Following recent developments in hypofractionated stereotactic radiation therapy (SRT) for brain and spine tumors, this new edition offers a fully updated and comprehensive "how-to" guidance on hypofractionated SRT for brain and spine metastases, glioma, benign tumors, and other tumor types. Presenting the state of the art of the technology and practice, this book: * Discusses the pros and cons of hypofractionated SRT compared to single-fraction radiosurgery, providing a deeper understanding of radiosurgery and radiobiology * Explains the toxicity and adverse effects of hypofractionated SRT including the dosage of 24 Gy in two spine SBRT fractionation schemes, aiding practitioners in communicating the risks and benefits of treatment and in obtaining consent from their patients * Outlines the current standards for safe practice, including checklists for implementation * Explores new technologies for brain and spine tumors including LITT, MR-guided focused ultrasound, and Zap technology, with chapters authored by well-recognized experts in the radiation, oncology, and neurosurgery communities; this book delivers a level of technological and clinical detail not available in journal papers This book is suitable for radiation oncologists, neurosurgeons, and medical physicists who specialize in brain and/or spine radiosurgery or want to start a program and need a comprehensive reference with key checklists for practice.

Includes over 250 solved problems to supplement graduate-level courses in fluid mechanics and turbomachinery. Enables students to practice applying key concepts of fluid mechanics and the governing conservation laws to solve real-world problems. Uses the physics-first approach, allowing for a good understanding of the problem physics and the results obtained. Covers problems on flowpath aerodynamics design. Covers problems on secondary air systems modeling of gas turbines.

The Basics of Investigating Forensic Science: A Laboratory Manual, Second Edition presents foundational concepts in forensic science through hands-on laboratory techniques and engaging exercises. The text offers numerous lab projects on a range of subjects including fingerprinting, shoeprint analysis, firearms, pathology, anthropology, forensic biology and DNA, drugs, trace evidence analysis, and more. This Second Edition is fully updated to include extensive full-color photos and diagrams to reflect current best-practices focussing on laboratory procedure, techniques, and interpretation of results. Each laboratory illustrates processes and concepts, and how the equipment should be set up for a given exercise. Many of the exercises can be done with minimal laboratory equipment and material while certain exercises also have additional options and advanced lab exercises-for those education institutions with access to more specialized or advance laboratory equipment. While the sequencing of laboratory exercises in the book is designed to follow The Basics textbook, the lab exercises are intentionally modular can be performed in any sequence desired by an instructor. The Basics of Investigating Forensic Science, Second Edition is an excellent resource for introduction to forensic sciences courses, including the companion textbook it was designed to accompany, Forensic Science: The Basics, Fourth Edition (ISBN: 9780367251499). The book can be used alongside any textbook, and even serve as a stand-alone text for two- and four-year college programs, as well as course at the high school level.

Volume 13: Pineal, Pituitary, and Spinal Tumors is organized in six sections, for convenience and quick access to critical information. Section I, Types of Tumors includes a chapter on molecular characterization of Embryonal tumors, a chapter on diagnosis of metastatic oligodendroglioma using fine-needle aspiration cytology, one covering intra-arterial chemotherapy of oligodendroglial tumors and another on the role of cyclooxygenase-2 in the development and growth of Schwannomas, and others, closing with a chapter on trigeminal neuralgia with cerebellopontine angle tumors. Section II, Diagnosis, includes two chapters on cell counting in histopathologic slides of tumors. Section III offers three chapters which discuss aspects of intraoperative ultrasonography. Section IV covers brain tumor surgery, and Section V surveys Brain Metastasis. The final section offers a wide-ranging review of General Diseases, with chapters on, among others, Alexander Disease; Lipoma; Transplantation of human umbilical cord blood mononuclear cells in cases of neonatal hypoxic-ischemic brain damage; and a chapter discussing the use of mobile phones and brain cancer risk in children. Like its twelve predecessors in the series, this volume merits distinction for its thorough approach, its roster of 78 distinguished contributors representing 14 different countries and its detailed examination of leading-edge technology and methods.

