Traditionally, genetics laboratory exercises at the university level focus on mono- and dihybrid crosses and phenotypic analysis-exercises under traditional time, materials, and process constraints. Lately, molecular techniques such as gene cloning, polymerase chain reactions (PCR), and bioinformatics are being included in many teaching laboratories-where affordable. Human chromosome analysis, when present at all, has often been restricted to simple identification of chromosomes by number, through the usual "cut-and-paste" method. Although several online karyotyping (chromosome identification) programs have become available, they are not meaningful for studying the dynamics of the chromosome system, nor do they help students understand genetics as a discipline. The software that accompanies this book has been shown to be an ideal tool for learning about genetics, which requires a combination of understanding, conceptualization, and practical experience.

Global food security is increasingly challenging in light of population increase, the impact of climate change on crop production, and limited land available for agricultural expansion. Plant breeding and other agricultural technologies have contributed considerably for food and nutritional security over the last few decades. Genetic engineering approaches are powerful tools that we have at our disposal to overcome substantial obstacles in the way of efficiency and productivity of current agricultural practices. Genome engineering via CRISPR/Cas9, Cpf1, base editing and prime editing, and OMICs through genomics, transcriptomics, proteomics, phenomics, an metabolomics have helped to discover underlying mechanisms controlling traits of economic importance. Principle and Practices of OMICs and Genome Editing for Crop Improvement provides recent research from eminent scholars from around the world, from various geographical regions, with established expertise on genome editing and OMICs technologies. This book offers a wide range of information on OMICs techniques and their applications to develop biotic, abiotic and climate resilient crops, metabolomics and next generation sequencing for sustainable crop production, integration bioinformatics, and multi-omics for precision plant breeding. Other topics include application of genome editing technologies for food and nutritional security, speed breeding, hybrid seed production, resource use efficiency, epigenetic modifications, transgene free breeding, database and bioinformatics for genome editing, and regulations adopted by various countries around globe for genome edited crops. Both OMICs and genome editing are vigorously utilized by researchers for crop improvement programs; however, there is limited literature available in a single source. This book provides a valuable resource not only for students at undergraduate and postgraduate level but also for researchers, stakeholders, policy makers, and practitioners interested in the potential of genome editing and OMICs for crop improvement programs.

This volume explores the latest techniques used for sustainable development of eco-friendly pest management systems. Chapters in this book look at the design of novel RNAi-mediated pest control strategies and related issues. Some of the topics covered in this book are identification and characterization of differentially expressed non-coding RNAs in insect genomes; functional small RNA design; analysis of endogenous RNAi pathways; RNAi screening; plant models of RNAi-mediated pest control; and dsRNA delivery. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, RNAi Strategies for Pest Management: Methods and Protocols is a valuable resource for any scientist or researcher interested in learning more about this exciting and developing field. Chapter 18 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

This volume presents a comprehensive overview of the latest advances in basic and translational research in the field of reconstructive transplantation and its potential therapeutic implications. Dr. Thomas E. Starzl and Dr. Raimund Margreiter, both pioneers in the field of transplantation, have written the foreword for the book. The volume spans such topics as skin rejection, immune monitoring, stem cell-based immunomodulatory strategies, costimulatory blockade, tolerance induction, chronic rejection, ischemia reperfusion injury, nerve regeneration, cortical reintegration, and small and large animal models for reconstructive transplantation. The book is intended for biomedical researchers and basic scientists in the field of reconstructive transplantation, transplant immunology and regenerative medicine, as well as clinicians, surgeons and multidisciplinary specialists, who are practicing or interested in this novel and exciting field. Postgraduate fellows and students will also find it a valuable reference.

Author Prof Jim Lynch is widely known and very experienced, well-connected with wide international networks, and globally distinguished. He was awarded the UNESCO Prize in Microbiology and Einstein Medal and Distinguished Scientist of the US Department of Agriculture. His OUP textbook Soil Microbiology was a bestseller. Taps directly into the topical area of the COVID-19 pandemic and One Health. Affordable and accessible to a wide interdisciplinary audience.

