- written by world leading experts in the field - contains many worked-out examples, taken from daily life fire related practical problems - covers the entire range from basics up to state-of-the-art computer simulations of fire and smoke related fluid mechanics aspects, including the effect of water - provides extensive treatment of the interaction of water sprays with a fire-driven flow - contains a chapter on CFD (Computational Fluid Dynamics), the increasingly popular calculation method in the field of fire safety science

Covers all emergent materials (natural and artificial) that are promising for optical, infrared, and terahertz applications Comparatively analyzes these materials, elucidating their unique advantages, limitations, and application scopes Provides an up-to-date record on achievements and progress in cutting-edge optical, infrared, and terahertz applications Offers a comprehensive overview to connect multidisciplinary fields, such as materials, physics, and optics, to serve as a basis for future progress

Cancer will remain a global major health problem unless new diagnostic, prognostic, and management approaches are discovered to address both loss of life and quality of life. Here we summarize the general physiology, pathology, heterogeneity, and evolution of cancer, current status, limitations and challenges associated with prevention, incidence, treatment, survival, and mortality, as well as future directions with regards to solid tumors. Perspectives are provided on how to improve pre-clinical understandings, outcomes, and patient care. Further, this comprehensive, timely overview of the literature has educational value as part of an academic course, seminar, or as a supplementary text. Features : This book summarizes the current status, successes, difficulties, advancements, limitations, and challenges in medical interventions that impact patients' quality of life. Includes concise descriptions of all relevant cell and molecular biology concepts including evolutionary paradigms, hallmarks of cancer, and heterogeneity to help understand the pathophysiology of cancer, cancer-associated disease conditions, and effective cancer therapy. Contains an array of colorful figures and schematics summarizing complex informative pathological, physiological, and biochemical concepts. Covers a multitude of sub-topics pertaining to cancer biology including diagnosis; chemotherapy, radiotherapy and targeted therapy; metastasis; disseminated and circulating tumor cells, and cancer stem cells; drug resistance and cellular reprogramming; complex epigenetics; tumor-derived exosomes; oncogenic viruses; metabolic syndrome and cancer metabolism; convoluted neovascularization; efficient biomarkers; immunotherapy; role of nutraceuticals and natural products. Provides perspectives on how to improve pre-clinical understandings, and outcomes, linking toxicological, and pharmacological aspects in patient care. This timely, relevant comprehensive assortment of scientific literature has educational value to a wider audience including as part of an academic course, seminar, or as a supplementary text.

Key features: Presents the first elementary introduction to quantum geometry Explores how to understand quantum geometry without prior knowledge beyond bachelor level physics and mathematics. Contains exercises, problems and solutions to supplement and enhance learning

Guides the reader into the mysteries of water. Provides a state-of-the-art overview in computer simulations and experiments on water. Brings together leading scientists in the field of water.

This reference text discusses processing, structure, and properties of metal matrix composites, polymer matrix composites, and ceramic matrix composites for applications in high end engineering equipment, biomedical and nano-biotechnology areas. The text begins by discussing fundamentals, classification, designing and fabrication of composite materials, followed by ultrasonic vibration assisted machining of advanced materials, fabrication of transparent advanced composites, fabrication of composites via microwave sintering, and hybrid machining of metal-matrix composites. It covers important topics including fabrication of shape-memory polymers, additive manufacturing for the fabrication of composites, 3D printing processes for biomedical applications, and ultrasonic vibration assisted machining of advanced materials. The text will be useful for undergraduate, graduate students, and academic researchers in areas including materials science, mechanical engineering, manufacturing science, aerospace engineering, electronics and communication engineering The book- Covers processing, structure, and properties of metal matrix composites, polymer matrix composites, and ceramic matrix composites. Discusses nano materials and their potential applications in the area of biomedical and nano-biotechnology. Provides modern processing techniques to synthesize advance materials. Explores applicability of the materials using mechanical, chemical, thermal and electrical tests. Discussing advanced materials, their manufacturing techniques and applications in diverse areas including automotive, aerospace engineering, biomedical, this text will be useful for undergraduate, graduate students, and academic researchers in areas including materials science, mechanical engineering, manufacturing science, aerospace engineering, electronics and communication engineering. It will further discuss electro discharge machining of steels using chromium alloy-based electrodes, and advanced machining techniques for hard materials.

Unique and timely volume as mRNA is a hot area of research making great strides. Covers the full-scale production systems that are needed to develop vaccines as well as elements of data needed to secure the IND approvals. Introduces a commercial-scale manufacturing process using novel techniques like the PCR, in addition to the traditional plasmid DNA. First book that offers commercial technology for developing and large-scale supply of mRNA products. Renowned author and entrepreneur in the field of drug discovery and production.

