With the rise of genomics, the life sciences have entered a new era. Maps of genomes have become the icons for a comprehensive knowledge of the organism on a previously unattained level of complexity. This book provides an in-depth history of mapping procedures as they were developed in classical genetics.
The book shows that the technology of genetic mapping is by no means a recent acquisition of molecular genetics or even genetic engineering. It demonstrates that the development of mapping technologies has accompanied the rise of modern genetics from its very beginnings. In the first section, Mendelian genetics is set in perspective from the viewpoint of the detection and description of linkage phenomena. The second section addresses the role of mapping for the experimental working practice of classical geneticists, their social interactions, and for their laboratory "life worlds."
With its detailed analyses of the scientific practices and its illustration of the diversity of mapping, this book is a significant contribution to the history of genetics.
A companion volume from the same editors - From Molecular Genetics to Genomics: The mapping cultures of twentieth-century genetics - covers the history of molecular genetics and genomics.

Computer scientists have increasingly been enlisted as "bioinformaticians" to assist molecular biologists in their research. This book is a practical introduction to bioinformatics for these computer scientists. The chapters are in-depth discussions by expert bioinformaticians on both general techniques and specific approaches to a range of selected bioinformatics problems. The book is organized into clusters of chapters on the following topics:
- Overview of modern molecular biology and a broad spectrum of techniques from computer science -- data mining, machine learning, mathematical modeling, sequence alignment, data integration, workflow development, etc.
- In-depth discussion of computational recognition of functional and regulatory sites in DNA sequences.
- Incisive discussion of computational prediction of secondary structure of RNA sequences.
- Overview of computational prediction of protein cellular localization, and selected discussions of inference of protein function.
- Overview of methods for discovering protein-protein interactions.
- Detailed discussion of approaches to gene expression analysis for the diagnosis of diseases, the treatment of diseases, and the understanding of gene functions.
- Case studies on analysis of phylogenies, functional annotation of proteins, construction of purposebuilt integrated biological databases, and development of workflows underlying the large-scale-effort gene discovery.
- Written in a practical, in-depth tutorial style
- Covers a broad range of bioinformatics topics and of techniques used in bioinformatics
- Comprehensive overviews of the development of various approaches in a number of selectedtopics
- In-depth exposition of a number of important topics
- Contributions by prominent researchers: Vladimir Bajic, Ming Li, Kenta Nakai, Limsoon Wong, Cathy Wu, etc.
- Extensive, integrated references to background literature

Computer scientists have increasingly been enlisted as "bioinformaticians" to assist molecular biologists in their research. This book is a practical introduction to bioinformatics for these computer scientists. The chapters are in-depth discussions by expert bioinformaticians on both general techniques and specific approaches to a range of selected bioinformatics problems. The book is organized into clusters of chapters on the following topics:* Overview of modern molecular biology and a broad spectrum of techniques from computer science - data mining, machine learning, mathematical modeling, sequence alignment, data integration, workflow development, etc.* In-depth discussion of computational recognition of functional and regulatory sites in DNA sequences.* Incisive discussion of computational prediction of secondary structure of RNA sequences.* Overview of computational prediction of protein cellular localization, and selected discussions of inference of protein function.* Overview of methods for discovering protein-protein interactions.* Detailed discussion of approaches to gene expression analysis for the diagnosis of diseases, the treatment of diseases, and the understanding of gene functions.* Case studies on analysis of phylogenies, functional annotation of proteins, construction of purpose-built integrated biological databases, and development of workflows underlying the large-scale-effort gene discovery.

The book presents a machine-generated literature review on CRISPR (clustered regularly interspaced short palindromic repeats) from 114 selected papers published by Springer Nature in the last few years, which are then organized by the book editors with a human-written introduction to each chapter. Each chapter presents summaries of predefined themes and provides the reader with a basis for further exploration of the topic. As one of the experimental projects initiated by Springer Nature for AI book content generation, this book shows the latest developments in the CRISPR field. It will be a useful reference for graduate students who are interested in CRISPR-related research and early-career researchers who need an overview of the current development of the field.