This volume compiles a comprehensive range of methods to study key aspects of mitochondrial DNA including nucleoid structure and packaging, replication, genome integrity, and disease. Chapters are organized into eight methodological sections that cover in vitro and in vivo methods, including for mtDNA isolation, visualization, deep sequencing, gene editing, and diagnostic aspects of mtDNA disease. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and methods, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Mitochondrial DNA: Methods and Protocols aims to be useful and informative for researchers and clinicians with an interest in mitochondrial DNA.

'Behavioral Neuroscience of Learning and Memory' brings together the opinions and expertise of some of the world's foremost neuroscientists in the field of learning and memory research. The volume provides a broad coverage of contemporary research and thinking in this field, focusing both on well established topics such as the medial temporal lobe memory system, as well as emerging areas of research such as the role of memory in decision making and the mechanisms of perceptual learning. Key intersecting themes include the molecular and cellular mechanisms of memory formation, the multiplicity of memory systems in the brain, and the way in which technological innovation is driving discovery. Unusually for a volume of this kind, this volume brings together research from both humans and animals-often relatively separate areas of discourse-to give a more comprehensive and integrated view of the field. The book will be of interest to both established researchers who wish to broaden their knowledge of topics outside of their specific areas of expertise, and for students who need a resource to help them make sense of the vast scientific literature on this subject.

The history of Science is replete with untold stories and this book is one of these accounts. The author shares a narrative of heredity, an active topic of inquiry long before Gregor Mendel - the father of genetics - planted his peas. One such interlude unfolded in Mendel's home city and involved the sheep breeder, Imre Festetics. He sought to improve wool and proposed important rules of heredity. Unfortunately, aspects of wool quality, now known to be polygenic, complicate interpretations of the work of Festetics and explain why it is neglected. The forebearers of Mendel never get the credit they deserve. Heredity Before Mendel resurrects Festetics, the grandfather of heredity. Key Features 1) Documents a vibrant community of scholars interested in heredity before Mendel 2) Highlights the work of Imre Festetics, the forgotten grandfather of genetics 3) Desribes political repression which stifled the nascent foundation of heredity research 4) Emphasizes the role sheep and wool played as the first model system of genetics 5) Challenges19th century taboos in Moravia leading to malicious rumors about the inbred royal House of Austria (Habsburgs).

The Human Genome Diversity Project (HGDP) was launched in 1991 by a group of population geneticists whose aim was to map genetic diversity in hundreds of human populations by tracing the similarities and differences between them. It quickly became controversial and was accused of racism and 'bad science' because of the special interest paid to sampling cell material from isolated and indigenous populations. The author spent a year carrying out participant observation in two of the laboratories involved and provides fascinating insights into daily routines and technologies used in those laboratories and also into issues of normativity, standardization and naturalisation. Drawing on debates and theoretical perspectives from across the social sciences, M'charek explores the relationship between the tools used to produce knowledge and the knowledge thus produced in a way that illuminates the HGDP but also contributes to our broader understanding of the contemporary life sciences and their social implications.

The major purpose of this book is to present Johann Gregor Mendel (1822-1884) in a real and interesting way based on the most recent historical research and analysis of authentic sources. The authors aim to show Mendels scientific thinking and inner feelings together with his environment and to communicate his message as a multifaceted personality and modern experimentalist. The book draws from the only existing short sketch of Mendels youth, his letters and the biographical ceiling paintings that were made according to his proposal. They form the basis of the self-portrait concept. The structure of the book follows thematic groups covering Mendels activities from a poor village boy in search for education and financial security, as not being physically suitable for running his father's farm. The book does not perpetuate the myths invented by some creative authors to make Mendels biography more attractive. Mendels life and work are dramatic enough without those embellishments. Mendel found happiness in science and he was able to explain the theory of new scientific facts. He was not a tragic figure, he did not work to become famous, but to be useful. His pea research has now been appreciated as a genius accomplishment of a scientist. The book is published at the occasion of Mendels birthday bicentennial.

