Drug discovery originating in Africa has the potential to provide significantly improved treatment of endemic diseases such as malaria, tuberculosis and HIV/AIDS. This book critically reviews the current status of drug discovery research and development in Africa, for diseases that are a major threat to the health of people living in Africa. Compiled by leading African and international experts, this book presents the science and strategies of modern drug discovery. It explores how the use of natural products and traditional medicines can benefit from conventional drug discovery approaches, and proposes solutions to current technological, infrastructural, human resources, and economic challenges, which are presented when attempting to engage in full-scale drug discovery. Topics addressed are varied; from African medicinal plants to marine bioprospecting, pharmacogenetics and the use of nanotechnology. This book brings together for the first time a collection of strategies and techniques that need to be considered when developing drugs in an African setting. It is an unprecedented and truly international effort, highlighting the remarkable effort made so far in the area of drug discovery research by African scientists, and scientists from other parts of the world working on African health problems.

This detailed volume provides a collection of protocols for the study of miRNA functions in plants. Beginning with coverage of miRNA function, biogenesis, activity, and evolution in plants, the book continues by guiding readers through methods on the identification and detection of plant miRNAs, bioinformatic analyses, and strategies for functional analyses of miRNAs. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Plant MicroRNAs: Method and Protocols aims to ensure successful results in the further study of this vital area of plant science.

This book highlights state-of-the-art research and practices for adaptation to climate change in food production systems (agriculture in particular) as observed in Japan and neighboring Asian countries. The main topics covered include the current scientific understanding of observed and projected climate change impacts on crop production and quality, modeling of autonomous and planned adaptation, and development of early warning and/or support systems for climate-related decision-making. Drawing on concrete real-world examples, the book provides readers with an essential overview of adaptation, from research to system development to practices, taking agriculture in Asia as the example. As such, it offers a valuable asset for all researchers and policymakers whose work involves adaptation planning, climate negotiations, and/or agricultural developments.

There are many books on biological control, but this will bring up to date the regulatory and other specific challenges facing biological control, and how they are being met. It is the first book to bring together a comprehensive account of global activities in biological control, region-by-region, amalgamating information from introduction biological control, conservation biological control and augmentative biological control (including commercial use). Offers a historical summary of organisms and main strategies used in biological control. Outlines key challenges confronting biological control in the 21st century and describes the main socioeconomic challenges that need to be addressed. Global overview: summarises biological control efforts around the globe and highlights important successes and failures, providing suggestions to best move biological control forward in a changing world. Biological control is a fairly specialized field but one that is spread across a broad array of socio-environments in agriculture and public health around the world. There is also a significant regulatory component to a subset of this field (classical biological control) that researchers must navigate to achieve the aims of their research and its application. This book will help!

This volume presents a compelling collection of state-of-the-art work in algorithmic computational biology, honoring the legacy of Professor Bernard M.E. Moret in this field. Reflecting the wide-ranging influences of Prof. Moret's research, the coverage encompasses such areas as phylogenetic tree and network estimation, genome rearrangements, cancer phylogeny, species trees, divide-and-conquer strategies, and integer linear programming. Each self-contained chapter provides an introduction to a cutting-edge problem of particular computational and mathematical interest. Topics and features: addresses the challenges in developing accurate and efficient software for the NP-hard maximum likelihood phylogeny estimation problem; describes the inference of species trees, covering strategies to scale phylogeny estimation methods to large datasets, and the construction of taxonomic supertrees; discusses the inference of ultrametric distances from additive distance matrices, and the inference of ancestral genomes under genome rearrangement events; reviews different techniques for inferring evolutionary histories in cancer, from the use of chromosomal rearrangements to tumor phylogenetics approaches; examines problems in phylogenetic networks, including questions relating to discrete mathematics, and issues of statistical estimation; highlights how evolution can provide a framework within which to understand comparative and functional genomics; provides an introduction to Integer Linear Programming and its use in computational biology, including its use for solving the Traveling Salesman Problem. Offering an invaluable source of insights for computer scientists, applied mathematicians, and statisticians, this illuminating volume will also prove useful for graduate courses on computational biology and bioinformatics.

