This volume details different genomic methods and resources to explore cereal genomics. Chapters guide readers through crop genomes, Next Generation Sequencing (NGS) technologies, protocol for CRISPR editing, transgenic wheat, NGS approach, virus induced gene silencing (VIGS), genomic tools, computational prediction of ncRNAs (miRNAs & ceRNAs) in cereal crops, genotyping-by-sequencing (GBS), Bayesian method, single cell sequencing, genome-wide association study (GWAS), QTL interval mapping, whole genome bisulfite sequencing, genome imprinting, and methods for study the receptor-metabolite interaction. Authoritative and cutting-edge, Genomics of Cereal Crops aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge.

Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. With a goal to accelerate advances by timely information exchange, this new book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature's longstanding and very successful Advances in Experimental Medicine and Biology book series is launched. Emerging areas of regenerative medicine and translational aspects of stem cells will be covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the first volume of a continuing series.

This book contains up-to-date methods for all aspects of breeding and studying mice as a model for the way that genes work to control development, physiology and behaviour. The mouse has recently become the model organism for human genetics. The chapters are written by experts in the field and aimed both at an audience of scientists new to the field, and those who want an overview of the latest techniques.

Biotic stresses cause yield loss of 31-42% in crops in addition to 6-20% during post-harvest stage. Understanding interaction of crop plants to the biotic stresses caused by insects, bacteria, fungi, viruses, and oomycetes, etc. is important to develop resistant crop varieties. Knowledge on the advanced genetic and genomic crop improvement strategies including molecular breeding, transgenics, genomic-assisted breeding and the recently emerging genome editing for developing resistant varieties in oilseed crops is imperative for addressing FPNEE (food, health, nutrition. energy and environment) security. Whole genome sequencing of these crops followed by genotyping-by-sequencing have facilitated precise information about the genes conferring resistance useful for gene discovery, allele mining and shuttle breeding which in turn opened up the scope for 'designing' crop genomes with resistance to biotic stresses. The eight chapters each dedicated to an oilseed crop in this volume elucidate on different types of biotic stress agents and their effects on and interaction with the crop plants; enumerate on the available genetic diversity with regard to biotic stress resistance among available cultivars; illuminate on the potential gene pools for utilization in interspecific gene transfer; present brief on the classical genetics of stress resistance and traditional breeding for transferring them to their cultivated counterparts; depict the success stories of genetic engineering for developing biotic stress resistant varieties; discuss on molecular mapping of genes and QTLs underlying biotic stress resistance and their marker-assisted introgression into elite varieties; enunciate on different emerging genomics-aided techniques including genomic selection, allele mining, gene discovery and gene pyramiding for developing resistant crop varieties with higher quantity and quality of yields; and also elaborate some case studies on genome editing focusing on specific genes for generating disease and insect resistant crops.

Learning and Memory provides a balanced review of the core methods and the latest research on animal learning and human memory. Topical coverage ranges from the basic and central processes of learning, including classical and instrumental conditioning and encoding and storage in long-term memory, to topics not traditionally covered, such as spatial learning, motor skills, and implicit memory. The general rules of learning are reviewed along with the exceptions, limitations, and best applications of these rules. Alternative approaches to learning and memory, including cognitive, neuroscientific, functional, and behavioral, are also discussed. Individual differences in age, gender, learning abilities, and social and cultural background are explored throughout the text and presented in a dedicated chapter. The relevance of basic principles is highlighted throughout the text with everyday examples that ignite reader interest in addition to more traditional examples from human and animal laboratory studies. Research examples are drawn from education, neuropsychology, psychiatry, nursing, and ecological (or everyday) memory. Each chapter begins with an outline and concludes with a detailed summary. Applications and extensions are showcased in text boxes as well as in distinct applications sections in every chapter, and review and recapitulation sections are interspersed throughout the chapters.

