Ancestral DNA, Human Origins, and Migrations describes the genesis of humans in Africa and the subsequent story of how our species migrated to every corner of the globe. Different phases of this journey are presented in an integrative format with information from a number of disciplines, including population genetics, evolution, anthropology, archaeology, climatology, linguistics, art, music, folklore and history. This unique approach weaves a story that has synergistic impact in the clarity and level of understanding that will appeal to those researching, studying, and interested in population genetics, evolutionary biology, human migrations, and the beginnings of our species.

Provides examples, to laboratories and lab personnel, on how to report the results of forensic biology examinations given activity level propositions, along with example reports and standard operating procedures Presents worked case examples, based on real crimes, showing how the theory of activity level evaluation can be applied in practice Illustrates how the theory of activity level evaluation, explained specifically for forensic genetic cases, can likewise be applied to other forensic disciplines Explains concepts in simple terms, making it ideal for law or science students wishing to understand the fundamental of forensic evidence evaluation

Statisticians have met the need to test hundreds or thousands of genomics hypotheses simultaneously with novel empirical Bayes methods that combine advantages of traditional Bayesian and frequentist statistics. Techniques for estimating the local false discovery rate assign probabilities of differential gene expression, genetic association, etc. without requiring subjective prior distributions. This book brings these methods to scientists while keeping the mathematics at an elementary level. Readers will learn the fundamental concepts behind local false discovery rates, preparing them to analyze their own genomics data and to critically evaluate published genomics research. Key Features: * dice games and exercises, including one using interactive software, for teaching the concepts in the classroom * examples focusing on gene expression and on genetic association data and briefly covering metabolomics data and proteomics data * gradual introduction to the mathematical equations needed * how to choose between different methods of multiple hypothesis testing * how to convert the output of genomics hypothesis testing software to estimates of local false discovery rates * guidance through the minefield of current criticisms of p values * material on non-Bayesian prior p values and posterior p values not previously published

Analysis of Genetic Association Studies is both a graduate level textbook in statistical genetics and genetic epidemiology, and a reference book for the analysis of genetic association studies. Students, researchers, and professionals will find the topics introduced in Analysis of Genetic Association Studies particularly relevant. The book is applicable to the study of statistics, biostatistics, genetics and genetic epidemiology. In addition to providing derivations, the book uses real examples and simulations to illustrate step-by-step applications. Introductory chapters on probability and genetic epidemiology terminology provide the reader with necessary background knowledge. The organization of this work allows for both casual reference and close study.

Bioinformatics brings computational methods to the analysis and processing of genomic data. Bioinformatics: Databases and Systems focuses on the issues of system building and data curation that dominate the day-to-day concerns of bioinformatics practitioners. Included are chapters by many of today's leading bioinformatics practitioners, describing most of the current paradigms of system building and curation, including both their strengths and weaknesses. Biological topics covered include sequence databases, metabolic pathways, phenotypes, variety collections, gene expression atlases and neuroinformatics. Species range from bacteria to mammals to plants. Software systems and technologies covered include OPM, CORBA, SRS, KLEISLI, ACEDB, Web-based integration and laboratory workflow. Bioinformatics: Databases and Systems provides a valuable introduction for newcomers to the field, and a useful reference for veterans.

Provides examples, to laboratories and lab personnel, on how to report the results of forensic biology examinations given activity level propositions, along with example reports and standard operating procedures Presents worked case examples, based on real crimes, showing how the theory of activity level evaluation can be applied in practice Illustrates how the theory of activity level evaluation, explained specifically for forensic genetic cases, can likewise be applied to other forensic disciplines Explains concepts in simple terms, making it ideal for law or science students wishing to understand the fundamental of forensic evidence evaluation

This title offers 62 chapters divided among three volumes covering the latest topics dealing with Doubled Haploid (DH) technology, as well as methods to produce DHs in different species through different in vivo and in vitro approaches. Volume 1 explores general topics and transversal methods in DH technology; DH production in two alliaceae, onion, and leek; and DH production in cereals such as barley, durum, bread, oat, and japonica rice. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and comprehensive, Doubled Haploid Technology, Volume 1: General Topics, Alliaceae, Cereals is a valuable resource for scientists and researchers looking to learn more about this interesting and developing field.

