Personalized nutrition involves the formulation of individualized nutritional recommendations to promote and maintain health based on an individual's genetic makeup and other unique intrinsic and extrinsic factors. Implementing personalized nutrition plans for individuals with certain diseases or who are in danger of developing health conditions could help control the onset and severity of symptoms. Personalized Nutrition as Medical Therapy for High-Risk Diseases offers a practical guide for physicians seeking to provide tailored dietary recommendations to their patients with disease treatment, modulation and prevention in mind. The book focuses on the biological mechanisms of specific diseases and provides evidence for how personalized nutrition positively impacts them. It explores conditions including cardiovascular diseases, hypertension, hypercholesteromia, diabetes, obesity, Crohn's disease, as well as multiple pediatric, renal and psychological disorders. Features: * Includes case studies that document how people respond differently towards food depending on their genetic structure and other factors. * Discusses genome wide association studies (GWIMS) to understand the interplay between genetic susceptibility and dietary interactions. * Provides users information to effectively implement personalized nutrition into practice. * Identifies possible challenges to the implementation of personalized nutritional interventions in a clinical setting. This book is for medical practitioners and will also appeal to researchers and students.

Epigenetics is emerging as an important factor in risk of diseases of global importance including obesity, cardiovascular disease and cancer. Unlike gene polymorphisms which have been the focus of understanding the role of inherited disease susceptibility for some time, epigenetic can be modified by environmental factors, in particular nutrition. Thus research into the role of epigenetics in disease has substantial potential for explaining the impact of the environmental factors such as diet on disease risk. Since epigenetic processes can be modified by nutrition, it may be possible to modify inappropriate epigenetic marks by nutritional interventions to reduce disease risk. This book will explore current understanding of the interaction between nutrition, epigenetics and disease risk, will place this knowledge in the context of global health and discuss the ethical implications of this research.

Population genomics research drawing on genetic databases has expanded rapidly, with some of this information being combined in 'biobanks'. Managing this information in an appropriate way is a highly complex ethical issue in the health policy arena. This book combines theoretical and empirical research to analyze the areas of conflict and consensus in the regulatory and ethical frameworks that have been developed to govern biobanks. Ethicists from the Department of Ethics, Trade, Human Rights and Health Law (ETH) of the World Health Organization, the Institute of Biomedical Ethics of Geneva University and the Institute of Biomedical Ethics of the University of Zurich, with the support of the Geneva International Academic Network (GIAN), examine the conditions under which genetic databases can be established, kept, and made use of in an ethically acceptable way. In addition to a comprehensive review of the scientific literature and a comparative analysis of existing normative frameworks, they present the results of in-depth interviews with experts around the world concerning the most unresolved and controversial issues. The results of that study, combined with their normative analysis, leads to recommendations for a better international framework.

The scope of these chapters reflects the strong influence that Sandra Wood Scarr's scholarship-her empirical research and theoretical contributions-has had on what we know about experience and development via the lens of the psychological sciences, especially the fields of developmental psychology, behavior genetics, early education and child care.

A comprehensive and critical review of the latest scientific advances in our understanding of the molecular genetics and biology of CLL and their application to the best management of CLL. The authors focus on diagnosis, prognosis, multifaceted treatment options, and complications. Among the diverse treatments considered are chemotherapy, autologous and allogenic transplantations, monoclonal antibody therapy, immunotoxin therapy, gene therapy, and several new therapeutic strategies. Familial and juvenile chronic lymphocytic leukemia are also discussed.

Race, ethnicity and nation are all intimately linked to family and kinship, yet these links deserve closer attention than they usually get in social science, above all when family and kinship are changing rapidly in the context of genomic and biotechnological revolutions. Drawing on data from assisted reproduction, transnational adoption, mixed race families, Basque identity politics and post-Soviet nation-building, this volume provides new and challenging ways to understand race, ethnicity and nation.