Leading gene therapy researchers and clinicians illuminate the field-from basic vector technology to current and future clinical applications in neurology. The authoritative contributors provide cutting-edge reviews of the vectors available for gene transfer to the central nervous system, the strategies against CNS tumors, the potential strategies against neurologic disorder, and the limitations of today's gene therapy approaches. Also discussed are significant applications of gene therapy to brain tumors, Parkinson's disease, ischemia, and Huntington's chorea. Readers will learn the current delivery methods for transgenes, will learn the characteristics of transgene delivery vectors, and come to understand the therapy for both neuro-oncologic and neurologic disorders.

The European Molecular Biology Open Software Suite (EMBOSS) is a high quality package of open source software tools for molecular biology. It includes over 200 applications integrated with a range of popular third party software packages under a consistent and powerful command line interface. The tools are available from a wide range of graphical interfaces, including easy to use web interfaces and powerful workflow software. The EMBOSS Administrator's Guide is the official, definitive and comprehensive guide to EMBOSS installation and maintenance: * Find all the information needed to configure, install and maintain EMBOSS, including recent additions for version 6.2 * Step-by-step instructions with real-world examples - saves readers time and helps them avoid the pitfalls on all the common platforms * In-depth reference to database configuration - learn how to set up and use databases under EMBOSS * Includes EMBOSS Frequently Asked Questions (FAQ) with answers - quickly find solutions to common problems

This textbook provides a concise introduction and useful overview of the field of human population genomics, making the highly technical and contemporary aspects more accessible to students and researchers from various fields. Over the past decade, there has been a deluge of genetic variation data from the entire genome of individuals from many populations. These data have allowed an unprecedented look at human history and how natural selection has impacted humans during this journey. Simultaneously, there have been increased efforts to determine how genetic variation affects complex traits in humans. Due to technological and methodological advances, progress has been made at determining the architecture of complex traits. Split in three parts, the book starts with the basics, followed by more advanced and current research. The first part provides an introduction to essential concepts in population genetics, which are relevant for any organism. The second part covers the genetics of complex traits in humans. The third part focuses on applying these techniques and concepts to genetic variation data to learn about demographic history and natural selection in humans. This new textbook aims to serve as a gateway to modern human population genetics research for those new to the field. It provides an indispensable resource for students, researchers and practitioners from disparate areas of expertise.

This book gives insight into the functional role of non-coding RNAs in central pathways contributing to the development of obesity, type 2 diabetes, non-alcoholic fatty liver disease, atherosclerosis, myocardial infarction, cardiomyopathy, and heart failure. It also sheds light on the relationship of this cluster with cancer. Tumor cells, in contrast to cells in cardiometabolic tissues, can regulate this cluster of non-coding RNAs to escape from oxidative stress and anti-tumor immunity and maintain insulin sensitivity, facilitating cancer progression. The book presents a cluster of non-coding RNAs that may be prospectively analyzed in extensive cohort studies to determine their value in risk-predicting machine learning algorithms. In addition, it emphasizes the role of microvesicles in communication between tumor-adjacent tissue, inflammatory cells, and tumor cells, with a special focus on the role of miR-155. The book intends to promote interdisciplinary research. Due to the comprehensive background information provided in each chapter, it is suitable for researchers in academia and industry and for graduate students in biology, bioengineering, and medicine.

Over the past few decades, chromatin modulation has emerged as an important regulator of gene expression. This second edition provides detailed information on the epigenetic mechanisms in plants, illustrating the value of this research in plants of agronomic importance. It examines recent advances regarding plants' epigenetic regulation in response to abiotic and biotic types of stress; the epigenetic basis of plant immunity; evolution and functions of plant histones; epigenetic variation and plant breeding; and epigenome editing and crop improvement. The content is intended to promote the development of future biotechnologies to manipulate and selectively activate/inhibit proteins and metabolic pathways to counter pathogens, to treat important diseases, and to increase crop productivity. The development of new fields, like epigenome editing and RNA epigenetics, will certainly improve our understanding of currently known epigenetic modifications and their roles in e.g. host-pathogen interactions, crop productivity, and in response to environmental stimuli. This volume contains twelve new/revised chapters, written by an international team of experts on plant epigenetics, and addresses the needs of researchers and professionals in the fields of agronomics, crop breeding, epigenetics, plant biochemistry, plant developmental biology, and related disciplines.