This is the fourth updated and revised edition of a well-received book that emphasises on fungal diversity, plant productivity and sustainability. It contains new chapters written by leading experts in the field. This book is an up-to-date overview of current progress in mycorrhiza and association with plant productivity and environmental sustainability. The result is a must hands-on guide, ideally suited for agri-biotechnology, soil biology, fungal biology including mycorrhiza and stress management, academia and researchers. The topic of this book is particularly relevant to researchers involved in mycorrhiza, especially to food security and environmental protection. Mycorrhizas are symbioses between fungi and the roots of higher plants. As more than 90% of all known species of plants have the potential to form mycorrhizal associations, the productivity and species composition and the diversity of natural ecosystems are frequently dependent upon the pre sence and activity of mycorrhizas. The biotechnological application of mycorrhizas is expected to promote the production of food while maintaining ecologically and economically sustainable production systems.

Knowledge of plant names can give insight into largely forgotten beliefs. For example, the common red poppy is known as "Blind Man" due to an old superstitious belief that if the poppy were put to the eyes it would cause blindness. Many plant names derived from superstition, folk lore, or primal beliefs. Other names are purely descriptive and can serve to explain the meaning of the botanical name. For example, Beauty-Berry is the name given to the American shrub that belongs to the genus Callicarpa. Callicarpa is Greek for beautiful fruit. Still other names come from literary sources providing rich detail of the transmission of words through the ages.
Conceived as part of the author's wider interest in plant and tree lore and ethnobotanical studies, this fully revised edition of "Elsevier's Dictionary of Plant Names and Their Origins" contains over 30,000 vernacular and literary English names of plants. Wild and cultivated plants alike are identified by the botanical name. Further detail provides a brief account of the meaning of the name and detailed commentary on common usage.

* Includes color images
* Inclusive of all Latin terms with vernacular derivatives
* The most comprehensive guide for plant scientists, linguists, botanists, and historians

The diversity and specialization in orchid floral morphology have fascinated botanists and collectors for centuries. In the past 10 years, the orchid industry has been growing substantially worldwide. This interesting book focuses on the recent advances in orchid biotechnology research since the last 10 years in Taiwan. To advance the orchid industry, enhancement of basic research as well as advanced biotechnology will provide a good platform to improve the flower quality and breeding of new varieties. Important topics covered include the new knowledge of basic genome, through floral morphogenesis, floral ontology, embryogenesis, micropropagation, to functional genomics such as EST, virus-induced gene silencing, and genetic transformation.

Great progress has been made in our understanding of pollen-pistil interactions and self-incompatibility (SI) in flowering plants in the last few decades. This book covers a broad spectrum of research into SI, with accounts by internationally renowned scientists. It comprises two sections: Evolution and Population Genetics of SI, Molecular and Cell Biology of SI Systems. The reader will gain an insight into the diversity and complexity of these polymorphic cell-cell recognition and rejection systems. Heteromorphic and homomorphic SI systems and our current understanding of the evolution and phylogeny of these systems, based on the most recent molecular sequence data, are covered. Further, the book presents major advances in our knowledge of the pistil and pollen S-determinants and other unlinked components involved in SI, as well as the apparently diverse cellular regulatory mechanisms utilised to ensure inhibition of self pollen. "

For several decades, Arabidopsis thaliana has been the organism of choice in the laboratories of many plant geneticists, physiologists, developmental biologists, and biochemists around the world. During this time, a huge amount of knowledge has been acquired on the biology of this plant species, which has resulted in the development of molecular tools that account for much more efficient research. The significance that Arabidopsis would attain in biological research may have been difficult to foresee in the 1980s, when its use in the laboratory started. In the meantime, it has become the model plant organism, much the same way as Drosophila, Caenorhabditis, or mouse have for animal systems. Today, it is difficult to envision research at the cutting edge of plant biology without the use of Arabidopsis. Since the first edition of Arabidopsis Protocols appeared, new developments have fostered an impressive advance in plant biology that prompted us to prepare Arabidopsis Protocols, Second Edition. Completion of the Arabidopsis genome sequence offered for the first time the opportunity to have in hand all of the genetic information required for studying plant function. In addition, the development of whole systems approaches that allow global analysis of gene expression and protein and metabolite dynamics has encouraged scientists to explore new scenarios that are extending the limits of our knowledge.

