Oviductal Recognition of Embryonic Signals; H.B. Croxatto, et al. Effect of Progesterone Antagonists on Ovo-Endometrial Interactions; A. Psychoyos. On the Requirement for Estrogen for Establishing Pregnancy in the Non-Human Primate; N.R. Moudgal. Embryonic Loss and Conceptus Interferon Production; R.M. Roberts. In Vitro Models of Implantation; S.R. Glasser, et al. Uterine EGF Ligand-Receptor Circuitry and Its Role in EmbryoUterine Interactions during Implantation in the Mouse; S.K. Dey, et al. Human Uterine Angiogenic Factor (HUAF). The Role of Lymphohematopoietic Cytokines in Signalling between the Immune and Reproductive Systems; T.G. Wegmann. Human Decidual Function in Trophoblast and Uterine interaction; T. Mori, et al. Cytokines at the Maternal Fetal Interface: Colony Stimulating Factor1 as a Paradigm for the Maternal Regulation of Muridae Rodents; C. Tachi. Hormonal Regulation of Uterine Complement; K.B. Isaacson, et al. Insulinlike Growth Factor Binding Proteins: A Paradigm for Conceptus-Maternal Interactions in the Primate; A.T. Fazleabas, et al. The Roles of Growth Factors and Their Receptors in Peri-Implantation Mouse Embryos and at the Embryomaternal Interface; Z. Werb, et al. Ligands and Receptors of the Insulin Family: Role in Early Mammalian Development; S. Heyner, et al. 6 additional articles. Index.

This book presenting the latest thinking on Reproductive Endocrinology and Infertility is truly international as the authors hail from no less than four different continents (North America, Europe, Australia and Asia). The idea for this book was conceived during the XII World Congress On Fertility and Sterility where the unique confluence of our distinguished authors occurred in Singapore in October 1986. The authors were involved in the Pre And Post Congress Scientific Programmes which we organised. The overwhelming success of the Congress and the Pre And Post Congress Scientific Programmes prompted this book so that those unable to attend the meeting will still be able to benefit from the vast range of topics covered. This book will be a valuable addition to the knowledge in Reproductive Endocrinology and Infertility and will be useful reading for those wishing to pursue this subspecialty. The authors are indebted to Lee Foundation (Singapore) for help in the publication of this book. We would also like to thank Miss Jam Siew Fong and Miss Tang May Mey for their excellent secretarial assistance. Singapore, January 1988 Charles SANg F H Maurine Tsakok S LTan K H Chan ix 1 Hypothalamic and Pituitary Disorders in Reproduction ROGER J PEPPERELL 1 HYPOTHALAMIC AND PrruITARY DISORDERS Disorders of ovulation are present in 15 to 25% of couples with infertility.

Vulval diseases are managed by dermatologists and by ObGyns and while expert referral centres do exist, the majority of patients are treated by non-specialists. These conditions are relatively common (approximately 15% of a gynaecologist's caseload) and can be difficult to diagnose. Gynecologic Dermatology is a practical, highly illustrated guide written with the needs of the general dermatologist or gynaecologist in mind. The book begins with chapters on normal anatomy; history taking and examination of the vulva; biopsy taking and general management options. Next, symptom-based chapters describe presenting problems such as pruritus, broken skin and scarring, using flowcharts to help the physician work through to a diagnosis. Finally, chapters devoted to key conditions (lichen sclerosus, lichen planus, etc) describe the pathogenesis, clinical presentation, differential diagnosis and management of the disease in question. Abundantly illustrated and written in a practical, clinically oriented style, Gynecologic Dermatology is an indispensable reference for non-specialists that bridges the gap between dermatology and gynaecology. Symptom-based section reflects how patients present in real life and provides algorithms/flowcharts to help with diagnosis Includes second-line treatment options to help physician when standard treatment is unsuccessful Lavishly illustrated with over 500 photos, diagrams, tables and boxes

Obesity epidemic is a global problem of the 21th century for women in reproductive age and also the obstetricians and pediatricians. There are influences of mother's prepragnancy and antepartal obesity, at delivery, for fetal programming and for maternal and fetal lifelong metabolism. The epidemiological results are important, but for the health care providers the skills for prevention of mother's obesity with all consequences are essential. Evaluated programms in nutrition and physical activity will be discussed.