Few, if any, genes have had the same level of impact on the field of evolutionary-developmental biology (evo-devo) as the Hox genes. These genes are renowned for their roles in patterning the body plans and development of the animal kingdom. This is complemented by the distinctive organisation of these genes in the genome, with them frequently being found as clusters in which gene position is linked to when and where the individual genes are expressed, particularly during embryogenesis. This book provides the latest overviews of Hox gene organisation and function for major clades of animals from across the animal kingdom. With the rapidly increasing availability of high-quality whole genome sequences from an ever-expanding range of species, it is becoming increasingly evident that there is great diversity in the organisation of Hox genes. These great strides in genome sequencing are wedded to important developments in our ability to detect expression and disrupt gene function in species that are not traditionally genetically-amenable animals. These technical developments are integrated with wide taxon-sampling in this volume to provide new perspectives on the roles of Hox genes in understanding fundamental issues such as embryo patterning, mechanisms of gene regulation, homology, evolvability, evolutionary novelties, phylogeny, the role of gene and genome duplications in evolution, and ancestral states for major clades of animals. Key features Integrative overviews from major animal groups including, arthropods, vertebrates, echinoderms, mollusks and other spiralians. Perspectives gleaned from the latest genome sequence and gene expression data. Individual chapters written by world-leading experts in Hox genes and evo-devo in each animal group. Related Titles Scholtz, G., ed. Evolutionary Developmental Biology of Crustacea (ISBN 978-9-0580-9637-1) Mattick, J. & P. Amaral. RNA, The Epicenter of Genetic Information (ISBN 978-0-3675-6778-1) Bard, J. Evolution: The Origins and Mechanisms of Diversity (ISBN 978-0-3673-5701-6)

This new series, based on a bi-annual conference and its topics, represents a major contribution to the emerging science of cancer research and regenerative medicine. Each volume brings together some of the most pre-eminent scientists working on cancer biology, cancer treatment, cancer diagnosis, cancer prevention and regenerative medicine to share information on currently ongoing work which will help shape future therapies. These volumes are invaluable resources not only for already active researchers or clinicians but also for those entering these fields, plus those in industry. Tissue Engineering and Regenerative Medicine is a proceedings volume which reflects papers presented at the 3rd bi-annual Innovations in Regenerative Medicine and Cancer Research conference; taken with its companion volume Stem Cells: Biology and Engineering it provides a complete overview of the papers from that meeting of international experts.

Taking as examples the lives of creative individuals through history, Genius and the Mind considers the nature of creativity and genius from a psychological standpoint. Eleven chapters, contributed by leading researchers, span the range of approaches used to understand the subject. A discussion of heredity considers the extent to which genes play a part in giftedness. The importance of social context in defining and acknowledging creativity is explored. Several chapters look at training and skill development in exceptional individuals, and a number of contributions scrutinize the links between creativity, temperament, and mental health. Mozart's precocity, Byron's mania, the personalities of the Italian Renaissance painters, and the psychoses of many celebrated writers are all discussed, making this a fascinating text for anyone with an interest in the psychology of genius and geniuses, as well as for students and researchers in the field.

According to Jon Karlsson, the influence of genetic factors on human mentality has been neglected for many years in the study of intelligence. He contends that the evidence for biological influences on human intelligence is too compelling to be ignored any longer. Karlsson believes that such influences can be positive, and that ways can be found to measure their importance.

