A discussion of all the key issues in the use of human pluripotent stem cells for treating degenerative diseases or for replacing tissues lost from trauma. On the practical side, the topics range from the problems of deriving human embryonic stem cells and driving their differentiation along specific lineages, regulating their development into mature cells, and bringing stem cell therapy to clinical trials. Regulatory issues are addressed in discussions of the ethical debate surrounding the derivation of human embryonic stem cells and the current policies governing their use in the United States and abroad, including the rules and conditions regulating federal funding and questions of intellectual property.

In the United States, over half of pregnant women receive some form of anesthesia for their deliveries; this translates into well over 2 million anesthetics per year. With this new handbook, anesthesiologists have easy access to step-by-step, to-the-point information on how to manage patients in specific situations. Every aspect of obstetric anesthesia practice is covered, including patient evaluation, anesthesia for labor and delivery, anesthesia for cesarean delivery, management of patients with concurrent medical problems, management of obstetric emergencies, fetal assessment, and neonatal resuscitation. Distilled, synthesized text is complemented by a generous number of tables, charts, figures and flow diagrams, all presented in accessible handbook format. Obstetric Anesthesia is an ideal introduction to the specialty as well as an essential daily guide for obstetric patient care and management.

This authoritative volume describes the role of free radicals and antioxidants in prenatal and perinatal disorders currently explored in clinical and pre-clinical trials. In twenty-two inclusive chapters, the book covers the gamut of oxidative stress and its relation to a variety of factors, including fertility, metabolism, redox biomarkers, antioxidant defense and protection, gene polymorphisms, angiogenesis, cell signaling, mutations and oxidative damage involving lipids, proteins and nucleic acids, membrane trafficking, inflammation, mitochondrial dysfunction, alterations in immunological function, hypoxia, and post-natal stressors. This comprehensive source will keep clinicians and research scientists up-to-date on translational research into medical applications. Perinatal and Prenatal Disorders is a significant addition to the well-known Oxidative Stress in Applied Basic Research and Clinical Practice series.

This book offers a critical review of the pelvic sciences past, present and future from an anatomical and physiological perspective and is intended for researchers, medical practitioners and paramedical therapists in the fields of urology, gynecology and obstetrics, proctology, physiotherapy, as well as for patients.

The book starts with a construction plan of the pelvis and shows its structural consequences. The historical background of pelvic studies proceeds from medieval and early Italian models to the definitive understanding of the pelvic anatomy in the Seventeenth century. During these eras of pelvic research, concepts and approaches developed that are illustrated with examples from comparative anatomy and from mutations, also with regard to the biomechanics of pelvic structures. Perceptions of the pelvis as an important element in sexual arousal and mating conduct are discussed, as well as attitudes to circumcision, castration and other mutilations, in its anthropological, social context.

The anatomy and physiology of the pelvic wall and its organs as well as the development of these pelvic organs are covered as a prerequisite to understanding, for example, the spread of pelvic carcinoma and male and female bladder muscle function. Connective pelvic tissue is examined in its reinforcing capacity for pelvic structures, but also as a hiding place for infections. Innervations and reflexes relayed through the pelvic nerves are discussed in order to explain incontinence, sphincter function and the control of smooth and striated muscles in the pelvis.

Catheters and drugs acting on pelvic function are described, and a critical review of alternative clinical methods for treating pelvic dysfunctions is provided."

This second edition of a groundbreaking book is substantially revised to deliver the foundation for an evidence-based model for best practices in midwifery a model critical to raising the United States current standing as the bottom-ranking country for maternity mortality among developed nations. With a focus on updated scientific evidence as the framework for midwifery practice, the book includes 21 completely new chapters that address both continuing and new areas of practice, the impact of institutional and national policies, and the effects of diversity and globalization. Incorporating the midwifery model of care, the book provides strategies for change and guidance for implementing evidence-based best practices. The book examines midwifery efforts to improve the health of women and children in the U.S., for example, Strong Start, US MERA, Centering Pregnancy, a focus on physiologic birth, and successful global endeavors. It encompasses a diverse nationwide authorship that includes leaders in midwifery, academicians, midwives representing diversity, hospital- and community-based practitioners, and policymakers. This coalition of authors from diverse backgrounds facilitates an engaging and robust discussion around best practices. Chapters open with a contemporary review of the literature, a comparison of current (often scientifically unsubstantiated and ineffective) practices, evidence-based recommendations, and best practices for midwifery. Key Features: Focuses on scientific evidence as the framework for midwifery practice Addresses continuing and new, controversial areas of practice with strategies and guidelines for change Includes 20 out of 27 completely new chapters Authored by a diverse group of 44 prominent midwifery leaders Examines practices that are in conflict with scientific evidence

