The new edition of this pocket guide has been fully updated to cover the common manifestations of liver disease, how to treat them and when to refer patients on to specialist centers. New chapters on Acute Liver Failure, Nutrition and Congenital Heart Disease have been added to reflect the key issues in management of liver diseases. The book outlines the common clinical liver diseases such as fatty liver disease and viral hepatitis, among others, and their current up to date management. Written by experts in the field and containing figures and tables, as well as case histories and questions, this is an enjoyable and reader-friendly book for the busy physician. With its authoritative, didactic style and short chapters, it covers the common presentations and complications of liver disease, and how to deal with them. Given the increasing prevalence of liver disease in the UK and Worldwide, this is an ideal reference book for primary care physicians, doctors in specialist training, clinical nurse specialists and for gastroenterologists, who see patients with liver disease in their working lives.

This atlas describes and illustrates in detail the surgical procedures employed in laparoscopic anatomical liver resection, according to tumor location. The surgical approach and techniques are explained for each type of laparoscopic liver resection based on the involved anatomical segment, section, and hemi-liver. Attention is also drawn to potential complications and the means of preventing and managing them. Beyond anatomical liver resection, guidance is provided on non-anatomical resections that do not pay regard to segmental, sectional, or lobar anatomy. The coverage is completed by the inclusion of useful information on instruments and energy devices as well as the basic skills required for laparoscopic liver resection. In presenting a clear practical approach to each laparoscopic anatomical major and minor resection, the Color Atlas of Laparoscopic Liver Resection will be an invaluable guide for trainees. In addition, it will equip more experienced surgeons with much useful information that will enable them to further improve their technique.

Signaling Pathways in Liver Diseases, Third Edition again provides hepatologists and hepatology researchers with an expert overview of the complex and novel cellular/extracellular signaling pathways in the liver, and their role in liver diseases. The last few years have seen a great number of developments in this field, which in turn have led to new opportunities for innovative treatments; however, the intricacy of these pathways and their interactions continue to provide a real challenge for clinicians. This outstanding book compiles the emerging knowledge into a single expert resource, cataloguing and organizing it into an accessible and understandable format. With increased focus on the comprehension of cellular mechanisms involved in steatohepatitis, cirrhosis, and liver tumors, which has led to changes in the management of these diseases, this new edition also sees the introduction of exciting new chapters on key emerging areas such as: * Autophagy * Notch Pathway * P13K/PTEN Signaling in Liver Diseases * Sirtuins * Hepcidin and Iron * Epigenetic Regulation of Hepatic Stellate Cells and Liver Fibrosis * Oxidative Stress and Signaling in the Liver. Professors Dufour and Clavien have assembled an all-star cast of chapter authors, each of whom has provided clear and appropriate illustrations to reinforce the text, with a key points box offering a concise and handy summary. Self-assessment questions and answers allow the reader to test their own knowledge. Signaling Pathways in Liver Disease, Third Edition is the perfect educational and reference tool to bridge the information exchange between the laboratory, the clinical ward, and the operating room, and an essential tool for the modern-day hepatologist.

The Understanding Hepatitis chart is a comprehensive overview of the different types of hepatitis, including symptoms, causes and treatments. External views of healthy and cirrhotic livers are shown, including a view of the liver lobules. Heavy cover stock with protective varnish for durability.

This book presents the latest application of digital medical imaging technology in biliary tract surgery, including three-dimensional visualization preoperative evaluation, preoperative surgical planning, and simulated biliary surgery. Digital surgical diagnosis and treatment of cholecystolithisasis, bile duct stones, hepatolithiasis, gallbladder cancer, and bile duct cancer is described in details with more than 900 illustrations. Written by experts with wealthy of clinical experience, it will be a useful reference for general surgeons, as well as practitioners in related disciplines.

This book provides a comprehensive overview of the diagnosis and management of diseases of the biliary tree. Topics covered include: congenital biliary abnormalities, genetic cholangiopathies, autoimmune cholangiopathies, inflammatory and drug-related cholangiopathies, and cholangiocarcinoma. Given their particular importance (even for clinicians working with adults), pediatric conditions are also examined. In addition, a special section is devoted to pregnancy and diseases of the biliary tree, and to transplants and diseases of the biliary tree. Each chapter offers up-to-date information on the management of the diseases discussed. Moreover, the book addresses new treatments for autoimmune cholestatic liver diseases, reflecting the new therapeutic targets that have recently been discovered. Examples include farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor (PPAR)-agonists, together with new drugs that affect the composition of bile flow. Given its scope, the book offers a valuable guide for a broad range of practitioners.