Medicinal Plants in the Asia Pacific for Zoonotic Pandemics provides an unprecedented, comprehensive overview of the phylogeny, botany, ethnopharmacology, and pharmacology of more than 100 plants used in the traditional medical systems of Asia and Pacific. It discusses their actions and potentials against viruses, bacteria, and fungi that represent a threat of epidemic and pandemic diseases, with an emphasis on the molecular basis and cellular pathways. This book presents scientific names, the botanical classification, traditional medicinal uses, active chemical constituents, and pharmacology. This volume is a critical reference for anyone involved in the discovery of lead molecules or phytopharmaceutical products for the prevention or treatment of pandemic viral, bacterial, or fungal infections. FEATURES Phylogenetic presentation of medicinal plants and a chemotaxonomical rationale of antiviral, antibacterial, and antifungal actions Discusses the chemical structure-activity relationship, pharmacokinetics, and oral bioavailability of antimicrobial principles Introduces the molecular mechanism of natural products on viruses, bacteria, and fungi Contains a selection of botanical plates and useful bibliographic references This book is a useful research tool for postgraduates, academics, and the pharmaceutical, herbal, and nutrition industries. Medicinal Plants in the Asia Pacific for Zoonotic Pandemics includes commentary sections that invite further research and reflection on the fascinating and timely subject of the development of drugs and herbals from Asia-Pacific medicinal plants to safeguard humanity and other life forms against the forthcoming waves of viral, bacterial, or fungal pandemics. This book is an ideal reference text for medicinal plant enthusiasts.

Surface Chemistry of Carbon Capture: Climate Change Aspects provides comprehensive and up-to-date literature on carbon capture and storage (CCS) technology and delineates the surface chemistry of this process. Mankind is dependent on energy from gas, oil, coal, atomic energy, and various other sources. In all fossil fuel combustion processes, carbon dioxide (CO2) is produced (ca. 25 Gt/year). In the past few decades, we have observed a constant increase in CO2 content in the air (currently ca. 400 ppm [0.04%]). This book discusses the technology related to carbon (i.e., CO2) capture and sequestration (CCS) from fossil fuel energy plants, which is considered an important means of CO2 control. It also covers the adsorption/absorption processes of CO2 on solids and similar procedures to help address growing climate change concerns.

Medicinal Plants in the Asia Pacific for Zoonotic Pandemics provides an unprecedented, comprehensive overview of the phylogeny, botany, ethnopharmacology, and pharmacology of more than 100 plants used in the traditional medical systems of Asia and Pacific. It discusses their actions and potentials against viruses, bacteria, and fungi that represent a threat of epidemic and pandemic diseases, with an emphasis on the molecular basis and cellular pathways. This book presents scientific names, the botanical classification, traditional medicinal uses, active chemical constituents, and pharmacology. This volume is a critical reference for anyone involved in the discovery of lead molecules or phytopharmaceutical products for the prevention or treatment of pandemic viral, bacterial, or fungal infections. FEATURES Phylogenetic presentation of medicinal plants and a chemotaxonomical rationale of antiviral, antibacterial, and antifungal actions Discusses the chemical structure-activity relationship, pharmacokinetics, and oral bioavailability of antimicrobial principles Introduces the molecular mechanism of natural products on viruses, bacteria, and fungi Contains a selection of botanical plates and useful bibliographic references This book is a useful research tool for postgraduates, academics, and the pharmaceutical, herbal, and nutrition industries. Medicinal Plants in the Asia Pacific for Zoonotic Pandemics includes commentary sections that invite further research and reflection on the fascinating and timely subject of the development of drugs and herbals from Asia-Pacific medicinal plants to safeguard humanity and other life forms against the forthcoming waves of viral, bacterial, or fungal pandemics. This book is an ideal reference text for medicinal plant enthusiasts.