1) Presents full guide to virus-like particles, by combination of classical virology with modern nanotechnology, for the first time 2) Outlines generation and sources of virus-like particles from different groups of viruses 3) Demonstrates the specific structural and immunological properties of virus-like particles 4) Presents up-to-date account of virus-like particles used for the generation of vaccines, diagnostic and therapeutic tools 5) Presents interconnection of virology, nanotechnology, and healthcare

Genetic Association Studies is designed for students of public health, epidemiology, and the health sciences, covering the main principles of molecular genetics, population genetics, medical genetics, epidemiology and statistics. It presents a balanced view of genetic associations with coverage of candidate gene studies as well as genome-wide association studies. All aspects of a genetic association study are included, from the lab to analysis and interpretation of results, but also bioinformatics approaches to causality assessment. The role of the environment in genetic disease is also highlighted. Genetic Association Studies will enable readers to understand and critique genetic association studies and set them on the way to designing, executing, analyzing, interpreting, and reporting their own.

Plant breeding has played a significant role in the development of human civilizations. Conventional plant breeding has significantly improved crop yield by genetically manipulating agronomically important traits. However, it has often been criticized for ignoring indigenous germplasm, failing to address the needs of the marginal and the poor farmers, and emphasizing selection for broad instead of local adaptation. Participatory plant breeding (PPB) is the process by which the producers and other stakeholders are actively involved in a plant-breeding programme, with opportunities to make decisions throughout. The Working Group on Participatory Plant Breeding (PPBwg) was established in 1996 under the framework of the Consultative Group on International Agricultural Research (CGIAR). Research in PPB can promote informed participation and trust in research among consumers and producers, and in recent years, PPB has had a significant impact on food production by quickly and cost-effectively producing improved crop varieties. At the same time, there has been significant research in the area. PPB offers significant advantages that are particularly relevant to developing countries where large investments in plant breeding have not led to increased production, especially in the marginal environments. In addition to the economic benefits, participatory research has a number of psychological, moral, and ethical benefits, which are the consequence of a progressive empowerment of the farming communities. PPB can empower groups such as women or less well-off farmers that are traditionally left out of the development process. This book explores the potential of PPB in the coming decades. The topic is more relevant since international breeding efforts for major crops are aimed at decentralizing local breeding methods to better incorporate the perspective of end users into the varietal development process. The first book incorporating the upcoming research on this novel breeding approach, it reviews the important tools and applications of PPB in an easy-to-read, succinct format, with illustrations to clarify these complex topics. It provides readers with a basic idea of participatory plant breeding as well as advances in the field and insights into the future to facilitate the successful integration of farmers into breeding programmes. This book is a valuable reference resource for agriculturists, agricultural advisers, policy makers, NGOs, post-doctoral students and scientists in agriculture, horticulture, forestry and botany.

This edited book covers all aspects of omics approaches used for the varietal improvement of millets in changing climatic conditions. Millets are the collection of small-grained cereal grasses, that are grown for human carbohydrate needs. They are among the oldest crops, mainly divided into two groups - Major and small millets based on seed size. Small millets are earlier considered orphan crops, but recently due to their nutritional values, they are getting importance in cultivation. This book explores the genomics, transcriptomics, proteomics, metabolomics, bioinformatics, and other omics tools that are being widely used to get a clear understanding of mechanistic approaches taken by plant genes to tolerate stress. Various reports are published based on field breeding on these crops, and recently the genome of some of the small millets is released, and many omics studies are published related to its application in varietal improvements. This book reviewed all those recent studies and is of interest to research students, plant breeding scientists, teachers that are working in agriculture and plant biotech universities. Along with this, the book serves as reference material for undergraduate and graduate students of agriculture, and biotechnology. National and international agricultural scientists, policymakers will also find this to be a useful read.

The wealth of primary information provided by genome sequencing projects in various species is of enormous potential value in our efforts to understand biological funtions and molecular interactions not only in normal development and cellular physiology, but also in diseases. However, utili- tion of these resources can come only from the development and application of a fully integrated set of molecular, biochemical, biophysical, and genetic skill bases. As key components of many cell signalling pathways, protein kinases are implicated in a broad variety of diseases, including cancers and neurodegenerative conditions, and offer considerable potential as tractable targets for therapeutic intervention. With these issues in mind, the present vlume has been compiled to provide examples of core skills required for ana- sis of knase-mediated signalling cascades, with particular emphasis on iden- fication of proteins according to interactive relationships and analysis of functional properties of signalling proteins. Compilation of Protein Kinase Protocols has been possible only as a - sult of the effort of all the contributors, and I am grateful to them for taking the time and having the patience to desseminate the detailied information - quired in order that others can succeed in the application of these techniques. Most importantly, I extend my deepest gratitude to Chris, Emma, and Helen for making it all worthwhile Alastair D. Reith v Contents Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . iv ix Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Protein Kinase-Mediated Signaling Networks: Regulation and Functional Characterization Alastair D. Reith. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