Key features: Presents summaries of key points after each chapter and includes color graphs to visualize the big-picture concepts Demonstrates how urban rooftop farms (URFs) can contribute to city greening and climate change mitigation worldwide while providing fresh locally-sourced produce for growing urban populations Provides cutting-edge ideas from the the emerging field of food law and places international and comparative legal concepts into an accessible context for non-lawyers Examines major disputes surrounding food products that have been brought before the World Trade Organization (WTO) to illustrate how trade trends have pushed toward GMO proliferation Uses examples of food labeling, pollinator protection, pesticide permitting, invasive species control, and GMO regulatory policy in the US and the EU to illustrate various methods of bringing public law to the forefront in the struggle toward achieving food integrity The proliferation of Genetically Modified Organisms (GMOs) in our increasingly globalized food system is trivializing the inherent risks to a sustainable world. Responding to the realities of climate change, urbanization, and a GMO-dominated industrialized food system, Gabriela Steier's seminal work addresses the interrelationship of these cutting-edge topics within a scholarly, legal context. In Advancing Food Integrity: GMO Regulation, Agroecology, and Urban Agriculture, Steier defines food integrity as the optimal measure of environmental sustainability and climate change resilience combined with food safety, security, and sovereignty for the farm-to-fork production and distribution of any food product. The book starts with a discussion of the food system and explores whether private law has sufficiently protected food or whether public law control is needed to safeguard food integrity. It proceeds to show how the proliferation of GMOs creates food insecurity by denying people's access to food through food system centralization. Steier discusses how current industrial agricultural policy downplays the dangers of GMO monocultures to crop diversity and biodiversity, thereby weakening food production systems. Striving to promote agroecology by providing a fresh and compelling narrative of interdisciplinary questions, Steier explores how farming can be geared toward more sustainable and environmentally friendly practices worldwide in the future. This book belongs in the libraries of all those interested in food law, environmental law, agroecology, sustainable agriculture, and urban living practices.

First published in 1923, this book explores the impact on development that heredity and environment has on children. Chaplin argues that too much reliance is placed on education and in fact parents, physicians and teachers should equally be taking into consideration the physical and mental constitution of the child, which could be linked to hereditary and environmental factors. In conjunction with the moral, spiritual and intellectual predispositions that the child may have, Chaplin argues the pros of eugenics (in the perspective of the early 20th century) and equally the importance of euthenics for future prosperity of generations to come.

Phylogenomics: A Primer, Second Edition is for advanced undergraduate and graduate biology students studying molecular biology, comparative biology, evolution, genomics, and biodiversity. This book explains the essential concepts underlying the storage and manipulation of genomics level data, construction of phylogenetic trees, population genetics, natural selection, the tree of life, DNA barcoding, and metagenomics. The inclusion of problem-solving exercises in each chapter provides students with a solid grasp of the important molecular and evolutionary questions facing modern biologists as well as the tools needed to answer them.

The book on Trends in Quorum Sensing and Quorum Quenching: New Perspectives and Applications focuses on the recent advances in the field of quorum sensing in bacteria and the novel strategies developed for quorum sensing inhibition. The topics covered are multidisciplinary and wide-ranging,and includes quorum sensing phenomenon in pathogenic bacteria, food spoilers, and agriculturally relevant bacteria. The applications of quorum sensing inhibitors such as small molecules, bioactives, natural compounds, and quorum quenching enzymes in controlling bacterial infections in clinical settings, agriculture and aquaculture are discussed. The potential use of quorum quenching enzymes for mitigating biofouling is also covered. Special focus is given to exploring quorum sensing inhibitors from microbes and flora inhabiting biodiversity rich regions including tropical rain forests and marine environments. Key features: Covers the fundamental aspects, the progress and challenges in the field of quorum sensing and quorum quenching Reviews quorum sensing in Gram-positive and Gram-negative bacteria of clinical, agricultural, and industrial relevance Discusses the application and future trends of quorum sensing inhibitors from lab to clinical and environmental settings Provides comprehensive coverage on molecular mechanisms in bacterial signaling

