This volume presents a scholarly analysis of psychopathic and sociopathic personalities and the conditions that give rise to them. In so doing, it offers a coherent theoretical and developmental analysis of socialization and its vicissitudes, and of the role played in socialization by the crime-relevant genetic traits of the child and the skills and limitations of the primary socializing agents, the parents.
This volume also describes how American psychiatry's (DSM-IV) category of "Antisocial Personality Disorder" is heterogeneous and fails to document some of the more interesting and notorious psychopaths of our era. The author also shows why the antinomic formula "Nature "vs." Nurture" should be revised to "Nature "via" Nurture" and reviews the evidence for the heritability of crime-relevant traits. One of these traits -- fearlessness -- seems to be one basis for the primary psychopathy and the author argues that the primary psychopath and the hero may be twigs on the same genetic branch.
But crime -- the failure of socialization -- is rare among traditional peoples still living in the extended-family environment in which our common ancestors lived and to which our species is evolutionarily adapted. The author demonstrates that the sharp rise in crime and violence in the United States since the 1960s can be attributed to the coeval increase in divorce and illegitimacy which has left millions of fatherless children to be reared by over-burdened, often immature or sociopathic single mothers. The genus "sociopathic personality" includes those persons whose failure of socialization can be attributed largely to incompetent or indifferent rearing.
Two generalizations supported by modern behavior genetic research are that most psychological traits have strong genetic roots "and" show little lasting influence of the rearing environment. This book demonstrates that the important trait of socialization is an exception. Although traits that obstruct or facilitate socialization tend to obey these rules, socialization itself is only weakly heritable; this is because modern American society displays such enormous variance in the relevant environmental factors, mainly in parental competence. Moreover, parental incompetence that produces sociopathy in one child is likely to have the same result with any siblings. This book argues that sociopathy contributes far more to crime and violence than psychopathy because sociopaths are much more numerous and because sociopathy is a familial trait for both genetic and environmental reasons. With a provocative thesis and an engaging style, this book will be of principal interest to clinical, personality, forensic, and developmental psychologists and their students, as well as to psychiatrists and criminologists.

This volume presents a scholarly analysis of psychopathic and sociopathic personalities and the conditions that give rise to them. In so doing, it offers a coherent theoretical and developmental analysis of socialization and its vicissitudes, and of the role played in socialization by the crime-relevant genetic traits of the child and the skills and limitations of the primary socializing agents, the parents.
This volume also describes how American psychiatry's (DSM-IV) category of "Antisocial Personality Disorder" is heterogeneous and fails to document some of the more interesting and notorious psychopaths of our era. The author also shows why the antinomic formula "Nature "vs." Nurture" should be revised to "Nature "via" Nurture" and reviews the evidence for the heritability of crime-relevant traits. One of these traits -- fearlessness -- seems to be one basis for the primary psychopathy and the author argues that the primary psychopath and the hero may be twigs on the same genetic branch.
But crime -- the failure of socialization -- is rare among traditional peoples still living in the extended-family environment in which our common ancestors lived and to which our species is evolutionarily adapted. The author demonstrates that the sharp rise in crime and violence in the United States since the 1960s can be attributed to the coeval increase in divorce and illegitimacy which has left millions of fatherless children to be reared by over-burdened, often immature or sociopathic single mothers. The genus "sociopathic personality" includes those persons whose failure of socialization can be attributed largely to incompetent or indifferent rearing.
Two generalizations supported by modern behavior genetic research are that most psychological traits have strong genetic roots "and" show little lasting influence of the rearing environment. This book demonstrates that the important trait of socialization is an exception. Although traits that obstruct or facilitate socialization tend to obey these rules, socialization itself is only weakly heritable; this is because modern American society displays such enormous variance in the relevant environmental factors, mainly in parental competence. Moreover, parental incompetence that produces sociopathy in one child is likely to have the same result with any siblings. This book argues that sociopathy contributes far more to crime and violence than psychopathy because sociopaths are much more numerous and because sociopathy is a familial trait for both genetic and environmental reasons. With a provocative thesis and an engaging style, this book will be of principal interest to clinical, personality, forensic, and developmental psychologists and their students, as well as to psychiatrists and criminologists.

