BIOS Instant Notes in Genetics, Fourth Edition, is the perfect text for undergraduates looking for a concise introduction to the subject, or a study guide to use before examinations. Each topic begins with a summary of essential facts, 'an ideal revision checklist', followed by a description of the subject that focuses on core information, with clear, simple diagrams that are easy for students to understand and recall in essays and exams.

Transcription Factors for Abiotic Stress Tolerance in Plants highlights advances in the understanding of the regulatory network that impacts plant health and production, providing important insights for improving plant resistance. Plant production worldwide is suffering serious losses due to widespread abiotic stresses increasing as a result of global climate change. Frequently more than one abiotic stress can occur at once, for example extreme temperature and osmotic stress, which increases the complexity of these environmental stresses. Modern genetic engineering technologies are one of the promising tools for development of plants with efficient yields and resilience to abiotic stresses. Hence deciphering the molecular mechanisms and identifying the abiotic stress associated genes that control plant response to abiotic stresses is a vital requirement in developing plants with increased abiotic stress resilience. Addressing the various complexities of transcriptional regulation, this book includes chapters on cross talk and central regulation, regulatory networks, the role of DOF, WRKY and NAC transcription factors, zinc finger proteins, CRISPR/CAS9-based genome editing, C-Repeat (CRT) binding factors (CBFs)/Dehydration responsive element binding factors (DREBs) and factors impacting salt, cold and phosphorous stress levels, as well as transcriptional modulation of genes involved in nanomaterial-plant interactions. Transcription Factors for Abiotic Stress Tolerance in Plants provides a useful reference by unravelling the transcriptional regulatory networks in plants. Researchers and advanced students will find this book a valuable reference for understanding this vital area.

"The Handbook of Behavioral Genetics and Phenotyping" represents an integrative approach to neurobehavioural genetics; worldwide experts in their field will review all chapters. Advanced overviews of neurobehavioural characteristics will add immense value to the investigation of animal mutants and provide unique information about the genetics and behavioural understanding of animal models, under both normal and pathological conditions. Cross-species comparisons of neurobehavioural phenotypes will pave the way for an evolutionary understanding of behaviour.

Moreover, while biological sciences are progressing towards a holistic approach to investigate the complexity of organisms (i.e., "systems biology" approach), an integrated analysis of behavioural phenotyping is still lacking. "The" "Handbook of Behavioral Genetics and Phenotyping" strengthens the cross-talk within disciplines that investigate the fundamental basis of behaviour and genetics. This will be the first volume in which traditionally distant fields including genomics, behaviour, electrophysiology, neuroeconomics, and computational neuroscience, among others, are evaluated together and simultaneously accounted for during discussions of future perspectives.

This book reviews the state-of-the-art in stem-cell-based therapies for neurodegenerative diseases, and highlights advances in both animal models and clinical trials. It comprehensively discusses most neurodegenerative diseases, including such as Parkinson's, Alzheimer's and Huntington's diseases, amyotrophic sclerosis, multiple sclerosis, muscular dystrophy and retinal degeneration, in which stem cells could potentially be used for therapy in the future. It also addresses the challenges and problems relating to the translation of stem-cell-based therapies into treatments. As such, the book will appeal to research scientists, physicians, graduate students, and medical professionals in the field of stem cells, neuroscience, neurology, neurorestoratology and major neurological disorders.

This book constitutes the refereed proceedings of the 19th Annual RECOMB Satellite Workshop on Comparative Genomics, RECOMB-CG which took place in La Jolla, USA, during May 20-21, 2022. The 18 full papers included in this book were carefully reviewed and selected from 28 submissions. The papers were organized in topical sections on evolution; phylogenetics; homology and reconciliation; genome rearrangements; metagenomics; and genomic sequencing.

The second edition of Instant Notes in Bioinformatics introduced the readers to the themes and terminology of bioinformatics. It is divided into three parts: the first being an introduction to bioinformatics in biology; the second covering the physical, mathematical, statistical and computational basis of bioinformatics, using biological examples wherever possible; the third describing applications, giving specific detail and including data standards. The applications covered are sequence analysis and annotation, transcriptomics, proteomics, metabolite study, supramolecular organization, systems biology and the integration of-omic data, physiology, image analysis, and text analysis.

