With the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. Nanoparticulate Drug Delivery Systems addresses the scientific methodologies, formulation, processing, applications, recent trends, and emerging technologies in the research of nanoparticulate drug delivery systems (NPDDS). It extensively covers applications of NPDDS- including lipid nanoparticles for dermal applications; nanocarriers for the treatment of restenosis; and for ocular, central nervous system, and gastrointestinal applications. It also explores its use as an adjuvant for vaccine development. Supplying insight from international experts, this guide Discusses formulation for poorly soluble drugs Presents biological requirements for nanotherapeutic applications Demonstrates the role of nanobiotechnology in the development of nanomedicine Documents recent advances in nanoparticulate technology-including electrospining, formation of microcrystals, and production of liquid crystalline phases Examines the technology of metallic nanoparticles

Molecular and Colloidal Electro-Optics presents cohesive coverage from internationally recognized experts on new approaches and developments in both theoretical and experimental areas of electro-optic science. It comprises a well-integrated yet multi-disciplinary treatment of fundamental principles, strategies, and applications of electro-optic techniques for the characterization of macromolecular, small-particle, and nanomolecular systems. Following a historical review of post-war advances in electro-optics of disperse systems, the first part of the book focuses on the latest achievements in electro-optic theory, particularly low-frequency relaxation. It offers comparative discussions and experimental data to accompany different viewpoints on the origin of the low-frequency effects and multiple theoretical constructions. The second part highlights the unique advantage of using electro-optics as an alternative to conventional characterization and analysis of colloidal systems. Demonstrating the sensitivity of electro-optic methods to interparticle interactions, the book explains how these methods are used to analyze particle surface electric states, evaluate phase transitions, and determine physical properties. As the first treatment of this subject to surface in more than fifteen years, Molecular and Colloidal Electro-Optics is a definitive, up-to-date portrait of modern colloidal electro-optic science. This one-stop reference to the latest theory, methods, and applications is ideal for advanced graduate students and researchers in biophysical chemistry, microbiology, polymer, colloid, and nanoscience.

This book guides designers, process engineers, or mechanics to select and use anaerobic machinery adhesives for sealing flanged joints, designing threaded connections for security and sealing, and designing adhesive assists for more durable shrink, press, and slip fitted assemblies.

Thin layer chromatography (TLC) is well suited for performing enantioseparations for research as well as larger-scale applications. A fast, inexpensive, and versatile separation technique, there are many practical considerations that contribute to its effectiveness. Thin Layer Chromatography in Chiral Separations and Analysis is the first book to focus solely on the theory, capabilities, and applications of TLC for direct and indirect enantioseparations. The first part of the book examines the fundamental principles of chirality and TLC. It describes the necessary materials, laboratory equipment, procedures, and strategies for the separation, quantification, isolation, and analysis of chiral compounds. The second part evaluates the real-world enantioseparations and densitometric analyses. Emphasizing pharmaceutical applications, the book discusses chiral separation mechanisms and methods for analyzing the chiral purity of diastereoisomers, amino acids, beta-blockers, and NSAIDS. Topics also include commercial stationary phases and chiral modifiers of mobile phases. Thin Layer Chromatography in Chiral Separations and Analysis presents a unified perspective of theory and experimental details underlying the collective developments in the field. The book offers scientists in a variety of disciplines and levels of expertise a complete guide to understanding the current and potential applications of chiral TLC.

As radiological residue, both naturally occurring and technologically driven, works its way through the ecosystem, we see its negative effects on the human population. Radionuclide Concentrations in Food and the Environment addresses the key issues concerning the relationship between natural and manmade sources of environmental radioactivity, their transportation through the ecosystem, and the subsequent radionuclide concentrations in foods and the human population. The book discusses the negative effects of environmental radioactivity on plants and animals, as well as the effects of radiocontaminated food on human health, and perspectives for transfer prevention. Beginning with the fundamentals of matter and the behavior of particles, the text lays a solid foundation for discussions on the source of radionuclides and their concentrations in air, water, and soil. Using predictive modeling, the authors examine the transfer of radionuclides through ecosystems and their effects on individual substances. The book provides up-to-date information on monitoring programs and legislation, detailed descriptions of detection systems, and evaluations of safety protocols in radioanalytical laboratories and in food processing. The authors devote considerable attention to the nuclear and radiological terrorist threat, illicit trafficking and masking of radioactive materials, event scenarios, and radiological forensics.

