Gynaecological practice has changed fundamentally in the last three decades and a large proportion of major pelvic operations has been replaced by minimally invasive approaches. This book will cover minimally invasive approaches in all aspects of gynaecology including general gynaecology, oncology, urogynaecology and reproductive medicine. The chapters are written at a level appropriate for trainees/residents and general gynaecology specialists but enough details and additional resources will be provided for those who require further information. Specific aim of the book is to provide direct to the point surgical pearls which can be adapted to the daily practice instantly by the target audience. The book includes chapters on relevant surgical anatomy, principles of MIS, management of camera systems, video/image editing, initiating a successful MIS practice, improving efficiency of current MIS program, how to develop successful teaching techniques in academic setting, avoiding & managing MIS related surgical complications and preoperative/postoperative care before covering MIS for individual conditions including intensive care managements. Chapters are written by world renown authorities. ACOG guideline recently published a statement recommending vaginal hysterectomy and endoscopic hysterectomy should be considered as a first step of surgical choice. Current practice has been shifting from open cases to laparoscopic/ robotic assisted cases while vaginal cases stays steady. This shift has created an urge among gynaecologists to learn, improve or adapt laparoscopic/ robotic techniques in their practice.

Childbed fever was by the far the most common cause of deaths associated with childbirth up to the Second World War, throughout Britain and Europe. Otherwise known as puerperal fever, it was an infection which followed childbirth and caused thousands of miserable and agonizing deaths every year. This book provides the first detailed account of this tragic disease from its recognition in the eighteenth century up to the second half of the twentieth century, examining it within a fully comprehensive history of infective diseases.

This second edition volume expands on the first edition with more detailed methodologies on prenatal testing and diagnosis, and also covers next-generation sequencing techniques. The chapters in this book are divided into three sections: preimplantation genetic testing, traditional prenatal testing, and non-invasive prenatal testing. This book covers topics such as molecular testing for preimplantation genetic diagnosis of single gene disorders; DNA extraction from various types of prenatal specimens; prenatal diagnosis of cystic fibrosis and Tay-Sachs disease; chromosomal SNP microarrays; and isolation of cell-free DNA from maternal plasma. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and thorough, Prenatal Diagnosis, Second Edition is a valuable resource for any researcher interested in reproducing these techniques in their clinical laboratories.

This book describes in fascinating detail the history of the use of anesthesia in childbirth and in so doing offers a unique perspective on the interaction between medical science and social values. Dr. Donald Caton traces the responses of physicians and their patients to the pain of childbirth from the popularization of anesthesia to the natural childbirth movement and beyond. He finds that physicians discovered what could be done to manage pain, and patients decided what would be done. Dr. Caton discusses how nineteenth-century physicians began to think and act like scientists; how people learned to reject the belief that pain and suffering are inevitable components of life; and how a later generation came to think that pain may have important functions for the individual and society. Finally he shows the extent to which cultural and social values have influenced "scientific" medical decisions.

This volume presents the latest developments and techniques used to study the physiopathology, diagnosis, and treatment of pre-eclampsia. Written for clinicians, obstetricians, basic scientists, researchers, and students the chapters in this book provide methods to study placental function using in vitro and ex vivo model systems, comprehensive genetic analysis of pre-eclampsia, identifying critical angiogenic factors associated with the development of pre-eclampsia, and controlled experiments that investigate potential therapies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, tips on troubleshooting and avoiding known pitfalls, as well as a description of the limitations and advantages of the described techniques. Cutting-edge and comprehensive, Pre-Eclampsia: Methods and Protocols is a valuable resource for anyone interested in learning more about the critical role of the placenta in the maternal-fetal relationship.

This book has been launched to commemorate the 24th Annual Conference of Indian Society for Assisted Reproduction. It is a unique effort to gather experiences from experts from all over the world - all of whom are authorities in their respective field, to provide concise and updated information and integrated management approach to deal with different situations.