Microbial relationships with all life forms can be as free living, symbiotic or pathogenic. Human beings harbor 10 times more microbial cells than their own. Bacteria are found on the skin surface, in the gut and other body parts. Bacteria causing diseases are the most worrisome. Most of the infectious diseases are caused by bacterial pathogens with an ability to form biofilm. Bacteria within the biofilm are up to 1000 times more resistant to antibiotics. This has taken a more serious turn with the evolution of multiple drug resistant bacteria. Health Departments are making efforts to reduce high mortality and morbidity in man caused by them. Bacterial Quorum sensing (QS), a cell density dependent phenomenon is responsible for a wide range of expressions such as pathogenesis, biofilm formation, competence, sporulation, nitrogen fixation, etc. Majority of these organisms that are important for medical, agriculture, aquaculture, water treatment and remediation, archaeological departments are: Aeromonas, Acinetobacter, Bacillus, Clostridia, Enterococcus, Pseudomonas, Vibrio and Yersinia spp. Biosensors and models have been developed to detect QS systems. Strategies for inhibiting QS system through natural and synthetic compounds have been presented here. The biotechnological applications of QS inhibitors (QSIs) in diverse areas have also been dealt with. Although QSIs do not affect growth and are less likely to impose selective pressure on bacteria, however, a few reports have raised doubts on the fate of QSIs. This book addresses a few questions. Will bacteria develop mechanisms to evade QSIs? Are we watching yet another defeat at the hands of bacteria? Or will we be acting intelligently and survive the onslaughts of this Never Ending battle?

Cancer will remain a global major health problem unless new diagnostic, prognostic, and management approaches are discovered to address both loss of life and quality of life. Here we summarize the general physiology, pathology, heterogeneity, and evolution of cancer, current status, limitations and challenges associated with prevention, incidence, treatment, survival, and mortality, as well as future directions with regards to solid tumors. Perspectives are provided on how to improve pre-clinical understandings, outcomes, and patient care. Further, this comprehensive, timely overview of the literature has educational value as part of an academic course, seminar, or as a supplementary text. Features : This book summarizes the current status, successes, difficulties, advancements, limitations, and challenges in medical interventions that impact patients' quality of life. Includes concise descriptions of all relevant cell and molecular biology concepts including evolutionary paradigms, hallmarks of cancer, and heterogeneity to help understand the pathophysiology of cancer, cancer-associated disease conditions, and effective cancer therapy. Contains an array of colorful figures and schematics summarizing complex informative pathological, physiological, and biochemical concepts. Covers a multitude of sub-topics pertaining to cancer biology including diagnosis; chemotherapy, radiotherapy and targeted therapy; metastasis; disseminated and circulating tumor cells, and cancer stem cells; drug resistance and cellular reprogramming; complex epigenetics; tumor-derived exosomes; oncogenic viruses; metabolic syndrome and cancer metabolism; convoluted neovascularization; efficient biomarkers; immunotherapy; role of nutraceuticals and natural products. Provides perspectives on how to improve pre-clinical understandings, and outcomes, linking toxicological, and pharmacological aspects in patient care. This timely, relevant comprehensive assortment of scientific literature has educational value to a wider audience including as part of an academic course, seminar, or as a supplementary text.

Adds three new chapters (constructed wetlands, stream sediments, and rice production systems) and is updated throughout Examines the adaptation of wetland plants to varying anaerobic soil conditions Provides the basic concepts involved in biogeochemical cycling of nutrients and contaminants in wetlands as related to environmental significance and ecological functions Examines the role of microbial processes in sulfate reduction, denitrification, and methane production Provides case studies for key biogeochemical processes governing wetland function in freshwater wetlands

NK Cells in Cancer Immunotherapy: Successes and Challenges explains the latest immunotherapeutic strategies, focusing on NK cells to allow the best and precise combination treatments to cancer patients. The book provides existing background knowledge in the field of immunotherapy and discusses future areas of research required to carry out cutting-edge, validated therapies. Chapters cover advances in immunotherapeutic strategies, in particular, the use of NK cells with and without T-cell therapy in the treatment of cancer. The book is a valuable resource for cancer researchers, oncologists, graduate students and those interested in learning more about novel strategies to treat cancer patients. Immunotherapy is fast becoming the method of choice for cancer therapy. Although remarkable advances have been made in the field of immunotherapy, there are significant challenges and difficulties ahead since many of the current immunotherapeutic strategies do not provide long-lasting treatment strategies, and therefore are not very effective.