With insight and research from world-renowned experts, this book provides specific approaches to diagnosis and treatment, addressing pharmacologic and non-pharmacologic management. Specific conditions examined include asthma, rhinitis and sinusitis, anaphylaxis, atopic and contact dermatitis, urticaria and angioedema, hereditary angioedema, drug allergies, and primary immune deficiency. An overview of obstetric management of the high risk asthmatic and allergic patient is provided, and the book concludes with a discussion of the prevention of asthma and allergic diseases during childhood.

Praise for the previous edition: this textbook is a useful resource for medical students it will provide them with the basic information they need to survive clinics and to pass exams Clear, concise and colourful; perfect for easy learning and revision Times Higher Education Obstetrics and Gynaecology by Impey and Child continues to be an invaluable and authoritative resource for healthcare and medical students. This comprehensive guide provides the perfect level of detail on history and examination, investigations and diagnosis, as well as common diseases, abnormalities, and complications in gynaecology and obstetrics. Fully updated in accordance with NICE and other national guidelines, this fifth edition now includes: * New sections on FGM and influenza * Expanded areas in medical disorders in pregnancy and mental illness * Improvements to the popular management section along with a new section on sepsis * Colour coded sections on obstetrics and gynaecology for ease of use This new edition of Obstetrics and Gynaecology will be an indispensable support to help not only students to revise for exams, especially OSCEs, but also healthcare practitioners and practising doctors to structure their knowledge and improve their practice.

This detailed volume provides a robust set of methods to understand variation between patients with ovarian cancers, in vitro models to better study different stages of the disease, and in vivo models to test therapies. Beginning with clinical perspectives to orient basic scientists, the book continues with sections exploring methods to characterize features of the tumor microenvironment (TME), techniques to isolate cells for in vitro study, and in vitro and in vivo models to study the disease. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Ovarian Cancer: Methods and Protocols serves as an ideal guide for researchers seeking to improve their study of ovarian cancer and find new therapeutic approaches.

The present book on Molecular & Diagnostic Imaging and Treatment Strategies of ovarian cancer is one of two companion books with the second one being focused on Cell and Molecular Biology of Ovarian Cancer. Both books include new exciting aspects of ovarian cancer research with chapters written by experts in their respective fields who contributed their unique expertise in specific ovarian cancer research areas and include cell and molecular details that are important for the specific subtopics. Comprehensive and concise reviews are included of key topics in the field.

This cutting-edge text for surgeons specializing in Reproductive Medicine details how the latest minimally invasive developments impact on operations in their repertoire. Illustrated with color photographs and surgical videos, this will be an essential reference in a fast-moving field.

Hormonal influences, both natural and iatrogenic, are implicated in the most frequent health issues of women. Endometrial cancer is now the most common gynecologic cancer in the United States and the industrialized world. This cancer is strongly related to hormonal and metabolic factors. In addition, breast cancer treated with hormone therapy (Tamoxifen) may, in some cases, be associated with uterine pathology. Hormone therapy is used to improve the physiological effects and counteract abnormal and deleterious effects of "natural" hormonal activity. Millions of women receive hormone therapy at some point of their life: using oral contraceptives, reproductive technology, treatment for post-menopausal symptoms, among other uses. This book addresses a range of women's health issues, from fertility to neoplasms, and their relationship with natural and iatrogenic hormonal effects. Chapters include clinical and pathological descriptions, theoretical and practical medical issues, and original studies and cases. Controversial issues in certain hormone therapies are presented with updated concepts based on clinical studies and novel statistical methods. The book will be useful for specialized and general physicians, oncologists, endocrinologists, researchers, medical students, and others in the field of women's health.

It seems like every time a new mother turns on her computer, radio, or television, she is greeted with news of yet another scientific study about infancy. Ignoring good information isn't the right course, but just how does one tell the difference between solid studies, preliminary results, and snake oil? In this friendly guide through the science of infancy, Science of Mom blogger and PhD scientist Alice Callahan explains how non-scientist mothers can learn the difference between hype and evidence. Readers of Alice's blog have come to trust her balanced approach, which explains the science that lies behind headlines. The Science of Mom is a fascinating, eye-opening, and extremely informative exploration of the topics that generate discussion and debate in the media and among parents. From breastfeeding to vaccines to sleep, Alice's advice will help you make smart choices so that you can relax and enjoy your baby.

