Presents cutting-edge research in biomedical engineering from materials, devices, imaging, and information perspectives All chapters are results of collaborative research in engineering and life sciences Useful resource for researchers, students, and general readers in biomedical engineering

Nanotechnology has the potential to change every part of our lives. Today, nanotechnology-based products are used in many areas, and one of the most important areas is drug delivery. Nanoparticulate drug delivery systems not only provide controlled delivery of drugs and improved drug solubility but also improve drug efficiency and reduce side effects via targeting mechanisms. However, compared with conventional drug delivery systems, few nanoparticle-based products are on the market and almost all are nontargeted or only passively targeted systems. In addition, obtaining targeted nanoparticle systems is quite complex and requires several evaluation mechanisms. This book discusses the production, characterization, regulation, and currently marketed targeted nanoparticle systems in a broad framework. It provides an overview of targeted nanoparticles' (i) in vitro characterization, such as particle size, stability, ligand density, and type; (ii) in vivo behavior for different targeting areas, such as tumor, brain, and vagina; and (iii) current advances in this field, including clinical trials and regulation processes.

Semiconductors with optical characteristics have found widespread use in evolving semiconductor photovoltaics, where optical features are important. The industrialization of semiconductors and their allied applications have paved the way for optical measurement techniques to be used in new ways. Due to their unique properties, semiconductors are key components in the daily employed technologies in healthcare, computing, communications, green energy, and a range of other uses. This book examines the fundamental optical properties and applications of semiconductors. It summarizes the information as well as the optical characteristics and applicability of semiconductors through an in-depth review of the literature. Accomplished experts in the field share their knowledge and examine new developments. FEATURES Comprehensive coverage of all types of optical applications using semiconductors Explores relevant composite materials and devices for each application Addresses the optical properties of crystalline and amorphous semiconductors Describes new developments in the field and future potential applications Optical Properties and Applications of Semiconductors is a comprehensive reference and an invaluable resource for engineers, scientists, academics, and industry R&D teams working in applied physics.

Features * Fully updated with the latest results from the spacecraft Hinode, Stereo, Solar Dynamics Observatory (SDO), Interface Region Imaging Spectrograph (IRIS), and Parker Solar Probe * Presents step-by-step explanations for calculating numerical models of the photosphere, convection zone, and radiative interior with exercises and simulation problems to test learning * Describes the structure of polytropic spheres and the acoustic power in the Sun and the process of thermal conduction in different physical conditions

Model integration - the process by which different modelling efforts can be brought together to simulate the target system - is a core technology in the field of Systems Biology. In the work presented here model integration was addressed directly taking cancer systems as an example. An in-depth literature review was carried out to survey the model forms and types currently being utilised. This was used to formalise the main challenges that model integration poses, namely that of paradigm (the formalism on which a model is based), focus (the real-world system the model represents) and scale.

A two-tier model integration strategy, including a knowledge-driven approach to address model semantics, was developed to tackle these challenges. In the first step a novel description of models at the level of behaviour, rather than the precise mathematical or computational basis of the model, is developed by distilling a set of abstract classes and properties. These can accurately describe model behaviour and hence describe focus in a way that can be integrated with behavioural descriptions of other models. In the second step this behaviour is decomposed into an agent-based system by translating the models into local interaction rules.

The book provides a detailed and highly integrated presentation of the method, encompassing both its novel theoretical and practical aspects, which will enable the reader to practically apply it to their model integration needs in academic research and professional settings. The text is self-supporting. It also includes an in-depth current bibliography to relevant research papers and literature. The review of the current state of the art in tumour modelling provides added value.

Using both epidemiological and model organism approaches, we have gained new insights into the physiological and molecular aspects of aging, which has led to significant advancements in potential anti-aging strategies. Reviews on Biomarker Studies in Aging and Anti-Aging Research presents a series of reviews in various aspects of aging and age-related disease research along with several methods which have shown progress as potential anti-aging approaches. The book is aimed at researchers in the areas of aging and chronic disease, as well as to clinical scientists, physicians and major drug companies. It provides important information on disease mechanisms, and each chapter is presented in the context of the aging process, specific chronic diseases or different therapeutic areas.