This is the second of two volumes that together provide a comprehensive analysis of the embryology, normal anatomy, and pathology of the liver and intrahepatic biliary tract as seen on modern diagnostic imaging techniques. In this second volume, readers will find comprehensive description and illustration of the imaging appearances of tumoral pathologies, both in the "normal liver" and in the context of chronic liver disease and liver cirrhosis. In addition, the imaging findings in relation to different treatment approaches are presented, with extensive coverage of imaging of tumor response and post-treatment changes. The authors are world-leading experts in the field, and the book will be an ideal reference for all members of the radiology community, from residents to experts. It will also aid clinicians during their daily practice.

There are many diagnostic imaging techniques for the radiological exarmna- tion of the abdomen. Noninvasive methods include supine and upright views of the abdomen (sometimes fluoroscopy and decubitus films); posteroanterior (PA) views of the chest; contrast studies of the alimentary tract; ultrasonogra- phy (US), scintigraphy, computed tomography (CT), and magnetic resonance imaging (MRI). Biopsy under fluoroscopic control and angiography are inva- sive techniques. Most of the errors described in this book are related to faulty interpretation; others are due to improper technique. For example, a patient with acute abdominal pain secondary to a perforated hollow viscus may be studied only by supine and upright views of the abdomen that do not include the subdi- aphragmatic regions. A complementary PA view of the chest or a left lateral decubitus film would, however, detect free air in the pentoneal cavity that the incomplete two-film study might have missed. Errors of techmque are due to under- or overexposure, long exammation times or an uncooperative patient (both of which can induce motion artIfacts), improper processing, and failure to perform the proper standard noninvasive or mvaSlVe modalitIes for examining the hollow viscus and the solid organs of the alimentary tract. In order to visualize the diaphragm and the supra- and mfradiaphragmatIc spaces, frontal and lateral chest roentgenograms complement the standard views of the abdomen. Fluoroscopy IS of great value m assessing diaphrag- matic motion as well as being essential when contrast media are utilized.

This title includes proceedings of the International Congress held in Chamrousse (France), 1-2 February 1991.

This book presents the first comprehensive review of all facets of liver transplantation using DCD donors. Each of the 19 chapters are written by leading experts in the field, representing some of the most experienced DCD liver transplant programs in the world. Several topics have overlapping coverage in different chapters, providing the reader with the perspective of multiple experts on crucial topics. Chapters also highlight the steps towards building a DCD liver transplant program, the importance of donor and recipient selection, as well as state-of-the-art developments and future directions in the utilization of these organs. Donation after Circulatory Death (DCD) Liver Transplantation serves as a valuable resource for all those involved in liver transplantation using DCD donors.

This book provides up-to-date information on all aspects of gallbladder disease. After an introductory section on laboratory findings, pathology, and diagnostic methods, it focuses on specific conditions and their management, covering gallbladder stones, acalculous cholecystitis, gallbladder lesions associated with IgG4-related disease and with anomalous pancreaticobiliary ductal union, and dyskinesia of the gallbladder. Moreover, it discusses incidental gallbladder carcinoma in detail, including epidemiology, risk factors, gene mutations, diagnostic imaging methods and treatment modalities. The book also features a section exploring important current issues, such as the diagnosis and therapy of polypoid lesions and gallbladder wall thickening, and the role of prophylactic cholecystectomy in patients with concomitant gallstones following removal of common bile duct stones by ERCP. It also compares endoscopic gallbladder drainage with percutaneous transhepatic gallbladder drainage. Lastly, the book offers stimulating future perspectives.

This is the first of two volumes that together provide a comprehensive analysis of the embryology, normal anatomy, and pathology of the liver and intrahepatic biliary tract as seen on modern diagnostic imaging techniques. In this volume, readers will find fundamental information on embryology, radiological anatomy, and anatomic variants. A thorough introduction is then provided to each imaging technique, including ultrasound, computed tomography, magnetic resonance imaging, nuclear medicine techniques, angiography, and interventional radiology. The remainder of the volume is devoted to non-tumoral pathology of the liver and intra-hepatic biliary tract. For each disease, readers will find full description of the roles of individual imaging modalities and extensive illustration of the imaging appearances. The authors are world-leading experts in the field, and the book will be an ideal reference for all members of the radiology community, from residents to experts. It will also aid clinicians during their daily practice.

This book focusses on the latest results related to the field of bile acids as signaling molecules and describes how these receptors have become a major pharmacological target. It covers all major areas of research in this field, from genetics, chemistry, in silico modeling, molecular biology to clinical applications, offering a cross-country view of the functional role of bile acids as signaling molecules, virtually acting on all major areas of metabolism. While FXR and GPBAR1 are essential bile acid sensors that integrate the de novo bile acid synthesis with intestinal microbiota and liver metabolism, in a broader sense, BARs play a pathogenic role in the development of common human alignments including liver, intestinal and metabolic disorders, such as steatosis (NAFLD) and steato-hepatitis (NASH), diabetes, obesity and atherosclerosis.