Interpreting Complex Forensic DNA Evidence is a handy guide to recent advances-and emerging issues-in interpreting complex DNA evidence and profiles for use in criminal investigations. In certain cases, DNA cannot be connected to a specific biological material such as blood, semen or saliva. How or when the DNA was deposited may be an issue. The possibility of generating DNA profiles from touched objects, where there may not be a visible deposit, has expanded the scope and number of exhibits submitted for DNA analysis. With such advances, and increasing improvements in technological capabilities in testing samples, this means it is possible to detect ever smaller amounts of DNA. There are also many efforts underway to seek was to interpret DNA profiles that are sub-optimal-either relative to the amount required by the testing kit and, potentially, the quality of the obtained sample. Laboratories often use enhancements in order to obtain a readable DNA profile. The broad-reaching implications of improving DNA sensitivity have led to this next, emerging generation of more complex profiles. Examples partial profiles that do not faithfully reflect the proposed donor, or mixtures of partial DNA from multiple people. A complexity threshold has been proposed to limit interpretation of poor-quality data. Research is now addressing the interpretation of transfer of trace amounts of DNA. Complex issues are arising in trial that need to be reconciled as such complexity has added challenges to the interpretation of evidence and its introduction or dismissal in certain cases in the courts. Key Features: Addresses DNA transfer, from person-to-person as well as to objects Outlines each stage required to produce a DNA profile from an exhibit-including collection, handling, storage, and analysis Discusses ethics, subjectivity, and bias-including cognitive dissonance-as they relate specifically to complex DNA evidence Highlights current techniques and the latest advances in DNA analysis, including advances in familial DNA searches Interpreting Complex Forensic DNA Evidence provides tools to assist the criminal investigator, forensic expert, and legal professional when posed with a DNA result in a forensic report or testimony. The result-and any associated statistic-may not reveal any ambiguity, complexity, or the assumptions involved in deriving it. Questions from resolved criminal cases are posed, and the relevant forensic literature, provided for the reader to assess a DNA result and any associated statistic. Case studies throughout illustrate concepts and emphasize the need for conclusions in the forensic report that are supported by the data.

This open access book describes recent innovations in food systems based on root, tuber and banana crops in developing countries. These innovations respond to many of the challenges facing these vital crops, linked to their vegetative seed and bulky and perishable produce. The innovations create value, food, jobs and new sources of income while improving the wellbeing and quality of life of their users. Women are often key players in the production, processing and marketing of roots, tubers and bananas, so successful innovation needs to consider gender. These crops and their value chains have long been neglected by research and development, hence this book contributes to filling in the gap. The book features many outcomes of the CGIAR Research Program in Roots, Tubers and Banana (RTB), which operated from 2012-21, encompassing many tropical countries, academic and industry partners, multiple crops, and major initiatives. It describes the successful innovation model developed by RTB that brings together diverse partners and organizations, to create value for the end users and to generate positive economic and social outcomes. RTB has accelerated the scaling of innovations to reach many end users cost effectively. Though most of the book's examples and insights are from Africa, they can be applied worldwide. The book will be useful for decision makers designing policies to scale up agricultural solutions, for researchers and extension specialists seeking practical ideas, and for scholars of innovation.

"Introducing Proteomics" gives a concise and coherent overview of every aspect of current proteomics technology, which is a rapidly developing field that is having a major impact within the life and medical sciences.

This student-friendly book, based on a successful course developed by the author, provides its readers with sufficient theoretical background to be able to plan, prepare, and analyze a proteomics study.

The text covers the following: Separation TechnologiesAnalysis of Peptides/Proteins by Mass SpectrometryStrategies in Proteomics

This contemporary text also includes numerous examples and explanations for why particular strategies are better than others for certain applications. In addition, "Introducing Proteomics" includes extensive references and a list of relevant proteomics information sources; essential for any student.

This no-nonsense approach to the subject tells students exactly what they need to know, leaving out unnecessary information. The student companion site enhances learning and provides answers to the end of chapter problems.

