The ability to predict the behavior of fermentation systems enhances the possibility of optimizing their performance. Mathematical equations of model systems represent a tool for this and the most recent advances in computer hardware and software have made the approach more effective than previous simplistic attempts. The current knowledge of biochemical microbial pathways and the experience in optimization of chemical reactors combined with extremely powerful and accessible computers, loaded with easy to use software and mathematical routines, are changing the way processes are being developed and operated.

This book has been written for all those who work with microbial cultures, providing a useful, quick and contemporary re-education for practitioners and students alike, breaking through interdisciplinary barriers. Biologists, engineers and biochemists will benefit from the methods of microbial process description and optimization based on mathematical equations. The basic techniques of modeling the bio-system are summarized in Part I. The useful concept of mass balancing is introduced in Part II for those who are not used to this simple and very useful engineering tool. An extensive and descriptive case study of a selected fermentation bio-process in Part III elucidates further the concepts of very pragmatic mathematical modeling of bioreactor systems.

The volume outlines how to simply develop mathematical models of microbial systems and demonstrates their power to: guide and minimize the experimental work; check the consistency of experimental results; predict the behavior of the bio-system and analyze biocatalytic processes; diagnose the anomalies in the microbial culture behavior and optimize the performance of bioreactors.

This book series focuses on current progress in the broad field of medical microbiology, and covers both basic and applied topics related to the study of microbes, their interactions with human and animals, and emerging issues relevant for public health. Original research and review articles present and discuss multidisciplinary findings and developments on various aspects of microbiology, infectious diseases, and their diagnosis, treatment and prevention. The book series publishes review and original research contributions, short reports as well as guest edited thematic book volumes. All contributions will be published online first and collected in book volumes. There are no publication costs. Advances in Microbiology, Infectious Diseases and Public Health is a subseries of Advances in Experimental Medicine and Biology, which has been publishing significant contributions in the field for over 30 years and is indexed in Medline, Scopus, EMBASE, BIOSIS, Biological Abstracts, CSA, Biological Sciences and Living Resources (ASFA-1), and Biological Sciences. 2018 Impact Factor: 2.126.

Protobiology as a physics of becoming emphasizes the dynamics underlying conservation laws, whereas the physics of being emphasize the dynamics presupposing conservation laws. Protobiology thus concerns itself with a convoluted problem of how both the law of motion and its boundary conditions develop with time without forgetting that these two are inseparable, in contrasts to the physics of being that assumes separability.

This book provides a comprehensive overview of the basic and advanced metabolic engineering technologies used to generate natural metabolites and industrially important biomolecules. Metabolic engineering has the potential to produce large quantities of valuable biomolecules in a renewable and sustainable manner by extending or modifying biosynthetic pathways in a wide range of organisms. It has been successfully used to produce chemicals, drugs, enzymes, amino acids, antibiotics, biofuels, and industrially important pharmaceuticals. The book comprehensively reviews the various metabolites detection, extraction and biosensors and the metabolic engineering of microbial strains for the production of industrially useful enzymes, proteins, organic acids, vitamins and antibiotics, therapeutics, chemicals, and biofuels. It also discusses various genetic engineering and synthetic biology tools for metabolic engineering. In closing, the book discusses ethical, patenting and regulatory issues in the metabolic engineering of microbes. This book is a valuable source not only for beginners in metabolic engineering, but also students, researchers, biotechnology and metabolic engineering based company.

This book provides a comprehensive examination of biochemical and genetic regulatory phenomena as they relate to the activity of actinomycete secondary metabolic pathways and the functioning of secondary metabolites as endogenous effectors of cytodifferentiation. Approximately 50 illustrations accompany the text.

This book is concerned primarily with operative endoscopy utilizing lasers, presenting proved and future endoscopic applications of lasers in medicine. It includes new concepts of cancer therapy, such as photodynamic therapy, because of the laser's endoscopic application.

This book provides an assessment of the understanding of soil microbiology and biochemistry as part of reclamation processes. It attempts to assemble more specialized literature on reclamation, where application of microbiological concepts has provided the understanding of the process.

Fermented foods play a major role in human nutrition and health, given the addition of flavor, improvement of texture, preservation against spoilage, and ease of digestion due to the fermentation process. This book provides information about the chemistry and bioactive compounds of African fermented food products, including their nutritional value and minor constituents. Chapters cover a wide range of topics, from the microorganisms involved in spontaneous fermentation to food safety considerations and quality assessment. The text can be used as a practical manual to better understand the nutritional and medicinal uses of various African fermented foods, as well as prepare recipes and product labels.