Plasticity in Plant-Growth-Promoting and Phytopathogenic Bacteria brings together the expertise of a panel of researchers from around the world to provide comprehensive up-to-date reviews on the most interesting aspects of genomic and phenotypic plasticity in plant-beneficial and phytopathogenic bacteria. The book covers various topics, including common and specific features in the genomes of symbiotic, plant-growth-promoting, and phytopathogenic bacteria; regulation of conjugative plasmid transfer in rhizobia; genetic and phenotypic variability in plant-beneficial pseudomonads and azospirilla; genomic fluxes in phytopathogenic xanthomonads and pseudomonads; genome plasticity in obligate parasitic Phytoplasmas; comparative genomics of plant-growth-promoting and phytopathogenic Herbaspirillum species; horizontal gene transfer in planta and microevolution of plant-associated bacteria in the phytosphere. Plasticity in Plant-Growth-Promoting and Phytopathogenic Bacteria is recommended for all microbiology and plant biology laboratories.

Emphasizes recent advances in metagenomics and microbiomes and their emerging applications in medicine, agriculture, industry and environment Provides detailed information on prebiotics and probiotics for enhanced human health Introduces microbiomes as the next frontiers in medicine, agriculture, industry and environment Reviews microbiota transplantation, health implications and the way forward Discuss microbiome - epigenetic-host interactions essential for the physiological functions of the body in health and disease

Emphasizes recent advances in biotechnology that could ameliorate the high level global food insecurity through the deployment of the technology in Nigeria. Provides detailed information on how to domesticate biotechnology and boost training of the biotechnology workforce in the universities and research institutes Introduces new frontiers in the area of organizing informal biotechnology capacity building courses and professional certification Reviews biosafety and bioethical guidelines that could enhance adoption of biotechnology in alignment with national priorities and research agenda Discuss current biotechnology policy advocacy, enlightenment and public engagement with stakeholders and Policy makers

Ribosome biogenesis is the process of making ribosomes which are responsible for mRNA translation into proteins. It is a tightly regulated process closely linked to nearly all biochemical and cellular processes, including cell division, growth, and development. Emerging Concepts in Ribosome Structure, Biogenesis, and Function provides a synthesized overview of all the parts engaged in this process. The book begins by providing an introduction to the ribosome factory, its origin, and its evolution of translation. It then goes on to describe ribosome structure including subunits, RNA, and protein components. Ribosome biogenesis and its emergence as a frontier research area for translational potential in cancer and other diseases are also discussed. In addition, the book explores current developments in ribosome research like the emergence of ribosomopathies, how deregulation of ribosome biogenesis can impact disease mechanisms and aging, and the discovery of specialized ribosomes that have specific functions that may translate differentially with consequences on normal and pathological processes. Emerging Concepts in Ribosome Structure, Biogenesis, and Function provides fundamental coverage and emerging research on ribosomes, biogenesis, and their structure and function and is a resourceful introduction for new researchers and those engaged in interdisciplinary ribosomal research.

This book focuses on the conventional breeding approach, and on the latest high-throughput genomics tools and genetic engineering / biotechnological interventions used to improve rice quality. It is the first book to exclusively focus on rice as a major food crop and the application of genomics and genetic engineering approaches to achieve enhanced rice quality in terms of tolerance to various abiotic stresses, resistance to biotic stresses, herbicide resistance, nutritional value, photosynthetic performance, nitrogen use efficiency, and grain yield. The range of topics is quite broad and exhaustive, making the book an essential reference guide for researchers and scientists around the globe who are working in the field of rice genomics and biotechnology. In addition, it provides a road map for rice quality improvement that plant breeders and agriculturists can actively consult to achieve better crop production.

