Laboratory Animals: Regulations and Recommendations for the Care and Use of Animals in Research, Second Edition, is the only publication to offer a global compilation of standards on the care, welfare and use of animals in research. The book provides updated information that will be of great interest to professionals across laboratory animal science and biomedical research. Users will find a broad picture of the regulations required in other areas of the world that will be essential to appropriately manage animal care and use programs.

The timeless classic -- the perfect gift for everyone's favorite child.

The Little Fur Family tells of a little fur child's day in the woods. The day ends when his big fur parents tuck him in bed "all soft and warm," and sing him to sleep with a lovely bedtime song.

The purpose of this book is to provide information which supports the fact that rat hybridomas are no more difficult to develop than mouse hybridomas. This is the first book devoted to the development of rat hybridomas. It includes theories, step-by-step techniques, ingredients and apparatus. The focus of this work is on the antibody repertoire, the unique biological properties of rat immunoglobulins, the one-step purification procedure by immunoaffinity chromatography, the absence of C-type particles, and the easy production of large amounts of ascitic fluid containing rat MAb. This rare publication is an absolute must for all scientists using MAbs and those interested in the fields of immunology, biotechnology, and biochemistry.

Principles of Animal Extrapolation addresses the conceptual basis for animal extrapolation and provides an abundance of documentation that illustrates how these principles may be applied in the selection of the more appropriate models and in the interpretation of toxicological studies. The book analyzes and documents each specific biological cause of interspecies differences in susceptibility to toxic agents, including differences in absorption, gut flora, tissue distribution, metabolism, mechanisms and efficiencies of repair, and excretion. The problem of the heterogenicity of the human population is addressed through several chapters that assess the availability and prospects of developing predictive animal models for normal humans, as well as selected potential high-risk groups. Other topics presented in this book include the biological basis of regulatory actions involving attempts to extrapolate from exceptionally high exposure levels to realistic values, especially carcinogens; an assessment of genotoxicity tests, their ability to predict carcinogenicity in whole animals, and the manner in which they should be used by regulatory agencies; birth defects; and predicting the risk of human teratogenesis. Principle of Animal Extrapolation is essential for environmental toxicologists. It also provides valuable information to biomedical scientists (especially those involved in drug development and testing) and regulatory personnel in agencies such as the EPA, the OSHA, the NIOSH, and the FDA.

The Biology of Lungfishes presents an up-to-date collection of reviews on some of the most important aspects of the life of lungfishes. The book draws on contributions from well-known experts with a long record of scientific work within their respective fields. The general natural history of the three genera of lungfishes, the fascinating fossil story, and modern ideas of lungfish phylogeny form the main part of the text. The book also covers the morphology and physiology of various organs.

Occupancy Estimation and Modeling: Inferring Patterns and Dynamics of Species Occurrence, Second Edition, provides a synthesis of model-based approaches for analyzing presence-absence data, allowing for imperfect detection. Beginning from the relatively simple case of estimating the proportion of area or sampling units occupied at the time of surveying, the authors describe a wide variety of extensions that have been developed since the early 2000s. This provides an improved insight about species and community ecology, including, detection heterogeneity; correlated detections; spatial autocorrelation; multiple states or classes of occupancy; changes in occupancy over time; species co-occurrence; community-level modeling, and more. Occupancy Estimation and Modeling: Inferring Patterns and Dynamics of Species Occurrence, Second Edition has been greatly expanded and detail is provided regarding the estimation methods and examples of their application are given. Important study design recommendations are also covered to give a well rounded view of modeling.

This study presents age-associated pathologic findings in aging rats that had been maintained under similar well-controlled laboratory conditions. The aim of the study was to evaluate two rat strains and their F1, hybrid.

This two-volume handbook provides important information concerning the development, implementation, evaluation, uses, advantages, and limitations of a wide variety of animal model of pulmonary disease. While the work focuses on stepwise procedures for inducing and quantifying disease, additional emphasis is placed on each model's relationship to human counterparts and on comparisons with similar models of injury. Thus, even the novice researcher will be able to more sharply define a particular research question, find suitable animal models for study, gain access to specialized techniques, and evaluate results within the context of an up-to-date body of information about related forms of lung diseases.

Detailed report on a topic that has already attracted much popular interest.

Provides fascinating reading for physicists, biologists and general readers alike.

Building from general principles, the authors clearly explain the fundamental role of epithelia in plasma electrolyte and water balance. Emphasis is placed on experimental approaches and methodology. A comprehensive glossary of terms is included.