Scientists have developed a featherless chicken designed to make industrial chicken production more efficient, while specially trained Pacific bottlenose dolphins are being deployed in the Persian Gulf to disarm mines and protect our Navy. Everyone knows Darwin's theory of natural selection, but what about his idea of artificial selection-how humans, not nature, rework natural organisms to meet our needs? Industrializing Organisms brings us to the threshold of the new field of evolutionary history-from the mobilization of war horses in the nineteenth century to today's engineered plants and manipulated animals.

Considered a classic in the field, Troy Duster's Backdoor to Eugenics was a groundbreaking book that grappled with the social and political implications of the new genetic technologies. Completely updated and revised, this work will be welcomed back into print as we struggle to understand the pros and cons of prenatal detection of birth defects; gene therapies; growth hormones; and substitute genetic answers to problems linked with such groups as Jews, Scandanavians, Native American, Arabs and African Americans. Duster's book has never been more timely.

Considered a classic in the field, Troy Duster's Backdoor to Eugenics was a groundbreaking book that grappled with the social and political implications of the new genetic technologies. Completely updated and revised, this work will be welcomed back into print as we struggle to understand the pros and cons of prenatal detection of birth defects; gene therapies; growth hormones; and substitute genetic answers to problems linked with such groups as Jews, Scandanavians, Native American, Arabs and African Americans. Duster's book has never been more timely.

Since the advent of cDNA microarrays, oligonucleotide array technology, and gene chip analysis, genomics has revolutionized the entire field of biomedical research. A byproduct of this revolution, toxicogenomics is a fast-rising star within toxicological analysis.

Gathering together leading authors and scientists at the forefront of the field, An Introduction to Toxicogenomics provides a comprehensive overview of this new discipline. With a focus on toxicology, it introduces the basic principles of microarray/oligonucleotide array-based genomic analysis and explains how it fits into the field of biomedical research. These discussions provide an overview to the actual mechanics of the analyses themselves and offer insights on handling and quality control. Then the book features an important section on the basics of data analysis and clustering methods such as genetic algorithms. Finally, it covers the application of expression profiling in the field of toxicology and addresses the two fundamental types of analysis in detail, with sections dedicated to both mechanistic and predictive studies.

Although toxicogenomics promises fast, efficient techniques and information-rich data, much of its potential remains untapped. An Introduction to Toxicogenomics consolidates the concepts underlying the field to provide a solid foundation from which to begin your research endeavors.

There is a revolution underway in biology. It is based on a new perception of bodies and genes, in which the former are the end product of the latter within the continuum of evolution. Twenty five years after Richard Dawkins helped revolutionize our thinking about "selfish genes," it is time to re-evaluate. "Revolutionary Biology" explains in simple, vivid terms what this exciting approach has to offer, and then applies its stunning insights to human beings. This novel perspective, galvanizes our understanding of how evolution works, what living things are all about and, not least what it means to be human. The controversial disciplines of sociobiology and evolutionary psychology have generated startling insights into longstanding questions concerning the nature and purpose of families, altruism vs. selfishness, and free will vs. biological determinism. Written by one of its foremost figures, "Revolutionary Biology" is a manifesto and educated layman's guide to this ongoing revolution.

Barash's purpose is to demystify the basic concepts of the genetic revolution and take the reader on a tour--accessible and authoritative--of the principles that underlie this fascinating turn in scientific thought. Much has been written about evolution, animals, and the animal and evolutionary origins of human behavior, yet only recently have biologists begun to appreciate these connections. The key concept is that genes--not species, not groups, and not even individuals--are the apple of evolution's eye. The result has been a major biological paradigm shift that is making itself felt in the social sciences as well. Barash explores the phenomenon of altruism both at the animal level, and the human level.