Generally, spontaneous pattern formation phenomena are random and repetitive, whereas elaborate devices are the deterministic product of human design.
Yet, biological organisms and collective insect constructions are exceptional examples of complex systems that are both self-organized and architectural.
This book is the first initiative of its kind toward establishing a new field of research, Morphogenetic Engineering, to explore the modeling and implementation of self-architecturing systems. Particular emphasis is placed on the programmability and computational abilities of self-organization, properties that are often underappreciated in complex systems science while, conversely, the benefits of self-organization are often underappreciated in engineering methodologies.
Altogether, the aim of this work is to provide a framework for and examples of a larger class of self-architecturing systems, while addressing fundamental questions such as
> How do biological organisms carry out morphogenetic tasks so reliably?
> Can we extrapolate their self-formation capabilities to engineered systems?
> Can physical systems be endowed with information (or informational systems be embedded in physics) so as to create autonomous morphologies and functions?
> What are the core principles and best practices for the design and engineering of such morphogenetic systems?
The intended audience consists of researchers and graduate students who are working on, starting to work on, or interested in programmable self-organizing systems in a wide range of scientific fields, including computer science, robotics, bioengineering, control engineering, physics, theoretical biology, mathematics, and many others.

The first book on Ultrafine bubbles (UFBs). Reviews research done on UFBs. Helpful for readers and researchers interested in the fundamentals of this emerging field

Although nitric oxide (NO) is an important biological signaling molecule, its free-radical electronic configuration makes it a most reactive molecule and the scariest colorless gas causing immense environmental and health hazards. Detection of NO levels in biological samples and in the atmosphere is therefore crucial. In the past few years, extensive efforts have been devoted to developing many active sensors and effective devices for detecting and quantifying atmospheric NO, NO generated in biological samples, and NO exhaled in the human breath. This book provides a concrete summary of recent state-of-the-art small-molecule probes and novel carbon nanomaterials used for chemical, photoluminescent, and electrochemical NO detection. One chapter is especially dedicated to the available devices used for detecting NO in the human breath that indirectly infers to lung inflammation. The authors with expertise in diverse dimensions have attempted to cover almost all areas of NO sensing.

Carbon Nanotubes for a Green Environment: Balancing the Risks and Rewards describes the synthesis, characterization, and unique applications of undoped/doped carbon nanotubes as well as hybrids of them with grapheme or nanocomposites, focusing on green aspects of carbon nanotube applications. The volume shows new approaches used for tapping the potential and promise of key materials in isolation or combined with other materials. The research-oriented chapters highlight a spectrum of applications of carbon nanotubes as novel materials for energy storage as well as for environmental remediation, wastewater treatment, green health care products, and more. Chapters explore the use of carbon nanotubes for remediation methods for wastewater treatment such as by using graphene oxide-carbon nanotube composites and by applying undoped and doped carbon nanotubes for removing contaminates. The book also looks at the application of carbon nanotubes for enhanced oil recovery and for heavy metal separation. Other chapters look at the rheological behavior of carbon nanotubes-based materials and their role in processing for various products, the thermal and electrical transport in carbon nanotubes composites, carbon nanotubes-based composite materials for electromagnetic shielding applications. The biomedical applications of carbon nanotube-based nanomaterials also explored, such as FTIR spectroscopy.

Covers key areas of heterojunction nanomaterials for easy understanding of students, researchers, and academicians to promote the research in this field Systematically summarizes synthetic strategies, physicochemical properties, photocatalytic mechanisms, and applications of heterojunction materials through high-quality illustrations and schematic diagrams and references accompanying each chapter Emphasizes the ongoing challenges and potential directions for future development of heterojunction photocatalysts

Scientists have long been looking for alternative methods for the cleaning of historical and cultural museum objects as conventional methods often fail to completely remove surface films, leaving contamination and surface residues behind. Low-temperature plasmas have recently been found to provide a new, efficient and durable approach that maintains the safety of both the materials and personnel. This book is the first to introduce the emerging use of low-temperature plasmas in the cleaning and decontamination of cultural heritage items. It provides a comprehensive exploration of the new possibilities of cleaning objects with plasma, before providing a practice guide to the individual cleaning methods and an overview of the technologies and conditions used in the different cleaning regimes. It is an ideal reference for researchers in plasma physics, in addition to professionals working in the field of historical and cultural conservation. Features: Provides a thorough overview of the cleaning potential of emerging plasma technologies in accessible language for professional restorers and conservators without a scientific background Includes the latest case studies from the field, which have not been published elsewhere yet Authored by a team of experts in the field About the Authors: Dr. Radko Tino is an Associate Professor at the Slovak University of Technology in Bratislava, Slovakia. Dr. Katarina Vizarova is an Associate Professor at the Slovak University of Technology in Bratislava, Slovakia. Dr. Frantisek Krcma is an Associate Professor at Brno University of Technology, Czech Republic. Dr. Milena Rehakova is an Associate Professor at the Slovak University of Technology in Bratislava, Slovakia. Dr. Viera Jancovicova is an Associate Professor at the Slovak University of Technology in Bratislava, Slovakia. Dr. Zdenka Kozakova is an Associate Professor at Brno University of Technology, Czech Republic.