Featuring contributions from leading experts, Organic Photochemistry and Photophysics is a unique resource that addresses the organic photochemistry and photophysical behavior in aromatic molecules, thiocarbonyls, selected porphyrins, and metalloporphyrins. The book presents theories pertaining to radiative and radiationless transitions. It describes excited-state proton-transfer reactions of aromatic compounds and the physical, energetic, and environmental effects of atom transfer reactions. The text discusses the role of the carbonyl and azo groups in ketones and azoalkanes in the development of photochemistry, followed by a review of nucleophilic substitution reactions in the photochemistry of aromatics (also called photosubstitution) and the various atomic bonds that result from these reactions. The book presents studies that explain the factors that govern the nature and efficiencies of SET-promoted photochemical reactions. It then focuses on photoamination as a convenient, powerful, and environmentally friendly synthetic process for transforming a variety of substrates into the corresponding aminated compounds. The final chapter explores how dye structure affects the sequence-dependence of DNA binding, which has potential applications in nonlinear optics and DNA detection as well as incorporating DNA into various nanostructures and devices. With an emphasis on the current uses of light in both materials chemistry and medicinal chemistry, this book serves as a comprehensive resource on photochemical reactions and discusses topics that are useful for researchers as well as newcomers in the fields of photochemistry, photobiology, photomedicine, and photophysics

"Presents the most comprehensive coverage available of the detection, isolation, identification, and estimation of all anionic surfactants in a wide variety of samples in trace and macro quantities. Features new chapters on volumetric and trace analysis, molecular and mass spectroscopy, and chromatographic processes."

Based on the premise that many, if not most, reactions in organic chemistry can be explained by variations of fundamental acid-base concepts, Organic Chemistry: An Acid-Base Approach provides a framework for understanding the subject that goes beyond mere memorization. Using several techniques to develop a relational understanding, it helps students fully grasp the essential concepts at the root of organic chemistry. This new edition was rewritten largely with the feedback of students in mind and is also based on the author's classroom experiences using the previous editions. Highlights of the Third Edition Include: Extensively revised chapters that improve the presentation of material. Features the contributions of more than 65 scientists, highlighting the diversity in organic chemistry. Features the current work of over 30 organic chemists, highlighting the diversity in organic chemistry. Many new reactions are featured that are important in modern organic chemistry. Video lectures are provided in a .mov format, accessible online as a 'built-in' ancillary for the book. The homework is available online, gratis to all users. The third edition of Organic Chemistry: An Acid-Base Approach constitutes a significant improvement upon a unique introductory technique to organic chemistry. The reactions and mechanisms it covers are the most fundamental concepts in organic chemistry that are applied to industry, biological chemistry, biochemistry, molecular biology, and pharmacy. Using an illustrated conceptual approach rather than presenting sets of principles and theories to memorize, it gives students a more concrete understanding of the material.

The study of the physical world had its origins in philosophy, and, two-and-one-half millennia later, the scientific advances of the twentieth century are bringing the two fields closer together again. So argues Lawrence Sklar in this brilliant new text on the philosophy of physics.Aimed at students of both disciplines, Philosophy of Physics is a broad overview of the problems of contemporary philosophy of physics that readers of all levels of sophistication should find accessible and engaging. Professor Sklar's talent for clarity and accuracy is on display throughout as he guides students through the key problems: the nature of space and time, the problems of probability and irreversibility in statistical mechanics, and, of course, the many notorious problems raised by quantum mechanics.Integrated by the theme of the interconnectedness of philosophy and science, and linked by many references to the history of both disciplines, Philosophy of Physics is always clear, while remaining faithful to the complexity and integrity of the issues. It will take its place as a classic text in a field of fundamental intellectual importance.