This book becomes an invaluable reference on the genetic resources, genome, genes, chemical compounds, and their therapeutic effects for the Lingzhi mushrooms. It is the first comprehensive compilation of genetic resources, nuclear genome, mitochondrial genome, genes, noncoding RNAs, such as long intergenic noncoding RNAs, microRNAs, circular RNAs, genes in the biosynthetic pathway, chemical compounds and their therapeutic effects, transformation system for the expression of key genes, a bibliometric analysis to identify the past research work and the future research direction, and a survey of products derived from the Lingzhi mushrooms. Each chapter of this book is written by authors of globally reputed experts on the relevant field who had published high-quality articles in the corresponding subject. The book has 12 chapters and each chapter has a length of approximately ten thousand words, including ten items (tables or figures), about 30-50 references. This book is useful to the students, teachers, and scientists in academia and relevant private companies interested in horticulture, genetics, physiology, molecular genetics, and breeding, in vitro culture and genetic engineering, and structural and functional genomics. This book is also useful to seed and pharmaceutical industries.

This volume contains the proceedings of the Tenth International Meeting of the International Study Group for Tryptophan Research (ISTR V), held at the University of Padova, Padova, Italy, from 25-29 June, 2002 under the auspices of the Ministry of Education, University and Research (MIUR) in Roma, the University of Padova, the Italian Chemical Society - Division of Pharmaceutical Chemistry, the Veneto Region and the City of Padova. The meeting was organized to cover the recent developments in the field of tryptophan research. Weare very honoured that so many speakers accepted our invitation to give plenary lectures which, with the other communications, demonstrated the high scientific value of the Meeting. The publications in this volume are subdivided into nine main chapters, and cover all the major aspects in immunology, neurobiology, psychiatry, pathology, clinics, metabolism, enzymology, pharmacology, toxicology, melatonin, exercise and analytical chemistry. The volume includes the contributions of 325 scientists from 24 countries, and the Musajo Memorial Lecture delivered by Prof. Osamu Hayaishi during the Opening Ceremony.

This book covers about 20 grape species that are vitally important in breeding programs and provide information on approximately 150 of the most familiar grape rootstocks in the world. Today, grape rootstocks play a fundamental role in resistance to biotic and abiotic stresses and adaptation of grapevine to different environmental conditions, a factor that has opened commercial grape growing up to regions that might otherwise be overlooked. Grape rootstocks can be used for adaptation to a variety of soil conditions, including soil texture, depth, nutrient availability, pH, salinity, lime content, water availability (drought), and water drainage. Rootstocks can also be used to shift scion cultivar; the timing of various key phenological events and indirectly affects vineyard design. There are around 1500 grape rootstocks developed in the world, of which around 50 are commonly used as commercial rootstock. North American species account for around 30 species, and two-third of them have already been used for rootstock breeding at one time or another. However, the most commonly available rootstocks are derived from just three American species (V. berlandieri, V. rupestris, and V. riparia). Therefore, the most common grape rootstocks have a narrow genetic base, and efforts to extend the gene pools for breeding programs by using the other species are of ongoing importance to the industry and scientific community.

Although the human genome exists apart from society, knowledge about it is produced through socially-created language and interactions. As such, genomicists' thinking is informed by their inability to escape the wake of the 'race' concept. This book investigates how racism makes genomics and how genomics makes racism and 'race,' and the consequences of these constructions. Specifically, Williams explores how racial ideology works in genomics. The simple assumption that frames the book is that 'race' as an ideology justifying a system of oppression is persistently recreated as a practical and familiar way to understand biological reality. This book reveals that genomicists' preoccupation with 'race'-regardless of good or ill intent-contributes to its perception as a category of differences that is scientifically rigorous.