'Essential reading for everyone' - Marian Keyes It's time for us to start talking about the menopause. Cracking the Menopause, from straight-talking broadcaster Mariella Frostrup and health journalist Alice Smellie, has all the information you need, delivered with characteristic wry humour. It's high time we renovated and elevated this life change. Despite the centuries of speculation and propaganda, we are not overheating or inherently cold, we are not hysterics or boiling vats of toxic poisons, we are not dried up or washed up, we are simply menopausal. In this no-holds-barred guide, Mariella shares her own journey through the menopause, along with the latest science, advice from leading experts and humorous illustrations - to provide an informative source of wisdom and enlightenment. Featuring case studies from women in every walk of life and all stages of their menopause journey, Cracking the Menopause opens up the conversation about an urgent topic that half the population will experience, but barely anyone is talking about. Designed to equip you with the knowledge to manage your symptoms from perimenopause onwards, this essential book separates the myths from the reality and offers expertise, hope and advice. 'I inhaled this book, it's fantastic. Women of all ages need to read it.' - Claudia Winkleman 'Mariella and Alice have just written one of the most important books of the year, bravo.' - Gabby Logan

Recent years have seen important advances in the technology and techniques available to surgeons performing gynecologic surgery as well as reconstructive of clinical pelvic procedures. These developments took place in a wide variety settings from regional teaching centers to private clinical facilities. In 1996, the leading investigators from around the world gathered to discuss the present status of pelvic surgery and adhesion prevention with a look toward the future of patient care. This volume contains the proceedings of that meeting: the Third Interna tional Congress on Pelvic Surgery and Adhesion Prevention. Each chapter in cludes the material presented at the congress as well as a timely update of the authors' latest research and clinical thinking. Presentation integrating basic and clinical science provide the basis for con sidering peritoneal repair after surgery including the interaction of growth factors and other biochemical messengers. Research has increased the understanding of mesothelial reepithelialization and has led to new surgical technologies to reduce adhesion fonnation. A state-of-the-art review of emerging surgical adjuvants for adhesion prevention is provided, including discussion of barriers, gels, and poly mers as well as "designer" drugs effective at modifying the peritoneal response to injury. Assessment of clinical outcome in a wide variety of gynecologic surgical procedures brings into focus the benefits available as a result of these new tech nologies."

Oncofertility integrates the two previously distinct fields of cancer treatment and fertility research and aims to explore and expand the reproductive future of cancer survivors. In order to achieve the goal of fertility preservation, the Oncofertility community must focus on communication and the way data is provided and received. Concomitant with the rapidly changing technology of Oncofertility, there have been radical shifts and advances in the way health educators and clinicians can produce and share information.As success rates of reproductive techniques such as egg freezing and banking continue to rise, providing increasing opportunities for young cancer patients to preserve their fertility prior to the onset of cancer treatments, communication among professionals in oncology, reproductive medicine, and psychosocial work, among others, becomes crucial, and clinical demand for Oncofertility information is expected to rise considerably.

"Oncofertility Communication" describes and addresses the myriad channels through which the multiple audiences involved in Oncofertility can be served with appropriate and accurate information about cancer-related fertility issues. The text answers frequently asked questions and provides invaluable insights to scientific and health care professionals about communication among the diverse Oncofertility audiences. It incorporates timely discussions about traditional and emerging electronic communication tools and discusses the impact of health care policy changes on the Oncofertility field. "

Prenatal testing for genetic abnormalities has transformed pregnancy and motherhood. Using sociological research, this book analyzes the social-psychological and ethical implications of invasive prenatal testing, particularly CVS and amniocentesis. Among the issues covered are changes in the genetic counseling profession and in client demographics; the challenge of nondirective genetic counseling; decisions on testing and on which test to have; the timing and risks of the procedures; abortion and grief; the ethics of sex selection; potential uses and abuses of genetic knowledge; and policy and ethical implications.

