This monograph will provide an in-depth mathematical treatment of modern multiple test procedures controlling the false discovery rate (FDR) and related error measures, particularly addressing applications to fields such as genetics, proteomics, neuroscience and general biology. The book will also include a detailed description how to implement these methods in practice. Moreover new developments focusing on non-standard assumptions are also included, especially multiple tests for discrete data. The book primarily addresses researchers and practitioners but will also be beneficial for graduate students.

An edited volume describing the latest developments in approaching the problem of polymer sequence analysis, with special emphasis on the most relevant biopolymers (peptides and DNA) but not limited to them. The chapters will include peptide sequence analysis, DNA sequence analysis, analysis of biopolymers and nonpolymers, sequence alignment problems, and more.

The book draws on Prof. Perkowitz's career as successful researcher, teacher, and writer and his broad interests to give him unique insights into how science and scientists connect with general culture and society. The book is especially strong in its coverage of science and art, and science in film. Illustrations from Hollywood films and independent and experimental films increase the book's appeal. The book's mix of varied topics in science and technology, and of short and long pieces written in accessible style, will appeal to general readers.

Reveals that the last major electrical discovery occurred in 1938 Identifies five scientific fundamentals that all the major discoveries were based on Shows how all five of those basics were abandoned in the mid-1930s, leaving us stuck with 19th century energy sources Steps on some pretty big toes as it traces back how this all occurred and details two plans (technical and administrative) the world can use to find a new, clean, cheap, and reliable source of electrical energy with which to combat global warming Is written in clear non-technical language

Electroinduced Drift of Neutral Charge Clusters in Salt Solutions presents studies of the processes accompanying the effect of periodic electric and magnetic fields on salt solutions in polar dielectric liquids. The authors explain phenomena from a physical point of view, without theoretical constructions and mathematical calculations. This is done in order to make the book accessible to a wide audience and to help the reader navigate in a multilateral topic that is touched upon when studying processes that occur in liquid media under the external influence of an electromagnetic nature. Additional Features: Explores the phenomenon of selective drift of solvated ions in polar dielectric liquids Applies general principles of electricity and magnetism to describe experimental results Demonstrates how small perturbations of the equilibrium distribution determine not the corrections to the effects but the effects themselves Approaches nonequilibrium molecular physics as a science of physical and chemical processes This book will be useful to specialists, engineers and graduate students, especially those recording and transmitting information in liquid media.

Surface Structure Modification and Hardening of Al-SI Alloys explores the hardening of material surfaces using concentrated energy flows resulting in the nanostructuring of surface layers. The authors demonstrate how these methods achieve a reduction in plastic deformation of the surface and a more uniform distribution of elastic stresses near the surface during operational use, significantly reducing part failure. It presents results from research and scientific and technological enterprises involved with the modification of light alloy surfaces for use in the automobile and aerospace industries. Additional key features include: Addresses theoretical and experimental research computer simulations of structural phase transformations at the nanolevel to create new materials Details and compares electroexplosion alloying, electron beam processing and electron-plasma alloying of an Al-Si Alloy Explains multiphase plasma jet treatment to obtain high-quality coatings with good and high functional properties This reference is a valuable resource for specialists in the field of physical material science, condensed state physics, metal science and thermal treatment and will be of interest to undergraduate and post-graduate students in these fields.

Organic chemistry research has moved rapidly toward synthesis and medicinal application of nitrogen-containing compounds such as triazenes, triazines, and hydroxytriazenes due to their excellent biological activities. Many of them are presently in clinical trials. Triazene compounds have excellent medicinal properties and limited toxicity. Hydroxytriazenes are excellent chelating agents for transition metals. Newer studies show very promising biological and medicinal applications of these classes of compounds. Hydroxytriazenes and Triazenes: The Versatile Framework, Synthesis, and Medicinal Applications highlights synthetic methods, recent advances, and potential applications of triazines, triazenes, and hydroxytriazenes. This book includes holistic information on synthetic methods for novel compounds based on this moiety, up-to-date information on the how and why of their diverse or even multitargeted medicinal application, and future state of the art of both aspects. Other features include: Highlights recent advances and diverse possible applications of biological functions Covers the chemistry of triazine, triazene, and hydroxytriazene systems On the basis of in silico predictions, the book highlights synthetic methods and their applications A valuable source of information for those actively engaged in medicinal chemistry, drug discovery, and synthetic organic chemistry

