Paleontologists and geologists struggle with research questions often complicated by the loss or even absence of key paleobiological and paleoenvironmental information. Insight into this missing data can be gained through direct exploration of analogous living organisms and modern environments. Creative, experimental and interdisciplinary treatments of such ancient-Earth analogs form the basis of Lessons from the Living. This volume unites a diverse range of expert paleontologists, neontologists and geologists presenting case studies that cover a spectrum of topics, including functional morphology, taphonomy, environments and organism-substrate interactions.

Molecular Signalling: Ca2+-Signaling in Cardiac Myocytes: Evidence from Evolutionary and Transgenic Models; M. Morad, Y.J. Suzuki. Diastolic Viscoelastic Properties of Rat Cardiac Muscle; Involvement of Ca2+; B.D.M.Y. Stuyvers, et al. The Contractile Mechanism and Energetics: Molecular Control of Myocardial Mechanics and Energetics: The Chemo-Mechanical Conversion; A. Landesberg. Myocardial Cell Energetics; H. Kammermeier. Cardiac Mechanics and Flow Dynamics: How Cardiac Contraction Affects the Coronary Vasculature; N. Westerhof, et al. Dynamic Interaction between Myocardial Contracton and Coronary Flow; R. Beyar, S. Sideman. Vascular Structure and Remodeling: Endothelial Gene Regulation by Laminar Shear Stress; N. Resnick, et al. Myocardial Structure and Function. Tissue Remodeling with Micro-Structurally Based Material Laws; P. Hunter, T. Arts. Electrical Activation and Propagation: Cardiac Excitation: An Interactive Process of Ion Channels and Gap Junctions; Y. Rudy, R.M. Shaw. The Cardionome: Concepts in Modeling: Design and Strategy for the Cardionome Project; J.B. Bassingthwaighte. 20 Additional Chapters. Index.

Bacterial Genomes provides an in-depth review of the latest research on the structure and stability of microbial genomes, and the techniques used to analyze and "fingerprint" them. Maps of a variety of microorganisms are featured, along with articles describing their construction and relevant features. Extensive tables summarizing the different types of techniques available to analyze the genomes of these microorganisms are also presented. Among those who will find this text most useful are genome researchers, microbiologists, molecular biologists, bacteriologists, infectious disease researchers, and molecular evolutionary biologists. Researchers and students working in the field of molecular evolution in general will also be interested in this book since microbes are such popular model systems.

Anaesthetising a fish, x-raying a frog and hospitalising a walrus are all in a day’s work for the world’s wildest veterinarian. Travelling from the rainforests of Sierra Leone to the jungles of Borneo, Romain Pizzi has caught, anaesthetised, diagnosed, operated on, medicated, and then released some of the world's most endangered wild animals. From disease testing Polynesian snails to keyhole surgery in Sumatran orangutans; from endoscopy in sharks to ultrasound on a chimpanzee. Sometimes this is high tech work, such as the first robotic surgery in a tiger, or giant panda cloning attempts. Sometimes the situations are more primitive, from anaesthetising a bear with a bicycle pump, old plumbing tubes and a plank, to operating on a vulture using an old metal spoon. In Exotic Vetting, Romain recalls his many interesting patients, while taking readers on a tour of the challenges of treating the world’s amazing spectrum of wild animal species.

This fully updated edition provides selected mouse genetic techniques and their application in modeling varieties of human diseases. The chapters are mainly focused on the generation of different transgenic mice to accomplish the manipulation of genes of interest, tracing cell lineages, and modeling human diseases. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Mouse Genetics: Methods and Protocols, Second Edition delivers fundamental techniques and protocols to geneticists, molecular biologists, cell and developmental biologists, students, and postdoctoral fellows working in the various disciplines of genetics, developmental biology, mouse genetics, and modeling human diseases.

The analysis and modification of glycans of recombinant proteins continues to be active and challenging area of research and for the successful manufacture of these proteins. In Cell Engineering, volume 3: Glycosylation, Dr. Mohammed Al-Rubeai has compiled a group of articles that will provide research workers not only with reviews of the advances that have been made in all facets of the subject but with an in-depth assessment of the state of the art methodology and the various approaches for the improvement of glycoprotein production. Particularly important in this respect is the advances made in the development of genetically engineered host cell lines with novel glycosylation properties, as well as the integration of mass spectrophotometric analysis with separation techniques.

This volume is intended not only for research students and senior scientists in cell culture and glycobiology, but also for industrial biotechnologists and biochemical engineers interested in the production of therapeutic glycoproteins, virus vector and ex vivo expansion of human cells for medical treatment.