"I think this book will be a popular and valuable resource for students and newcomers to the field who would like to have an overview and initial understanding of what proteomics is about. The contents are well organized and address the major issues."
--Professor Walter Kolch, Director, Systems Biology Ireland & Conway Institute, University College Dublin

Companion Website
www.wiley.com/go/lovric

An introduction to machine learning methods and their applications to problems in bioinformatics Machine learning techniques are increasingly being used to address problems in computational biology and bioinformatics. Novel computational techniques to analyze high throughput data in the form of sequences, gene and protein expressions, pathways, and images are becoming vital for understanding diseases and future drug discovery. Machine learning techniques such as Markov models, support vector machines, neural networks, and graphical models have been successful in analyzing life science data because of their capabilities in handling randomness and uncertainty of data noise and in generalization. From an internationally recognized panel of prominent researchers in the field, Machine Learning in Bioinformatics compiles recent approaches in machine learning methods and their applications in addressing contemporary problems in bioinformatics. Coverage includes: feature selection for genomic and proteomic data mining; comparing variable selection methods in gene selection and classification of microarray data; fuzzy gene mining; sequence-based prediction of residue-level properties in proteins; probabilistic methods for long-range features in biosequences; and much more. Machine Learning in Bioinformatics is an indispensable resource for computer scientists, engineers, biologists, mathematicians, researchers, clinicians, physicians, and medical informaticists. It is also a valuable reference text for computer science, engineering, and biology courses at the upper undergraduate and graduate levels.

RNAi technology are used for large-scale screens that systematically shut down each gene in the cell, which can help identify the components necessary for a particular cellular process or an event such as cell division. Exploitation of the pathway is also a promising tool in biotechnology and medicine. This book reviews the selective and robust effect of RNAi on gene expression which makes it a valuable research tool, both in cell culture and in living organisms because synthetic dsRNA introduced into cells can induce suppression of specific genes of interest. This book will introduce new technology in the study of RNA interference in microorganisms, plants and animals.

Data from molecular genetics have changed our views on the origin, spread and timescale of our species across this planet. But how can we reveal more detail about the demography of ancient human populations? For example, is it possible to determine when and how many people arrived at a certain continent, and which route they took from a choice of geographically plausible options? One of the most promising tools for such investigation is computer simulation incorporating various demographic scenarios. The simulation outcomes must be evaluated by teams with archaeological expertise, since archaeological evidence is generally the best evidence currently available on the population histories of geographical regions. This book is a summary of the landmark conference held in Cambridge in 2005, where specialists in simulations and molecular genetics as well as archaeologists came together to present and evaluate the state of the art, and to discuss future possibilities.

DNA testing and its forensic analysis are recognized as the "gold standard" in forensic identification science methods. However, there is a great need for a hands-on step-by-step guide to teach the forensic DNA community how to interpret DNA mixtures, how to assign a likelihood ratio, and how to use the subsequent likelihood ratio when reporting interpretation conclusions. Forensic DNA Profiling: A Practical Guide to Assigning Likelihood Ratios will provide a roadmap for labs all over the world and the next generation of analysts who need this foundational understanding. The techniques used in forensic DNA analysis are based upon the accepted principles of molecular biology. The interpretation of a good-quality DNA profile generated from a crime scene stain from a single-source donor provides an unambiguous result when using the most modern forensic DNA methods. Unfortunately, many crime scene profiles are not single source. They are described as mixed since they contain DNA from two or more individuals. Interpretation of DNA mixtures represents one of the greatest challenges to the forensic DNA analyst. As such, the book introduces terms used to describe DNA profiles and profile interpretation. Chapters explain DNA extraction methods, the polymerase chain reaction (PCR), capillary electrophoresis (CE), likelihood ratios (LRs) and their interpretation, and population genetic models-including Mendelian inheritance and Hardy-Weinberg equilibrium. It is important that analysts understand how LRs are generated in a probabilistic framework, ideally with an appreciation of both semicontinuous and fully continuous probabilistic approaches. KEY FEATURES: * The first book to focus entirely on DNA mixtures and the complexities involved with interpreting the results * Takes a hands-on approach offering theory with worked examples and exercises to be easily understood and implementable by laboratory personnel * New methods, heretofore unpublished previously, provide a means to innovate deconvoluting a mixed DNA profile, assign an LR, and appropriately report the weight of evidence * Includes a chapter on assigning LRs for close relatives (i.e., "It's not me, it was my brother"), and discusses strategies for the validation of probabilistic genotyping software Forensic DNA Profiling fills the void for labs unfamiliar with LRs, and moving to probabilistic solutions, and for labs already familiar with LRs, but wishing to understand how they are calculated in more detail. The book will be a welcome read for lab professionals and technicians, students, and legal professionals seeking to understand and apply the techniques covered.

