This essential volume presents comprehensive information on cell death and autophagy in liver diseases, including the role and molecular signaling pathways of cell death in alcohol and non-alcoholic fatty liver disease, bile acids, hepatitis C virus and drug-induced liver injury. The book starts with a discussion of lipotoxicity in non-parenchymal cells, followed by a discussion of cell death and autophagy in cholangiocytes, hepatic stellate cells and Kupffer cells in hepatic biliary diseases, fibrosis and liver inflammation. The book also covers Bcl-2 family proteins, beta-catenin and HMGB1 signaling in regulating cell death in the liver as well as mitochondria, ER stress and gut microbiota on liver injury. The Cell Death in Biology and Diseases series has recruited world experts ranging from basic scientists to clinicians on cell death in liver diseases. Likewise the contributors of this volume are leaders in their fields with worldwide expertise and perspective. Molecul es, Systems and Signaling in Liver Injury is an essential companion to Hepatocytes and Non-Parenchymal Cells and Diseases. It is beneficial for both clinicians and basic scientists and is relevant to those working on drug discovery for preventing and treating liver diseases by targeting cell death and autophagy pathways.

This book presents current recommendations for vaccination for pre- and post-exposure prophylaxis in all suitable target populations and groups. It provides immunization guidelines from the Occupational Safety and Health Administration for health care workers and others at occupational risk of exposure and for routine vaccinations by the Immune Practices Advisory Committee of the Centers for Disease Control.;Covering all aspects of the production, testing and applications of Hepatitis B vaccines, this book: lists all available vaccines worldwide; discusses all serological assays in the field; examines how the vaccine was tested in international clinical trials; describes new programmes for universal immunization of infants; and reveals how the vaccine may prevent some forms of hepatocellular carcinoma.;The book should be of interest to: infectious disease specialists, clinical virologists, immunologists, haematologists, oncologists, hepatologists and gastroenterologists, paediatricians, pharmacologists, molecular biologists, biochemists, biotechnologists, genetic engineers, occupational safety administrators and public health specialists; and upper level undergraduate, graduate and medical school students of these disciplines.

An easy to follow step-by-step guide to the most useful surgical skills from knot tying to simple procedures. Illustrated with colour photographs and video clips to demonstrate techniques, this book makes these practical skills as clear and easy to follow as possible. Including coverage of surgical instruments, wound management and suturing, and minor surgical procedures, it also explains how to use these essential surgical skills to make the most of a surgical placement. Healthcare students or junior professionals undertaking a placement in surgery or emergency medicine will feel confident and capable, and will be able to take an active role in surgical placements. Learning basic surgical skills is important for such placements, as well as for undertaking exams such as the Membership of the Royal College of Surgeons (MRCS).

"...excellent, well-organized, and timely." -Lester Packer and Enrique Cardenas, University of Southern California, Los Angeles, from the Series Preface The liver is a vital organ that is responsible for a wide range of functions, most of which are essential for survival. The multitude of functions the liver performs makes it vulnerable to a wide range of diseases. Mitochondrial dysfunction plays an important role in many liver diseases including drug-induced liver injury, alcoholic liver disease, and nonalcoholic fatty liver disease. Mitochondria in Liver Disease gathers the most current research regarding the role of mitochondria in the liver and various diseases to which it is susceptible. The book is separated into two sections, the first of which highlights the latest developments in mitochondrial research. It includes cutting-edge topics such as the regulation of mitochondrial respiration using hydrogen sulfide and the regulation of mitochondrial fusion-fission via the endoplasmic reticulum. The second section reviews the most current research on the role of mitochondria in a wide range of liver diseases. It also addresses novel topics such as the importance of liver mitochondrial constituents as biomarkers of liver injury in plasma and as regulators of the immune system. Mitochondria in Liver Disease represents the current state of knowledge and research on mitochondrial roles in liver diseases. Written by a group of global experts, it provides an authoritative and comprehensive overview of the latest advances and methods that mark key starting points for future research.

A new revision guide designed to help candidates prepare for the first part of the FRCS general surgery exam. Due to a lack of preparatory resources for the exam, this book bridges the gap, offering updated guidelines and information which will help candidates succeed. It acts as a supportive revision guide which will enrich other FRCS exam resources. This resource provides an updated approach to the FRCS exam. Using questions written by practicing surgeons, the book offers more contemporary revision materials, touching on topics not widely covered in other FRCS revision aids. Readers will gain a familiarity with the style of the FRCS exam, as Higher FRCS uses a style reflective of the exam to enhance the candidate's knowledge, confidence, and preparation. The audience for this book includes general surgery trainees who are preparing for their higher exams (including FRCS), alongside surgical trainees taking the MRCS. It is also a beneficial resource for students in other medical courses studying for surgical exams.

Diseases of the Liver in Children: Evaluation and Management provides a comprehensive, state-of-the art review of pediatric liver disease, with a practical approach useful for the primary care provider or general gastroenterologist. With an emphasis on tables and images, this book serves as a reference for understanding basic hepatic processes and the significance of laboratory findings. It also discusses the state of the art of diagnosis and treatment of diseases that affect the pediatric liver. The text captures the key elements of treatment and monitoring important for the primary care provider partnering in the care of these patients with pediatric hepatologists. The current state of transplantation and other surgical approaches are also discussed. The importance of aggressive bowel rehabilitation in the prevention of end-stage total parenteral nutrition-induced liver disease is also covered. Written by experts in their fields and including the most up to date clinical information, Diseases of the Liver in Children: Evaluation and Management serves as a very useful resource for physicians.