Barash draws not only on a wealth of biological evidence but on literature, philosophy, and the familiar details of everyday life to communicate the essentials of this increasingly influential approach to the study of the human species. Clearly and engagingly written, "Revolutionary Biology" will be fascinating reading for those seeking an entry into this new science.

Mesenchymal stem cells (MSCs), a type of adult stem cells, have attracted the attention of scientists and physicians alike due to their unique biological properties and potential for disease treatment. As stem cell research is complex and progressing rapidly, it is important that the experts in this field share their views and perspectives. This book, co-edited by leading global researchers, is divided into three major sections and covers a broad range of topics concerning MSCs during their transition from benchside to bedside. The book is intended for researchers and clinicians in the field of stem cells. Dr. Robert Chunhua Zhao, MD. Ph.D is Cheung Kong Professor of Stem Cell Biology, Professor of Cell Biology at the Institute of Basic Medical Sciences & School of Basic Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, China Director of Center for Tissue Engineering, PUMC Chief scientist of 973 program Regional Editor of Stem Cells and Development.

Mapping of animal genomes has generated huge databases and several new concepts and strategies, which are useful to elucidate origin, evolution and phylogeny. Genetic and physical maps of genomes further provide precise details on chromosomal location, function, expression and regulation of academically and economically important genes. The series Genome Mapping and Genomics in Animals provides comprehensive and up-to-date reviews on genomic research on a large variety of selected animal systems, contributed by leading scientists from around the world. Laboratory animals are those species that by accident of evolution, domestication and selective breeding are amenable to maintenance and study in a laboratory environment. Many of these species are studied as 'models' for the biology and pathology of humans. Laboratory animals included in this volume are sea-urchin, nematode worm, fruit fly, sea squirts, puffer fishes, medaka fish, African clawed frog, mouse and rat.

In recent years, new paradigms have emerged to replace-or augment-the traditional, mathematically based approaches to optimization. The most powerful of these are genetic algorithms (GA), inspired by natural selection, and genetic programming, an extension of GAs based on the optimization of symbolic codes.

Robust Control Systems with Genetic Algorithms builds a bridge between genetic algorithms and the design of robust control systems. After laying a foundation in the basics of GAs and genetic programming, it demonstrates the power of these new tools for developing optimal robust controllers for linear control systems, optimal disturbance rejection controllers, and predictive and variable structure control. It also explores the application of hybrid approaches: how to enhance genetic algorithms and programming with fuzzy logic to design intelligent control systems. The authors consider a variety of applications, such as the optimal control of robotic manipulators, flexible links and jet engines, and illustrate a multi-objective, genetic algorithm approach to the design of robust controllers with a gasification plant case study.

The authors are all masters in the field and clearly show the effectiveness of GA techniques. Their presentation is your first opportunity to fully explore this cutting-edge approach to robust optimal control system design and exploit its methods for your own applications.

Functional Microbial Genomics, edited by two leading experts in the field, provides the researcher with an up-to-date collection of articles on post-genome technologies central to studying the function of microorganisms.
Since the release of the first complete genome sequence of a free-living organism in 1995, over 100 microbial genomes have been completely sequenced. The advent of new technologies for post-genomic analyses has allowed the rapid exploitation of this genome sequence information, heralding a golden era in microbial research. Functional Microbial Genomics provides in-depth accounts from scientists working with these new technologies explaining both the techniques and the ways in which they have been applied to the study of gene function in different microbial species.
Methods in Microbiology is the most prestigious series devoted to techniques and methodology in the field. Established for over 30 years, Methods in Microbiology will continue to provide you with tried and tested, cutting edge protocols to directly benefit your research.
* Bioinformatic approaches to genome sequence analysis
* Details the design, construction and applications of DNA microarrays
* Covers advances in bacterial proteome and metagenome analysis
* Describes functional genomic approaches for novel antibiotic target and vaccine candidate discovery
* Presents case studies where functional genomic analyses have revolutionized our understanding of model species

In the second volume of this three-volume series, leading researchers in genomics and agriculure present a general discussion on the fundamentals of molecular breeding and applications of molecular markers for germplasm characterization, They investigate basic concepts and the application of molecular mapping and breeding to create improved yield and quality, as well as desired related component traits; limiting biotic and abiotic stresses; and improving physiological traits of economic importance.