Traditionally, the search for new compounds from natural products has been a time- and resource-intensive process. The recent application of combinatorial methods and high-throughput synthesis has allowed scientists to generate a range of new molecular structures from natural products and observe how they interact with biological targets. Combinatorial Synthesis of Natural Product-Based Libraries summarizes the most important perspectives on the application of combinatorial chemistry and natural products to novel drug discovery. The book details the latest approaches for implementing combinatorial research and testing methodologies to the synthesis of natural product-based libraries. Interconnecting the important aspects of this emerging field through the work of several leading scientists, it covers the computational analysis of natural molecules and details strategies for designing compound libraries, using bioinformatics in particular. The authors describe numerous synthetic methods for producing natural products and their analogs, including engineered biosynthesis and polymer-supported reagents. They also discuss additional considerations for generating libraries, such as screening, scaffolding, and yield optimization. Other chapters examine specific classes of libraries derived from natural products including carbohydrates, polyketides, peptides, alkaloids, terpenoids, steroids, flavonoids, and fungal compounds. Drawing attention to the interplay of drug discovery, natural products, and organic synthesis, Combinatorial Synthesis of Natural Product-Based Libraries contains the most recent and significant methods used to search and assess new compounds for their ability to mitigate biological processes that may lead to improved treatments for various diseases.

Increasingly viewed as the future of medicine, the field of tissue engineering is still in its infancy. As evidenced in both the scientific and popular press, there exists considerable excitement surrounding the strategy of regenerative medicine. To achieve its highest potential, a series of technological advances must be made. Putting the numerous breakthroughs made in this field into a broad context, Tissue Engineering disseminates current thinking on the development of engineered tissues. Divided into three sections, the book covers the fundamentals of tissue engineering, enabling technologies, and tissue engineering applications. It examines the properties of stem cells, primary cells, growth factors, and extracellular matrix as well as their impact on the development of tissue engineered devices. Contributions focus on those strategies typically incorporated into tissue engineered devices or utilized in their development, including scaffolds, nanocomposites, bioreactors, drug delivery systems, and gene therapy techniques. Finally, the book presents synthetic tissues and organs that are currently under development for regenerative medicine applications. The ability to engineer biocompatible tissue is the hallmark of modern biomedical engineering, integrating all aspects of every sub-discipline in the field. Featuring chapters drawn from the third edition of the best-selling Handbook of Biomedical Engineering as well as new contributions not found in the handbook, Tissue Engineering surveys the latest advances in this relatively young area. The contributing authors are a diverse group with backgrounds in academia, clinical medicine, and industry. Furthermore, the text includes contributions from Europe, Asia, and North America, helping to broaden the views on the development and application of tissue engineered devices.

The publication date of the first edition is not stated, but the new edition is apparently considerably revised and expanded. It was written to serve as a multi-purpose text at the senior or graduate level and as a reference for the practicing scientist or engineer. Readers should have a math backgr

Drawing from the third edition of the bestselling Powder Technology Handbook, this book concentrates on handling methods and unit operations for powder and particle processing techniques. Itexamines the purpose and factors involved in each process-including planning, equipment, measurements, and other necessary considerations. This book carefully incorporates the progressive work and vision of new authors while retaining the concepts that continue to promote innovative research and applications. In addition to detailing the purpose and implementation of processes including kneading, drying, filtration, and powder coating, the authors highlight recent developments in combustion and heating, electrostatic powder coating, and simulation. They also emphasize practical information including multipurpose equipment, instrumentation for key measurements, and modeling techniques. The text concludes with a review of recent data on the health effects of small particles and the types of protective devices that are currently available. Powder Technology: Handling and Operations, Process Instrumentation, and Working Hazards offers material scientists and chemical engineers a well-rounded guide to utilizing particle and powder processes for a rapidly expanding array of applications.

Drawing on the author's extensive personal experience, Medicinal Plants of Asia and the Pacific provides comprehensive coverage of the medicinal plants of the region. Describing more than 300 compounds, the book discusses every important class of natural products while highlighting cutting-edge research and recent developments. With its broad scope and extensive compound listings, the presentation and approach of the book is completely original.

Metal Cutting Mechanics outlines the fundamentals of metal cutting analysis, reducing the extent of empirical approaches to the problems as well as bridging the gap between design and manufacture. The author distinguishes his work from other works through these aspects: considering the system engineering of the cutting process identifying the singularity of the cutting process among other closely related manufacturing processes by chip formation, caused by bending and shear stresses in the deformation zone suggesting a distinctive way toward predictability of the metal cutting process devoting special attention to experimental methodology Metal Cutting Mechanics provides an exceptional balance between general reading and research analysis, presenting industrial and academic requirements in terms of basic scientific factors as well as application potential.