Addresses simple to advance microscopy techniques for the effective analyses of trace evidence Pairs chapters on a particular type of microscopy, explaining it fully, before delving into specific usage for forensic applications Presents theories and as well as the real-world applications outlining current standards and best practices Provides numerous micro-photographs from authors' and editors' collections, including graphical representations and flow charts to clearly illustrate concepts

The presence of concentrations of organic substances and cations in sea water is a matter of increasing concern to the water industry, environmentalists and the general public alike. There is a threat of possible health hazards to both human, fish and crustacea. Occurrence, Toxicity and Analysis of Marine Biota discusses bioaccumulation in biota as well as occurrence and analysis of toxicants in biota. The main thrust of this book will be a review of the levels of toxicants found in the tissues of fish and invertebrates at various sites throughout the world. In addition, results will be reported on the levels of toxicants found in marine biota enabling ill health or death to occur. This will involve a discussion of toxicity index LC50 and percentile S95 concentration of toxicants and their implications on animal health and mortality, also that of humans who eat these sea creatures. The book will be a complete logical survey of this topic.

Currently, the reliance on fossil fuels raises concerns on the increasing global energy demand, the rapid anthropogenic climate changes and growing environmental problems. The grand challenge is to search for viable carbon-neutral sources of renewable energy. Nanomaterials are arguably the base that integrates nanotechnology, information technology, and biotechnology; the major drivers of technological development today. Over the past decades, the understanding of form-function relations surrounding nanomaterials has significantly brightened the prospects of the transition from fossil fuels to solar fuels. This book introduces the latest developments in nanomaterials aimed at the applications in clean energy areas. It overviews the close link between nanomaterials development and energy applications from the experience and perspective of the authors. It discusses the bottom-up synthesis and interface engineering of new materials of different dimensions and describes their applications in future energy devices such as secondary batteries, novel solar cells, luminescent devices, and water splitting electrolyzers. .

- integrates contemporary science, philosophy, and psychoanalysis - first book on the market to discuss more than one area of contemporary science in relation to psychoanalysis

- integrates contemporary science, philosophy, and psychoanalysis - first book on the market to discuss more than one area of contemporary science in relation to psychoanalysis

This book provides a well-focused and comprehensive overview of novel technologies involved in advanced microfluidics based diagnosis via various types of prognostic and diagnostic biomarkers. This authors examine microfluidics based diagnosis in the biomedical field as an upcoming field with extensive applications. It provides a unique approach and comprehensive technology overview for diagnosis management towards early stages of various bioanalytes via cancer diagnostics diabetes, alzheimer disease, toxicity in food products, brain and retinal diseases, cardiovascular diseases, and bacterial infections etc. Thus, this book would encompass a combinatorial approach of medical science, engineering and biomedical technology. The authors provide a well-focused and comprehensive overview of novel technologies involved in advanced microfluidics based diagnosis via various types of prognostic and diagnostic biomarkers. Moreover, this book contains detailed description on the diagnosis of novel techniques. This book would serve as a guide for students, scientists, researchers, and microfluidics based point of care technologies via smart diagnostics and to plan future research in this valuable field.

Are Amazon Alexa and Google Home limited to our bedrooms, or can they be used in hospitals? Do you envision a future where physicians work hand-in-hand with voice AI to revolutionize healthcare delivery? In the near future, clinical smart assistants will be able to automate many manual hospital tasks-and this will be only the beginning of the changes to come. Voice AI is the future of physician-machine interaction and this Focus book provides invaluable insight on its next frontier. It begins with a brief history and current implementations of voice-activated assistants and illustrates why clinical voice AI is at its inflection point. Next, it describes how the authors built the world's first smart surgical assistant using an off-the-shelf smart home device, outlining the implementation process in the operating room. From quantitative metrics to surgeons' feedback, the authors discuss the feasibility of this technology in the surgical setting. The book then provides an in-depth development guideline for engineers and clinicians desiring to develop their own smart surgical assistants. Lastly, the authors delve into their experiences in translating voice AI into the clinical setting and reflect on the challenges and merits of this pursuit. The world's first smart surgical assistant has not only reduced surgical time but eliminated major touch points in the operating room, resulting in positive, significant implications for patient outcomes and surgery costs. From clinicians eager for insight on the next digital health revolution to developers interested in building the next clinical voice AI, this book offers a guide for both audiences.