Invertebrate Zoology: A Tree of Life Approach is a comprehensive and authoritative textbook adopting an explicitly phylogenetic organization. Most of the classical anatomical and morphological work has not been changed - it established the foundation of Invertebrate Zoology. With the explosion of Next-Generation Sequencing approaches, there has been a sea-change in the recognized phylogenetic relationships among and between invertebrate lineages. In addition, the merger of evolutionary and developmental biology (evo-devo) has dramatically contributed to changes in the understanding of invertebrate biology. Synthesizing these three approaches (classical morphology, sequencing data, and evo-devo studies) offers students an entirely unique perspective of invertebrate diversity. Key Features One of the first textbooks to combine classical morphological approaches and newer evo-devo and Next-Generation Sequencing approaches to address Invertebrate Zoology Organized along taxonomic lines in accord with the latest understanding of invertebrate phylogeny Will provide background in basic systematic analysis useful within any study of biodiversity A wealth of ancillary materials for students and teachers, including downloadable figures, lecture slides, web links, and phylogenetic data matrices

Formerly titled "Pathology of the Fischer Rat, " "Boorman s Pathology of the Rat" continues to be the most comprehensive pathology reference and standard on rat strains. A vital resource for researchers across science and medicine using rat models in the laboratory, "Boorman s Pathology of the Rat" offers an added emphasis on the Sprague-Dawley and Wistar rat strains, in line with current research across academia, government, and industry. In addition, the book provides standard diagnostic criteria, basic content on histology, histological changes that result from drug toxicity and neoplasm, pathology terminology, and four-color photographs from the NTP archive and database.

With updated references and photographs, as well as coverage of all rat strains, "Boorman s Pathology of the Rat" is the standard in the field, invaluable to toxicologists, biologists, and other scientists engaged in regulatory toxicology who must make the transition from pathology results to promulgation of meaningful regulations.
Full-color photographs Coverage of all strains of rats Organ-by-organ and system-by-system approach Background incidence data Detailed descriptive content regarding changes in rat model during research"

The importance of fungal infections in both human and animals has increased over the last few decades. This book presents an overview of the different categories of fungal infections that can be encountered in animals (including lower vertebrates) originating from environmental sources with or without transmission to humans. In addition, the endemic infections with indirect transmission from the environment, the zoophilic fungal pathogens with near-direct transmission, the zoonotic fungi that can be directly transmitted from animals to humans, mycotoxicoses and antifungal resistance in animals will also be discussed. This book includes case studies and reviews the current state of knowledge on the mechanism of fungal attraction, recognition, infection, extracellular hydrolytic enzymes and pathogenesis of nematophagous fungi. The book also covers diagnostics, fungal formulations, as well as prevention methods. It discusses strategies to access the fungal pathogen groups, metagenomic analyses, genomics, secretomics, metabolomics, proteomics and transcriptomics. In addition, pathogen description, understanding, distribution and recent research results are provided.

A companion to the author's previous GI publication, State Wildlife Laws Handbook, and the only one of its kind, this handbook provides a single, comprehensive source of information on 280 wildlife and wildlife-related laws, treaties, and other federal documents. You'll find summaries of all federal laws, treaties, and executive orders that affect the subject of wildlife laws and insight into the range of actions the federal government has taken to conserve America's wildlife.

This book discusses the fundamental concepts of the green synthesis of nanoparticles and presents the latest advances in this emerging field. Providing a comprehensive overview of developments related to nanoparticle synthesis using fungi, algae, bryophytes, pteridophytes, gymnosperms, monocotyledons, dicotyledonous (angiosperms) and animal systems, it also explores techniques for the characterization of these nanoparticles. Lastly, it reviews the applications and toxicity of biologically synthesized green nanoparticles. Given its scope, it is a valuable resource for students, researchers and policymakers working in the field of nanobiotechnology and nanoscience.

The main theme of this book is how reproduction in fungi is controlled by genetic and environmental factors. The genetics of fungi is at a crossroads - the methods of classical genetics are giving way to those of recombinant DNA technology. Reproduction in Fungi takes stock of what has been learned to date and points the way to future research.

Key features: The first reference book to provide a comprehensive treatment of the biogreography of the Andean region Includes lists of the synonyms for each area and examples of the plant and animal taxa characterizing them. An extensive reference section serves as an entry point for more in-depth research on individual subjects Discusses the relationships between the areas, formulating hypotheses explaining the relationships of different biotas, based on track and cladistic biogeographic analyses Identifies cenocrons that were assembled in the different biotas Contains maps that illustrate the distribution of particular taxa, area cladograms and vegetation profiles This book presents a regionalization of the Andean region, based on an evolutionary biogeographic approach. Aimed at anyone wishing to understand biogeographic patterns of distribution of Andean plants and animals, the book provides a comprehensive treatment of three subregions, one transition zone, and 16 provinces. Lists of the synonyms and examples of taxa characterizing each area are given, and the relationships between the areas discussed, alongside hypotheses explaining the assembly of different biotas. Several maps illustrate the distribution of particular taxa, as well as area cladograms, diagrams and full-color vegetation profiles.