Image Analysis of Food Microstructure offers a condensed guide to the most common procedures and techniques by which quantitative microstructural information about food can be obtained from images. The images are selected from a broad range of food items, including macroscopic images of meat and finished products such as pizza, and the microstructures of cheeses, dough and baked goods, ice cream, fruits and vegetables, emulsions, foams, and gels. The book informs food scientists about the image processing and measurement tools used to characterize a variety of microstructures in foods, using high-quality image techniques to illustrate chemical composition, thermo-mechanical processing, and genetic and structural properties. These different types of images used to measure various aspects of structure include: macroscopic light photography, confocal light microscopy, electron microscopy, atomic force microscope images, magnetic resonance, and computed tomography. Then the text explains how to interpret images to produce data, plot the results in different graphs, and identify trends. Examples using these image analysis techniques show typical results that researchers can expect and recreate. Image Analysis of Food Microstructure summarizes the basic procedures that can be useful in various aspects of food research, from nutraceuticals to cooking and food processing. It presents the processing of images and mathematical principles needed for image analyses in a step-by-step approach to extract key information from the images obtained.

Although the use of composites has increased in many industrial, commercial, medical, and defense applications, there is a lack of technical literature that examines composites in conjunction with concrete construction. Fulfilling the need for a comprehensive, explicit guide, Reinforced Concrete Design with FRP Composites presents specific information necessary for designing concrete structures with fiber reinforced polymer (FRP) composites as a substitute for steel reinforcement and for using FRP fabrics to strengthen concrete members. In a reader-friendly, design-oriented manner, this book discusses the analysis, design, durability, and serviceability of concrete members reinforced with FRP. The authors first introduce the elements that constitute composites-the structural constituent and matrix-and discuss how composites are manufactured. Following an examination of the durability of FRP composites that contain fibers, such as glass, carbon, or aramid, the book illustrates how FRP external reinforcement systems (FRP-ER) can be used for enhancing the strength and stiffness of concrete structures using theory and design principles. The concluding chapter concentrates on serviceability aspects of concrete members internally reinforced with FRP. An excellent resource of design and construction practices, Reinforced Concrete Design with FRP Composites is a state-of-the-art reference on concrete members reinforced with FRP.

Principles of Soil Physics examines the impact of the physical, mechanical, and hydrological properties and processes of soil on agricultural production, the environment, and sustainable use of natural resources. The text incorporates valuable assessment methods, graphs, problem sets, and tables from recent studies performed around the globe and offers an abundance of tables, photographs, and easy-to-follow equations in every chapter. The book discusses the consequences of soil degradation, such as erosion, inhibited root development, and poor aeration. It begins by defining soil physics, soil mechanics, textural properties, and packing arrangements . The text continues to discuss the theoretical and practical aspects of soil structure and explain the significance and measurement of bulk density, porosity, and compaction. The authors proceed to clarify soil hydrology topics including hydrologic cycle, water movement, infiltration, modeling, soil evaporation, and solute transport processes. They address the impact of soil temperature on crop growth, soil aeration, and the processes that lead to the emission of greenhouse gases. The final chapters examine the physical properties of gravelly soils and water movement in frozen, saline, and water-repellant soils. Reader-friendly and up-to-date, Principles of Soil Physics provides unparalleled coverage of issues related to soil physics, structure, hydrology, aeration, temperature, and analysis and presents practical techniques for maintaining soil quality to ultimately preserve its sustainability.

Derived from the fourth edition of the well-known Plastics Technology Handbook, Industrial Polymers, Specialty Polymers, and Their Applications covers a wide range of general and special types of polymers, along with a wealth of information about their applications. The book first focuses on commonly used industrial polymers, including polypropylenes, low- and high-density polyethylenes, and poly(vinyl chloride), as well as less widely used polymer types, such as acrylics, ether polymers, cellulosics, sulfide polymers, silicones, polysulfones, polyether ether ketones, and polybenzimidazoles. It then explores polymer derivatives and polymeric combinations that play special and often critical roles in diverse fields of human activities. The polymers covered include liquid crystal, electroactive, ionic, and shape memory polymers; hydrogels; and nanocomposites. The volume concludes with a comprehensive overview of new developments in the use of polymers in a variety of areas.