This innovative collection extends the emerging field of stress biology to examine the effects of a substantial source of early-life stress: child abuse and neglect. Research findings across endocrinology, immunology, neuroscience, and genomics supply new insights into the psychological variables associated with adversity in children and its outcomes. These compelling interdisciplinary data add to a promising model of biological mechanisms involved in individual resilience amid chronic maltreatment and other trauma. At the same time, these results also open out distinctive new possibilities for serving vulnerable children and youth, focusing on preventing, intervening in, and potentially even reversing the effects of chronic early trauma. Included in the coverage: Biological embedding of child maltreatment Toward an adaptation-based approach to resilience Developmental traumatology: brain development and maltreated children with and without PTSD Childhood maltreatment and pediatric PTSD: abnormalities in threat neural circuitry An integrative temporal framework for psychological resilience The Biology of Early Life Stress is important reading for child maltreatment researchers; clinical psychologists; educators in counseling, psychology, trauma, and nursing; physicians; and state- and federal-level policymakers. Advocates, child and youth practitioners, and clinicians in general will find it a compelling resource.

Dr. Muir and Dr. Rose are key opinion leaders in the area of endocrinology, and they have created a state-of-the-art issue for neonatologists. The clinical reviews will prepare perinatologists and neonatologists for the challenges in clinical endocrinology that arise in fetuses and newborns. More specifically, authors will provide updates on the biological basis of disorders in order to illustrate the rationale for diagnostic approaches and current therapies and to provide readers with a basis to consider and evaluate new clinical offerings. Articles on the following topics are included in the issue: Congenital hypothyroidism; Thyroid function in the NICU; Neonatal thyrotoxicosis; Neonatal diabetes; Hypersinsulinism; Hypopituitarism; Glucocorticoid use in the NICU/ neonatal adrenal function; Adrenal insufficiency, CAH, Prenatal treatment of CAH; Neonatal Cushing Disease/Congenital endocrine tumors; Early ID of Turner Syndrome/Preserving fertility; and Bone mineral/ Calcium disorders in the neonate.

Despite its universality in human female ageing, the menopause and its biology are not completely understood. New biologic mechanisms by which sex hormones may be detrimental or confer protection are continually being discovered. We are now starting to understand that the role of the oestrogen receptor is not identical in all tissues. Important nongenomic effects for sex hormones have also been described. Hormone replacement therapy (HRT) has produced effects on health risks: some are reduced, some are increased, and the rest remain uncertain. HRT is being used by an increasing number of women to alleviate climacteric symptoms in the perimenopausal period and to prevent osteoporosis and cardiovascular disease later. Positive effects on Alzheimer's disease and dementia on the one hand, and an increase in venous thrombosis on the other, are currently being reported by several groups. Both the preventive benefits and the risk of breast cancer seem to be linked to long-term and current use. HRT requires further testing through specific clinical trials, currently underway in the United States, before confident recommendations may be made about the full range of benefits and risks.

Dr. Caughey has recruited top experts to address the current questions and thinking with regard to the management of labor and delivery. Authors have presented current clinical reviews on the following topics: Defining and managing normal and abnormal first stage of labor; Defining and managing normal and abnormal second stage of labor; Laborist models on labor and delivery; Quality Improvement on Labor and Delivery; Fetal Malposition; Is there a place for outpatient pre-induction cervical ripening; Management of twins on labor and delivery; Cervical ripening techniques: Which is the best; Augmentation of labor: What are the approaches; Elective induction of labor: What is the impact; VBAC trends: Which way is the pendulum swinging; and Update on fetal monitoring. Readers will come away with the current clinical trends and information they need to successfully manage labor and delivery.

This issue of MRI Clinics of North America focuses on Imaging of the Female Pelvis, and is edited by Katherine Maturen. Articles will include: MR Imaging of Adnexal Mass Characterization; MR Imaging of Abnormal Placentation; MR Imaging of the Pelvic Floor; MR-Pathologic Correlation of Ovarian Neoplasms; MR Imaging of Benign Uterine Pathologies; MR Imaging for Gynecologic Brachytherapy; MR Imaging of Mullerian Fusion Anomalies; MR Imaging in Cervical Cancer; MR Imaging in Female Pelvic Emergencies; MR Imaging in Endometrial Cancer; MR Imaging of the Female Perineum; PET/MR in Gynecologic Oncology; MR Imaging of Vulvar and Vaginal Cancer; and more!