Animal Locomotion: Physical Principles and Adaptations is a professional-level, state of the art review and reference summarizing the current understanding of macroscopic metazoan animal movement. The comparative biophysics, biomechanics and bioengineering of swimming, flying and terrestrial locomotion are placed in contemporary frameworks of biodiversity, evolutionary process, and modern research methods, including mathematical analysis. The intended primary audience is advanced-level students and researchers primarily interested in and trained in mathematics, physical sciences and engineering. Although not encyclopedic in its coverage, anyone interested in organismal biology, functional morphology, organ systems and ecological physiology, physiological ecology, molecular biology, molecular genetics and systems biology should find this book useful.

Neotropical Biogeography: Regionalization and Evolution presents the most comprehensive single-source treatment of the Neotropical region derived from evolutionary biogeographic studies. The book provides a biogeographic regionalization based on distributional patterns of plant and animal taxa, discusses biotic relationships drawn from track and cladistic biogeographic analyses, and identifies cenocrons (subsets of taxa within biotas identified by their common origin and evolutionary history). It includes maps, area cladograms and vegetation profiles. The aim of this reference is to provide a biogeographic regionalization that can be used by graduate students, researchers and other professionals concerned with understanding and describing distributional patterns of plants and animals in the Neotropical region. It covers the 53 biogeographic provinces of the Neotropical region that are classified into the Antillean, Brazilian and Chacoan subregions, and the Mexican and South American transition zones.

Pinnipeds are a fascinating group of marine mammals that play a crucial role as apex predators and sentinels of the functioning and health of marine ecosystems. They are found in the most extreme environments from the Polar regions to the tropics. Pinnipeds are comprised of about 34 species, and of those at least 25% live permanently in tropical zones. This book reviews and updates current research on the biology, marine ecology, bio-monitoring, and conservation of tropical pinniped populations, including their behavior, anthropogenic stressors, and health. It also looks at challenges to be faced for the conservation of tropical pinnipeds, many of which are threatened species.

This book is the first in a projected series on Evolutionary Cell Biology, the intent of which is to demonstrate the essential role of cellular mechanisms in transforming the genotype into the phenotype by transforming gene activity into evolutionary change in morphology. This book -Cells in Evolutionary Biology - evaluates the evolution of cells themselves and the role cells have been viewed to play as agents of change at other levels of biological organization. Chapters explore Darwin's use of cells in his theory of evolution and how Weismann's theory of the separation of germ plasm from body cells brought cells to center stage in understanding how acquired changes to cells within generations are not passed on to future generations. Chapter 7 of this book is freely available as a downloadable Open Access PDF under a Creative Commons Attribution-Non Commercial-No Derivatives 3.0 license. https://s3-us-west-2.amazonaws.com/tandfbis/rt-files/docs/Open+Access+Chapters/9781315155968_oachapter7.pdf

Dating back to the early Cambrian period, crustaceans had ample time to undertake endless experimentation with form and function. Today, no other group of plants or animals on the planet exhibit the range of morphological diversity seen among extant Crustacea. With more than 52,000 species, they are placed fourth in terms of overall species diversity. This book comprehensively elucidates the reproduction and development of all the taxonomic groups of Crustacea and bridges the gap between conventional zoologists and molecular biologists. Reproductive modes from the point of embryonic stem cells and primordial germ cells is discussed with a special section on cysts.

Heinrich involves us in his quest to get inside the mind of the raven. But as animals can only be spied on by getting quite close, Heinrich adopts ravens, thereby becoming a "raven father," as well as observing them in their natural habitat. He studies their daily routines, and in the process, paints a vivid picture of the ravens' world. At the heart of this book are Heinrich's love and respect for these complex and engaging creatures, and through his keen observation and analysis, we become their intimates too.

Heinrich's passion for ravens has led him around the world in his research. Mind of the Raven follows an exotic journey--from New England to Germany, and from Montana to Baffin Island in the high Arctic--offering dazzling accounts of how science works in the field, filtered through the eyes of a passionate observer of nature. Each new discovery and insight into raven behavior is thrilling to read, at once lyrical and scientific.

This agenda-setting collection argues for the importance of fieldwork for philosophy and provides reflections on methods for such 'field philosophy' from the interdisciplinary vantage point of the environmental humanities. Field philosophy has emerged from multiple sources - including approaches focused on public and participatory research - and others focused on ethology, multispecies studies, and the environmental humanities more broadly. These approaches have yet to enter the mainstream of the discipline, however, and 'field philosophy' remains an open and uncharted terrain for philosophical pursuits. This book brings together leading and emerging philosophers who have engaged in critical and constructive forms of fieldwork, for some over decades, and who, through these articles, demonstrate new possibilities and new experiments for philosophical practices. This collection will be of interest to scholars working across the disciplines of continental philosophy, environmental humanities, science and technology studies, animal studies, cultural anthropology, art, and more. The chapters in this book were originally published as a special issue of Parallax.