Serious efforts are necessary to extend the scope of basic conceptions concerning the structure of the brain and to explore the mysteries of the physiological mechanisms that govern the human mind. The research reported in this volume suggests some approaches that might prove useful. Karlsson believes that an effective approach to the genetics of mentality can be built around studies of serious brain abnormalities. Beginning with the idea that psychosis probably has a genetic bond to creativity, he argues that parallel possibilities exist in relation to other frequently occurring disorders. The product of many years of research, this work is certain to be a source of both controversy and of new ideas for the study of human intellectual development.

Drosophila is the scientist's favourite lab organism because it reproduces quickly and has straightforwartd chromosomes. It has long been the organism of choice in experiments in genetics and is also popular in developmental and behavioural studies. The second edition of this popular Practical Approach book brings the methodology up to date, with contributions from the world's leading Drosophila researchers. It will be valuable to the novice and experienced worker alike.

This book is the first comprehensive compilation describing the botanical traits, genetic resources, whole genome sequencing, Mitochondrial genome, transcriptomes of different organs with developmental stages, transcription factors, delineating gene evolution of gene family in Bambusoideae, alternative splicing (AS) and polyadenylation, case studies for economically important traits such as internode length, shoot fast growing, flowering, ageing and stress-resistant genes and small RNAs-mediated gene regulation of moso bamboo flowering and other developmental stages. Applications of transcriptome and genome approaches in moso bamboo in general and the prospects of transgenic breeding and genome editing technologies in bamboo are also discussed. Altogether, the book comprises eleven chapters covered over 200 pages authored by the researchers involved in genomic science, molecular biology, and breeding. This book appeals to graduate students, post-graduate students, research scholars, researchers, and industry players in the field of plantation bamboo in general, bamboo processing and bamboo garden owner and fans of bamboo culture in particular.

Legumes include many very important crop plants that contribute very critical protein to the diets of both humans and animals around the world. Their unique ability to fix atmospheric nitrogen in association with Rhizobia enriches soil fertility, and establishes the importance of their niche in agriculture. Divided into two volumes, this work presents an up-to-date analysis of in vitro and recombinant DNA technologies for the improvement of grain, forage and tree legumes.
Volume 10A examines the current status and future prospects of challenges of the following: in vitro morphogenesis; biotic and abiotic stress tolerance; genomics; nitrogen fixation and utilization; nutritional improvement, and biodiversity of wild and tribal legumes.
Volume 10B presents the current state and future prospects of in vitro regeneration and genetic transformation expression and stability of transgenes modification of traits in almost all the important legumes, for example: soybean; peanut; pea; french bean; chick pea; pigeon pea; cowpea; mung bean; black gram; azuki bean; lentil; Lathyrus; lupinus; Lotus spp; Medicago spp; Trifolium spp; Winged bean; Guar; and tree legumes for their improvement. Written by international experts, these volumes will be of great value to researchers, as well as graduate students and all those requiring an advanced level overview of the subject area.

Hormonal Cross-Talk, Plant Defense and Development: Plant Biology, Sustainability and Climate Change focuses specifically on plants and their interaction to auxins, gibberellins, cytokinins, ethylene, abscisic acid, jasmonates, brassinosteroids, strigolactones, and the potential those interactions offer for improved plant health and production. Plant hormones (auxins, gibberellins, cytokinins, ethylene, abscisic acid, jasmonates, brassinosteroids, salicylic acid, strigolactones etc.) regulate numerous aspects of plant growth and developmental processes. Each hormone initiates a specific molecular pathway, with each pathway integrated in a complex network of synergistic, antagonistic and additive interactions. This is a valuable reference for those seeking to understand and improve plant health using natural processes. The cross-talks of auxins - abscisic acid, auxins - brassinosteroids, brassinosteroids- abscisic acid, ethylene - abscisic acid, brassinosteroids - ethylene, cytokinins - abscisic acid, brassinosteroids - jasmonates, brassinosteroids - salicylic acid, and gibberellins - jasmonates - strigolactones have been shown to regulate a number of biological processes in plant system. The cross-talk provides robustness to the plant immune system but also drives specificity of induced defense responses against the plethora of biotic and abiotic interactions.