Vulvar disorders are prevalent but often overlooked conditions in the curricula of obstetrics and gynecology, dermatology, and primary care residency training programs. This has led many outpatient clinicians to feel unprepared to evaluate the patient with a vulvar complaint. Often patients with complex, chronic vulvar disorders have seen multiple providers in consultation before they are appropriately diagnosed and treated, leading to frustration amongst patients and providers alike as well as excessive health care costs. The goal of this issue is to present a practical review on vulvar disease for outpatient clinicians to improve patient care. The topics highlighted in this issue represent gaps in knowledge among residents, fellows, providers, and course and conference attendees. The issue begins with a general approach to the evaluation and management of vulvar disorders and then moves on to an article on vulvar pathology that will help clinicians obtain the most useful pathology reads from their biopsies. Also addressed are specific vulvar disorders or presenting findings that are common or challenging. A pelvic floor physical therapy colleague provides information on how this modality can help manage vulvar pain. The issue concludes with an article on hot topics in vulvar disease. In the last several years there has been a growing number of newly trained physicians committed to advancing patient care in the area of vulvar disease, and many of this issue's authors are part of this group. This issue should serve as a useful resource in the office of any provider who evaluates patients with vulvar complaints.

The Guest Editors have collaborated on a state-of-the-art presentation of current clinical reviews on Quality in Neonatal Care. Top experts have prepared articles in the following areas: Standardizing Practices: How and why to standardize, using checklists, measuring variation; Health Informatics and Patient Safety; Using Statistical Process Control to Drive Improvement in Neonatal Care; Improving Value in Neonatal Intensive Care; Culture and Context in Quality of Care: Improving Teamwork and Resilience; Has Quality Improvement Improved Neonatal Outcomes; National Quality Measures in Perinatal Care; Perinatal and Obstetric Quality Initiatives; Family Involvement in Quality Improvement; Perinatal Quality Improvement: A Global Perspective; Delivery Room Care / Golden Hour; Respiratory Care and Bronchopulmonary Dysplasia; Reducing Incidence of Necrotizing Enterocolitis; Alarm Safety and Alarm Fatigue; and Patient Safety: Reducing Unplanned Extubations. Readers will come away with the clinical information they need improve quality in the NICU.

The acquisition and implementation of new findings for clinical care in obstetrics and gynecology is at a more rapid pace than ever before. More understanding of the pathophysiology of disease coupled with improved screening technology and genetic information requires physicians to constantly update their knowledge-base and familiarize themselves with guidelines and advances in techniques as well as question old euphemisms. Medical specialties, including obstetrics and gynecology have moved from board certification as a solitary achievement to maintaining current knowledge- a continuous lifelong learning process. This issue of Obstetrics and Gynecology Clinics is dedicated to clinical care for patients with evidence-based recommendations: "state of the art" advice and updates. Articles are specifically devoted to Contraception: menarche to menopause; Vaginitis: beyond symptoms; Abnormal uterine bleeding; Recognition and therapeutic options for malignancy of the cervix and uterus; Gestational diabetes: Diagnosis, classification and clinical care; Hypertensive disorders in pregnancy; Obstetric emergencies: Shoulder dystocia and postpartum hemorrhage; Prenatal diagnosis: tools and tests for screening; Clinical recognition and screening for common breast disorders and malignancy; and Recognizing and managing common urogynecologic disorders.

In recent years a lot of emphasis has been placed on obtaining consent for surgical and medical procedures to avoid litigation. This has become an integral part of clinical risk management and clinical governance. Problems relating to consent are the reason for a great proportion of medico-legal claims. Adequate, informed consent and better record keeping will avoid a lot of complaints and litigation. This book aims to help to understand the types of consent , how to obtain consent, and its medico-legal implications when things go wrong. It is designed to help in obtaining consent for common procedures undertaken in obstetrics and gynaecology. It is intended not only for doctors, but also for midwives, nursing staff, medical students and allied health professionals. And it is also particularly relevant for overseas doctors who are new and generally less familiar with the risk management, clinical governance and litigation system in the UK. Another use of this book is to provide an invaluable on the spot reference for various operations and their complications, ways and means of minimising risk, and dealing with difficult situations. The speciality of obstetrics and gynaecology is sued more frequently than any other. This book should help all those who are involved in the ob/gyn department to minimise the risk and danger of incurring such action.