The marine environment covers 70% of the earth's surface and accounts for 98% of the potentially habitable space. The bioactives from marine microorganisms include antibiotic compounds, polysaccharides, inhibitors, enzymes, peptides, and pigments. These are used in various fields of biology that range from nutraceuticals to cosmeceuticals. Recent scientific investigations have revealed that marine microbial compounds exhibit various beneficial biological effects, such as anti-inflammatory, anti-cancer, anti-HIV, anti-hypertensive, and anti-diabetic. Marine Microorganisms: Extraction and Analysis of Bioactive Compounds sheds light on the extraction, clean-up, and detection methods of major compounds from marine organisms. The book includes information on the different classes of marine microorganisms and the different bioactives that can be extracted from bacteria, fungi and microalgae. Divided into 7 chapters, the book covers bioactive marine natural products, such as marine microbes, seaweeds, and marine sponges as potential sources of drug discovery, and focuses on analysis methods of the biocomponents from marine microorganisms. A useful reference tool for researchers and students, this book provides current knowledge about isolation and analysis methods of the bioactives and provides insight into the various bioactives of marine microbes toward nutraceutical and pharmaceutical development.

Xenobiotic compounds including pesticides, nitrophenols, pyridine, polycyclic aromatic compounds and polychlorinated biphenyls are widely spread in environment due to anthropogenic activities. Most of them are highly toxic to living beings due to their mutagenic and carcinogenic properties. Therefore, the removal of these compounds from environment is an essential step for environmental sustainability. Microbial remediation has emerged as an effective technology for degradation of these xenobiotic compounds as microorganisms have unique ability to utilize these compounds as their sole source of carbon and energy. The primary goal of this book is to provide detailed information of microbial degradation of many xenobiotic compounds in various microorganisms.

The annual Evolutionary Biology Meetings in Marseilles serve to gather leading scientists, promote the exchange of ideas and encourage the formation of international collaborations.

This book contains the most essential contributions presented at the 14th Evolutionary Biology Meeting, which took place in September 2010. It comprises19 chapters organized according to the following categories:

. Evolutionary Biology Concepts

. Biodiversity and Evolution

. Macroevolution

. Genome Evolution

Offering an up-to-date overview of recent results in the field of evolutionary biology, this book is an invaluable source of information for scientists, teachers and advanced students. "

This book correlates the vast genetic diversity associated with environmental samples and still underexploited potential for the development of biotechnology products. The book points out the potential of different types of environmental samples. It presents the main characteristics of microbial diversity, the main approaches used for molecular characterization of the diversity, and practical examples of application of the exploration of the microbial diversity. It presents a not-yet-explored structure for discussing the main topics related to molecular biology of environmental prokaryotes and their biotechnological applications.

This book describes many novel approaches of microbial bioremediation including conventional and modern approaches, metagenomics, biosurfactants and nano-based bioremediation. Also presents up-to-date knowledge about biodegradation of solid and liquid contaminants in the rhizospheric zone by plant (rhizo)-microbiome interface. It also illustrates communication pathways based on evolving methodologies, bioinformatic tools which provides insights into the functional dynamics of bioremediation process by the host-microbiome interface. The different chapters explain the mechanism and outcomes during the process of bioremediation. The book broadly depicts the following: Advances in bioremediation through nanoremediation, rhizo-remediation, bioremediation of different ecosystems like polluted waters, industrial effluents, bioremediation of metal and organic pollutants, toxic dyes etc. The book is very useful for researchers and students in the fields of applied and environmental microbiology. It is also meant for industry experts and professionals working in the field of bioremediation and waste management.

Although known for its sandy beaches and pounding surf, historic Cape Cod is also home to a unique community of mushrooms that can be found on its heaths, pine and oak barrens, and on the borders of its bogs, kettle ponds, and cedar swamps.

Here is the definitive guide to the highly varied mycoflora of Cape Cod and the National Seashore. It contains accurate and up-to-date descriptions and over 150 color illustrations that help the reader identify over 250 indigenous mushroom species.

The scope of this work goes well beyond the identification of mushrooms. The authors provide information that increases the readers awareness of the fragile nature of Cape Cod's various ecosystems and the critical role that mushrooms play in helping to preserve them.