For all introductory genetics courses. Focus on essential genetic topics and explore the latest breakthroughs Known for its focus on conceptual understanding, problem solving, and practical applications, the bestselling Essentials of Genetics strengthens problem-solving skills and explores the essential genetics topics that today's students need to understand. The 10th Edition has been extensively updated to provide comprehensive coverage of important, emerging topics such as CRISPR-Cas, epigenetics, and genetic testing. Additionally, a new Special Topic chapter covers Advances in Neurogenetics with a focus on Huntington Disease, and new essays on Genetics, Ethics, and Society emphasize ethical considerations that genetics is bringing into everyday life. The accompanying Mastering Genetics online platform includes new tutorials on topics such as CRISPR-Cas and epigenetics, and new Dynamic Study Modules, which support student learning of key concepts and prepare them for class. Also available as a Pearson eText or packaged with Mastering Genetics: Pearson eText is a simple-to-use, mobile-optimized, personalized reading experience that can be adopted on its own as the main course material. It lets students highlight, take notes, and review key vocabulary all in one place, even when offline. Seamlessly integrated videos and other rich media engage students and give them access to the help they need, when they need it. Educators can easily share their own notes with students so they see the connection between their eText and what they learn in class - motivating them to keep reading, and keep learning. If your instructor has assigned Pearson eText as your main course material, search for: 0135588847 / 9780135588840 Pearson eText Essentials of Genetics -- Access Card, 10/e OR 0135588782 / 9780135588789 Pearson eText Essentials of Genetics -- Instant Access, 10/e Also available with Mastering Genetics By combining trusted author content with digital tools and a flexible platform, Mastering personalizes the learning experience and improves results for each student.Mastering Genetics allows students to develop problem-solving skills, learn from tutorials on key genetics concepts, and gain a better understanding of emerging topics. If you would like to purchase both the physical text and Mastering Genetics, search for: 0135173604 / 9780135173602 Essentials of Genetics Plus Mastering Genetics -- Access Card Package Package consists of: 0134898419 / 9780134898414 Essentials of Genetics 0135188687 / 9780135188682 Mastering Genetics with Pearson eText -- ValuePack Access Card -- for Essentials of Genetics Note: You are purchasing a standalone book; Pearson eText and Mastering A&P do not come packaged with this content. Students, ask your instructor for the correct package ISBN and Course ID. Instructors, contact your Pearson representative for more information.

Author Prof Jim Lynch is widely known and very experienced, well-connected with wide international networks, and globally distinguished. He was awarded the UNESCO Prize in Microbiology and Einstein Medal and Distinguished Scientist of the US Department of Agriculture. His OUP textbook Soil Microbiology was a bestseller. Taps directly into the topical area of the COVID-19 pandemic and One Health. Affordable and accessible to a wide interdisciplinary audience.

This book is an overview of primary sensory maps of vertebrates, characterized by continuous and discrete properties. The eight primary sensory maps of vertebrates have unique features and use distinct molecular cues, cell cycle exit, and activity combinations during development, regeneration, and plasticity. As an introduction and overview, the book provides a short overview for all eight sensory senses and presents through evolution and gene regulatory networks, the molecular cues needed for sensory processing. Independent contributions are included for olfactory, vision, trigeminal, taste, vestibular, auditory, lateral line, and electroreception.

Recent advances in high-throughput gene sequencing and other omics biotechnologies have served as a springboard for the field of pharmacogenomics. Pharmacogenomics is now generally accepted as the major determinant of variable drug safety, efficacy, and cost-effectiveness. Therefore, widespread use of pharmacogenomics for patient care has become a critical requirement. There is an unprecedented urgency for aspiring and practicing clinicians to become trained on how to interpret data from pharmacogenomic testing in preparation for the future of healthcare-i.e., personalized medicine. Applying Pharmacogenomics in Therapeutics provides timely coverage of the principles, practice, and potential of pharmacogenomics and personalized medicine. Comprised of chapters contributed by well-established pharmacologists and scientists from US and Chinese academia and industry, this authoritative text: Demonstrates how to apply the principles of pharmacogenomics and its biotechnologies in patient care Depicts the use of genetic biomarkers in drug discovery and development, laboratory medicine, and clinical services Describes the practice of pharmacogenomics in the treatment of cancers, cardiovascular diseases, neurologic and psychiatric disorders, and pulmonary diseases Discusses the merging of pharmacogenomics and alternative medicine, as well as the integration of pharmacogenomics into pharmacoeconomics Each chapter begins with the key concepts, followed by in-depth explorations of case reports or critical evaluations of genetic variants/biomarkers, and concludes with questions for self-examination.