A comprehensive treatment of a large family of polymers useful in a wide range of applications in such fields as automotive, pharmaceutical, cosmetic, metal-working, mining, industrial coating, textile, construction, and home furnishings. Summarizes the chemistry and mechanisms; provides basic prepa

In the early 1970s, fuzzy systems and fuzzy control theories added a new dimension to control systems engineering. From its beginnings as mostly heuristic and somewhat ad hoc, more recent and rigorous approaches to fuzzy control theory have helped make it an integral part of modern control theory and produced many exciting results. Yesterday's "art" of building a working fuzzy controller has turned into today's "science" of systematic design. To keep pace with and further advance the rapidly developing field of applied control technologies, engineers, both present and future, need some systematic training in the analytic theory and rigorous design of fuzzy control systems. Introduction to Fuzzy Sets, Fuzzy Logic, and Fuzzy Control Systems provides that training by introducing a rigorous and complete fundamental theory of fuzzy sets and fuzzy logic, and then building a practical theory for automatic control of uncertain and ill-modeled systems encountered in many engineering applications. The authors proceed through basic fuzzy mathematics and fuzzy systems theory and conclude with an exploration of some industrial application examples. Almost entirely self-contained, Introduction to Fuzzy Sets, Fuzzy Logic, and Fuzzy Control Systems establishes a strong foundation for designing and analyzing fuzzy control systems under uncertain and irregular conditions. Mastering its contents gives students a clear understanding of fuzzy control systems theory that prepares them for deeper and broader studies and for many practical challenges faced in modern industry.

Ultra-Cold Neutrons is a complete, self-contained introduction and review of the field of ultra-cold neutron (UCN) physics. Over the last two decades, developments in UCN technology include the storage of UCN in material and magnetic bottles for time periods limited only by the beta decay rate of the free neutron. This capability has opened up the possibility of a wide range of applications in the fields of both fundamental and condensed state physics. The book explores some of these applications, such as the search for the electric dipole moment of the neutron that constitutes the most sensitive test of time reversal invariance yet devised. The book is suitable as an introduction to the field for research students, as a useful compendium of results and techniques for researchers, and is of general interest to nonspecialists in other areas of physics such as neutron, atomic, and fundamental physics and neutron scattering.

Drawing from the third edition of the bestselling Powder Technology Handbook, this book is focused solely on analyzing the fundamental properties and behavior of particles and particle beds. Powder Technology: Fundamentals of Particles, Powder Beds, and Particle Generation concentrates on the most useful analytical methods of observation, measurement, modeling, and prediction. This volume carefully incorporates the progressive work and vision of new authors while retaining the concepts that continue to promote innovative research and applications. The authors highlight new information and developments from areas including surface properties and analysis, particle motion in fluids, mechanical properties of a powder bed, and the design and formation of composite particles. They explain how particles deposit, coagulate, and settle in various media, explore different techniques for generating particles in different states, and detail methods of surface modification. Particularly useful for scientists studying nanoparticle applications, Powder Technology: Fundamentals of Particles, Powder Beds, and Particle Generation incorporates the latest developments in areas including surface properties and analysis, particle motion in fluids, mechanical properties of a powder bed, and the design and formation of composite particles.

Considers three fundamental aspects of molecular interactions important in chromatography, taking care not to duplicate information readily available in other references. Surveys the basic factors involved in complex formation, which governs the retention mechanism and selectivity in either donor or

The final volume of this new innovative and informative three-volume set explains and explores the essential basic and advanced concepts from various areas within the nanosciences. This volume primarily focuses on increasing awareness of sustainable nanochemistry, meaning the social and economic impact of nanochemistry, in order to mitigate ecological resource depletion and to promote the exploration of nature as a resource for future benefits. This volume adopts a pharmacological lens, examining the multitude of ways in which nano-research can contribute to the development of pharmaceutical drugs and paying particular attention to toxicology and renewable energy within nanochemistry. Under the vast expertise of the editor, the volume contains 34 entries contributed by renowned international scientists and scholars. The content in this volume covers topics such as anti-HIV agents, ecotoxicology, solar cells and photovoltaic phenomena, spectral-SAR, and more-alphabetically organized and accompanied by equations, figures, and brief letters in order to emphasize the potential applications of the concepts discussed.