Nanosensors are innovative devices that exploit the unique properties exhibited by matter at the nanoscale. A growing and exciting field, nanosensors have recently spurred considerable research endeavors across the globe, driving a need for the development of new device concepts and engineering nanostructured materials with controlled properties. Nanosensors: Physical, Chemical, and Biological, Second Edition offers a panoramic view of the field and related nanotechnologies with extraordinary clarity and depth. Presenting an interdisciplinary approach, blending physics, chemistry and biology, this new edition is broad in scope and organised into six parts; beginning with the fundamentals before moving onto nanomaterials and nanofabrication technologies in the second part. The third and fourth parts provide a critical appraisal of physical nanosensors, and explore the chemical and biological categories of nanosensors. The fifth part sheds light on the emerging applications of nanosensors in the sectors of society, industry, and defense and details the cutting-edge applications of state-of-the-art nanosensors in environmental science, food technology, medical diagnostics, and biotechnology. The final part addresses self-powering and networking issues of nanosensors, and provides glimpses of future trends. This is an ideal reference for researchers and industry professionals engaged in the frontier areas of material science and semiconductor fabrication as well as graduate students in physics and engineering pursuing electrical engineering and electronics courses with a focus on nanoscience and nanotechnology. Key features: Provides an updated, all-encompassing exploration of contemporary nanosensors and highlights the exclusive nanoscale properties on which nanosensors are designed. Presents an accessible approach with a question-and-answer format to allow an easy grasp of the intricacies involved in the complex working mechanisms of devices. Contains clear, illustrative diagrams enabling the visualization of nanosensor operations, along with worked examples, end of chapter questions, and exhaustive up-to-date bibliographies appended to each chapter.

The self-contained properties of discotic liquid crystals (DLCs) render them powerful functional materials for many semiconducting device applications and models for energy and charge migration in self-organized dynamic functional soft materials. The past three decades have seen tremendous interest in this area, fueled primarily by the possibility of creating a new generation of organic semiconductors and wide viewing displays using DLCs. While a number of books on classical calamitic liquid crystals are available, there are, as yet, no books that are dedicated exclusively to the basic design principles, synthesis, and physical properties of DLCs. The first reference book to cover DLCs, Chemistry of Discotic Liquid Crystals: From Monomers to Polymers highlights the chemistry and thermal behavior of DLCs. Divided into six chapters, each with a general description, background, and context for the concepts involved, the book begins with a basic introduction to liquid crystals, describing molecular self-assembly and various types of liquid crystals. It outlines their classification, covers their history and general applications, and focuses on DLCs and their discovery, structure, characterization, and alignment. The book goes on to examine the chemistry and physical properties of various monomeric DLCs, including 25 sections describing the synthesis and mesomorphic properties of monomeric DLCs formed by different cores. The bulk of the book covers the chemistry and mesomorphism of discotic dimers, oligomers, and polymers and concludes with a look at some applicable properties of DLCs. A comprehensive and up-to-date resource, this book is designed to be accessible and of value not just for students and researchers but also to the directors and principal investigators working in this field, providing the foundation and fuel to advance this fast-growing technological field.

This reference text discusses conduction mechanism, structure construction, operation, performance evaluation and applications of nanoscale semiconductor materials and devices in VLSI circuits design. The text explains nano materials, devices, analysis of its design parameters to meet the sub-nano-regime challenges for CMOS devices. It discusses important topics including memory design and testing, fin field-effect transistor (FinFET), tunnel field-effect transistor (TFET) for sensors design, carbon nanotube field-effect transistor (CNTFET) for memory design, nanowire and nanoribbons, nano devices based low-power-circuit design, and microelectromechanical systems (MEMS) design. The book discusses nanoscale semiconductor materials, device models, and circuit design covers nanoscale semiconductor device structures and modeling discusses novel nano-semiconductor devices such as FinFET, CNTFET, and Nanowire covers power dissipation and reduction techniques Discussing innovative nanoscale semiconductor device structures and modeling, this text will be useful for graduate students, and academic researchers in diverse areas such as electrical engineering, electronics and communication engineering, nanoscience, and nanotechnology. It covers nano devices based low-power-circuit design, nanoscale devices based digital VLSI circuits, and novel devices based analog VLSI circuits design.