The Understanding Hepatitis chart is a comprehensive overview of the different types of hepatitis, including symptoms, causes and treatments. External views of healthy and cirrhotic livers are shown, including a view of the liver lobules. Heavy gauge 3ml lamination with sealed edges and two metal eyelets for hanging makes chart highly durable. Write-on/wipe-off with dry erase marker (not included).

This volume provides the most comprehensive coverage of clinical management of borderline resectable pancreatic cancer available. Authored by leaders in the field, the book focuses on current clinical management of this disease stage, the importance of multimodality treatment algorithms, and an interdisciplinary approach to care. Surgical chapters are well-illustrated to provide surgeons and surgical trainees with important technical pearls. Clinical trials and trial design are also discussed. Multimodality Management of Borderline Resectable Pancreatic Cancer is a valuable resource for gastroenterologists, medical oncologists, radiation oncologists, surgical oncologists, general surgeons, and trainees interested in the treatment of pancreatic cancer.

This volume provides a concise yet comprehensive overview on surgical procedures performed on the cirrhotic patient. The text explains the underlying pathophysiologic alterations in liver disease and cirrhosis, provides assessment of disease severity and risk factors, and helps to predict potential outcomes based on the nature of the operation. Operations discussed in detail include bariatric surgery, colorectal surgery, hepatic surgery, kidney transplantation, gynecological procedures, neurosurgical procedures, and ophthalmic surgery. The book is also supplemented with instructive color illustrations and tables. Written by experts in the field, Surgical Procedures on the Cirrhotic Patient is a valuable, multidisciplinary resource for clinicians who treat the cirrhotic patient. With a Foreword by Thomas E. Starzl, the father of liver transplantation.

Postgraduate education courses taught by the leading hepato-gastroenterologists in Europe, members of the EAGE, are published each year as part of this collection.

* Hepatocellular carcinoma (HCC) used to be regarded as a rare disease. However, the increasing numbers of chronic HCC carriers in the U.S. and subsequent increased incidences of HCC seen in most large medical centers means that it is no longer an uncommon disease for gastroenterologists or oncologists to encounter and its incidence and epidemiology are changing. During this exciting time in the field of HCC basic science and clinical management, many changes are simultaneously occurring at multiple levels of our understanding and management of the disease. Suddenly, there are several new choices of therapy to offer patients. Hepatocellular Carcinoma, 3rd edition addresses this fast-changing disease and gives the reader a clearer understanding of the many mechanisms involved in carcinogenesis of the liver. This comprehensive and detailed review of how to diagnose and treat hepatocellular carcinoma is written by international leaders in the field, covering both clinical treatment choices and the basic science underlying HCC development. Updated and enhanced from the last edition in 2009, Hepatocellular Carcinoma, 3rd edition features 12 new chapters including discussion of molecular markers, molecular hepatocarcinogenesis, microenvironment, heterogeneity, the new and exciting contributions of immunotherapy, and updates on the major effective hepatitis therapies that will transform HCC incidence and perhaps also the therapy. This cutting-edge text is a vital resource and must-have for today's hepatologists and medical and surgical oncologists. "This is a well written text and should be a good reference book for those who see patients with HCC.." - Practical Gastroenterology "...a useful tool for both physicians and surgeons with a specific interest in the management of patients with HCC." - Digestive and Liver Disease

This book helps scientists, clinicians and other interested individuals understand recent clinical advances and challenges for the future. It covers many basic aspects of the pathogenesis of chronic hepatitis C, HCV infections in particular populations, approaches to therapy, and prevention and control of HCV Infection. The book provides a succinct review of the large amount of data generated by multiple groups over the past two decades that has revealed the natural history of HCV infection. Similarly, it summarizes current understanding of the origins of HCV-associated hepatocellular carcinoma, cirrhosis and hepatic fibrosis. Extra-hepatic manifestation and metabolic disorders related to HCV infection are described. In this volume, these clinically important aspects of HCV infection are comprehensively described. Highlights are description of newly developed direct- acting antivirals. The authors represent a worldwide distribution of leaders in the field reflecting the global nature of HCV infection. Based on recent data concerning the genetic- and geographical diversity of HCV, and increased global disease burden of HCV infection, challenges for global control of HCV infections are described.