Rare Isotope Beams (RIBs) are ion beams of exotic radioactive nuclei. The study of these nuclei is key to understanding the limits of nuclear existence, nucleo-synthesis in such violent stellar sites as supernovae and merging neutron stars, and the fundamental symmetries of nature. These nuclei also provide a unique probe to study condensed matter and many of them are potentially new radioisotopes for more effective medical diagnostics and therapy. Rare Isotope Beams: Concepts and Techniques gives an up-to-date overview of all these aspects of RIB science in a single volume containing the scientific motivation, production techniques, experimental techniques for studying exotic nuclei, methods used in condensed matter research, and medical applications. The emphasis throughout is on concepts to facilitate understanding of the essence of each topic in this diverse and cross-disciplinary field involving nuclear physics, astrophysics, and particle accelerators. A brief description of major RIB facilities is also presented. Exotic nuclei are difficult to produce in enough numbers and their production involves different nuclear reaction routes and a wide range of advanced technologies, which are presented in a comprehensive manner. Experimental techniques used to study exotic nuclei are provided with examples highlighting the intricate nature of such experiments. Another unique feature is the open-ended nature of the discussions, bringing out the future challenges and possibilities in this evolving field. The book offers an excellent overview of concepts and techniques involved in RIB science for new researchers entering the field as well as professionals.

This new volume presents various research studies that focus on the development of advanced nanomaterials and their composites and blends for different applications in sensing, electrical, biomedical, coating, industrial applications, etc. This book includes detailed discussions on the synthesis, properties, processing, and potential applications of nanomaterials and their blends and composites. Some chapters also explain the basic theoretical aspects of these nanostructured materials and systems, which help readers to develop a better understanding various application areas, including construction. Nanostructured Smart Materials: Synthesis, Characterization and Potential Applications responds to the need for advanced polymeric materials and nanostructured materials with ultimate performance and enhanced qualities and properties for varied applications. The chapters highlight information and research that will be valuable for development of new smart materials. This book will be a useful reference source for universities, colleges, researchers from R&D groups, scientists, postdoctoral fellows, industrialists, graduate and postgraduate students, and faculty.

Generally speaking, quantitative-structure activity relationship (QSAR) is a technique which correlates the biological activities of a set of compounds to their structures using a mathematical equation represented in its general form by Biological Activity = f (x1, ..., xn), where f is a mathematical function and x1, ..., xn are n molecular descriptors. Since the introduction of the initial concept of QSAR in the early 1960s, numerous advances have been introduced into the field transforming it into an essential tool in drug discovery and medicinal chemistry. Quantitative Structure - Activity Relationship: A Practical Approach provides a detailed overview of computational approaches in QSAR studies. It covers the applications of different algorithms in various steps of a QSAR analysis and shows clear examples. Each chapter introduces the tools and software involved. Moreover, challenges and issues which may be faced in any step of the analysis are thoroughly broken down based on the OECD guidelines, enabling the reader to familiarize themselves with potential end results. The book was kept concise, making it suitable for students (pharmacy, chemistry and biological science) and lecturers, as well as researchers in the field.

Artemisia annua is a well-known medicinal plant that has been utilized for a number of purposes, including malaria, for centuries. This is the first comprehensive book to cover the importance of Artemisia annua in the global health crisis and in the treatment against diseases. A component and extract, artemisinin, is the source of other derivatives which are also suitable for pharmaceutical use. The present demand for artemisinin far outpaces its supply. Researchers are working globally towards improving artemisinin content in the plant by various means. Artemisia annua: Prospects, Applications and Therapeutic Uses highlights the different approaches, including 'omics', that are being used in current research on this immensely important medicinal plant. Providing comprehensive coverage of the agricultural and pharmaceutical uses of this plant, Artemisia annua will be essential reading for botanists, plant scientists, herbalists, pharmacognosists, pharmacologists and natural product chemists.

Trace Elements in Abiotic and Biotic Environments helps readers understand the fundamental principles and phenomena that control the transfer of trace elements. This book describes the occurrence and behavior of trace elements in rocks, soil, water, air, and plants, and also discusses the anthropogenic impact to the environment. In addition, it covers the presence of trace elements in feeds, as either contaminants or as nutritional or zootechnical additives, and their transfer across the food chain to humans. Also discussed is international legislation on trace elements for both micronutrients and contaminants in soil and plant food. A special focus is placed on the human health effects of both trace element deficiency and excess. All trace elements are covered-from aluminum to zirconium-as well as rare-earth elements (actinides and lanthanides).