This volume details methods of identifying synthetic lethal, genetic interactions by various approaches in different model systems including human cancer cells. Chapters guide readers through genetic interactions in model organisms, RNA interference, CRISPR/Cas9 based genome editing technologies, drug-gene interactions, mapping chemical genetic interactions, synergistic drug-gene relations, single cell sequencing, gene expression profiling, and novel genetic interactions. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Genetic Interaction Mapping aims to be a useful practical guide to researches to help further their study in this field.

Bioactive compounds produced by natural sources, such as plants, microbes, endophytic fungi, etc., can potentially be applied in various fields, including agriculture, biotechnology and biomedicine. Several bioactive compounds have proved to be invaluable in mediating plant-microbe interactions, and promoting plant growth and development. Due to their numerous health-promoting properties, these compounds have been widely used as a source of medication since ancient times. However, there is an unprecedented need to meet the growing demand for natural bioactive compounds in the flavor and fragrance, food, and pharmaceutical industries. Moreover, discovering new lead molecules from natural sources is essential to overcoming the rising number of new diseases. In this regard, natural bioactive compounds hold tremendous potential for new drug discovery. Therefore, this field of research has become a vital area for researchers interested in understanding the chemistry, biosynthetic mechanisms, and pharmacological activities of these bioactive metabolites. This book describes the basics of bioactive plant compounds, their chemical properties, and their pharmacological biotechnological properties with regard to various human diseases and applications in the drug, cosmetics and herbal industries. It offers a valuable asset for all students, educators, researchers, and healthcare experts involved in agronomy, ecology, crop science, molecular biology, stress physiology, and natural products.

Why is blood thicker than water'? Are we innately violent or pacific? Why are plants and animals sexual? Why do we grow old and die? Such questions have motivated the life-work of W.D. Hamilton, widely acknowledged as the most important theoretical biologist of the 20th century. His papers continue to exert an enormous influence and they are now being republished for the first time. This first volume contains all of Hamilton's publications prior to 1981, a set especially relevant to social behavior, kinship theory, sociobiology, and the notion of selfish genes'. Each paper is introduced by an autobiographical essay written especially for this collection. Accessible to non-specialists, this fascinating volume features several of the most read and famous papers of modern biology.

Oncogenes and tumour suppressor genes have been the focus of much research because of their role not only in cancer but also in normal cell growth and differentiation. Oncogenes and Tumour Suppressors is a unique volume that brings together a team of leading researchers to present and critically assess our current knowledge. The book covers two major areas of interest: oncogenes and signal transduction, and tumour supressors and cell cycle control. Topics covered include the mechanisms of oncogene perturbation; growth factors and their receptors in cell transformation; oncogenic cytoplasmic protein tyrosine kinases; the RAS/RAP/ERK signal transduction pathway; oncogenic transcription factors; mammalian cell cycle control; the retinoblastoma gene product and its relatives; the tumour suppressor gene p53; tumour suppressors and the inheritance of cancer; the clinical relevance of oncogenes. Oncogenes and Tumour Suppressors is a major review work that provides an unparalleled summary of our current understanding of this field as viewed by some of its leading researchers. It is of interest to all those involved in research on the cell cycle, signal transduction, and cancer biology. The book is also an excellent reference source with over 1800 selected citations to the primary literature.

This volume covers the global history of the Lysenko controversy, while exploring in greater depth the background of D. Lysenko's career and influence in the USSR. By presenting the rise and fall of T.D. Lysenko in a variety of aspects-his influence upon art, unrecognized predecessors, and the extent to which genetics continued in the USSR even while he was in power, and the revival of his reputation today-the authors provide a fresh perspective on one of the most notorious episodes in the history of science.

New directions in plant systems research are presented and discussed in this book. The book offers new insights in physiology and genetics of crop adaptation for wheat and maize, along with innovative approaches in architectural and physiology-based modelling of crop functioning. An outlook and dialogue on future directions in plant system research challenges readers with contrasting opinions on the way forward.