'Maisie's knowledge of hormones changed my life... you need this book' Anna Jones 'Hill's advice is straightforward and no-nonsense' The Guardian 'An informative must-read for any woman - whatever their age' Vogue online During perimenopause three quarters of women will experience symptoms such as mood changes, insomnia, hot flushes, and night sweats, but there is little in the way of evidence-based information out there to help and guide us. Perimenopause Power is the essential handbook to understanding what the hell's going on and to empower us to improve our experience of the dreaded 'change'. Maisie Hill, the highly qualified women's health expert, best-selling author of Period Power and founder of The Flow Collective, takes us through the physiological changes of perimenopause and menopause, step by step, with calm positivity. In this invaluable guide she shares tips and advice to support women through the challenge of wildly fluctuating hormones. A must-read for anyone looking for a well-researched, evidenced-based book on perimenopause and menopause that gives women the information they need to address their hormonal needs. Perimenopause Power will help women to understand what's going on with their bodies and how to deal with troublesome symptoms, and share valuable insights into making it a positive and powerful experience. 'Maisie Hill helps you understand the changes in your body and psyche during the lead-up to menopause and how to handle symptoms.' Top Sante 'Maisie Hill gets rid of myths, sheds light and allows for an open, honest and much-needed conversation' Mind

No single area of medicine promises more acrimonious and intense debate in the coming decades than the implications of new medical technologies on the maternal-fetal relationships. This is the only book to combine comprehensive coverage of the legal and social issues raised as a result of both emerging technologies for fetal intervention and increasing knowledge of fetal development. It examines such issues as the effects of maternal behavior on the fetus's health, hazards in the workplace, teenage pregnancy, and the use of therapeutic and diagnostic techniques. The volume also summarizes the legal/political context of policies regarding the mother's responsibility for the welfare of the fetus and describes the current status of these issues in public law. The work opens with a framework for examining rights and, in chapter 2, gives an in-depth description of knowledge about the impact of maternal actions on fetal development. Attention then turns to current trends in case law, as Chapter 3 traces the growing acceptance of causes of legal action for prenatal injury or death of the fetus. Chapter 4 extends this analysis to look at the changing legal context for defining standards of care for pregnant women. Chapter 5 examines three disparate but critical topics illustrating the pressures women face in the 1990s: workplace hazards, teenage pregnancy, and surrogate motherhood. The final chapter integrates the technological, legal, social, and political dimensions surrounding the maternal-fetal relationship into a context for creating an effective public policy.

The landmark text that has served generations of obstetrician-gynecologists-fully updated with the most current perspectives of the field Williams Obstetrics has defined the discipline for generations of obstetrician-gynecologists. Written by authors from the nationally renowned University of Texas Southwestern Medical Center and Parkland Hospital, the new edition of this authoritative, evidence-based work maintains its trademark comprehensive coverage and applicability at the bedside, while offering the most current information and insights. The culmination of a century of clinical thought, Williams Obstetrics, 26th Edition delivers expert coverage of obstetrical complications, such as preterm labor, pregnancy-related hypertension, infection, and hemorrhage. It additionally offers foundational content on reproductive anatomy, physiology, and prenatal care. The authors have enhanced this edition with 1,000+ full-color illustrations, plus an increased emphasis on the fast-growing subspecialty of Maternal-Fetal Medicine. No other text matches the long-established scientific rigor and accessibility of Williams Obstetrics. With its state-of-the-art design and review of the newest advances and protocols, this not-be-missed clinical companion brings positive outcomes within reach. New and updated content includes: Increased focus on Maternal-Fetal Medicine Greater coverage of hypertension and hemorrhage Deeper insights into in-utero complications Expanded fetal t section includes cutting-edge fetal imaging, genetics, prenatal diagnosis, and fetal disorders and therapy Basic science, physiology of labor, preterm labor updated with contemporaneous publications in the literature More obstetrical sonography figures Eye-catching illustrations, including updated graphs, sonograms, MRIs, photographs, and photomicrographs

Polycystic ovary syndrome (PCOS) is a classic female infertility condition affecting an estimated 6-10% of all women, many of whom are unaware of the problem. A disease that affects women from adolescence to menopause, PCOS is the single most common endrocrinologic abnormality affecting women. This book is an edited collection of writings that comprehensively covers the disease, from diagnosis and epidemiology of PCOS to clinical evaluation.