Handbook of the Zoology of Amphistomes provides a comprehensive survey on the morphology, ecology, systematics, and zoogeography of amphistomes, which are a group of digenetic trematodes parasitic in vertebrates. The handbook features the special morphological characteristics of amphistomes, including the structure and types of muscular organs; a short diagnosis for each species (when possible), as well as a line drawing of each adult fluke; a zoogeographical analysis, including the host-parasite coevolution, distributional patterns, and characterization of faunas within the zoogeographical realm; and a possible evolutionary scenario based on holomorphological characteristics. Parasitologists, helminthologists, zoologists, and biologists working with ecological associations will find this book an essential reference source for their work with amphistomes.

Even though the gorilla is our closest living relative, information about its anatomy, and particularly its musculature, is scarce. This book is the first photographic and descriptive musculoskeletal atlas of the gorilla. It includes high-quality photographs of musculoskeletal structures from most anatomical regions of the body, along with textual information about the attachments, innervations, and weight of the reported muscles. The atlas is an up-to-date review of the anatomical variations within gorillas as well as an extensive list of the synonyms used in the literature to designate the structures covered in the book. It also contains dissection observations of other primates and vertebrates, which are crucial for examining and understanding the homologies between the muscular structures of gorillas, humans, and other taxa.

Arthropod Vector: Controller of Disease Transmission, Volume 1: Vector Microbiome and Innate Immunity of Arthropods is built on topics initially raised at a related Keystone Symposium on Arthropod Vectors. Together with the separate, related Volume 2: Vector Saliva-Host Pathogen Interactions, this work presents a logical sequence of topic development that leads to regulatory considerations for advancing these and related concepts for developing novel control measures. The three themes of symbionts, vector immune defenses and arthropod saliva modulation of the host environment are central to the concept of determinants of vector competence that involves all aspects of vector-borne pathogen development within the arthropod that culminates in the successful transmission to the vertebrate host. These three areas are characterized at the present time by rapid achievement of significant, incremental insights, which advances our understanding for a wide variety of arthropod vector species, and this work is the first to extensively integrate these themes.

The study of animal movement has always been a key element in ecological science, because it is inherently linked to critical processes that scale from individuals to populations and communities to ecosystems. Rapid improvements in biotelemetry data collection and processing technology have given rise to a variety of statistical methods for characterizing animal movement. The book serves as a comprehensive reference for the types of statistical models used to study individual-based animal movement. Animal Movement is an essential reference for wildlife biologists, quantitative ecologists, and statisticians who seek a deeper understanding of modern animal movement models. A wide variety of modeling approaches are reconciled in the book using a consistent notation. Models are organized into groups based on how they treat the underlying spatio-temporal process of movement. Connections among approaches are highlighted to allow the reader to form a broader view of animal movement analysis and its associations with traditional spatial and temporal statistical modeling. After an initial overview examining the role that animal movement plays in ecology, a primer on spatial and temporal statistics provides a solid foundation for the remainder of the book. Each subsequent chapter outlines a fundamental type of statistical model utilized in the contemporary analysis of telemetry data for animal movement inference. Descriptions begin with basic traditional forms and sequentially build up to general classes of models in each category. Important background and technical details for each class of model are provided, including spatial point process models, discrete-time dynamic models, and continuous-time stochastic process models. The book also covers the essential elements for how to accommodate multiple sources of uncertainty, such as location error and latent behavior states. In addition to thorough descriptions of animal movement models, differences and connections are also emphasized to provide a broader perspective of approaches.

Millipedes are common components of the leaf-litter fauna of most terrestrial environments. The Biology of Millipedes is the first single-volume review of this important group and covers their ecology, behaviour, physiology, and evolution.

Arthropod Vector: Controller of Disease Transmission, Volume 2: Vector Saliva-Host Pathogen Interactions is built on topics initially raised at a related Keystone Symposium on Arthropod Vectors. Together with the separate, related Volume 1: Controller of Disease Transmission, this work presents a logical sequence of topic development that leads to regulatory considerations for advancing these and related concepts for developing novel control measures. The three themes of symbionts, vector immune defenses and arthropod saliva modulation of the host environment are central to the concept of determinants of vector competence that involves all aspects of vector-borne pathogen development within the arthropod that culminates in the successful transmission to the vertebrate host. These three areas are characterized at the present time by rapid achievement of significant, incremental insights, which advances our understanding for a wide variety of arthropod vector species, and this work is the first to extensively integrate these themes.