Covers the most recent researches in hollow fibers and nanofibers in the different fields of membrane applications Provides and discusses the arguments relying on concrete examples from scientific literature Is illustrated throughout, with remarkable figures and illustrations accompanying each section

G protein coupled receptors (GPCRs) comprise an important protein family, which is involved in signal transduction in the cell. Besides that a large number of drugs, available on market, address GPCRs. For an efficient and improved development of appropriate drugs, molecular modelling of GPCRs is in order to understand the ligand-receptor interactions and functionality of GPCRs on molecular level - an important tool. The book Modelling of GPCRs a practical handbook is focussed onto a practical introduction into molecular modelling of GPCRs. This book is very useful for beginners in GPCR modelling, but also addresses the advanced GPCR modeller: On the one hand, the book introduces principles of GPCR modelling, including extensive examples. On the other hand, detailed outlooks onto advanced GPCR modelling techniques are presented. Furthermore, the book includes important data, like information about crystal structures in a summarized manner or amino acid sequences, which are essential for GPCR modelling in general. Due to an increase in efficacy and data handling most modellers use LINUX as operating system. To address this, a summary of most important LINUX commands with examples is presented within the book.

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The book covers the fundamental concepts of phases, phase diagrams and their applications. Stress is on understanding and not on memorization. The book has descriptive passages and diagrams (cooling curves) that help students gain a solid foundation in subject. This text will help them learn phase rule faster. It also contains numerous phase diagrams. Note: T& F does not sell or distribute the Hardback in India, Pakistan, Nepal, Bhutan, Bangladesh and Sri Lanka.

Microbial relationships with all life forms can be as free living, symbiotic or pathogenic. Human beings harbor 10 times more microbial cells than their own. Bacteria are found on the skin surface, in the gut and other body parts. Bacteria causing diseases are the most worrisome. Most of the infectious diseases are caused by bacterial pathogens with an ability to form biofilm. Bacteria within the biofilm are up to 1000 times more resistant to antibiotics. This has taken a more serious turn with the evolution of multiple drug resistant bacteria. Health Departments are making efforts to reduce high mortality and morbidity in man caused by them. Bacterial Quorum sensing (QS), a cell density dependent phenomenon is responsible for a wide range of expressions such as pathogenesis, biofilm formation, competence, sporulation, nitrogen fixation, etc. Majority of these organisms that are important for medical, agriculture, aquaculture, water treatment and remediation, archaeological departments are: Aeromonas, Acinetobacter, Bacillus, Clostridia, Enterococcus, Pseudomonas, Vibrio and Yersinia spp. Biosensors and models have been developed to detect QS systems. Strategies for inhibiting QS system through natural and synthetic compounds have been presented here. The biotechnological applications of QS inhibitors (QSIs) in diverse areas have also been dealt with. Although QSIs do not affect growth and are less likely to impose selective pressure on bacteria, however, a few reports have raised doubts on the fate of QSIs. This book addresses a few questions. Will bacteria develop mechanisms to evade QSIs? Are we watching yet another defeat at the hands of bacteria? Or will we be acting intelligently and survive the onslaughts of this Never Ending battle?

This 21st Century Nanoscience Handbook will be the most comprehensive, up-to-date large reference work for the field of nanoscience. Handbook of Nanophysics by the same editor published in the fall of 2010 and was embraced as the first comprehensive reference to consider both fundamental and applied aspects of nanophysics. This follow-up project has been conceived as a necessary expansion and full update that considers the significant advances made in the field since 2010. It goes well beyond the physics as warranted by recent developments in the field. This ninth volume in a ten-volume set covers industiral applications. Key Features: Provides the most comprehensive, up-to-date large reference work for the field. Chapters written by international experts in the field. Emphasises presentation and real results and applications. This handbook distinguishes itself from other works by its breadth of coverage, readability and timely topics. The intended readership is very broad, from students and instructors to engineers, physicists, chemists, biologists, biomedical researchers, industry professionals, governmental scientists, and others whose work is impacted by nanotechnology. It will be an indispensable resource in academic, government, and industry libraries worldwide. The fields impacted by nanophysics extend from materials science and engineering to biotechnology, biomedical engineering, medicine, electrical engineering, pharmaceutical science, computer technology, aerospace engineering, mechanical engineering, food science, and beyond.