Analyzes Randomness in Major Genetic Processes and Events No matter how far science advances, the proportion of what is knowable to what is random will remain unchanged, and attempts to ignore this critical threshold are futile at best. With the revolutionary explosion in genetic information discovery, it is crucially important to recognize the underlying limitations of scientific prediction in genetics. Genetics and Randomness furthers the understanding of the role randomness plays in critical biological processes. The book also navigates the complex nature of genetic uncertainty from different points of view and at various levels of biological organization. Avoids Unnecessary Technical Details and Specific Terminology Exploring areas ranging from basic quantum mechanics and molecular genetics to modern evolutionary genetics and the philosophy of mathematics, this well-organized text discusses: Spontaneity of mutations and their relation to subatomic randomness Deep links between subatomic fluctuations and long-term macroscopic changes in living organisms The multitude of random events that occur during development Segregation, genetic drift, and natural selection Randomness and uncertainty are not occasional and regretful deviations from the "true" principles upon which life is built. Genetics and Randomness illustrates the ubiquitous nature of randomness as an integral feature of all essential processes, effectively embracing a probabilistic understanding of the phenomena of life.

Access to genetic resources and Benefit Sharing (ABS) has been promoted under the Convention on Biological Diversity, with the aim of combining biodiversity conservation goals with economic development. However, as this book shows, since its inception in 1992, implementation has encountered multiple challenges and obstacles. This is particularly so in the marine environment, where interest in genetic resources for pharmaceuticals and nutrients has increased. This is partly because of the lack of clarity of terminology, but also because of the terms of the comprehensive law of the sea (UNCLOS) and transboundary issues of delineating ownership of marine resources. The author explains and compares relevant provisions and concepts under ABS and the law of the sea taking access, benefit sharing, monitoring, compliance, and dispute settlement into consideration. He also provides an overview of the implementation status of ABS-relevant measures in user states and identifies successful ABS transactions. A key unique feature of the book is to illustrate how biological databases can serve as the central scientific infrastructure to implement the global multilateral benefit sharing mechanism, proposed by the Nagoya Protocol. The research for this book was supported by both the Bremen International Graduate School for Marine Sciences (GLOMAR) and the International Research Training Group INTERCOAST - Integrated Coastal Zone and Shelf-Sea Research.

The maintenance of telomeres-repetitive sequences at the end of chromosome-is essential to health. Dysfunction in telomere maintenance pathways plays a role in aging, cancer, atherosclerosis and other diseases. This has led to telomere maintenance as a prime target for patient therapies. This book describes the advances in telomere research as it applies to human health and especially how lifestyle and dietary factors could modify the telomerase maintenance process. The book examines the mechanisms involved, the primary of which are oxidative stress and the role of sirtuins, and how they can be modified by dietary patterns such as Mediterranean diet.

This volume attempts to show molecular modeling as a new multidisciplinary area of research that transcends the boundaries traditionally separating biology, chemistry and physics. To this purpose, leading scientists present applications of molecular modeling to a variety of important problems such as: drug design, protein modeling, catalyst modeling, properties of glass, mechanical properties of materials and materials design. The emphasis here is on the atomistic approach.

This book provides a comprehensive compilation of the evidence available regarding the role of genetic differences in the etiology of human obesities and their health and metabolic implications. It also identifies the most promising research areas, methods, and strategies for use in future efforts to understand the genetic basis of obesities and their consequences on human health. Leading researchers in their respective fields present contributed chapters on such topics as etiology and the prevalence of obesities, nongenetic determinants of obesity and fat topography, and animal models and molecular biological technology used to delineate the genetic basis of human obesities. A major portion of the book is devoted to human genetic research and clinical observations encompassing adoption studies, twin studies, family studies, single gene effects, temporal trends and etiology heterogeneity, energy intake and food preference, energy expenditure, and susceptibility to metabolic derangements in the obese state. Future directions of research in the field are covered in the book as well.