Topology and Physics of Circular DNA presents comprehensive coverage of the physical properties of circular DNA. The author examines how topological constraints arising from cyclization of DNA lead to distinctive properties that make closed molecules radically different from linear DNA. The phenomenon of supercoiling, its geometric and topological analysis, and the formation of noncanonical structures in circular DNA under the influence of supercoiling are emphasized. The combination of consistent theoretical analysis and detailed treatment of major experimental approaches make Topology and Physics of Circular DNA an important reference volume for biophysicists, biochemists, molecular biologists, and researchers and students who want to expand their understanding of circular DNA.

Completely updated and rewritten, with 150 new figures Genomes from a wide variety of organisms included, from viruses to humans Techniques fully integrated into the text, including those investigating the genome, transcriptome, and proteome Coverage of expression, regulation, and evolution is on a genomic scale Short answer questions and in-depth problems at the end of each chapter Same structure as Genomes 3 but streamlined

Viruses do not behave as other microbes; their life cycles require infecting healthy cells, commandeering their cellular apparatus, replicating and then killing the host cell. Methods for virus detection and identification have been developed only in the past few decades. These recently developed methods include molecular, physical, and proteomic techniques. All these approaches (Electron Microscopy, Molecular, Direct Counting, and Mass Spectrometry Proteomics) to detection and identification are reviewed in this succinct volume. It is written in approachable language with enough detail for trained professionals to follow and want to recommend to others. Key Features Covers common detection methods Reviews the history of detection from antiquity to the present Documents the strengths and weaknesses of various detection methods Describes how to detect newly discovered viruses Recommends specific applications for clinical, hospital, environmental, and public health uses

Devised in the 1940s by the biologist C. H. Waddington, the epigenetic landscape is a metaphor for how gene regulation modulates cellular development. As a scientific model, it fell out of use in the late 1960s but returned at the beginning of the twenty-first century with the advent of big-data genomic research because of its utility among scientists across the life sciences to think more creatively about and to discuss genetics. In Epigenetic Landscapes Susan Merrill Squier follows the model's cultural trail, from its first visualization by the artist John Piper to its use beyond science. Squier examines three cases in which the metaphor has been imaginatively deployed to illustrate complex systems that link scientific and cultural practices: graphic medicine, landscape architecture, and bioArt. Challenging reductive understandings of epigenetics, Squier boldly reclaims the broader significance of the epigenetic landscape as a figure at the nexus of art, design, and science.

Human Reproduction-The Missing Parts of the Puzzle; B.P. Setchell. Genes, Chromosomes and Fertility: Human Y Chromosome Deletions in Yq11 and Male Fertility; P.H. Vogt. Frequency of Y-Chromosome Microdeletions; (Yq11.22-23) in Men with Reduced Sperm Quality Requesting Assisted Reproduction; A. Bonhoff, et al. Germ Cell Differentiation and Tumorigenesis: Endocrine Control of Germ Cell Proliferation in the Primate Testis: What Do We Really Know?; G.F. Weinbauer, E. Nieschlag. The Role of the Testicular Accessory Cells: Molecular Pathophysiology of the Pituitary-Gonadal Axis; M. Simoni, et al. Compartmentalization, Vascularization and Angiogenesis: Compartmentalization of the Intertubular Space in the Human Testis; A.F. Holstein, M. Davidoff. Post-Testicular Sperm Maturation: The Role of Apocrine Released Proteins in the Post-Testicular Regulation of Human Sperm Function; G. Aumuller, et al. Control of the Male and Female Tracts: Interactions Between Leukocytes and the Male Reproductive System: The Unanswered Question; A.G. Rossi, R.J. Aitken. Gamete Interaction and Fertilization: The Cell Biology of Fertilization; R.J. Aitken. 45 Additional Articles. Index.

Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses-including cancer and cardiovascular, metabolic, and neurodegenerative diseases-are explored in detail. This book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease.

In this volume, world leaders in potato research review historical and contemporary discoveries resulting in a range of advances. Topics include nutritional quality, yield, disease and insect resistance, processing, plant growth and development, and other aspects. The book also examines research yielding significant molecular resources that facilitate breeding, linkage and gene mapping, cytology, functional and structural genomics, proteomics, and metabolomics. Future research developments that are likely to significantly advance efforts to understand and improve the potato are also explored.

Albinism in Africa: Historical, Geographic, Medical, Genetic, and Psychosocial Aspects provides the first in-depth reference for understanding and treating patients of human albinism in Africa. Leading international contributors examine the historical, geographic, psychosocial, genetic and molecular considerations of importance in effectively and sensitively managing this genetic disorder. Foundational chapters covering the historical and psychosocial aspects of albinism are supplemented by discussions of the pathobiology of the disease, as well as a thorough analysis of the genetics of skin pigmentation, eye pigmentation, hair pigmentation, and incidents of skin cancer involved in the manifestations of this disorder. New prenatal diagnostics and genetic testing methods, genetic risk assessment for individuals, families, and communities, and novel genetic markers that may be used for developing new therapeutics for treating albinism are also discussed in detail. The book provides care management approaches that may be applied to instances of albinism in other regions, along with guiding principles for treating rare genetic disorders and stigmatized patient populations across the globe.

Cancer threatens the lives of people around the world. Women, in particular, are at risk of certain cancers with a genetic cause. Certain mutations in the BRCA1 and BRCA2 genes put mothers and daughters at risk of breast and ovarian cancers. Unlike many cancers that most commonly occur after age 60, these inheritable cancers threaten women's lives, health and fertility even when they are young, before most would even begin to go for annual mammogram screenings to check for breast cancer. Three Daughters, Three Journeys takes on the biggest health issue of our time from a global perspective with three heroines fighting for their lives against cancer. Marzena, a Polish oncology nurse, has spent her life treating child patients with cancer. Then, she confronts it in her own family and her own body. Kamola, a rural Indian girl, knows she has symptoms of the same disease that took her mother, but feels afraid to discuss it with her father and brothers, knowing her family cannot afford medical treatment. Kamola confides in Dr Rini Mishra, a doctor testing a new treatment called Neelazin, using a bacterial anticancer protein in food, to destroy cancer cells. Selena, a wealthy woman of color in Chicago, finds out about her genetic risks of breast and ovarian cancer. She has a choice of preventative surgery that will save her life but remove any chance of having children. As she meets women who struggle to afford cancer treatment, Selena dedicates her life to providing affordable homes and counseling to families affected by the disease. Although the drug Neelazin is fictional, the possibility of new cancer treatments using bacterial anticancer proteins is being researched now. A problem with the current chemotherapy for cancer treatment is the high toxicity of most of these drugs, as these drugs can enter both normal and cancer cells, though preferably cancer cells, causing the death of normal cells as well that are important in maintaining health. Another problem is that current chemotherapeutic drugs mostly target a single or few key steps that are important for cancer growth and proliferation and inhibit the growth of cancer cells. The cancer cells respond by quickly changing these single targets, thereby becoming resistant to the drugs, as is reflected in stage IV cancer patients. An alternative to chemotherapy would be to exploit the bacterial evolutionary wisdom and use certain proteins that can have preferential entry to cancer cells in order to minimize normal cell toxicity and multiple targets in cancer cells through protein-protein complex formation, thus reducing resistance development in cancer cells. An interesting advantage of protein drugs is to express them as part of food, and some recent research seems to suggest that oral consumption of such foods may allow the therapeutic protein to reach the blood stream to target the cancer. Women with the genetic risk factors could soon have the choice of taking a pill or such anticancer protein-expressing food to treat or prevent cancer, rather than removing the healthy tissue of the breasts and ovaries. Hopefully, they would not have to choose between fertility and survival, as is the implied message in this book, fictional as it is at this time.