Biogeography represents one of the most complex and challenging aspects of macroevolutionary research, requiring input from both the earth and life sciences. Palaeogeographic reconstruction is frequently carried out by researchers with backgrounds in geology and palaeontology, who are less likely to be familiar with the latest biogeographic techniques: conversely, biogeographic methods are often devised by neontologists who may be less familiar with the fossil record, stratigraphy, and palaeogeography. Palaeogeography and Palaeobiogeography: Biodiversity in Space and Time bridges the gap between these two communities of researchers, who work on the same issues but typically use different types of data. The book covers a range of topics, and reflects some of the major overall questions in the field such as: Which approaches are best suited to reconstructing biogeographic histories under a range of circumstances? How do we maximize the use of organismal and earth sciences data to improve our understanding of events in earth history? How well do analytical techniques devised for researching the biogeography of extant organisms perform in the fossil record? Can alternative biodiversity metrics, particularly those based on morphological measurements, enhance our understanding of biogeographic patterns and processes? This book approaches palaeobiogeography with coverage of technological applications and detailed case studies. It spans a wide selection of overlapping and integrative disciplines, including evolutionary theory, vicariance biogeography, extinctions, and the philosophical aspects of palaeogeography. It also highlights new technological innovations and applications for research. Presenting a unique discussion of both palaeogeography and palaeobiogeography in one volume, this book focuses both historically and philosophically on the interface between geology, climate, and organismal distribution.

The book approaches the language experiments with great apes performed in the last 50 years from the point of view of logical semantics, speech act theory, and philosophy of the social sciences based on the linguistic turn in philosophy. The author reconstructs the experiments with the great apes Washoe, Chantek, Lana, Sherman, Austin, Kanzi, Sarah and Sheba who were taught various kinds of languages, including the language of mathematics. From the point of view of the philosophy of science these experiments are interpreted as being part of the social sciences. The book proposes new mathematical experiments that are based on modern semantical reconstruction of the language of mathematics. The author shows that modern scientific research into great apes has shifted from natural science to social science.

This book presents an evolutionary biogeographic analysis of the Mexican Transition Zone, which is situated in the overlap of the Nearctic and Neotropical regions. It includes a comprehensive review of previous track, cladistic and molecular biogeographic analyses and is illustrated with full color maps and vegetation photographs of the respective areas covered. Given its scope, the book will be of interest to students and researchers whose work involves systematic and biogeographic analyses of plant and animal taxa of the Mexican Transition Zone or other transition zones of the world, and to ecologists working in biodiversity conservation, who will be able to appreciate the evolutionary relevance of the Mexican Transition Zone for establishing conservation areas..

The Stage Lives of Animals examines what it might mean to make theatre beyond the human. In this stunning collection of essays, Una Chaudhuri engages with the alternative modes of thinking, feeling, and making art offered by animals and animality, bringing insights from theatre practice and theory to animal studies as well as exploring what animal studies can bring to the study of theatre and performance. As our planet lives through what scientists call "the sixth extinction," and we become ever more aware of our relationships to other species, Chaudhuri takes a highly original look at the "animal imagination" of well-known plays, performances and creative projects, including works by: Caryl Churchill Rachel Rosenthal Marina Zurkow Edward Albee Tennesee Williams Eugene Ionesco Covering over a decade of explorations, a wide range of writers, and many urgent topics, this volume demonstrates that an interspecies imagination deeply structures modern western drama.

The Stage Lives of Animals examines what it might mean to make theatre beyond the human. In this stunning collection of essays, Una Chaudhuri engages with the alternative modes of thinking, feeling, and making art offered by animals and animality, bringing insights from theatre practice and theory to animal studies as well as exploring what animal studies can bring to the study of theatre and performance. As our planet lives through what scientists call "the sixth extinction," and we become ever more aware of our relationships to other species, Chaudhuri takes a highly original look at the "animal imagination" of well-known plays, performances and creative projects, including works by: Caryl Churchill Rachel Rosenthal Marina Zurkow Edward Albee Tennesee Williams Eugene Ionesco Covering over a decade of explorations, a wide range of writers, and many urgent topics, this volume demonstrates that an interspecies imagination deeply structures modern western drama.

The evolutionary biology of protozoa is a field in which exciting changes are taking place. Relationships between different groups of protozoa are undergoing extensive review and the revised views will have significant repercussions for future investigations. New data from molecular and ultrastructural studies have changed our perception of evolution among this diverse group of organisms in recent years. This volume, part of the Systematics Association Special Volume Series, aims to review this important area and give an up-to-date synthesis of current understanding. The various chapters are deliberately broad in scope and explore areas such as the contribution of different techniques and approaches to the understanding of protistan evolution and the biochemical and physiological aspects of that evolution; there are also chapters that analyse and explore specific protistan groups. In addition some of the chapters discuss topics that are currently very controversial within this field, such as the finding that the 18S rRNA phylogenetic tree of protozoa is probably unreliable. The world-renowned editors have assembled an international team of outstanding scientists whose contributions have produced a volume of interest to all evolutionary biologists and especially those interested in protozoa.