective which gained international acceptance in the recent years. According to the first principle of the Declaration of the United Nations Conference on the Human Environment which took place in Stockholm in 1972, "man .... bears a solemn responsibility to protect and improve the environment for present and future genera tions." The United Nations again in their desire to improve the sanitation conditions allover the world decided to proclaim the period between 1981-1990 as the "International Drinking Water Supply and Sanitation Decade." Although attempts have been made by inter national organizations to prevent pollution, it is difficult to say that these attempts gave satisfactory results in developing countries. The most common reasons of failure are: a) To find solutions to their environmental problems, develop ing countries usually seek the assistance of engineers and scientists from developed countries. Many times, how ever, either out of ignorance of the local condition or due to financial motivations, these experts come out with solutions which are far from being considered as the "most appropriate." As a result, the basic objective of protecting the environment is not achieved. b) Attempts made by developed countries to "export" their wastes - especially the hazardous ones - to the developing world, is another danger - and sometimes reason of failure encountered in the field of Environmental Management."

A stand-alone, monograph present results on mechanochemical synthesis of nanostructured composite materials on the base of inorganic and organic components The book summarizes and systematizes the results of a fundamentally new complex approach to the creation of composite polymer-inorganic systems by mechanochemical treatment, both as a result of the traditional approach with the use of dynamic mills (mechanical reactors) and ultrasonic action on powder mixtures In addition, the book will present a chapter that will focus on the method of mechanochemical preparation of materials for high-energy systems, which are the most promising, since it allows the most productive management of the formation of new structural compositions that increase the energy intensity of the system.

Features * Provides a self-contained introduction to General Relativity and to its standar applications. * Presents readers with all the tools necessary for further learning and research in the field. * Accessible to readers with just foundational knowledge of linear algebra and Lagrangian mechanics.

Project managers in drug development are the driving force behind the coordination of efforts. This book provides a practical reference for project managers in the pharmaceutical and biotech drug development industry, with the goal of assisting in creating an efficient and effective team structure and environment. The text details the role of project managers at each stage of drug development, the key interfaces that the PM will need to work closely with, and essential tools of the trade including frequently used techniques and methodologies. This book is useful for both entry-level and advanced-level PMs, as well as non-project managers from other functions. Features Includes authors' recent experience with improved tactics and technologies/software at various stages of drug development. Provides the most up-to-date and best practices, techniques, and methodologies in project management. Details the role of the PM at each stage of drug development, including working with the key interfaces throughout the process. Diverse audience including nonproject managers in clinical development, clinical operations, regulatory affairs, medical affairs, clinical pharmacology, and biostatistics. Provides templates and timelines for critical paths from development to commercialization and has potential as a textbook on relevant courses.

Cold Plasma in Food and Agriculture: Fundamentals and Applications is an essential reference offering a broad perspective on a new, exciting, and growing field for the food industry. Written for researchers, industry personnel, and students interested in nonthermal food technology, this reference will lay the groundwork of plasma physics, chemistry, and technology, and their biological applications. Food scientists and food engineers interested in understanding the theory and application of nonthermal plasma for food will find this book valuable because it provides a roadmap for future developments in this emerging field. This reference is also useful for biologists, chemists, and physicists who wish to understand the fundamentals of plasma physics, chemistry, and technology and their biological interactions through applying novel plasma sources to food and other sensitive biomaterials.

Describes various electrochemical processes related to the renewable compounds, including hydrogen evolution, oxygen evolution, oxygen reduction, carbon dioxide reduction, nitrogen reduction, methanol oxidation, urea oxidation and ammonia oxidation. Highlights fundamental aspects, catalysts designing principles and measurement criteria of different electrochemical transformations. Covers the important electrocatalysts, including transition metal phosphide-based electrocatalysts, earth-abundant electrocatalysts, graphene-supported nanomaterials, self-supported nanoarrays, single-atom catalysts and MOFs derived electrocatalysts. Explores the strategies and mechanisms for improving the electrocatalytic performance of various electrocatalysts. Discusses future development of renewable compounds produced by electrochemical transformation.

This book covers a wide range of problems involving the applications of stochastic processes, stochastic calculus, large deviation theory, group representation theory and quantum statistics to diverse fields in dynamical systems, electromagnetics, statistical signal processing, quantum information theory, quantum neural network theory, quantum filtering theory, quantum electrodynamics, quantum general relativity, string theory, problems in biology and classical and quantum fluid dynamics. The selection of the problems has been based on courses taught by the author to undergraduates and postgraduates in Electronics and Communications Engineering. Print edition not for sale in South Asia (India, Sri Lanka, Nepal, Bangladesh, Pakistan or Bhutan).