This timely and unique publication is designed for graduate students and researchers in inorganic and materials chemistry and covers bonding models and applications of symmetry concepts to chemical systems. The book discusses the quantum mechanical basis for molecular orbital concepts, the connections between molecular orbitals and localized views of bonding, group theory, bonding models for a variety of compounds, and the extension of these ideas to solid state materials in band theory. Unlike other books, the concepts are made tangible to the readers by guiding them through their implementation in MATLAB functions. No background in MATLAB or computer programming is needed; the book will provide the necessary skills. Key Features Visualization of the Postulates of Quantum Mechanics to build conceptual understanding MATLAB functions for rendering molecular geometries and orbitals Do-it-yourself approach to building a molecular orbital and band theory program Introduction to Group Theory harnessing the 3D graphing capabilities of MATLAB Online access to a growing collection of applications of the core material and other appendices Bonding through Code is ideal for first-year graduate students and advanced undergraduates in chemistry, materials science, and physics. Researchers wishing to gain new tools for theoretical analysis or deepen their understanding of bonding phenomena can also benefit from this text. About the Author Daniel Fredrickson is a Professor in the Department of Chemistry at the University of Wisconsin-Madison, where his research group focuses on understanding and harnessing the structural chemistry of intermetallic phases using a combination of theory and experiment. His interests in crystals, structure, and bonding can be traced to his undergraduate research at the University of Washington (B.S. in Biochemistry, 2000) with Prof. Bart Kahr, his Ph.D. studies at Cornell University (2000-2005) with Profs. Stephen Lee and Roald Hoffmann, and his post-doctoral work with Prof. Sven Lidin at Stockholm University (2005-2008). As part of his teaching at UW-Madison since 2009, he has worked to enhance his department's graduate course, Physical Inorganic Chemistry I: Symmetry and Bonding, through the incorporation of new material and the development of computer-based exercises.

This book is dedicated to the fundamental physical aspects of stability, the influence of structural defects on the properties and structural phase transformations of BCC alloys. The authors present patterns that occur in the structural-phase states of functional alloys with low stability or instability under thermal cycling effects. Structural-phase transformations and the physical laws governing the influence of the thermomechanical effect on the properties of alloys are examined to advance development of technological processes for processing functional materials. Features: Studies the correlation between structural phase states and changes in the physico-mechanical properties of intermetallic compounds Explores the influence of thermomechanical cycling on the properties of functional alloys Details low-stability pretransition states in alloys

In the manufacturing sector, nanomaterials offer promising outcomes for cost reduction in production, quality improvement, and minimization of environmental hazards. This book focuses on the application of nanomaterials across a wide range of manufacturing areas, including in paint and coatings, petroleum refining, textile and leather industries, electronics, energy storage devices, electrochemical sensors, as well as in industrial waste treatment. This book: Examines nanofluids and nanocoatings in manufacturing and their characterization. Discusses nanomaterial applications in fabricating lightweight structural components, oil refining, smart leather processing and textile industries, and the construction industry. Highlights the role of 3D printing in realizing the full potential of nanotechnology. Considers synthetic strategies with a focus on greener protocols for the fabrication of nanostructured materials with enhanced properties and better control, including these materials' characterization and significant properties for ensuring smart outputs. Offers a unique perspective on applications in industrial waste recycling and treatment, along with challenges in terms of safety, economics, and sustainability in industrial processes. This work is written for researchers and industry professionals across a variety of engineering disciplines, including materials, manufacturing, process, and industrial engineering.

Biomedical Applications of Magnetic Particles discusses fundamental magnetic nanoparticle physics and chemistry and explores important biomedical applications and future challenges. The first section presents the fundamentals of the field by explaining the theory of magnetism, describing techniques to synthesize magnetic particles, detailing methods to characterize magnetic particles, and quantitatively describing the applied magnetic forces, torques, and the resultant particle motions. The second section describes the wide range of biomedical applications, including chemical sensors, cellular actuators, drug delivery, magnetic hyperthermia, magnetic resonance imaging contrast enhancement, and toxicity. Additional key features include: Covers both introduction to physics and characterization of magnetic nanoparticles and the state of the art in biomedical applications Authoritative reference for scientists and engineers for all new or old to the field Describes how the size of magnetic nanoparticles affects their magnetic properties, colloidal properties, and biological properties. Written by a team of internationally respected experts, this book provides an up-to-date authoritative reference for scientists and engineers.