The Evolution of Human Cleverness presents a unique introduction to the way human cognitive abilities have evolved. The book comprises a series of mini-essays on distinct topics in which technical terms are simplified, considering how humans made the long journey from our ape-like ancestors to become capable of higher-level reasoning and problem solving. All the topics are cross-linked, allowing the reader to dip in and out, but certain key concepts run through the underlying reasoning. Chiefly, these are adaptation and selection, the distinction between ultimate and proximate causes of behaviour, gene-culture co-evolution, and domain-general versus domain-specific cognitive processes. The book should help the reader draw lessons for the human species as a whole, especially in view of the environmental threats to its own existence. Entries have been carefully crafted to cut through scientific jargon, providing bite-sized and digestible chunks of knowledge, making the topic accessible for students and lay readers alike. The author draws on research from diverse fields including Psychology, Anthropology, Archaeology, Biology, and Neuroscience to provide an unbiased account of the field, making it an ideal text for students of all levels.

Genetic Ancestry focuses on the scientific nature and limitations of genetic ancestry testing. Co-authored by a genetic anthropologist and a cultural anthropologist, it examines the social, historical, and cultural dimensions of how people interpret genetic ancestry data. Utilizing examples from popular culture around the world and case studies from the Caribbean, the chapters highlight how genetic technology can sometimes bolster racial thinking and serve as tool of resistance and social justice.

The Evolution of Human Cleverness presents a unique introduction to the way human cognitive abilities have evolved. The book comprises a series of mini-essays on distinct topics in which technical terms are simplified, considering how humans made the long journey from our ape-like ancestors to become capable of higher-level reasoning and problem solving. All the topics are cross-linked, allowing the reader to dip in and out, but certain key concepts run through the underlying reasoning. Chiefly, these are adaptation and selection, the distinction between ultimate and proximate causes of behaviour, gene-culture co-evolution, and domain-general versus domain-specific cognitive processes. The book should help the reader draw lessons for the human species as a whole, especially in view of the environmental threats to its own existence. Entries have been carefully crafted to cut through scientific jargon, providing bite-sized and digestible chunks of knowledge, making the topic accessible for students and lay readers alike. The author draws on research from diverse fields including Psychology, Anthropology, Archaeology, Biology, and Neuroscience to provide an unbiased account of the field, making it an ideal text for students of all levels.

This monograph introduces current genome editing technologies-clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated (Cas) systems, transcription activator-like effector nucleases (TALENs), and zinc-finger nucleases (ZFNs)-and provides an assessment of the risk of misuse of these technologies based on the following parameters: accessibility, ease of misuse, magnitude of potential harm, and imminence of potential misuse. The findings from this assessment are applied to analyze and evaluate the threat posed by the intentional misuse of genome editing technologies to develop biological weapons. Furthermore, the book discusses the implications of misuse for different applications of genome editing, such as making existing pathogens more dangerous, modifying the human microbiome, weaponizing gene drives, engineering super soldiers, and augmenting the general population to confer economic advantages. Technologies that enable genome editing with programmable nucleases-including CRISPR, TALEN, and ZFN-allow for the precise genetic modification of organisms and cultured cells. While these technologies are used for a variety of beneficial applications, intelligence and defense experts have raised concerns that genome editing technologies, especially CRISPR, could be misused to develop new and improved biological weapons. Furthermore, experts worry that the number and type of actors who could potentially misuse genome editing is dramatically increasing given the democratization of biology, which is allowing biology to become more accessible to everyone including nonexperts. The book provides a comprehensive assessment of how feasible it is for users with different levels of knowledge and skill to acquire and then to apply the technologies to develop a biological weapon. It also provides an assessment of governability and a tailored set of recommendations that address security concerns. These recommendations are sensitive to the cost-benefit trade-off of regulating genome editing technologies. The book targets researchers as well as intelligence analysts, defense and security personnel, and policymakers.

This collection of essays considers the foundation and historical development of population biology and its relationship to population genetics and population ecology. It also considers its relationship to the rapidly growing fields of molecular quantitative genetics, genomics and bioinformatics. Although set in historical context, the volume's up-to-date coverage of relevant material reveals the central role of population biology in all aspects of its connection to population genetics and population ecology.

Provides historical context for the many contributions made by using the Xenopus model System. Chapters written by an international team of leading researchers using Xenopus as a model organism. Chapters deal with cell biology, developmental biology, genomics, and evolutionary biology and include the results of the research. Well illustrated with color diagrams and photos.