Using Forensic DNA Evidence at Trial: A Case Study Approach covers the most common DNA analysis methods used in criminal trials today, including STR techniques, mitochondrial DNA, and Y-STRs. It presents some novel techniques including familial testing and analyzing domestic animal hair that have been recently introduced in unique cases, each of which is outlined in detail. It also illustrates special issues related to forensic DNA evidence by using court proceedings such as trials and appeals, commissions of inquiry, and government and laboratory reviews. With forensic DNA analysis becoming increasingly important at trial, the lively and sometimes bizarre cases presented in this book have been carefully chosen to highlight specific concepts, methods, and interpretations used in DNA analysis. Sections throughout examine the nature of expertise with a special focus on the role of subjectivity in the interpretation of forensic DNA evidence, emphasizing cognitive bias and extraneous context. Using both convictions and exonerations as examples, the book also discusses the strengths and limitations of DNA evidence and testing. The book is written in an accessible manner for the non-scientific reader, such that criminal lawyers, judges, and forensic experts will all understand the nature of analysis and application of DNA evidence in a variety of court cases. Extensive references including notable trial proceedings, cross references of cases, and specific forensic statistics round out the book and help to provide a complete understanding of forensic DNA analysis and its current usage in the courtroom.

From DNA sequences stored on computer databases to archived forensic samples and biomedical records, bioinformation comes in many forms. Its unique provenance the fact that it is 'mined' from the very fabric of the human body makes it a mercurial resource; one that no one seemingly owns, but in which many have deeply vested interests. Who has the right to exploit and benefit from bioinformation? The individual or community from whom it was derived? The scientists and technicians who make its extraction both possible and meaningful or the commercial and political interests which fund this work? Who is excluded or even at risk from its commercialisation? And what threats and opportunities might the generation of 'Big Bioinformational Data' raise? In this groundbreaking book, authors Bronwyn Parry and Beth Greenhough explore the complex economic, social and political questions arising from the creation and use of bioinformation. Drawing on a range of highly topical cases, including the commercialization of human sequence data; the forensic use of retained bioinformation; biobanking and genealogical research, they show how demand for this resource has grown significantly driving a burgeoning but often highly controversial global economy in bioinformation. But, they argue, change is afoot as new models emerge that challenge the ethos of privatisation by creating instead a dynamic open source 'bioinformational commons' available for all future generations.

Serves as a comprehensive review to the substantial impact of gene amplification in molecular biology, genetic engineering and medical science. The book covers the mechanism of gene amplification, organization and structure of amplified genes.

Learn how your DNA can empower you to make life choices that lead to a happier, healthier life The personalized medicine wave is here. In this book, biotechnology entrepreneur and CEO of The DNA Company Kashif Khan offers an action plan to help you live your best life. It starts by understanding your genetic makeup. The DNA Way is a preventative guide to various health issues and their link to an individual’s DNA. In it, readers will discover what the DNA Company experts have learned about chronic illness and genetic predispositions, based on years of in-depth genetic analysis of the DNA results of more than 7,000 people. Topics that will be addressed include mood and behavior, energy, diet and nutrition, weight management, sleep, and more. The book will delve into Kashif’s personal journey of overcoming his own genetic legacy and health challenges—using his own DNA results as a case study—and in navigating that journey, how he came to develop a company whose aim is to elevate humanity. It also outlines recommendations—including what foods to eat, how to exercise, and where and how to work—that have helped him prevent or reverse illness, slow down the aging process, and optimize his performance. Learn how to access your human instruction manual—the DNA way.

What should individuals and society do when genetic screening becomes widely available and with its impact on current and future generations still uncertain? How can our education systems around the world respond to these developments? Reproductive and genetic technologies (RGTs) are increasingly controversial and political. We are entering an era where we can design future humans, firstly, by genetic screening of "undesirable" traits or indeed embryos, but perhaps later by more radical genetic engineering. This has a profound effect on what we see as normal, acceptable and responsible. This book argues that these urgent and biopolitical issues should be central to how biology is taught as a subject. Debate about life itself has always been at the forefront of connected molecular, genetic and social/personal identity levels, and each of these levels requires processes of communication and debate, what Anthony Giddens called in passing life politics. In this book Padraig Murphy opens the term up, with examples from field research in schools, student responses to educational films exploring the future of RGTs, and science studies of strategic biotechnology and the lab practices of genetic screening. Life political debate is thoroughly examined and is identified as a way of connecting mainstream education of biology with future generations. Biotechnology, Education and Life Politics will appeal to post-graduates and academics involved with science education, science communication, communication studies and the sociology of education.