This easy-to-understand pocketbook in the highly respected Clark's stable of diagnostic imaging texts is an invaluable tool for students, sonographers and other ultrasound practitioners, providing practical guidance on clinical ultrasound procedures, summarising current relevant literature and professional body guidelines. The content is arranged by anatomical system and organ for ease of reference, with each section comprising a short introduction, the indications for the procedure, patient preparation, the imaging procedure itself, along with an image analysis, supported throughout by positioning photographs and clinical images. Clark's Essential Guide to Clinical Ultrasound is ideal for all users of clinical ultrasound at both undergraduate and postgraduate level and will also provide a convenient distillation of the latest best practice and guidelines for sonographers, midwives, vascular technologists, ECG technologists, medical doctors, sports injury specialists, paramedics, and other health professionals.

Extensive reviews have been published on the mor aspects, anatomy, ultrastructure, physiology, bio phology, anatomy, and physiology of the mam chemistry, endocrinology, pharmacology, and physiopathology of the mammalian ovary. The malian ovary. However, little attention has been given to the gaps between the physiological, endo contributors, who prepared their chapters metic ulously, are recognized experts in their respective crine and histochemical parameters of the ovary as disciplines and their writings reflect extensive per it relates to clinical aspects. There is a wealth of sonal experience and unpublished data of both publications concerning the biology of the ovary: basic and clinical sciences. Without the assistance of the purpose of this volume is to integrate this information with emphasis on modern concepts in good friends and permission to draw extensively microanatomy, physiology, methodology, clinical from investigations, this volume would not have complications, and therapeutic approaches. An been possible. attempt is made to place fundamental research in Thanks are due to G. F. Franchitto, F. Barberini, clear perspectives. P. Stoops. Lori Rust and J. Squiers for their editorial It is hoped that this volume will fulfil a long skills and for checking the references to the original standing need and serve as an important source for sources. Thanks are particularly due to 1. K. Smith investigators and clinicians concerned with the of Martinus Nijhoff Publishers BV for his excellent physiopathology of the ovaries for years to come. It cooperation during the production of the book."

This book presents expert opinions on a variety of key topics related to the management of breast cancer, with a focus on the implications of recent advances and research findings for clinical practice. It also explores the controversy regarding mammography screening and reviews the contribution of new imaging modalities. Considerable attention is paid to developments in surgical procedures, including the potential for the safe and effective use of sentinel lymph node dissection alone-even in patients with positive nodes-and to the advantages and contraindications of new radiotherapy techniques. Genetic aspects are discussed in detail, including an assessment of the role of genetic testing and the potential impact of genetic signatures on breast cancer management. New systemic strategies, such as anti-HER2 therapy, endocrine agents, and agents to reverse endocrine resistance, are considered, and the optimal use of chemotherapy for early-stage and advanced-stage disease is addressed. In closing, the book shares important new insights into lifestyle risk factors, risk reduction strategies, and survivor issues, including sexual dysfunction and fertility maintenance.

This book highlights the impact of nutrients on early placentation processes and their relevance for fetal growth and pregnancy outcome. The role of maternal nutrition on fetal growth and development has been evidenced in many epidemiological studies that included infamous Dutch famine, Helsinki Birth cohort and others. Fetal programming hypothesis states that the nutritional and other environmental conditions under which an individual develops from pre-conception to birth has a major impact on the future health of the newborn child. The developmental environment of the fetus is primarily dependent on two major factors that are maternal nutritional state (excess/low/imbalance) and placental function. Placentation is characterized by the extensive remodeling of the maternal uterine vasculature producing low-resistance blood vessels that facilitate the exchange of nutrients and wastes between the mother and the fetus. Cellular and molecular mechanisms involved in human placental blood vessel formation, which are now well established, are discussed.