Forensic Genetic Approaches for Identification of Human Skeletal Remains: Challenges, Best Practices, and Emerging Technologies provides best practices on processing bone samples for DNA testing. The book outlines forensic genetics tools that are available for the identification of skeletal remains in contemporary casework and historical/archaeological investigations. Although the book focuses primarily on the use of DNA for direct identification or kinship analyses, it also highlights complementary disciplines often used in concert with genetic data to make positive identifications, such as forensic anthropology, forensic odontology, and forensic art/sculpting. Unidentified human remains are often associated with tragic events, such as fires, terrorist attacks, natural disasters, war conflicts, genocide, airline crashes, homicide, and human rights violations under oppressive totalitarian regimes. In these situations, extensive damage to soft tissues often precludes the use of such biological samples in the identification process. In contrast, bone material is the most resilient, viable sample type for DNA testing. DNA recovered from bone often is degraded and in low quantities due to the effects of human decomposition, environmental exposure, and the passage of time. The complexities of bone microstructure and its rigid nature make skeletal remains one of the most challenging sample types for DNA testing.

Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on non-hematopoietic cells within the tumor microenvironment.Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include fibroblasts, adipocytes, mesenchymal stem cells, stellate cells, and more. Taken alongside its companion volumes, Tumor Microenvironment: Non-Hematopoietic Cells updates us on what we know about the different aspects of the tumor microenvironment as well as future directions. Useful for introducing the newer generation of researchers to the history of how scientists focused in the tumor microenvironment and how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment. All of the chapter authors are renowned international experts in the cancer biology field in specific subfields that will be the focus of their chapters.

Recent advances in high-throughput gene sequencing and other omics biotechnologies have served as a springboard for the field of pharmacogenomics. Pharmacogenomics is now generally accepted as the major determinant of variable drug safety, efficacy, and cost-effectiveness. Therefore, widespread use of pharmacogenomics for patient care has become a critical requirement. There is an unprecedented urgency for aspiring and practicing clinicians to become trained on how to interpret data from pharmacogenomic testing in preparation for the future of healthcare-i.e., personalized medicine. Applying Pharmacogenomics in Therapeutics provides timely coverage of the principles, practice, and potential of pharmacogenomics and personalized medicine. Comprised of chapters contributed by well-established pharmacologists and scientists from US and Chinese academia and industry, this authoritative text: Demonstrates how to apply the principles of pharmacogenomics and its biotechnologies in patient care Depicts the use of genetic biomarkers in drug discovery and development, laboratory medicine, and clinical services Describes the practice of pharmacogenomics in the treatment of cancers, cardiovascular diseases, neurologic and psychiatric disorders, and pulmonary diseases Discusses the merging of pharmacogenomics and alternative medicine, as well as the integration of pharmacogenomics into pharmacoeconomics Each chapter begins with the key concepts, followed by in-depth explorations of case reports or critical evaluations of genetic variants/biomarkers, and concludes with questions for self-examination.

This volume details technologies on recombinant DNA and nucleic acid manipulation that underpin much of the biological sciences and instructions on how to conduct them successfully. Chapters guide the reader through the basics of oligonucleotide synthesis and DNA sequencing; recombinant DNA plasmid work; cell-free experiments and the latest developments in CRISPR approaches to genome modification. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and methods, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols.   Authoritative and cutting-edge, Gene Modification and Nucleic Acid Technologies aims to be the comprehensive guide for life scientists moving into the field of recombinant DNA and nucleic acid manipulation.

First Published in 1996. Routledge is an imprint of Taylor & Francis, an informa company.