This book provides an interdisciplinary guide to quasicrystals, the 2011 Nobel Prize in Chemistry winning topic, by presenting an up-to-date and detailed introduction to the many fundamental aspects and applications of quasicrystals science. It reviews the most characteristic features of the peculiar geometric order underlying their structure and their reported intrinsic physical properties, along with their potential for specific applications. The role of quasiperiodic order in science and technology is also examined by focusing on the new design capabilities provided by this novel ordering of matter. This book is specifically devoted to promoting the very notion of quasiperiodic order, and to spur its physical implications and technological capabilities. It, therefore, explores the fundamental aspects of intermetallic, photonic, and phononic quasicrystals, as well as soft-matter quasicrystals, including their intrinsic physical and structural properties. In addition, it thoroughly discusses experimental data and related theoretical approaches to explain them, extending the standard treatment given in most current solid state physics literature. It also explores exciting applications in new technological devices of quasiperiodically ordered systems, including multilayered quasiperiodic systems, along with 2D and 3D designs, whilst outlining new frontiers in quasicrystals research. This book can be used as a reader-friendly introductory text for graduate students, in addition to senior scientists and researchers coming from the fields of physics, chemistry, materials science, and engineering. Key features: * Provides an updated and detailed introduction to the interdisciplinary field of quasicrystals in a tutorial style, considering both fundamental aspects and additional freedom degrees provided by designs based on quasiperiodically ordered materials. * Includes 50 fully worked out exercises with detailed solutions, motivating, and illustrating the different concepts and notions to provide readers with further learning opportunities. * Presents a complete compendium of the current state of the art knowledge of quasicrystalline matter, and outlines future next generation materials based on quasiperiodically ordered designs for their potential use in useful technological devices. Dr. Enrique Macia-Barber is Professor of condensed matter physics at the Universidad Complutense de Madrid. His research interests include the thermoelectric properties of quasicrystals and DNA biophysics. In 2010 he received the RSEF- BBVA Foundation Excellence Physics Teaching Award. His book Aperiodic Structures in Condensed Matter: Fundamentals and Applications (CRC Press, Boca-Raton, 2009) is one of the Top Selling Physics Books according to YBP Library Services.

Lithium-ion batteries are the most promising among the secondary battery technologies, for providing high energy and high power required for hybrid electric vehicles (HEV) and electric vehicles (EV). Lithium-ion batteries consist of conventional graphite or lithium titanate as anode and lithium transition metal-oxides as cathode. A lithium salt dissolved in an aprotic solvent such as ethylene carbonate and diethylene carbonate is used as electrolyte. This rechargeable battery operates based on the principle of electrochemical lithium insertion/re-insertion or intercalation/de-intercalation during charging/discharging of the battery. It is essential that both electrodes have layered structure which should accept and release the lithium-ion. In advanced lithium-ion battery technologies, other than layered anodes are also considered. High cell voltage, high capacity as well as energy density, high Columbic efficiency, long cycle life, and convenient to fabricate any size or shape of the battery, are the vital features of this battery technology. Lithium-ion batteries are already being used widely in most of the consumer electronics such as mobile phones, laptops, PDAs etc. and are in early stages of application in HEV and EV, which will have far and wide implications and benefits to society. The book contains ten chapters, each focusing on a specific topic pertaining to the application of lithium-ion batteries in Electric Vehicles. Basic principles, electrode materials, electrolytes, high voltage cathodes, recycling spent Li-ion batteries and battery charge controller are addressed. This book is unique among the countable books focusing on the lithium-ion battery technologies for vehicular applications. It provides fundamentals and practical knowledge on the lithium-ion battery for vehicular application. Students, scholars, academicians, and battery and automobile industries will find this volume useful.