In this unique book emphasis is placed on tests necessary to evaluate fetal well-being and to detect those fetuses at risk of hypoxia and acidosis in utero. Written by pioneers in the neonatal field, this publication contains chapters on the pathophysiology , obstetric management, and collagen diseases of intrauterine growth retardation. Ultrasound in detection of growth retarded fetuses is explored, as well as magnetic resonance imaging and magnesium substitution for the prevention of intrauterine growth retardation. Containing never-before-published information, this volume is an excellent reference source for both investigators in the field and those entering it. Topics Include: Perinatal growth chart for international reference Ultrasound guided procedures in small for gestation fetuses Utero-placental and fetal circulation

This volume comprehensively focuses on polycystic ovary, metabolic syndrome and obesity and their impact on women's health, reproduction and quality of life from adolescence to old age. PCOS is analyzed form the early origins - highlighting the importance of diagnosis, management and treatment starting from the high-risk period of adolescence - throughout infertility PCOS-related issues, pregnancy and menopause transition. All aspects of this syndrome are covered also in relation with endocrine and metabolic features that affects women's health. This book is a very useful tool for gynecologists, endocrinologists, obstetricians, reproductive medicine and general practitioners and is an important resource for all physicians involved in women's health.

This easy-to-understand pocketbook in the highly respected Clark's stable of diagnostic imaging texts is an invaluable tool for students, sonographers and other ultrasound practitioners, providing practical guidance on clinical ultrasound procedures, summarising current relevant literature and professional body guidelines. The content is arranged by anatomical system and organ for ease of reference, with each section comprising a short introduction, the indications for the procedure, patient preparation, the imaging procedure itself, along with an image analysis, supported throughout by positioning photographs and clinical images. Clark's Essential Guide to Clinical Ultrasound is ideal for all users of clinical ultrasound at both undergraduate and postgraduate level and will also provide a convenient distillation of the latest best practice and guidelines for sonographers, midwives, vascular technologists, ECG technologists, medical doctors, sports injury specialists, paramedics, and other health professionals.

Pregnancy and the Pharmaceutical Industry: The Movement towards Evidence-Based Care for Pregnant Women explores the issues surrounding the decision to undertake clinical trials with pregnant women. There is currently a lack of data on the safety and effectiveness of medications used during pregnancy as it is impossible to extrapolate that information from drug studies on men and non-pregnant women. As a majority of pregnant women confront a medical condition during their pregnancy, from simple pain, to ongoing or new medical issues, this book quantifies the current absence of pregnant women in drug studies and identifies ethical issues, barriers, litigation fears and opportunities. Those in the pharmaceutical industry, IRB members who approve or deny drug study plans, doctors, nurses and midwives working in obstetrics or involved in conducting studies at their institutions will find this book an essential resource.

The book provides detailed information on breast cancer and covers all the aspects of this rapidly spreading disease, such as applied anatomy and physiology, causative factors, various Investigations to reach a concise, definitive and complete diagnosis. The management of breast cancer involves multi-modality treatment and the book describes all the modalities in a very clear manner. It also discusses in a very lucid and practical way. the multi-prong treatment that the patient requires . Additionally, the book covers lesser-known areas of the subject like rehabilitation, management of lymphoedema, Extravasation of chemo-Infusion, organization of breast cancer management group, breast cancer awareness and patient education, follow up of the patient, and psychological support to these patients who have undergone mutilation of their organ. Edited by experts the chapters are contributed by renowned onco-sugeons from high volume and reputed centers in India such as, PGIMER, Chandigarh, AIIMS, New Delhi, and TMH, Mumbai among others. The book serves as a useful resource for surgeons, medical oncologists, radiotherapists, pathologists, radiologists and many other specialists interested in the field of breast cancer and actively working in this area. It is useful for practitioners and residents as well as for those who want to learn the different aspects of this disease.

This volume provides an overview of the research describing the effects of child maltreatment on mental health, cognitive and social-emotional development. It offers descriptions of selected empirically based treatments (EBTs) written by scholars associated with its development, training, or research on its effectiveness. Each contributor presents the theoretical foundation of the EBT and evidence of its efficacy, describes the treatment process and illustrates this process with a case study of its use with a maltreated child, and discusses possible limitations. Following the chapters describing the interventions, the editors address key issues of the dissemination and implementation of these EBTs. They describe the strategies the selected interventions have used to ensure treatment fidelity in training and dissemination from the perspective of implementation science's core components of implementation. The challenges of implementing EBTs, and the difficulty of fitting protocol to the reality of clinical practice in community mental health settings are also discussed. This volume offers a central source of information for students and practitioners who are seeking effective interventions to address problems associated with child maltreatment.