For people with alcohol excess and liver disease, successful management must be two-fold with management of both their psychological/physical addiction to alcohol and their liver disease. Alcohol Abuse and liver disease, with its joint focus on hepatology and psychiatry, provides both hepatologists and psychiatrists of all levels with a practical, concise and didactic guide to the investigation and clinical management of those with alcohol-related problems. Edited by a practicing hepatologist in the UK and a practising specialist in psychiatry/substance abuse in the US, it covers areas such as: Risk factors for alcoholic liver disease Interaction of alcohol with other co-morbidities Clinical assessment of alcohol intake Detoxification and management of withdrawal Psychotherapeutic and pharmaceutical interventions Treatment of liver disease Key points, management diagrams and high-quality images are all be supported by the very latest in clinical guidelines from the major hepatology and psychiatry societies such as the APA, EPA, AASLD and EASL. With increasing emphasis on multi-disciplinary speciality care in this area, this is the ideal tool to consult in order to provide the best care possible care for what are very challenging patients to manage.

This book is directed towards post-graduates who have passed Part I of the examination for Membership of the Royal College of Physicians and are preparing for Part II. However, it is hoped that physicians at all stages of their careers will find some parts that interest them. Most of the material has appeared in the Hospital Update series, 'Preparation for MRCP', but this has been modified and expanded; many useful points arising from correspondence relating to the series have been included, and the authors would like to express their thanks to those who have written. It is not intended that this should be used as a work of reference, although there is detailed discussion of some subjects. Only the written part of the examination is dealt with in detail, but the introduction contains hints on tackling the clinical sections which the authors hope the candidates will find valuable. There is, however, no substitute for clinical practice under supervision. The questions in Vll PREFACE the written section of the examination require short answers so that marking may be easy and objective. This book contains questions similar to those that may be encountered in the examination, but the answers have been expanded as a basis for discussion. It is hoped that this will encourage the candidate to read around the subjects covered, and the authors recommend that the questions are used as a basis for group discussion, as answers other than those in the text may be considered.

This clinical casebook provides a comprehensive yet concise state-of-the-art review of pancreatic disease. Presented in a case-based format, each case focuses on a different varient of pancreatic disease and pancreatic cancer, with sections on diagnosis and early detection, management of the disease, and treatment of complications from the disease. The role of neoadjuvant therapy for pancreatic cancer and emerging treatment algorithms for chronic pancreatitis are also highlighted in the text. Written by experts in the field, Pancreatology: A Clinical Casebook is a valuable resource for clinicians, surgeons, and researchers interested in caring for patients with pancreatic disease.

As there is a high incidence of disease recurrence after liver transplantation, this volume is designed around the need for a reference text dealing exclusively with this problem. The book places special emphasis on pre- and post-transplant predictors of recurrence, severity assessment, prophylaxis, and treatment. Pathobiology of disease recurrence is discussed in detail where applicable. Issues including quality of life and cost burden are also covered in the text. Written by well-known authorities in each field, Disease Recurrence After Liver Transplantation: Natural History, Treatment and Survival serves as a comprehensive reference for physicians and surgeons who take care of liver transplant recipients and a major addition to the literature detailing the current understanding of disease recurrence.

Iron Physiology and Pathophysiology in Humans provides health professionals in many areas of research and practice with the most up-to-date and well-referenced volume on the importance of iron as a nutrient and its role in health and disease. This important new volume is the benchmark in the complex area of interrelationships between the essentiality of iron, its functions throughout the body, including its critical role in erythropoiesis, the biochemistry and clinical relevance of iron-containing enzymes and other molecules involved in iron absorption, transport and metabolism, he importance of optimal iron status on immune function, and links between iron and the liver, heart, brain and other organs. Moreover, the interactions between genetic and environmental factors and the numerous co-morbidities seen with both iron deficiency and iron overload in at risk populations are clearly delineated so that students as well as practitioners can better understand the complexities of these interactions. Key features of the volume include an in-depth index and recommendations and practice guidelines are included in relevant chapters. The volume contains more than 100 detailed tables and informative figures and up-to-date references that provide the reader with excellent sources of information about the critical role of iron nutrition, optimal iron status and the adverse clinical consequences of altered iron homeostasis. Iron Physiology and Pathophysiology in Humans is an excellent new text as well as the most authoritative resource in the field.

This book reports the recent progress in gene and cell therapy through the liver and aims to facilitate a comprehensive understanding of the current aspects and future prospects from basic research to clinical therapies. Edited by pioneering researchers, this volume presents extensive information to principal investigators, researchers, postdocs and clinicians for examining the wide varieties of pathological conditions both inside and outside the liver. Providing not only the basic and clinical aspects of therapy, this volume is special in that it focuses on the administrative and regulatory difficulties of actual clinical application and legal regulations in different parts of the globe. By indicating the advantages and limitations of the most promising gene and cell therapies targeting the liver, this book will inspire readers to develop a feasible treatment in the next generation.