Aquatic Chemistry Concepts, Second Edition, is a fully revised and updated textbook that fills the need for a comprehensive treatment of aquatic chemistry and covers the many complicated equations and principles of aquatic chemistry. It presents the established science of equilibrium water chemistry using the uniquely recognizable, step-by-step Pankow format, which allows a broad and deep understanding of aquatic chemistry. The text is appropriate for a wide audience, including undergraduate and graduate students, industry professionals, consultants, and regulators. Every professional using water chemistry will want this text within close reach, and students and professionals alike will expect to find at least one copy on their library shelves. Key Features Extremely thorough, one-of-a-kind treatment of aquatic chemistry which considers: a) chemical thermodynamics fundamentals; b) acid/base, titration, and buffer calculations; c) CO2 chemistry and alkalinity; d) complexation of metal ions by ligands and chelates; e) mineral solubility processes; f) redox chemistry, including the chemistry of chlorine (as in disinfection), oxygen, CO2 and methane, nitrogen, sulfur, iron, and lead, including the story of lead in the drinking water of Flint, Michigan; and g) electrical effects in aqueous solutions including the Debye-Huckel Law (and related equations for activity corrections), double layers, and colloid stability Discussions of how to carry out complex calculations regarding the chemistry of lakes, rivers, groundwater, and seawater Numerous example problems worked in complete detail Special foreword by Jerry L. Schnoor 'There's a lot to like about a book on water chemistry that lays it out simply. Einstein said that everything should be as simple as it can be, but not simpler. Wise advice. And that is what James F. Pankow has accomplished in the second edition of his textbook, Aquatic Chemistry Concepts. It covers the "waterfront" of essential inorganic chemistry topics, and it supplies enough examples to lead the student toward problem solving.' -From the Foreword, Jerry L. Schnoor

New innovations are needed for the invention of more efficient, affordable, sustainable and renewable energy systems, as well as for the mitigation of climate change and global environmental issues. In response to a fast-growing interest in the realm of renewable energy, Renewable Energy Systems: Efficiency, Innovation and Sustainability identifies a need to synthesize relevant and up-to-date information in a single volume. This book describes a systems approach to renewable energy, including technological, political, economic, social and environmental viewpoints, as well as policies and benefits. This unique and concise text, encompassing all aspects of the field in a single source, focuses on truly promising innovative and affordable renewable energy systems. Key Features: Focuses on innovations in renewable energy systems that are affordable and sustainable Collates the most relevant and up-to-date information on renewable energy systems, in a single and unique volume Discusses lifecycle assessment, cost and availability of systems Emphasizes bio-related topics Provides a systems approach to the renewable energy technologies and discusses technological, political, economic, social, and environmental viewpoints as well as policies

This new edition of College Physics Essentials provides a streamlined update of a major textbook for algebra-based physics. The first volume covers topics such as mechanics, heat, and thermodynamics. The second volume covers electricity, atomic, nuclear, and quantum physics. The authors provide emphasis on worked examples together with expanded problem sets that build from conceptual understanding to numerical solutions and real-world applications to increase reader engagement. Including over 900 images throughout the two volumes, this textbook is highly recommended for students seeking a basic understanding of key physics concepts and how to apply them to real problems.

Spin-label electron paramagnetic resonance (EPR) spectroscopy is a versatile molecular probe method that finds wide application in molecular biophysics and structural biology. This book provides the first comprehensive summary of basic principles, spectroscopic properties, and use for studying biological membranes, protein folding, supramolecular structure, lipid-protein interactions, and dynamics. The contents begin with discussion of fundamental theory and practice, including static spectral parameters and conventional continuous-wave (CW) spectroscopy. The development then progresses, via nonlinear CW-EPR for slower motions, to the more demanding time-resolved pulse EPR, and includes an in-depth treatment of spin relaxation and spectral line shapes. Once the spectroscopic fundamentals are established, the final chapters acquire a more applied character. Extensive appendices at the end of the book provide detailed summaries of key concepts in magnetic resonance and chemical physics for the student reader and experienced practitioner alike. Key Features: Indispensable reference source for the understanding and interpretation of spin-label spectroscopic data in its different aspects. Tables of fundamental spectral parameters are included throughout. Forms the basis for an EPR graduate course, extending up to a thorough coverage of advanced topics in Specialist Appendices. Includes all necessary theoretical background. The primary audience is research workers in the fields of molecular biophysics, structural biology, biophysical chemistry, physical biochemistry and molecular biomedicine. Also, physical chemists, polymer physicists, and liquid-crystal researchers will benefit from this book, although illustrative examples used are often taken from the biomolecular field. Readers will be postgraduate researchers and above, but include those from other disciplines who seek to understand the primary spin-label EPR literature.