The economic importance of Tortricidae in agriculture and forestry is great: crops and forests in the temperate climatic zones suffer considerable loss due to this lepidopterous family. This volume covers the entire spectrum from taxonomy, morphology and physiology to chemical and biological control. It will provide an opening to the scientifc literature on Tortricidae for scientists in research institutions, universities and experimental stations. The indices include entries for synonyms referring to the species names used in this volume.

This second edition provides new and updated chapters from expert researchers in the field detailing methods used to study the multi-facet deep sequencing data field. Chapters guide readers through techniques for processing RNA-seq data, microbiome analysis, deep learning methodologies, and various approaches for the identification of sequence variants. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Deep Sequencing Data Analysis: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field.

This volume strives to present current technical approaches to most aspects of post-transcriptional control and provide the reader with a useful and versatile laboratory bench resource. With chapters split into sections covering bioinformatics, fundamental aspects of the study of RNA biology, and techniques for specific aspects of RNA biology, the expert authors have filled the book with invaluable tricks of the trade, perfected in their laboratories.

This volume details generation of gene-edited cell lines and organisms as models for human diseases, pest control, and large animal welfare and production outcomes. Chapters guide readers through gene regulation, editing, screening of cell lines, genome editing, and an overview of the tools for efficient genome editing including; ZFNs, TALENs, and CRISPR. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step- by-step, readily reproducible protocols. Authoritative and cutting-edge, Applications of Genome Modulation and Editing aims to be a useful and practical guide for researchers to commence or advance their study in this field.

This book discusses the nature of meiotic chromosome pairing effects which may play a role in the determination of fertility. In particular, data and illustrations from the application of recently developed electron microscopic spreading techniques will allow researchers in related fields to come to grips with the recent advances in the cytogenetics of meiotic chromosome pairing behavior. Topics dealt with include meiotic and synaptonemal complex behavior in humans and mice with a variety of chromosomal and genetic abnormalities, sex chromosome pairing in mammals and birds, the significance for fertility or pairing in mammals and birds, the significance for fertility of XY pairing and crossing over, the effects of hybridity on pairing and fertility in plants, and the genetic control of synaptonemal complex formation and crossing over in polyploids. This is a timely reference book for graduate level medical and veterinary students, and scientists in the field of genetics and cell biology.

Kruppel-like factors (KLFs) are attracting great attention across a wide spectrum of biological sciences and medicine because of their remarkable biological potency and the diversity of roles they play in the physiological and pathological changes of cells and tissues. This book is a comprehensive compendium of the latest research on the molecular mechanisms of KLFs, describing their roles in transcriptional regulation, cellular differentiation and development, the pathogenesis of the liver and cardiovascular systems and cancer, and generation of ES cells and iPS cells. As the only concise treatise written to date by leading experts in the field, it serves as an authoritative review of this family of molecules and is an essential reference for all who are interested in KLFs. The book also explores the potential of KLFs as targets for novel therapeutics and diagnostics, and will be invaluable in those fields.

This title includes a number of Open Access chapters. Climate change will severely impact the world's food supply unless steps are taken to increase crop resilience. Otherwise, the negative effects on both the yield and the quality of crop plants are predicted to be immense. Plant genomics is a potentially powerful defense against this looming threat. This compendium volume offers a global perspective on the topic, with contributions from 42 eminent researchers from 12 nations around the world. The editor is a respected and published scientist in the bioinformatics field, who has chosen articles in the following topics: An overview of the genetic challenges presented by climate change A genomic toolkit for crop-related research Specific methods of improvement for specific crop by means of genomic applications The hand-picked up-to-date research makes this volume an excellent reference not only for university-level academics, but also for policymakers and stakeholders who must tackle the challenge of the world's food security.