Researchers in chemistry, chemical engineering, pharmaceutical science, forensics, and environmental science make routine use of chemical analysis, but the information these researchers need is often scattered in different sources and difficult to access. The CRC Handbook of Basic Tables for Chemical Analysis: Data-Driven Methods and Interpretation, Fourth Edition is a one-stop reference that presents updated data in a handy format specifically designed for use when reaching a decision point in designing an analysis or interpreting results. This new edition offers expanded coverage of calibration and uncertainty, and continues to include the critical information scientists rely on to perform accurate analysis. Enhancements to the Fourth Edition: Compiles a huge array of useful and important data into a single, convenient source Explanatory text provides context for data and guidelines on applications Coalesces information from several different fields Provides information on the most useful "wet" chemistry methods as well as instrumental techniques, with an expanded discussion of laboratory safety Contains information of historical importance necessary to interpret the literature and understand current methodology. Unmatched in its coverage of the range of information scientists need in the lab, this resource will be referred to again and again by practitioners who need quick, easy access to the data that forms the basis for experimentation and analysis.

Planning a Career in Biomedical and Life Sciences presents useful information, insights, and tips to those pursuing a career in the biomedical and life sciences. The book focuses on making educated choices during schooling, training, and job searching in both the academic and non-academic sectors. The premise of Planning a Career in Biomedical and Life Sciences is that by understanding the full path of a career in either the biomedical or life science fields, you can proactively plan your career, recognize any opportunities that present themselves, and be well prepared to address important aspects of your own professional development. Topics include choosing your training path, selecting the best supervisor/mentor, and negotiating a job offer.

This book presents selected papers on statistical model development related mainly to the fields of Biostatistics and Bioinformatics. The coverage of the material falls squarely into the following categories: (a) Survival analysis and multivariate survival analysis, (b) Time series and longitudinal data analysis, (c) Statistical model development and (d) Applied statistical modelling. Innovations in statistical modelling are presented throughout each of the four areas, with some intriguing new ideas on hierarchical generalized non-linear models and on frailty models with structural dispersion, just to mention two examples. The contributors include distinguished international statisticians such as Philip Hougaard, John Hinde, Il Do Ha, Roger Payne and Alessandra Durio, among others, as well as promising newcomers. Some of the contributions have come from researchers working in the BIO-SI research programme on Biostatistics and Bioinformatics, centred on the Universities of Limerick and Galway in Ireland and funded by the Science Foundation Ireland under its Mathematics Initiative.

Updating Neanderthals: Understanding Behavioral Complexity in the Late Middle Paleolithic provides comprehensive knowledge on Neanderthals who lived throughout the European and Asian continents. The book synthesizes historical information about the study of Middle Paleolithic populations and presents current debates about their genetics, subsistence, technology, social and cognitive behaviors. It focuses on the last phase of Neanderthal settlements and presents the main patterns of modern humans across Europe. Written by international experts on the Middle Paleolithic who have conducted innovative studies in the last three decades, this book explores the implications of interactions between different human species, including Neanderthals, Denisovans and Sapiens. In addition, the book discusses the diversity and variability of human adaptations and behaviors in the changing climate and environment of the Late Pleistocene, and the relationship between these behaviors, demography and cognitive capabilities.

The isolation of graphene in 2004 by two scientists at the University of Manchester-a breakthrough later recognised by the Nobel Prize for physics-revealed to the world a brand new 'wonder material' which had been 'completely hidden from science'. Graphene, the world's first two-dimensional material, promises huge opportunities for a range of sectors, from aerospace to energy to biomedical. But how can the UK be known for 'Made in Britain' as well as discovered in Britain? As an answer, this book explores how the Manchester model of innovation has evolved to not only support great science but also accelerate the adoption of graphene into real-world products and anchoring an innovation ecosystem in the place of UK discovery. This book features first-hand experience, case studies and interviews with key strategic players in the graphene story to illustrate how Manchester has built a unique model of collaboration with industry to create an ecosystem that features a supply chain of companies not only producing graphene material but also starting to disrupt the marketplace with new products and application as we approach the tipping point of commercialisation.

Presents simplified but useful and practical equations that can be applied in estimating performance and design of energy-efficient systems in low-temperature systems or cryogenics Contains practical approaches and advanced design materials for insulation, shields/anchors, cryogen vessels/pipes, calorimeters, cryogenic heat switches, cryostats, current leads, and RF couplers Provides a comprehensive introduction to the necessary theory and models needed for solutions to common difficulties and illustrates the engineering examples with about 300 figures

This book examines the synthesis of graphene obtained from different natural raw materials and waste products as a low-cost, environmentally friendly alternative that delivers a quality final product. Expert researchers review potential sources of natural raw materials and waste products, methods or characterization, graphene synthesis considerations, and important applications. FEATURES Explores the different approaches to the synthesis of graphene oxide (GO) and reduced graphene oxide (rGO) from natural and industrial carbonaceous wastes Outlines the modification and characterization methods of GO and rGO Addresses the characterization methods of GO and rGO Details applications of GO and rGO created from natural sources Graphene is a multidisciplinary material with applications in almost every sector of science and engineering. Graphene from Natural Sources: Synthesis, Characterization, and Applications is a noteworthy reference for material scientists and engineers in academia and industry interested in reducing costs and employing green synthesis methods in their work.