For critical care of laboratory rodents, there is a scarcity of sources for comprehensive, feasible, and response-oriented information on clinical interventions specific to spontaneous and induced models of disease. With the more complex cases that need critical care management, many treatment approaches to veterinary emergencies cannot be applied directly to the laboratory rodent. The first text of its kind devoted to the challenges of critical care management for laboratory rodents, Critical Care Management for Laboratory Mice and Rats provides a specialized resource for all veterinary, husbandry, technical, and research professionals who utilize rodent models for biomedical research.The book covers the varied approaches to laboratory rodent patient care, health assessments, characteristics of specific disease models, monitoring and scoring of disease parameters, and humane interventions. Giving primary consideration to preservation of animal health and welfare, the text also considers how best to balance welfare with the achievement of proposed scientific objectives. Organized into five chapters, this full-color book covers the following topics: General Approaches for Critical Care Critical Care Management for Laboratory Mice Critical Care Management for Laboratory Rats Special Considerations for Critical Care Management in Laboratory Rodents Resources and Additional Information The author provides treatment guidelines with the expectation that they will be applied with apt professional judgment, allowing for further modification of clinical recommendations for improved patient-based care and welfare for research animals.

Reproductive Biology and Phylogeny of Lizards and Tuatara is a remarkable compendium of chapters written by the world's leading experts from over four continents. The book begins with a chapter recounting historical discoveries in reproductive biology and a review of phylogenetics and up-to-date hypotheses concerning evolutionary relationships among lizards. Following these chapters are detailed reviews with additional new data concerning chemical communication, sexual selection, reproductive cues, female reproductive anatomy, female reproductive cycles, oogenesis, parthenogenesis, male reproductive anatomy, male reproductive cycles, spermatogenesis, reproductive investment, viviparity and placentation, multiple paternity, and parental care. The book culminates in two chapters on tuatara reproduction giving unique insight into evolutionary patterns in reproductive biology in squamates and tuatara. This is an essential resource for anyone studying reproduction in reptiles and/or vertebrates and offers a fascinating read for those interested in reproductive biology.

Nanotechnology offers a revolutionary and definitive approach for the efficient delivery of drug molecules to non-healthy tissues and cells. This first volume of a series of two volumes analyzes the basics in the development of drug-loaded nanoplatforms, the so-called nanomedicines. Special attention is given to physicochemical engineering, pharmacokinetics, biocompatibility and biodegradability, representative nanoplatforms (based on lipids, polymers, cyclodextrins, metals, carbon, silica, iron oxides, etc.), and advanced nano-engineering strategies for passive, ligand-mediated, and/or stimuli-sensitive drug delivery and release.

This textbook introduces research on dinosaurs by describing the science behind how we know what we know about dinosaurs. A wide range of topics is covered, from fossils and taphonomy to dinosaur physiology, evolution, and extinction. In addition, sedimentology, paleo-tectonics, and non-dinosaurian Mesozoic life are discussed. There is a special opportunity to capitalize on the enthusiasm for dinosaurs that students bring to classrooms to foster a deeper engagement in all sciences. Students are encouraged to synthesize information, employ critical thinking, construct hypotheses, devise methods to test these hypotheses, and come to new defensible conclusions, just as paleontologists do. Key Features Clear and easy to read dinosaur text with well-defined terminology Over 600 images and diagrams to illustrate concepts and aid learning Reading objectives for each chapter section to guide conceptual learning and encourage active reading Companion website (teachingdinosaurs.com) that includes supporting materials such as in-class activities, question banks, lists of suggested specimens, and more to encourage student participation and active learning Ending each chapter with a specific "What We Don't Know" section to encourage student curiosity Related Titles Singer, R. Encyclopedia of Paleontology (ISBN 978-1-884964-96-1) Fiorillo, A. R. Alaska Dinosaurs: An Ancient Arctic World (ISBN 978-1-138-06087-6) Caldwell, M. W. The Origin of Snakes: Morphology and the Fossil Record (ISBN 978-1-4822-5134-0)

Scientists have developed a featherless chicken designed to make industrial chicken production more efficient, while specially trained Pacific bottlenose dolphins are being deployed in the Persian Gulf to disarm mines and protect our Navy. Everyone knows Darwin's theory of natural selection, but what about his idea of artificial selection--how humans, not nature, rework natural organisms to meet our needs? Industrializing Organisms brings us to the threshold of the new field of evolutionary history--from the mobilization of war horses in the 19th century to today's engineered plants and manipulated animals.