Spreading to every corner of the Earth, the COVID-19 virus has had an unparalleled impact on all aspects of our lives. This book explores in detail how the COVID-19 pandemic has affected clinical practice, education, and research in medical physics, and how colleagues on the frontline dealt with this unpredictable and unprecedented pandemic. It tackles key questions such as: How did medical physicists first respond to the situation? What innovative strategies were taken and how effective were they? How are medical physicists preparing for the future? There will be a focus on the different experiences of regional medical physicists and the responses and outlooks in clinical practice, education, and research in the affected continents, Asia-Pacific, the Middle East, Europe, Africa and North and Latin America. With over 91 contributors from 39 countries, this unique resource contains key perspectives from teams from each territory to ensure a global range of accounts. The collective opinion and wisdom from the major medical physics journal editors-in-chief are also explored, alongside how the pandemic has affected the quantity and quality of publications. Voices of early-career researchers and students of medical physics will be included, with narratives of their experiences coping with life during the pandemic. Lastly, communicating leadership in times of adversity is highlighted. This book will be a historic account of the impact of the COVID-19 virus on the field of medical physics. It will be an ideal reference for medical physicists, medical physics trainees and students, hospital administrators, regulators, and healthcare professionals allied with medical physics. Key features: The first book to cover the impact of COVID-19 on the field of medical physics Edited by two experts in the field, with chapter contributions from subject area specialists around the world Broad, global coverage, ranging from the impact on teaching, research, and publishing, with unique perspectives from journal editors and students and trainees

With contributions from experts from both academia and industry, this book provides up-to-date reviews and promising approaches for corrosion control of metals and alloys via sustainable biopolymers and carbon nanomaterials coatings, focusing on the wonder material "graphene" which is more solid than steel. This book delivers essential information for improving the environmental and economic viability of current coating technologies. It is also a valuable reference for those who are interested in corrosion science and corrosion protection including professionals from the industry as well as academia.

Covers important supramolecules. Contains compilation of the different threads of supramolecular chemistry. Covers important supramolecules. Covers important environmental and biological applications. Covers important techniques at relevant places.

This book provides an up-to-date overview of the foundations of spacetime physics. It features original essays written by world-class experts in the physics and philosophy of spacetime. The foundational questions regarding the origin and nature of spacetime are branching into new and exciting directions. These questions are not restricted to the quantum gravity program but also arise in the context of a well-established theory like general relativity. Against the background of these quick and diverse developments, this volume features a broad range of perspectives on spacetime. Part I focuses on the nature of spacetime in non-quantum theories, such as Newtonian mechanics and relativity. Part II explores some intriguing conceptual implications of developing a quantum theory of spacetime. The Foundations of Spacetime Physics is an essential resource for scholars and advanced students working in philosophy of physics, philosophy of science, and scientific metaphysics.

Features: Includes over 104 codes in OOPs python, all of which can be used either as a standalone program or integrated with any other main program without any issues. Every parameter in the input, output and execution has been provided while keeping both beginner and advanced users in mind. The output of every program is explained thoroughly with detailed examples. A detailed mathematical commenting is done along side the code which enhances clarity about the flow and working of the code

Features Combines all topics into one comprehensive introduction. Explores practical applications of theory to healthcare. Can be used to accompany the NHS Modernising Scientific Careers syllabus.

Ensuring National Biosecurity: Institutional Biosafety Committees reviews the various responsibilities and associated challenges Institutional Biosafety Committees (IBCs) face and proposes changes that may help improve this system and increase national biosecurity and worker safety. In recent years IBCs in academic and other institutions have been tasked with increasing levels of responsibility, overseeing work with recombinant genetic material and hazardous agents. IBC members often lack the training to effectively ensure that the work performed is truly safe for scientists and the general community, and so increasingly rely upon the expertise of the researchers themselves. With the proposed US dual-use research policies soon to be implemented, this strain may increase. This book provides readers with the necessary information to be able to enhance national biosecurity within the US, EU, Australia, New Zealand, Japan and more. Ensuring National Biosecurity is as an invaluable reference for biosafety professionals or for researchers who need to understand the regulatory landscape that impacts their research.

Many physiological conditions such as host defense or aging and pathological conditions such as neurodegenerative diseases, and diabetes are associated with the accumulation of high levels of reactive oxygen species and reactive nitrogen species. This generates a condition called oxidative stress. Low levels of reactive oxygen species, however, which are continuously produced during aerobic metabolism, function as important signaling molecules, setting the metabolic pace of cells and regulating processes ranging from gene expression to apoptosis. For this book we would like to recruit the experts in the field of redox chemistry, bioinformatics and proteomics, redox signaling and oxidative stress biology to discuss how organisms achieve the appropriate redox balance, the mechanisms that lead to oxidative stress conditions and the physiological consequences that contribute to aging and disease.