Dr. Nicholson's issue is devoted to providing health care to the underserved woman. Leading experts in the area have written reviews to address the leading thinking and management of patient outcomes in the following areas: Racial/ethnic Disparities in Health and Healthcare; Perinatal Quality Indicators and Achieving Birth Equity among Underserved Women; Reducing Disparities in Unintended Pregnancy; Family planning American style: Why it's so hard to control birth in the United States; Breaking the Cycle of Obesity in Women in Underserved Communities; Addressing Healthcare Disparities Among Sexual and Gender Minorities with Community Initiatives; Comparing Options for Patient-Centered Treatment for Uterine Fibroids: Addressing Patient-Centered Fibroid Management in Underserved Women of Childbearing Age; Aiding Underserved Women with Substance Use Disorders before and after Pregnancy; Tthe Role of Qualitative Research in Gynecologic and Reproductive Care; and Using the Electronic Health Record to Conduct Reserch in Population Health. Readers will come away with state-of-the-art information that they can immediately integrate into patient care.

This second edition offers an expanded and updated history of the field of fetal and neonatal development, allowing readers to gain a comprehensive understanding of the biological aspects that contribute to the wellbeing or pathophysiology of newborns. In this concluding opus of a long and prominent career as a clinical scientist, Dr. Longo has invited new contributions from noted colleagues with expertise in various fields to provide a historical perspective on the impact of how modern concepts emerged in the field of fetal physiology and contributed to the current attention paid to the fetal origins of diseases in adults. In addition to new chapters on maternal physiology and complications during pregnancy, others trace the history of the Society for Reproductive Investigation, governmental funding of perinatal research, and major initiatives to support training in the new discipline of maternal fetal medicine, including the Reproductive Scientist Development program. The extensive survey provided by the author, who personally knew most of the pioneers in the field, offers a unique guide for all clinical and basic scientists interested in the history of - and future approaches to diagnosing and treating - pathologies that represent the leading causes of neonatal mortality and, far too often, life-long morbidity.

Despite advances in medical technology and patient safety initiatives, maternal morbidity and mortality rates continue to increase. Maternal mortality trends in the US as reported from the CDC from 1989-2009 demonstrate increasing mortality trends from 7.2 deaths per 100,000 live births in 1987 to 17.8 deaths per 100,000 live births in 2009. To combat this problem, a thorough understanding of the critical medical and surgical issues that are often encountered in pregnancy is essential. Each article addresses a topic relevant to care of the critically ill gravida.

Gynecologic malignancies, especially endometrial and ovarian cancers are among the most important and most severely affected by obesity. This volume of Energy Balance and Cancer, written by the world's leading experts in this field, is arranged to provide a transdisciplinary assessment of the pertinent issues, results of relevant research on mechanisms, and control, strategies for dealing with affected patients and improving outcomes and future research needs. The volume comprehensively covers the epidemiology linking obesity to endometrial and ovarian cancer as well as the public awareness of this critical problem. Subsequent chapters explain biologic aspects of linkages between energy balance and gynecologic malignancies. The volume further outlines strategies to disrupt the linkage between obesity and gynecologic malignancies and concludes with a series of chapters focused on management strategies for obese patients with gynecologic malignancies. This volume provides a valuable resource for all physicians, scientists and other transdisciplinary investigators and practitioners interested and involved in energy balance and cancer. It should be a particularly useful guide to optimize outcomes for all practitioners dealing with patients with gynecologic malignancies challenged by energy balance issues. Moreover, it should serve as a useful guide to students and investigators interested in conducting further research on defining and disrupting the important linkage between energy balance and gynecologic malignancies.

It astounds the western world that such a highly industrialized nation as the Netherlands, with all the resources of modern medicine and technology, has a marked preference for home birth assisted by midwives. Van der Mark examines Dutch attitudes and practices surrounding birth from a sociohistorical point of view, explaining the importance of ideological consensus, the private nature of the Dutch family, the high regard for comfort and well being, and the professional development of midwives as trained and licensed practitioners. This volume will be welcomed by those convinced of the value of low-intervention home birth, but it will also be of interest to practitioners who must rely on technological procedures to manage the birth process. Since the Dutch hold one of the world records of pregnancy outcome statistics, readers will be interested in the Dutch midwifery model described here by various contributors.