Addressing the persistent environmental threat of organic chemicals with a fresh approach to degradation and transformation processes, Organic Chemicals in the Environment: Mechanisms of Degradation and Transformation, Second Edition examines a wide range of compounds as well as abiotic and microbiological reactions mediated by microorganisms. The book emphasizes the pathways used and the broad classes of enzymes involved. It provides an overview of experimental procedures with detailed coverage of the organic compounds that are considered to be xenobiotics. The book begins by providing a broad perspective on abiotic and biotic reactions, including the significance of a range of environmental determinants. The following chapters briefly introduce experimental procedures and emphasize those procedures for establishing the structure of metabolites using isotopes and physical methods. Next, the authors outline details of biochemical reactions involved in the biodegradation of the major groups of aliphatic, carbocyclic aromatic, and heterocyclic compounds. They end with coverage of bioremediation that has attracted increasing concern because of the hazard presented by the disposal of unwanted chemicals or by-products from their manufacture. Broad and comprehensive, this book provides a cohesive treatment of the subject. It contains an extensive set of literature references and numerous illustrative figures. The authors use a mechanistic approach with emphasis on the pathways, and the principles that emerge provide a guide not only for specific compounds but also for those having a more remote structural resemblance.

A timely and authoritative treatise on the chemistry and diverse applications of chalcogenadiazoles - the five-membered rings containing two carbons, two nitrogens, and one chalcogen (an member of group 16, the oxygen family). The number of different chalcogenadiazoles and their structural diversity make it difficult to gain a clear understanding of the subject by studying an individual system in isolation. Chalcogenadiazoles: Chemistry and Applications emphasizes general features of this class of heterocyclic compounds. It concentrates on properties of each class of chalcogenadiazoles and their cycle-fused derivatives, considering chemical reactions of functional groups only in cases when these reactions permit to characterize the heterocycles as substituents or in respect of its aromaticity.Covering an important and rapidly developing branch of heterocyclic chemistry, this book is an essential resource for students, young professionals and experienced specialists in adjacent fields who are interested in: Trends in the search for compounds with established bioactivity or use in medicine, as agrochemicals, or as reagents for environmental and biochemical analysis Differences in classes of chalcogenadiazoles with respect to their degree of aromaticity and similar general concepts helpful to the nonspecialist The effects of the chalcogen nature and the alternation manner of all atomic constituents on properties of these heterocyclic compounds Combining data from organic, biological, medicinal, materials science, and supramolecular chemistry, Chalcogenadiazoles: Chemistry and Applications is an important source of information not only for chemists in the fields of organic, inorganic, and organometallic chemistry, but also for anyone interested in the research and development of chalcogenadiazoles and related species.

Thermodynamic data form the basis for separation processes used in different fields of science and industry, from specialty chemicals to foods and pharmaceuticals. One obstacle to developing new production processes, products, or optimization is the lack, or inaccessibility, of experimental data related to phase equilibrium. Access More Than 1200 Data Sets, Including 810 Binary Systems, 325 Ternary Systems, and 25 Quaternary (or Higher) Systems The CRC Handbook of Liquid-Liquid Equilibrium Data of Polymer Solutions provides a thorough and up-to-date compilation of experimental liquid-liquid equilibrium (LLE) data and their original sources. Arranged in a consistent format, the handbook provides convenient access to cloud-point and coexistence data as well as upper and lower critical solution temperatures and important demixing data for each system. An Excellent Companion to the Author's Previous Collections of Thermodynamic Data! While the author's previous data compilations center around specific types of polymer systems, Wohlfharth'slatest work distinguishes itself by focusing instead on representing LLE data for all types of polymer systems in a single source.