Southeast Asia is regarded as one of the birthplaces of modern humans. Recent genetic evidence shows that it was probably the entry point of modern humans from Africa into East Asia and Oceania. With the help of new markers X mostly from the Y-chromosome and mtDNA X several recent efforts have been made to study the populations of Southeast Asia, which have been somewhat neglected in the past.A new picture of the origin and migrations of modern humans in this region is quickly emerging. In this book, the leading researchers in the studies of Southeast Asian, East Asian, and Oceanian populations present the most up-to-date results of their research.

In Cereal Genomics: Methods and Protocols, expert researchers provides modern protocols for the analysis and manipulation of cereal genomes. Techniques for isolation and analysis of DNA and RNA from both the vegetative tissues and from the more challenging seeds of cereals are described. Tools for the isolation, characterization and functional analysis of cereal genes and their transcripts are detailed. Methods for molecular screening of cereals and for their genetic transformation are also covered. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cereal Genomics: Methods and Protocols provides a comprehensive resource for those studying cereal genomes.

Twenty-four true, wide-ranging tales of crime, history, human behavior, illness, and ethics, told from the personal perspective of the author, an eminent physician-lawyer who uses the stories to illustrate the principles of human genetics and to discuss the broader issues.

Nowadays, genetics focuses on DNA. Just like the first edition, the theme of this new edition, Introduction to Genetics: A Molecular Approach, is therefore the progression from molecules (DNA and genes) to processes (gene expression and DNA replication) to systems (cells, organisms and populations). This progression reflects both the basic logic of life and the way in which modern biological research is structured. The molecular approach is particularly suitable for students for whom genetics is part of a broader program in biology, biochemistry, the biomedical sciences or biotechnology. This book presents the basic facts and concepts with enough depth of knowledge to stimulate students to move on to more advanced aspects of the subject.

This second edition has been thoroughly updated to cover new discoveries and developments in genetics from the last ten years. There are new chapters that introduce important techniques such as DNA sequencing and gene editing, and the applications of genetics in our modern world are covered in chapters describing topics as diverse as gene therapy and the use of ancient DNA to study prehistoric ecosystems.

Key Features:

This book provides a molecular approach to the study of genetics.

It is a highly accessible and well-structured book with chapters organized into four parts to aid navigation.

It presents high-quality illustrations to elucidate the various concepts and mechanisms.

Each chapter ends with a Key Concepts section, which serves to summarize the most essential points.

Self-study questions enable the reader to assess their comprehension of chapter content, and discussion topics facilitate a deeper understanding of the material by encouraging conversation and critical evaluation.

Key terms are emboldened throughout the text and are listed at the end of each chapter, and definitions can be found in the Glossary.

For instructors who adopt the book, an affiliated question bank is free to download.