Completing the primary genomic sequence of Arabidopsis thaliana was a major milestone, being the first plant genome and well established as the premiere model species in plant biology. Since working drafts of rice (Oryza sativa L.) genome became available (Yu et al. 2002), it has become the s- ond-best model organism in plants representing monocotyledons. Understanding how the genome sequence comprehensively encodes de- lopmental programs and environmental responses is the next major ch- lenge for all plant genome projects. This requires functional characterization of genes, including identification of regulatory sequences. Several functional genomics approaches were initiated to decode the linear sequence of the model plant Arabidopsis thaliana, including full-length cDNA collections, microarrays, natural variation, knockout collections, and comparative sequence analysis (Borevitz and Ecker 2004). Genomics provides the ess- tial tools to speed up the research work of the traditional molecular gene- cist, and is now a scientific discipline in its own right (Borevitz and Ecker 2004).

Given the universal interest in whether extraterrestrial life has developed or could eventually develop, it is vital that an examination of planetary habitability go beyond simple assumptions. This book has resulted from a workshop at the International Space Science Institute (ISSI) which brought together experts to discuss the multi-faceted problem of how the habitability of a planet co-evolves with the geology of the surface and interior, the atmosphere, and the magnetosphere.

Rapid changes and significant progress have been made in the Agrobacterium field, such as genetically transforming plants for both basic research purposes and agricultural development. In Agrobacterium Protocols, Third Edition, Volumes 1 and 2, a team of leading experts and veteran researchers describe in detail techniques for delivering DNA to plant cells and permanently altering their genomes. This edition emphasizes agricultural crops and plant species with economic values, with updated protocols on 32 plant species and protocols involving 19 new species. Together with the 1st and 2nd editions, these two volumes offer Agrobacterium-mediated genetic transformation protocols for a total of 76 plant species. For a number of important plants such as rice, barley, wheat and citrus, multiple protocols using different starting plant materials for transformation are included. Volume 2 contains 29 chapters with updated techniques for industrial plants, root plants, nuts and fruits, tropic plants, and other important plant species. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Agrobacterium Protocols, Third Edition facilitates the transfer of this rapidly developing technology to all researchers in both fundamental and applied biology.

This book offers a methodical explanation of our biomass-driven ecosystem, the undeniable uncertainties posed by the response of vegetation to changes in environmental conditions and the fact that humans everywhere have an interest, even an obligation, to cooperate in a global campaign to combat climate change.

Microbial Nanobionics: Volume 2, Basic Research Applications continues the important discussion of microbial nanoparticle synthesis with a focus on the mechanistic approach of biosynthesis towards nanobionics. This volume also explores the toxicity of nanomaterials in microbes and their effect on human health and the environment. Special Emphasis is given to the use of polymeric nanomaterials in smart packing for the food industry and agricultural sector. The future of nanomaterials for detection of soil microbes and their interactions and tools for environmental remedies is also comprehensively covered. The rich biodiversity of microbes make them excellent candidates for potential nanoparticle synthesis biofactories. Through a better understanding of the biochemical and molecular mechanisms of the microbial biosynthesis of metal nanoparticles, the rate of synthesis can be better developed and the monodispersity of the product can be enhanced. The characteristics of nanoparticles can be controlled via optimization of important parameters, such as temperature, pH, concentration and pressure, which regulate microbe growth conditions and cellular and enzymatic activities. Large scale microbial synthesis of nanoparticles is a sustainable method due to the non-hazardous, non-toxic and economical nature of these processes. The applications of microbial synthesis of nanoparticles are wide and varied, spanning the industrial, biomedical and environmental fields. Biomedical applications include improved and more targeted antimicrobials, biosensing, imaging and drug delivery. In the environmental fields, nanoparticles are used for bioremediation of diverse contaminants, water treatment, catalysis and production of clean energy. With the expected growth of microbial nanotechnology, this volume will serve as a comprehensive and timely reference.

The Origin of Species is the landmark book that for better of worse put science and religion at odds. Very few people who have read this book and come away not believing in evolution. The detail of research is even by today's standards stunning; and the writing is still eminently readable. Second only to the Bible in its scope of influence, this book is a pertinent today as when it was first written.

This volume examines the molecular basis of all aspects of cell division and cytokinesis in plants. It features 19 chapters contributed by world experts in the specific research fields, providing the most comprehensive and up-to-date knowledge on cell division control in plants. The editors are veterans in the field of plant molecular biology and highly respected worldwide.