A comprehensive, cutting-edge review of the complex interactions between maternal and fetal-placental tissues that control the establishment and maintenance of pregnancy, the proper development of the fetus, the birth process, and the behavioral aspects of bonding between mother and newborn. Expert researchers review the endocrine and physiological events that culminate in the delivery of offspring, and provide a solid base of comparative information on the menstrual cycle of primates, including humans. They also discuss the sources and functions of both steroid and protein hormones from the placenta and the details of their effects on uterine function, placental development, fetal growth and well-being, and maternal responses to pregnancy. This book will become the standard reference source not only for reproductive scientists, but also for those clinicians who want better to understand the complex factors that affect pregnancy-and their pregnant patients.

Key Clinical Topics in Obstetrics and Gynaecology offers an indispensable and practical guide for exam revision and clinical practice. Written and edited by specialists with a wealth of experience, this book provides rapid access to the core topics in obstetrics and gynaecology. Each topic is written in a concise and easy-to-digest format, making this book an essential resource for exam revision and quick reference at the point of care. Over 100 topics presented in alpha order, from abnormality of the genital tract, to venous thromboembolism Effective exam revision for MRCOG Part 2 candidates Succinct coverage of clinical features, diagnosis and patient management Includes clinical photos and diagrams to improve understanding of concepts Contributions from experienced specialists to ensure authoritative, accurate content

Pelvic Inflammatory Disease is an in-depth, thorough guide for the clinician on the most common complication of sexually transmitted pathogens. Edited and written by the preeminent experts in the field, this volume presents the etiology, treatment, and diagnosis of PID, as well as chapters on risk factors, epidemiology, and prevention. In addition, the myriad clinical complications and challenges are discussed in chapters on tuboovarian abscess, PID and HIV infection, sequelae of PID, PID in adolescence, and PID in pregnancy. This is a must-have resource for obstetrician-gynecologists, primary care physicians, and all clinicians who provide health care to women of all ages.

This stimulating volume addresses vital questions about gene/environment interactions as they affect cell health from the prenatal period through later life. Beginning with a tour of epigenetic processes in the human body, the book assembles current theoretical and empirical developments across the discipline, among them transgenerational epigenetic inheritance, the effects of maternal nutrition on epigenetic change, and possible links between epigenetics and childhood obesity. Public health and policy aspects of the field are discussed in depth, with the understanding that much can be done to improve our epigenetic health as a species. And in this vein, contributors consider future possibilities, such as the reprogramming of genes to reverse cancer and other diseases. Included in the coverage: The role of environmental epigenetics in perinatal and neonatal development The epigenetic biomarker H2AX: from bench science to clinical trials What's the risk? Dental amalgam, mercury exposure, and human health risks throughout the lifespan Post-traumatic stress disorder: neurological, genetic, and epigenetic bases Children's exposure to alcohol, tobacco, and drugs: long-term outcomes Ethical implications of epigenetics Epigenetics, the Environment, and Children's Health Across Lifespans brings real-world knowledge and applications of this increasingly important field to public health practitioners, maternal and child health researchers, and environmental health experts.

Advances in technology now offer promising solutions to deal with the chronological aging of the cell, tissue or organ to synchronize its existence and its use. This book covers the developments in and benefits of the latest vitrification technology and its extensive applications in reproductive medicine. Protocols of gametes (oocyte and sperm), embryos, blastocysts and ovarian tissue cryopreservation have been reviewed by leaders in the field. In order to address the escalation in cross-border reproductive tourism entailing the transfer of reproductive cells and tissues rather than the patient, the challenges, caution and emerging possibilities of nitrogen vapor shipment of vitrified cells have been discussed. Current perspectives on oocyte banking present the reader with options and solutions to effectively utilize these gametes despite the physiological deterrents.The versatile applications and potential of vitrification of human embryonic stem cells, discussed in the concluding chapter, is an exciting reality offered by vitrification to help overcome numerous stumbling blocks in the management of various disorders.