This edited volume emphasizes how microorganisms have become a reliable pillar of biotechnology. The authors discuss advances in synthetic biology and genetic engineering that have made it possible to reprogram the microbial cellular capabilities. This enables an economically viable production of high-value products at an industrial level. The first part of the book provides an overview of synthetic biology and genome editing tools for engineering microbial cell factories in modern fermentation. Readers also learn how high-throughput bioprocessing methods are used to recover and purify microbial products. The remaining parts of this book explore the implementation and challenges of these upstream and downstream processing techniques for manufacturing high-value products. Cost-effectiveness and quality-control are key factors, when discussing the production of low-molecular-weight products, biopharmaceuticals, biopolymers and protein-based nanoparticles. This book is a valuable resource for biotechnologists both in the industry and in academia.

Incorporates the Experiences of World-Class Researchers Microbial Biotechnology: Progress and Trends offers a theoretical take on topics that relate to microbial biotechnology. The text uses the "novel experimental experiences" of various contributors from around the world-designed as case studies-to highlight relevant topics, issues, and recent developments surrounding this highly interdisciplinary field. It factors in metagenomics and microbial biofuels production, and incorporates major contributions from a wide range of disciplines that include microbiology, biochemistry, genetics, molecular biology, chemistry, biochemical engineering, and bioprocess engineering. In addition, it also provides a variety of photos, diagrams, and tables to help illustrate the material.The book consists of 15 chapters and contains subject matter that addresses: Microbial biotechnology from its historical roots to its different processes Some of the new developments in upstream processes Solid-state fermentation as an interesting field in modern fermentation processes Recent developments in the production of valuable microbial products such as biofuels, organic acids, amino acids, probiotics, healthcare products, and edible biomass Important microbial activities such as biofertilizer, biocontrol, biodegradation, and bioremediation Students, scientists, and researchers can benefit from Microbial Biotechnology: Progress and Trends, a resource that addresses biotechnology, applied microbiology, bioprocess/fermentation technology, healthcare/pharmaceutical products, food innovations/food processing, plant agriculture/crop improvement, energy and environment management, and all disciplines related to microbial biotechnology.

This book brings together a collection of methods for the successful detection, culture and investigation of H. pylori, and its associated diseases. Chapters guide the reader through overviews on H. pylori infection, protocols for analyzing human clinical samples, and protocols for characterizing H. pylori, its functional components and its interactions with host cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Helicobacter pylori: Methods and Protocols aims to be a useful practical guide to researchers to help further their study in this field.

Great Salt Lake is an enormous terminal lake in the western United States. It is a highly productive ecosystem, which has global significance for millions of migrating birds who rely on this critical feeding station on their journey through the American west. For the human population in the adjacent metropolitan area, this body of water provides a significant economic resource as industries, such as brine shrimp harvesting and mineral extraction, generate jobs and income for the state of Utah. In addition, the lake provides the local population with ecosystem services, especially the creation of mountain snowpack that generates water supply, and the prevention of dust that may impair air quality. As a result of climate change and water diversions for consumptive uses, terminal lakes are shrinking worldwide, and this edited volume is written in this urgent context. This is the first book ever centered on Great Salt Lake biology. Current and novel data presented here paint a comprehensive picture, building on our past understanding and adding complexity. Together, the authors explore this saline lake from the microbial diversity to the invertebrates and the birds who eat them, along a dynamic salinity gradient with unique geochemistry. Some unusual perspectives are included, including the impact of tar seeps on the lake biology and why Great Salt Lake may help us search for life on Mars. Also, we consider the role of human perceptions and our effect on the biology of the lake. The editors made an effort to involve a diversity of experts on the Great Salt Lake system, but also to include unheard voices such as scientists at state agencies or non-profit advocacy organizations. This book is a timely discussion of a terminal lake that is significant, unique, and threatened.

Microbial physiology, biochemistry and genetics allowed the formulation of concepts that turned out to be important in the study of higher organisms. In the first section, the principles of bacterial growth are given, as well as the description of the different layers that enclose the bacterial cytoplasm, and their role in obtaining nutrients from the outside media through different permeability mechanism described in detail. A chapter is devoted to allostery and is indispensable for the comprehension of many regulatory mechanisms described throughout the book. Another section analyses the mechanisms by which cells obtain the energy necessary for their growth, glycolysis, the pentose phosphate pathway, the tricarboxylic and the anaplerotic cycles. Two chapters are devoted to classes of microorganisms rarely dealt with in textbooks, namely the Archaea, mainly the methanogenic bacteria, and the methylotrophs. Eight chapters describe the principles of the regulations at the transcriptional level, with the necessary knowledge of the machineries of transcription and translation. The next fifteen chapters deal with the biosynthesis of the cell building blocks, amino acids, purine and pyrimidine nucleotides and deoxynucleotides, water-soluble vitamins and coenzymes, isoprene and tetrapyrrole derivatives and vitamin B12. The two last chapters are devoted to the study of protein-DNA interactions and to the evolution of biosynthetic pathways. The considerable advances made in the last thirty years in the field by the introduction of gene cloning and sequencing and by the exponential development of physical methods such as X-ray crystallography or nuclear magnetic resonance have helped presenting metabolism under a multidisciplinary attractive angle.