In this entertaining account of the origins of modern molecular biology, the lives of pioneering scientists in the field of nucleic acid research, and the discovery of DNA, Ulf Lagerkvist speaks not only to scientists but to all students and general readers with an interest in science. The author, whose career in the nucleic acid field began in the late 1940s, recreates historical episodes from the nineteenth and early twentieth centuries and introduces for a modern audience the scientists whose discoveries revolutionized the field of biology. Knowledge of these pioneers as professionals and as human beings, Lagerkvist believes, may help us see modern problems in a new light and appreciate the greatness of the researchers who contributed to the foundations of molecular biology and biochemistry. Among these scientific pioneers was nineteenth-century biochemist Friedrich Miescher, discoverer of nuclein, the material now known as DNA. The book also explores early research into general problems of the chemistry of biological materials. Lagerkvist vividly describes the research of such influential scientists as Albrecht Kossel, another early leading figure; Emil Fischer, who received the Nobel Prize in 1902 for his work on carbohydrates and purines and was regarded as the foremost chemist of his time; P. A. Levene, known for his discoveries concerning the structure of nucleotides and the way these nucleic acid building blocks are linked to one another; and Oswald T. Avery, often considered the grandfather of molecular genetics.

First published in 1957, this essential classic work bridged the gap between analytical and theoretical biology, thus setting the insights of the former in a context which more sensitively reflects the ambiguities surrounding many of its core concepts and objectives. Specifically, these five essays are concerned with some of the major problems of classical biology: the precise character of biological organisation, the processes which generate it, and the specifics of evolution. With regard to these issues, some thinkers suggest that biological organisms are not merely distinguishable from inanimate 'things' in terms of complexity, but are in fact radically different qualitatively: they exemplify some constitutive principle which is not elsewhere manifested. It is the desire to bring such ideas into conformity with our understanding of analytical biology which unifies these essays. They explore the contours of a conceptual framework sufficiently wide to embrace all aspects of living systems.

This book is the first comprehensive compilation of deliberations on elucidation and augmentation of the genome of Brassica juncea, one of the leading oilseed crops of the world, popularly called as brown mustard, Indian mustard, Chinese mustard, or Oriental mustard. It includes discussions on genepools; genetic diversity and its characterization; classical genetic and traditional breeding; basics and application of heteroploidy; techniques and applications of introgressive hybridization; in vitro culture for micro-propagation, somatic mutation, somatic embryogenesis, and somatic hybridization; genetic engineering including genetic transformation and gene silencing; and molecular genetic mapping and mapping of genes and comprehensive delineations on genome sequencing and comparative genomics; resequencing for elucidation of origin and diversity; large-scale genome analysis; plastid genome sequence; transcriptomics; metabolomics; proteomics; evolutionary genomics; role of regulatory genes in development and adaptation and their utilization in trait improvement; precise breeding for yield, quality, and resistance to biotic and abiotic stresses; and prospects of genome editing.

Stem Cell Biology in Health and Disease presents an up-to-date overview about the dual role of stem cells in health and disease. The Editors have drawn together an international team of experts providing chapters which, in this fully-illustrated volume, discuss:

- the controversial debate on the great expectations concerning stem cell based regeneration therapies raised by the pluripotency of various stem cells.
- the advantages and concerns about embryonic stem cells (ES cells), induced pluripotent stem cells (iPS cells) and adult stem cells, such as bone marrow-derived stem cells (BMDCs).
- the type of stem cells, which has become of interest in the past decade, namely so-called cancer stem cells (CSCs). CSCs are now in the focus of cancer research since the eradication of tumour initiating cells would raise the changes of definitely cure cancer.

Professor Dittmar and Professor Zanker have edited a must-read book for researchers and professionals working in the field of regenerative medicine and/or cancer."

Demonstrating the shortcomings of current policy and legal approaches to access and benefit-sharing (ABS) in the Convention on Biological Diversity (CBD), this book recognizes that genetic resources are widely distributed across countries and that bilateral contracts undermine fairness and equity. The book offers a practical and feasible regulatory alternative to ensure the goal of fairness and equity is effectively and efficiently met. Through a legal analysis that also incorporates historic, economic and sociological perspectives, the book argues that genetic resources are not tangible resources but information. It shows that the existing preference for bilateralism and contracts reflects resistance on the part of many of the stakeholders involved in the CBD process to recognize them as such. ABS issues respond very well to the economics of information, yet as the author explains, these have been either sidelined or overlooked. At a time when the Nagoya Protocol on ABS has renewed interest in feasible policy options, the author provides a constructive and provocative critique. The institutional, policy and regulatory framework constitute "bounded openness" under which fairness and equity emerge.