This book deals with a variety of problems in Physics and Engineering where the large deviation principle of probability finds application. Large deviations is a branch of probability theory dealing with approximate computation of the probabilities of rare events. It contains applications of the LDP to pattern recognition problems like analysis of the performance of the EM algorithm for optimal parameter estimation in the presence of weak noise, analysis and control of non-Abelian gauge fields in the presence of noise, and quantum gravity wherein we are concerned with perturbation to the quadratic component of the Einstein-Hilbert Hamiltonian caused by higher order nonlinear terms in the position fields and their effect on the Gibbs statistics and consequently quantum probabilities of events computed using the quantum Gibbs state. The reader will also find in this book applications of LDP to quantum filtering theory as developed by Belavkin based on the celebrated Hudson-Parthasarathy quantum stochastic calculus. Print edition not for sale in South Asia (India, Sri Lanka, Nepal, Bangladesh, Pakistan and Bhutan).

Machine Learning in Bioinformatics of Protein Sequences guides readers around the rapidly advancing world of cutting-edge machine learning applications in the protein bioinformatics field. Edited by bioinformatics expert, Dr Lukasz Kurgan, and with contributions by a dozen of accomplished researchers, this book provides a holistic view of the structural bioinformatics by covering a broad spectrum of algorithms, databases and software resources for the efficient and accurate prediction and characterization of functional and structural aspects of proteins. It spotlights key advances which include deep neural networks, natural language processing-based sequence embedding and covers a wide range of predictions which comprise of tertiary structure, secondary structure, residue contacts, intrinsic disorder, protein, peptide and nucleic acids-binding sites, hotspots, post-translational modification sites, and protein function. This volume is loaded with practical information that identifies and describes leading predictive tools, useful databases, webservers, and modern software platforms for the development of novel predictive tools.

This book explains omics at the most basic level, including how this new concept can be properly utilized in molecular and systems biology research. Most reviews and books on this topic have mainly focused on the technicalities and complexity of each omics' platform, impeding readers to wholly understand its fundamentals and applications. This book tackles such gap and will be most beneficial to novice in this area, university students and even researchers. Basic workflow and practical guidance in each omics are also described, such that scientists can properly design their experimentation effectively. Furthermore, how each omics platform has been conducted in our institute (INBIOSIS) is also detailed, a comprehensive example on this topic to further enhance readers' understanding. The contributors of each chapter have utilized the platforms in various manner within their own research and beyond. The contributors have also been interactively integrated and combined these different omics approaches in their research, being able to systematically write each chapter with the conscious knowledge of other inter-relating topics of omics. The potential readers and audience of this book can come from undergraduate and postgraduate students who wish to extend their comprehension in the topics of molecular biology and big data analysis using omics platforms. Furthermore, researchers and scientists whom may have expertise in basic molecular biology can extend their experimentation using the omics technologies and workflow outlined in this book, benefiting their research in the long run.

Covers the fundamentals and research on graphene, including synthesis, properties, and various applications of graphene nanosheets Is a unique book on such an advanced research topic Gives an overview of the current status of the research and development in graphene Is illustrated throughout with excellent figures and includes latest references to accompany each section

Presents cutting-edge research in biomedical engineering from materials, devices, imaging, and information perspectives All chapters are results of collaborative research in engineering and life sciences Useful resource for researchers, students, and general readers in biomedical engineering

Nanotechnology has the potential to change every part of our lives. Today, nanotechnology-based products are used in many areas, and one of the most important areas is drug delivery. Nanoparticulate drug delivery systems not only provide controlled delivery of drugs and improved drug solubility but also improve drug efficiency and reduce side effects via targeting mechanisms. However, compared with conventional drug delivery systems, few nanoparticle-based products are on the market and almost all are nontargeted or only passively targeted systems. In addition, obtaining targeted nanoparticle systems is quite complex and requires several evaluation mechanisms. This book discusses the production, characterization, regulation, and currently marketed targeted nanoparticle systems in a broad framework. It provides an overview of targeted nanoparticles' (i) in vitro characterization, such as particle size, stability, ligand density, and type; (ii) in vivo behavior for different targeting areas, such as tumor, brain, and vagina; and (iii) current advances in this field, including clinical trials and regulation processes.

Collates the most relevant and up to date information on renewable energy systems in a user friendly format for undergraduate and high school students Focused on power production technologies from renewable energy sources. An introduction to how sources of renewable energy work; their advantages and drawbacks. Timely text with the need for fast adoption of renewable energy technologies around the world. Diverse audience including students with some scientific background such as final year in high school wanting to know more about combatting climate change.