The book examines basic principles of the structure and organization of living organisms and their differences from objects of inanimate nature. It covers how a single program-information structure permeates all evolutionary stages of life, including the cell, multicellular organisms and humans. The author explains how this structure is arranged and how it functions, as well as the role of the information system. KEY FEATURES Reviews persistent questions and addresses fundamental themes in biology Provides systematic coverage Includes original insights into basic principles of living organization and structure Demonstrates the applicability of a proposed approach to particular evolutionary grades RELATED TITLES J.W. Schopf, Life in Deep Time: Darwin's "Missing" Fossil Record (ISBN 978-1-138-38549-8) C.H. Waddington, ed., The Origin of Life: Toward a Theoretical Biology (ISBN 978-0-202-36302-8) J. Wiegel, A.W.W. Michael, eds., Thermophiles: The Keys to the Molecular Evolution and the Origin of Life (ISBN 978-0-7484-0747-7)

The book examines basic principles of the structure and organization of living organisms and their differences from objects of inanimate nature. It covers how a single program-information structure permeates all evolutionary stages of life, including the cell, multicellular organisms and humans. The author explains how this structure is arranged and how it functions, as well as the role of the information system. KEY FEATURES Reviews persistent questions and addresses fundamental themes in biology Provides systematic coverage Includes original insights into basic principles of living organization and structure Demonstrates the applicability of a proposed approach to particular evolutionary grades RELATED TITLES J.W. Schopf, Life in Deep Time: Darwin's "Missing" Fossil Record (ISBN 978-1-138-38549-8) C.H. Waddington, ed., The Origin of Life: Toward a Theoretical Biology (ISBN 978-0-202-36302-8) J. Wiegel, A.W.W. Michael, eds., Thermophiles: The Keys to the Molecular Evolution and the Origin of Life (ISBN 978-0-7484-0747-7)

Most adults take at least one prescription medication for example, for high blood pressure, high cholesterol levels, depression, asthma, diabetes, COPD, or a variety of other reasons, but most people (and many healthcare providers) are totally unaware that medications can have direct negative effects on sexual functioning and performance. This informative and timely book written by three well-known medications experts explores the chemistry behind sexual arousal in men and women and clearly and authoritatively explains how the common categories of prescription and over-the-counter medications and abused substances might be the reason for their declining sexual performance or even interest.

Biological materials and their applications have drawn increasing attention among scientists. Cellulose is an abundant, renewable, biodegradable, economical, thermally stable, and light material, and it has found application in pharmaceuticals, coatings, food, textiles, laminates, sensors, actuators, flexible electronics, and flexible displays. Its nano form has extraordinary surface properties, such as higher surface area than cellulose; hence, nanocellulose can be used as a substitute for cellulose. Among many other sustainable, functional nanomaterials, nanocellulose is attracting growing interest in environmental remediation technologies because of its many unique properties and functionalities. Nanocellulose and Its Composites for Water Treatment Applications supplies insight into the application of nanocellulose and its nanocomposites for water purification and remediation. It covers different classes of nanocellulose-cellulose nanocrystal (CNC), microfibrillated cellulose (MFC), hairy cellulose nanocrystalloid (HCNC), and bacterial nanocellulose (BNC)-for their competency with other renewable and carbonaceous materials such as pectin, alginate, and CNTs. Future perspectives of nanocellulose and nanocomposites gleaned from different biodegradable origins are also discussed. This book delves into an updated description of the basic principles and developments in synthesis, characterization methods, properties (chemical, thermal, optical, structural, surface, and mechanical structure), property relationships, crystallization behavior, and degradability of biodegradable nanocomposites. The book also supplies vivid information about various cellulose nanomaterials and their applications in absorbing organic and inorganic toxins, membrane filtration of bacteria, viruses, and ionic impurities, photocatalytic dye removal, and sensing of water toxins. Features Details the synthesis and characterization methods of nanocellulose Illustrates the applications of nanocellulose and its nanocomposites Shows in-depth accounts of the various types of properties of nanocellulose and its composites Features emerging trends in the use of nanocellulose as adsorbents, sensors, membranes, and photocatalysis materials This book will be useful for academics, researchers, and engineers working in water treatment and purification.