This book provides an in-depth review of the history, fundamental theory, design strategies, and applications of nanogenerators. Working principles, device mechanisms, material characteristics, types of nanogenerators, and their different uses are fully explored. Top researchers in the field of sustainable technology from different backgrounds and fields contribute their expertise to deliver a must-have practical resource for students, academic researchers, and industry professionals. FEATURES Describes the fundamental aspects and theory of nanogenerators Explores design strategies including material assessment based upon planned application Tailors the introduction and essential concept discussion for the industrial and research community Explores current applications, existing challenges, and the future outlook for the field

Semiconductors with optical characteristics have found widespread use in evolving semiconductor photovoltaics, where optical features are important. The industrialization of semiconductors and their allied applications have paved the way for optical measurement techniques to be used in new ways. Due to their unique properties, semiconductors are key components in the daily employed technologies in healthcare, computing, communications, green energy, and a range of other uses. This book examines the fundamental optical properties and applications of semiconductors. It summarizes the information as well as the optical characteristics and applicability of semiconductors through an in-depth review of the literature. Accomplished experts in the field share their knowledge and examine new developments. FEATURES Comprehensive coverage of all types of optical applications using semiconductors Explores relevant composite materials and devices for each application Addresses the optical properties of crystalline and amorphous semiconductors Describes new developments in the field and future potential applications Optical Properties and Applications of Semiconductors is a comprehensive reference and an invaluable resource for engineers, scientists, academics, and industry R&D teams working in applied physics.

"Biodegradable Composites for Packaging Applications" describes design, processing, and manufacturing of advanced biodegradable composites in packaging industry applications. It covers fundamentals of biodegradable polymers followed by introduction to biodegradable materials for food packaging industry and its processing mechanisms. Pertinent applications are explained across different chapters including intelligent packaging, applied technologies, degradation problems and its impact on environment and associated challenges. Features Covers biodegradable composites and targeted applications in packaging for industrial applications. Includes exhaustive processing and characterizations of biodegradable composites. Discusses innovative commodities packaging applications. Reviews advanced integrated design and fabrication problems for conductive and sensors applications. Explores various properties and functionalities through extensive theoretical and experimental modeling. This volume is aimed at researchers and graduate students in sustainable materials, composite technology, biodegradable plastics, and food technology and engineering.

Include advance knowledge and detailed developments in natural product science Discusses about the most important phytopharmaceuticals used in pharmaceutical industries Explores the analysis and classification of novel plant-based medicinal compounds Includes standardization, quality control, global trade of natural products Gives a deep understanding related to recent advances in the herbal medicines to treat various ailments Discusses about national and WHO regulations and policies related to herbal medicine Covers the complete profile of some important traditional medicinal plants especially their historical background, biology and chemistry

This book addresses how to estimate substance use and thereby evaluate policies intended to reduce the harms caused by drugs and other substances. Wastewater analysis (WWA) can provide efficient, affordable, fine-grained and objective data on population substance use trends on a very large scale. The authors discuss the potential implications of WWA as a new method for understanding substance use in a variety of settings and ignite a discourse with policy makers, criminologists, epidemiologists and other disciplines about the need for collaboration with WWA scientists. The book also features an explanation of the costs and harms of substance use with academic literature from criminological and epidemiological sources and reports from lead agencies. Additional features include: Details on the origin of wastewater analysis in environmental science Description of analytical chemistry methods for tracing a wide variety of substances, including illicit drugs, alcohol, tobacco and other chemicals Exploration of the major empirical problems in estimating population consumption of alcohol, tobacco and drugs at the international and national level Examination of the principles of human research ethics and their application to wastewater analysis Wastewater Analysis for Substance Abuse Monitoring and Policy Development is a valuable tool for analytical chemists, wastewater scientists and criminologists, as well as researchers and policy makers across disciplines who work in drug sectors.