Table of Contents

1. What is Genetics and Why is it So Important?

PART 1. GENES AS UNITS OF BIOLOGICAL INFORMATION

2. DNA

3. Genes

4. Transcription of DNA to RNA

5. Types of RNA Molecule: Messenger RNA

6. Types of RNA Molecule: Ribosomal and Transfer RNA

7. The Genetic Code

8. Protein Synthesis

9. Control of Gene Expression

10. DNA Replication

11. Mutation and DNA Repair

PART 2. GENES AS UNITS OF INHERITANCE

12. Inheritance of Genes during Virus Infection Cycles

13. Inheritance of Genes in Bacteria

14. Inheritance of Genes during Eukaryotic Cell Division

15. Inheritance of Genes during Eukaryotic Sexual Reproduction

16. Inheritance of Genes in Populations

PART 3. HOW GENES ARE STUDIED

17 Mapping the Positions of Genes in Chromosomes

18 Sequencing Genes and Genomes

PART 4. GENETICS IN OUR MODERN WORLD

19. Genes in Differentiation and Development

20. The Human Genome

21. Genes and Medicine

22. DNA in Forensic Genetics and Technology

23. Genes in Industry and Agriculture

24. The Ethical Issues Raised by Modern Genetics

The past few years have witnessed extraordinary advances in molecular genetic techniques and the accumulation of structural genomics information and resources in both human and model organisms. With the development of new technologies and the availability of resources like the sequence of eukaryotic genomes, problems of a previously unthinkable scope are now being routinely solved in neuroscience and many other areas of biomedical research. The results of these studies, in turn, are having, and will continue to have, profound impact on experimental approaches and designs for manipulating genes, the genome, and model organisms as a means of gaining insights into nervous system functioning and complex behavior. Methods in Genomic Neuroscience provides newcomers and experienced researchers with a reference guide for applying powerful, state-of-the-art molecular genetic techniques to the study of neural and behavioral systems. It thereby provides a foundation by which data on gene expression and function may be used to develop new therapeutic strategies for brain diseases. Authored by researchers in the forefront of genomic neuroscience, the book addresses state-of-the-art tools and technologies for global analysis of genes influencing the nervous system and its disorders. An emphasis is placed on massively parallel approaches for analyzing the avalanche of data that is being generated from the full genomic sequence of humans and model systems. Specific topics include human sequence variation, methods for discovering disease vulnerability genes, gene-environmental interaction, gene expression analysis using DNA microarrays, random mutagenesis, gene trap approaches for studying brain development, neural stem cells, gene targeting, and gene delivery.

Let's face it, say Barash and Lipton: Males and females, boys and girls, men and women are different. To be sure, these differences are often heightened by distinctions in learning, cultural tradition, and social expectation, but underpinning them all is a fundamental difference that derives from biology. Throughout the natural world, males are those creatures that make sperm; females make eggs. The oft-noticed "gender gap" derives, in turn, from this "gamete gap." In "Gender Gap," Barash and Lipton (husband and wife, professor and physician, biologist and psychiatrist) explain the evolutionary aspects of male-female differences.

After describing the theory underlying the evolutionary explanation of male-female differences-in accessible, lay-person's language-they show how it applies to specific examples of animal behavior. Then, they demonstrate comparable male-female differences in the behavior of human beings cross-culturally, as well as within the United States. Barash and Lipton apply this approach to male-female differences in sexual inclinations, propensities for violence, parenting styles, and childhood experiences. They invoke much work within the traditional social sciences, such as psychology, anthropology, and sociology, which have typically ignored biological factors in the past.

Part of the highly successful revolution in scientific thought has been the recognition that evolutionary insights can illuminate behavior, no less than anatomy and physiology. This new discipline, sometimes called "sociobiology" or "evolutionary psychology," promises to help us make sense of ourselves and of our most significant others, shedding new light on what it means to be male or female. Now available in paperback with a new introduction by the authors, this accessible volume integrates work from a variety of fields, applying a new paradigm to research on gender differences.

Still widely used as gene markers, isozymes detected by zymogram techniques have proven valuable in a range of other biological applications over the last few years. Along with these new applications, many new techniques have also emerged. Yet more than eight years since the Handbook of Detection of Enzymes on Electrophoretic Gels was first published, it remains the only book completely devoted to zymogram methods. The time has come to bring its contents up to date. New in the Second Edition: An overview of new applications of enzyme electrophoresis and zymogram techniques Zymogram techniques for approximately 100 enzymes not included in the first edition, bringing the total to more than 900 methods for detecting more than 400 different enzymes Information on subunit structure included within the enzyme sheets to facilitate interpretation of isozyme patterns detected on zymograms An appendix containing information on the buffer systems most commonly used for enzyme electrophoresis in starch, cellulose acetate, and polyacrylamide gels. The second edition of this bestselling handbook makes significant additions to the set of reliable gene markers suitable for electrophoretic analysis. It also strengthens the value of enzyme electrophoresis as a powerful tool proven successful in solving a variety of problems encountered across many biological areas, including the post-genome biology.