This book focuses on performing hands-on meta-analysis using MetaXL, a free add-on to MS Excel. The illustrative examples are taken mainly from medical and health sciences studies, but the generic methods can be used to perform meta-analysis on data from any other discipline. The book adopts a step-by-step approach to perform meta-analyses and interpret the results. Stata codes for meta-analyses are also provided. All popularly used meta-analytic methods and models - such as the fixed effect model, random effects model, inverse variance heterogeneity model, and quality effect model - are used to find the confidence interval for the effect size measure of independent primary studies and the pooled study. In addition to the commonly used meta-analytic methods for various effect size measures, the book includes special topics such as meta-regression, dose-response meta-analysis, and publication bias. The main attraction for readers is the book's simplicity and straightforwardness in conducting actual meta-analysis using MetaXL. Researchers would easily find everything on meta-analysis of any particular effect size in one specific chapter once they could determine the underlying effect measure. Readers will be able to see the results under different models and also will be able to select the correct model to obtain accurate results.

Understanding the genetic architecture underlying complex multigene disorders is one of the major goals of human genetics in the upcoming decades. Advances in whole genome sequencing and the success of high throughput functional genomics allow supplementing conventional reductionist biology with systems-level approaches to human heredity and health as systems of interacting genetic, epigenetic, and environmental factors. This integrative approach holds the promise of unveiling yet unexplored levels of molecular organization and biological complexity. It may also hold the key to deciphering the multigene patterns of disease inheritance.

Semiconducting polymers are of great interest for applications in electroluminescent devices, solar cells, batteries, and diodes. This volume provides a thorough introduction to the basic concepts of the photophysics of semiconducting polymers as well as a description of the principal polymerization methods for luminescent polymers. Divided into two main sections, the book first introduces the advances made in polymer synthesis and then goes on to focus on the photophysics aspects, also exploring how new advances in the area of controlled syntheses of semiconducting polymers are applied. An understanding of the photophysics process in this kind of material requires some knowledge of many different terms in this field, so a chapter on the basic concepts is included. The process that occurs in semiconducting polymers spans time scales that are unimaginably fast, sometimes less than a picosecond. To appreciate this extraordinary scale, it is necessary to learn a range of vocabularies and concepts that stretch from the basic concepts of photophysics to modern applications, such as electroluminescent devices, solar cells, batteries, and diodes. This book provides a starting point for a broadly based understanding of photophysics concepts applied in understanding semiconducting polymers, incorporating critical ideas from across the scientific spectrum.

In this book, the fundamentals of micro- and nanofabrication are described on the basis of the concept of "using gases as a fabrication tool." Unlike other books available on the subject, this volume assumes only entry-level mathematics, physics, and chemistry of undergraduates or high-school students in science and engineering courses. Necessary theories are plainly explained to help the reader learn about this new attractive field and enable further reading of specialized books. The book is an attractive guide for students, young engineers, and anyone getting involved in micro- and nanofabrication from various fields including physics, electronics, chemistry, and materials sciences.

Every electrochemical source of electric current is composed of two electrodes with an electrolyte in between. Since storage capacity depends predominantly on the composition and design of the electrodes, most research and development efforts have been focused on them. Considerably less attention has been paid to the electrolyte, a battery's basic component. This book fills this gap and shines more light on the role of electrolytes in modern batteries. Today, limitations in lithium-ion batteries result from non-optimal properties of commercial electrolytes as well as scientific and engineering challenges related to novel electrolytes for improved lithium-ion as well as future post-lithium batteries.

Although many texts describe plants from China, the focus of this book is to draw on the rich culture and environment of medicinal plants and fungi/mushrooms of Yunnan Province. In fact, Yunnan Province covers two global hotspots of biodiversity, with the richest biological and cultural diversity in China. In particular, the Kunming Institute of Botany (KIB) of the Chinese Academy of Sciences (founded in 1938 and located in the capital city of Yunnan Province) has made great contributions in the fields of botany and phytochemistry, earning an international reputation. This book covers those medicinal plants and fungi/mushrooms specific to Yunnan Province, and is written mainly by KIB experts in this research field. Key Features: Distinct sections cover the breadth of the topic including resource availability (wildly grown or cultivated), sustainability, and distribution Discusses plant parts used for medicinal uses (the folklore, the ancient and modern uses) Describes the important natural products and the known pharmacologically active components Presents biological activities related to medicinal uses or clinical evidence Cover image: Shilin, the stone forest (eroded vertical pinnacles of limestone), landmark of Kunming, Yunnan.