Laboratory studies in hemostasis have traditionally focused on abn- malities of platelet function or the quantitative and qualitative disorders that affect the proteins involved in blood coagulation. However, over the last 10 years there has been an explosion in our understanding of the molecular bases that underlie many of the inherited and acquired disorders of hemostasis. Many of these disorders are now routinely diagnosed and assessed by methods that involve genotypic analysis. Indeed in the late 1990s the distinction between molecular methods for research and for routine diagnosis is becoming incre- ingly blurred. The techniques and approaches that are used in hemostasis are manifold and published in isolation in a variety of publications. The aim, therefore, of this volume Hemostasis and Thrombosis Protocols is to pull together, into a single volume, the variety of techniques that are frequently used in the field of hemostasis. We have targeted this volume at laboratories who wish to move into the field of molecular hemostasis or who may already have some expe- ence in this area but wish to develop new areas of research and diagnosis. The chapters are wide-ranging and hopefully provide a broad overview of the d- fering applications in which these standard techniques can be used. Though the articles may appear relatively specific, the techniques contained within them are applicable to the study of many different disorders and we hope that they provide a series of ideas and concepts well-suited to problem solving.

&>ALERT: Before you purchase, check with your instructor or review your course syllabus to ensure that you select the correct ISBN. Several versions of Pearson's MyLab & Mastering products exist for each title, including customized versions for individual schools, and registrations are not transferable. In addition, you may need a CourseID, provided by your instructor, to register for and use Pearson's MyLab & Mastering products. Packages Access codes for Pearson's MyLab & Mastering products may not be included when purchasing or renting from companies other than Pearson; check with the seller before completing your purchase. Used or rental books If you rent or purchase a used book with an access code, the access code may have been redeemed previously and you may have to purchase a new access code. Access codes Access codes that are purchased from sellers other than Pearson carry a higher risk of being either the wrong ISBN or a previously redeemed code. Check with the seller prior to purchase. Informed by many years of genetics teaching and research expertise, authors Mark Sanders and John Bowman use an integrated approach that helps contextualize three core challenges of learning genetics: solving problems, understanding evolution, and understanding the connection between traditional genetics models and more modern approaches. Genetic Analysis: An Integrated Approach, 2/e is extensively updated with relevant, cutting-edge coverage of modern genetics and is supported by MasteringGenetics, the most widely-used homework and assessment program in genetics. Featuring expanded assignment options, MasteringGenetics complements the book's problem-solving approach, engages students, and improves results by helping them master concepts and problem-solving skills.

First published in 1935 (this edition in 1946), this short account of the science of embryology was the first book in English to provide a simple outline of the whole of this important subject. The study of development is perhaps the best method of approach to the most fundamental of all biological problems, the problem of how all the diverse activities are integrated so as to make up a complete individual organism. The book gives a short sketch of the general pattern on which all animals are built, but devotes more attention to the factors which cause the development of the elements in the pattern, and which then bring them into correct relations with one another. This volume is simply written in order to enable the general reader to understand the revolutionary advances made in the subject at that time.

RNA Modification provides a useful examination of the science and its role in biological regulation, the current frontier of life science research, and includes various RNA modications and their role in gene expression. It represents the most up-to-date knowledge and protocols available today.

Although the basic statistical theory behind modern genetics is not very difficult, most statistical genetics papers are not easy to read for beginners in the field, and formulae quickly become very tedious to fit a particular area of application.
Introduction to Statistical Methods in Modern Genetics distinguishes between the necessary and unnecessary complexity in a presentation designed for graduate-level statistics students. The author keeps derivations simple, but does so without losing the mathematical details. He also provides the required background in modern genetics for those looking forward to entering this arena. Along with some of the statistical tools important in genetics applications, students will learn:
How a gene is found
How scientists have separated the genetic and environmental aspects of a person's intelligence
How genetics are used in agriculture to improve crops and domestic animals
What a DNA fingerprint is and why there are controversies about it
Although the author assumes students have a foundation in basic statistics, an appendix provides the necessary background beyond the elementary, including multinomial distributions, inference on frequency tables, and discriminant analysis. With clear explanations, a multitude of figures, and exercise sets in each chapter, this text forms an outstanding entr?e into the rapidly expanding world of genetic data analysis.

First published in 1939 (second impression in 1950), this book provides an account of the changes in, and main principles of, genetics at that time. These are illustrated by references to the most authoritative and then recent investigations. Special attention is paid to the way in which genetics overlaps with other fields of inquiry, since it is often in these border-line subjects that the most important advances are to be expected. The book is particularly arranged to suit the convenience of students whose previous knowledge of genetics is small, and contains annotated bibliographies of suggestions for further reading.