Global yields of legumes have been relatively stagnant for the last five decades, despite the adoption of conventional and molecular breeding approaches. The use of plant growth-promoting (PGP) bacteria for improving agricultural production, soil and plant health has become one of the most attractive strategies for developing sustainable agriculture. Actinomycetes are bacteria that play an important role in PGP and plant protection, produce secondary metabolites of commercial interest, and their use is well documented in wheat, rice, beans, chickpeas and peas. In order to promote legumes, the general assembly of the UN recently declared 2016 the "International Year of Pulses." In view of this development, this book illustrates how PGP actinomycetes can improve grain yield and soil fertility, improve control of insect pests and phytopathogens, and enhance host-plant resistance. It also addresses special topics of current interest, e.g. the role of PGP actinomycetes in the biofortification of legume seeds and bioremediation of heavy metals.

This book series focuses on current progress in the broad field of medical microbiology, and covers both basic and applied topics related to the study of microbes, their interactions with human and animals, and emerging issues relevant for public health. Original research and review articles present and discuss multidisciplinary findings and developments on various aspects of microbiology, infectious diseases, and their diagnosis, treatment and prevention. The book series publishes review and original research contributions, short reports as well as guest edited thematic book volumes. All contributions will be published online first and collected in book volumes. There are no publication costs. Advances in Microbiology, Infectious Diseases and Public Health is a subseries of Advances in Experimental Medicine and Biology, which has been publishing significant contributions in the field for over 30 years and is indexed in Medline, Scopus, EMBASE, BIOSIS, Biological Abstracts, CSA, Biological Sciences and Living Resources (ASFA-1), and Biological Sciences. 2019 Impact Factor: 2.450. 5 Year Impact Factor: 2.324; Cite Score: 3.0; Eigenfactor Score: 0.03583; Article Influence Score: 0.603

The six years that have passed since the publication of the first edition have brought significant advances in both biofilm research and biofilm engineering, which have matured to the extent that biofilm-based technologies are now being designed and implemented. As a result, many chapters have been updated and expanded with the addition of sections reflecting changes in the status quo in biofilm research and engineering. Emphasizing process analysis, engineering systems, biofilm applications, and mathematical modeling, Fundamentals of Biofilm Research, Second Edition provides the tools to unify and advance biofilm research as a whole. Retaining the goals of the first edition, this second edition serves as: A compendium of knowledge about biofilms and biofilm processes A set of instructions for designing and conducting biofilm experiments A set of instructions for making and using various tools useful in biofilm research A set of computational procedures useful in interpreting results of biofilm research A set of instructions for using the model of stratified biofilms for data interpretation, analysis, and biofilm activity prediction

The aim and scope of this book is to highlight the sources, isolation, characterization and applications of bioactive compounds from the marine environment and to discuss how marine bioactive compounds represent a major market application in food and other industries. It discusses sustainable marine resources of macroalgal origin and gives examples of bioactive compounds isolated from these and other resources, including marine by-product and fisheries waste streams. In addition, it looks at the importance of correct taxonomic characterization.

Microbial production: From genome design to cell surface engineering affords a comprehensive review of novel technology and approaches being implemented for manufacturing microorganisms, written by specialists in both academia and industry. This book is divided into three sections: the first includes technology for improvement of fermentation strains and many supporting technologies and information; the second examines novel technology useful for analysis of cell activities, analyzing gene function, and designing genomes of producer strains; and finally, a discussion of the practical application of the techniques and success case studies in many fields of bio-production, such as microbiological production, pharmaceuticals, chemicals, foods and cosmetics.

Microbial defacement and degradation of artistic or historic artifacts is a worldwide problem affecting all countries regardless of their history, geographical location, or economic conditions. This is the first comprehensive study of the role of microbial colonization on the degradation of different cultural artifacts (from buildings to books, wall paintings, textiles, sculptures and glass) and of the investigations into the compounds utilized to control microbial invasion. The book focuses on three main areas: the identification of the microorganisms which cause structural damage; methods to reduce or prevent microbial colonization and damage; and the use of microorganisms for the protection and bioremediation of cultural artifacts.