For surgeons, physicians, and anatomists involved in the management and study of disorders of the liver, bile ducts and pancreas, eponyms are part of everyday communication. They help to describe anatomical features, operative procedures, surgical instruments, and diseases. Unfortunately, many have become distorted or are inaccurately applied. Few of us understand their derivation or the remarkable people and controversies behind them. This book explores the origins of seventy eponyms in the field of hepatobiliary and pancreatic surgery and anatomy. Each section is deliberately short and intended for quick reference, providing accurate information about the origin of the eponym and the figure behind it. Meticulously researched, and beautifully illustrated with more than 150 photographs, Eponyms in Surgery and Anatomy of the Liver, Bile Ducts and Pancreas is aimed at surgeons, physicians and anatomists, and is sure to enrich the reader's historical perspective of this fascinating branch of surgery and anatomy.

Featuring more than 4100 references, Drug-Induced Liver Disease is an invaluable reference for gastroenterologists, hepatologists, family physicians, internists, pathologists, pharmacists, pharmacologists, and clinical toxicologists, and graduate and medical school students in these disciplines. This book supplies an in-depth discussion of drug-induced hepatoxicology, covering mechanisms, histopathology, management, risk factors, and patterns of drug and toxin-induced disease. It includes contributions international experts.

Chronic viral hepatitis affect hundreds of millions of people worldwide, and each year millions more people become infected. In Chronic Viral Hepatitis, Second Edition, a panel of distinguished clinicians and clinical investigators build upon the first edition by comprehensively reviewing all the relevant new information regarding resistance, side effects, and therapies for chronic viral hepatitis. The text covers recent advances in the understanding of pathogenesis of viral hepatitis while discussing promising agents in development for its treatment. The authors devote special attention to reactivation of hepatitis B with chemotherapy and immunosuppression, herbal and non-traditional therapies, chronic viral hepatitis in the pediatric population, and immunology and immunotherapy of HCV and provide relative costs for all diagnostic and therapeutic options. Authoritative and up-to-date, Chronic Viral Hepatitis, Second Edition offers today's gastroenterologists, internists, hepatologists, and infectious disease specialists a practical guide to the recognition, diagnosis and treatment of chronic viral hepatitis from a multidisciplinary approach.

Cholestatic disorders of infancy and adulthood represent a major group of causes of end-stage chronic liver disease. There has been great scientific interest in these disorders in recent years, so the time has come to evaluate treatment modalities in old and even new cholestatic diseases. Since secondary malnutrition plays an important role in inducing multiorgan morbidity in these patients, nutritional and metabolic aspects need better understanding. The influence of disease and nutrition-related problems on liver transplantation as the ultimate therapy of cholestatic disorders is also of current interest. This book, the proceedings of an International Falk Workshop held in Hamburg, Germany, 25-26 January 1996, brings together a group of experts from around the world to explore and elucidate these topics. It will be of interest to all hepatologists and clinicians, especially paediatricians.

Chronic hepatitis B and C affect 520 million people worldwide, and are a major cause of chronic liver disease and of mortality, despite the efficacy of the vaccine. Hepatitis B and C: Management and Treatment second edition provides a practical explanation of the natural history and management of the disease, and examines the benefits of the most recent drugs, and their effects, whether used in isolation or as part of a combination therapy. This second edition expands the coverage of treatment of various difficult-to-treat patients and will be a welcome guide to the physician in both clinical decision-making and in explaining the benefits and side-effects to the patient.

Protect your mighty liver! Learn how it keeps you healthy, how to keep it healthy, and why you need to act now! The liver is the most overlooked and misunderstood of all our body's organs. Because of the sudden, potentially fatal consequences of heart attack and stroke, everyone's attention is always focused on the heart or the brain, but without a healthy liver, you ultimately cannot survive. Of all your organs, none does more for you than the liver. Still, until something goes wrong with the liver, it's usually completely overlooked. The Liver Cure: Natural Solutions for Liver Health to Target Symptoms of Fatty Liver Disease, Autoimmune Diseases, Diabetes, Inflammation, Stress & Fatigue, Skin Conditions, and Many More explains the major reasons why you need to take action NOW to protect your liver, because it is assaulted everyday by factors in our modern-day life. The liver is the site for the body's most powerful detoxification, but over the years an unhealthy diet, sedentary lifestyle choices, and environmental toxins can take their toll on liver health. World renowned physician and author Dr. Russell Blaylock provides a comprehensive overview of the liver, outlines the latest health information on the many dangers to your liver-health, and what you can do to protect it: Why the Liver is Your Body's Most Important Organ Your Liver's Role in Disease The Dangers of Cancer, Cirrhosis, Hepatitis & Fatty Liver Disease Medication & Environmental Hazards Poor Lifestyle Choices that Will Hurt Your Liver The Best Exercise for Liver Health How to Follow a Pro-Liver Diet Transplant Options & Cautions The Liver Cure offers natural remedies, lifestyle strategies, and dietary solutions that can take your liver off overload to resolve a wide range of symptoms and conditions, along with the latest treatment solutions from conventional and alternative therapies to new scientific discoveries and interventions.

Liver Regeneration: Basic Mechanisms, Relevant Models and Clinical Applications presents cutting-edge information on liver regeneration research through an integrated, systems-wide perspective. The book addresses discoveries on hepatic progenitor cells, liver regeneration after chemical damage, and liver regeneration as a prime therapy for liver failure and disease. By addressing the urgent need for translating basic research findings into clinically relevant modalities and potential therapeutic applications, the book provides the data needed to improve liver patient management. Hundreds of full-color, graphic photographs and illustrations underline key elements and show researchers and students important aspects of liver transplantation, immunofluorescence, and other techniques used in liver regeneration.