Key Features of the book: Simple, direct, and lucid language. Comprehensive coverage of concepts for better understanding. Well labeled illustrations, flowcharts, and tables for enhanced learning. Every chapter is followed up with a detailed summary and questionnaire. Detailed Glossary at end of the book for users to know the right words. Chapters contributed/reviewed by experienced experts in this field.

Advances in Genetics, Volume 98 provides the latest information on the rapidly evolving field of genetics, presenting new medical breakthroughs that are occurring as a result of advances in our knowledge of the topic. The book continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, critically analyzing future directions. Topics of interest in this updated volume include the Genetics of Mitochondrial Disease, a Genetic analysis of depression, happiness and other normal personality traits, The Evolving Centromere and Kinetochore, and The Genetics of Parkinson's Disease.

Advances in Agronomy, Volume 146 is the latest in a series that continues to be recognized as a leading reference for the latest research in agronomy. Updated chapters in this new release include the Significance and Role of Si in Crop Production, National Comparison of the Total and Sequestered Organic Matter Contents of Conventional and Organic Farm Soils, Purine - N Metabolism in Drought or Salinity Challenged Food Security Crops, Plant Rooting and Cropping Systems Management to Improve N Use Efficiency, and The Important Role of Layered Double Hydroxides in Soil Chemical Processes and Remediation: What We Have Learned Over the Past 20 Years. Each volume in the evolving series contains an eclectic group of reviews by leading scientists throughout the world. As always, the subjects covered are rich, varied and exemplary of the abundant subject matter addressed by this long-running serial.

This book focuses on the previously neglected interface between the conservation of plant genetic resources and their utilization. Only through utilization can the potential value of conserved genetic resources be realized. However, as this book shows, much conserved germplasm has to be subjected to long-term pre-breeding and genetic enhancement before it can be used in plant breeding programs.The authors explore the rationale and approaches for such pre-breeding efforts as the basis for broadening the genetic bases of crop production. Examples from a range of major food crops are presented and issues analyzed by leading authorities from around the world.

This book presents the basic and applied aspects of sequencing of genes and genomes and their implication in the fine-scale elucidation of the plant genomes. The third volume presents an overview on the advances of plant genomics made in the past century; deliberations on the genomics resources; concepts, tools, strategies, and achievements of comparative, evolutionary, and functional genomics and whole-genome sequencing. It also presents critical reviews on the already completed genome initiatives and glimpses on the currently progressing genome initiatives. This volume is an ideal reference book for students, scholars and scientists in academia, industry, and government.

Advances in Genetics, Volume 97 provides the latest information on the rapidly evolving field of genetics, presenting new medical breakthroughs that are occurring as a result of advances in our knowledge of the topic. New chapters in this recent release include Plant photomorphogenesis, TBC, and Exosome/EV Biomolecule Delivery "transfer". Users will find a series that continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, critically analyzing future directions.

Fungal Phylogenetics and Phylogenomics, Volume 100, the latest release in the Advances in Genetics series, presents users with new chapters that delve into such topics as the Advances of fungal phylogenomics and the impact on fungal systematics, Data crunching for fungal phylogenomics: insights into data collection and phylogenetic inference based on genome data for fungi, Genomic and epigenomic traits of emerging fungal pathogens, Advances in fungal gene cluster diversity and evolution, Phylogenomics of Fusarium oxysporum species complex, Phylogenomic analyses of pathogenic yeasts, and the Phylogenetics and phylogenomics of rust fungi. The series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, critically analyzing future directions.