"Once again, Gerald Weissmann, with a firm and easy knowledge of everyone who matters from Auden to Zola, bridges the space between science and the humanities, and particularly between medicine and the muses, with wit, erudition, and, most important, wisdom." --Adam Gopnik, author of Angels and Ages Admired by Nobel prize--winning scientists and literary tastemakers alike, Weissmann will continue to amaze and beguile new and faithful readers as both a masterful commentator on contemporary culture and a transcendent intellectual historian. By turns satirical and insightful, Mortal and Immortal DNA takes us on a nuanced exploration of the western canon, from Greek mythology through Dante to W.H. Auden and offers hilarious insights into popular culture along the way, from Paris Hilton to the true life story of Kathryn Lee Bates, the lesbian poet who penned "America the Beautiful." Gerald Weissmann is a physician, scientist, editor, and essayist whose collections include Epigenetics in the Age of Twitter: Pop Culture and Modern Science; Mortal and Immortal DNA: Science and the Lure of Myth; and Galileo's Gout: Science in an Age of Endarkenment. He is professor emeritus and research professor of medicine at New York University School of Medicine. His essays and reviews have appeared in numerous publications worldwide, including the London Review of Books and New York Times Book Review. The former editor-in-chief of the FASEB Journal, he is now its book reviews editor. He lives in Manhattan and Woods Hole, Massachusetts.

This volume explores the latest methods used by researchers to study the detection, characterization, and various aspects of viroids. The chapters in this book are organized into seven parts and cover topics such as detection methods based on the biology of viroids; detection techniques based on electrophoresis and hybridization techniques; PCR-based techniques that provide high degrees of sensitivity; emerging area of nucleic acid sequence-based technology; and emerging techniques in viroid research such as RNA silencing, splicing, and viroid structure. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Viroids: Methods and Protocols is a valuable resource for researchers and graduate students who are working with viroid diseases.

This concise introduction offers students and researchers an overview of the discipline that connects genetics and evolution. Addressing the theories behind population genetics and relevant empirical evidence, John Gillespie discusses genetic drift, natural selection, nonrandom mating, quantitative genetics, and the evolutionary advantage of sex. First published to wide acclaim in 1998, this brilliant primer has been updated to include new sections on molecular evolution, genetic drift, genetic load, the stationary distribution, and two-locus dynamics. This book is indispensable for students working in a laboratory setting or studying free-ranging populations.

Ice is melting around the world and glaciers are disappearing. Water, which has been solid for thousands and even millions of years, is being released into streams, rivers, lakes and oceans. Embedded in this new fluid water, and now being released, are ancient microbes whose effects on today's organisms and ecosystems is unknown and unpredictable. These long sleeping microbes are becoming physiologically active and may accelerate global climate change. This book explores the emergence of these microbes. The implications for terrestrial life and the life that might exist elsewhere in the universe are explored. Key Selling Points: Explores the role of long frozen ancient microbes will have when released due to global warming Describes how ice preserves microbes and microbial genomes for thousands or millions of years Reviews work done on permafrost microbiology Identifies potential health hazards and environmental risks Examines implications for the search for extraterrestrial life.

This open access book offers a comprehensive overview of the history of genomics across three different species and four decades, from the 1980s to the recent past. It takes an inclusive approach in order to capture not only the international initiatives to map and sequence the genomes of various organisms, but also the work of smaller-scale institutions engaged in the mapping and sequencing of yeast, human and pig DNA. In doing so, the authors expand the historiographical lens of genomics from a focus on large-scale projects to other forms of organisation. They show how practices such as genome mapping, sequence assembly and annotation are as essential as DNA sequencing in the history of genomics, and argue that existing depictions of genomics are too closely associated with the Human Genome Project. Exploring the use of genomic tools by biochemists, cell biologists, and medical and agriculturally-oriented geneticists, this book portrays the history of genomics as inseparably entangled with the day-to-day practices and objectives of these communities. The authors also uncover often forgotten actors such as the European Commission, a crucial funder and forger of collaborative networks undertaking genomic projects. In examining historical trajectories across species, communities and projects, the book provides new insights on genomics, its dramatic expansion during the late twentieth-century and its developments in the twenty-first century. Offering the first extensive critical examination of the nature and historicity of reference genomes, this book demonstrates how their affordances and limitations are shaped by the involvement or absence of particular communities in their production.

"A Companion to Genethics" is the first substantial study of the multifaceted dimensions of the genetic revolution and its philosophical, ethical, social and political significance.
Brings together the best and most influential writing about the ethics of genetics;
Includes 33 newly-commissioned essays, all written by prominent figures in the field;
Shows how there is scarcely a part of our lives left unaffected by the impact of the new genetics.

A geneticist tells the stories of men, women, and children whose genes have shaped their lives in unexpected ways.

It was while listening to a colleague tell the parents of a newborn girl that their daughter was going to die that a lifelong interest in genetic medicine was sparked in Dr Edwin Kirk. Warmth and gentleness tempered a direct, sure manner - this was the medicine he wanted to practise, where the most advanced science and the most deeply human meet. Twenty-five years later, Dr Kirk works both with patients and in the lab, and he spearheads a campaign that will change the way we think about having babies. His experience is without parallel, but it is his humour and insight that make all the difference.

Find out why Dr Kirk found himself among hundreds of people, each with a glass of poison in front of them - and how you might perform the same experiment yourself (without the poison). Learn how the realisation that a young boy wasn't short ended up saving the life of his mother - and how Angelina Jolie has saved the lives of many more. Sit in the room with Dr Kirk and his patients as they navigate the world of heartbreaking uncertainties, tantalising possibilities, and thorny questions of morality. In genetics, it is the particularities of an individual's history that matter, and here, in clear and considerate writing, those individual stories are given voice.

Potato is a crop grown on all inhabited continents of the globe. It is included in the top five crops of the world, used as staple food in several countries, and the number of people daily consuming the potato may surpass one billion. Despite the high quantities of seed potato produced worldwide, there are yield gaps due to challenges such as abiotic stresses, pests, climate change and poor production practices. A region-wide critical analysis of yield declining factors can help formulate management strategies that can improve potato yields. Bridging yield gaps in potato will ultimately ensure the role of this crop in securing current and future food security. Potato Production Worldwide presents information on this global crop from its history, morphology, and taxonomy to the growth and development of the potato crop, including the latest strategies in addressing today's biotic and abiotic challenges. This book identifies the reasons for yield gaps in various potato production regions of the world, as well as presenting the best production practices, pest management strategies and approaches to deal with climate change from the perspective of potato production. Chapters provide important insights into potato production cultures and approaches in the major potato production countries. Potato Production Worldwide will be a valuable resource for researchers, scientists and students seeking a comprehensive view of successful potato production.

Race, while drawn from the visual cues of human diversity, is an idea with a measurable past, an identifiable present, and an uncertain future. The concept of race has been at the center of both triumphs and tragedies in American history and has had a profound effect on the human experience. "Race Unmasked" revisits the origins of commonly held beliefs about the scientific nature of racial differences, examines the roots of the modern idea of race, and explains why race continues to generate controversy as a tool of classification even in our genomic age.

Through rigorous historical research, "Race Unmasked" reveals how genetics and related biological disciplines formed and preserved ideas of race and, at times, racism throughout the twentieth century. Surveying the work of some of the twentieth century's most notable scientists, the book tests and then proves the limitations of a racial worldview. This new work is a gripping history of science and scientists that throws the contours of our current and evolving understanding of human diversity into sharp relief.

A look at the extraordinary ways the brain turns thoughts into actions-and how this shapes our everyday lives Why is it hard to text and drive at the same time? How do you resist eating that extra piece of cake? Why does staring at a tax form feel mentally exhausting? Why can your child expertly fix the computer and yet still forget to put on a coat? From making a cup of coffee to buying a house to changing the world around them, humans are uniquely able to execute necessary actions. How do we do it? Or in other words, how do our brains get things done? In On Task, cognitive neuroscientist David Badre presents the first authoritative introduction to the neuroscience of cognitive control-the remarkable ways that our brains devise sophisticated actions to achieve our goals. We barely notice this routine part of our lives. Yet, cognitive control, also known as executive function, is an astonishing phenomenon that has a profound impact on our well-being. Drawing on cutting-edge research, vivid clinical case studies, and examples from daily life, Badre sheds light on the evolution and inner workings of cognitive control. He examines issues from multitasking and willpower to habitual errors and bad decision making, as well as what happens as our brains develop in childhood and change as we age-and what happens when cognitive control breaks down. Ultimately, Badre shows that cognitive control affects just about everything we do. A revelatory look at how billions of neurons collectively translate abstract ideas into concrete plans, On Task offers an eye-opening investigation into the brain's critical role in human behavior.