The treatment of bile duct benign pathology demands a multidisciplinary approach, involving a team of both specialised physicians and solid infrastructure. Radiologists, endoscopists, and surgeons are all involved in the treatment of these kinds of patients. This statement is also true for the diagnosis and treatment of the catastrophic results of bile duct injury. Cholecystectomy is one of the most common surgical procedures done either openly or through laparoscopy. The presence of bile duct injury is one of its most severe complications. The solution for this unfortunate event poses a technically demanding approach that involves an array of alternatives comprising surgical and radio-interventional procedures. This book focuses on benign bile duct diseases, mainly related to iatrogenic bile duct injury. The reader will find a complete and profound review of bile duct anatomy and function, a thorough explanation about the type of bile duct injuries and how to approach them, beautiful descriptions of both the surgical and radiological techniques used in the management of bile duct injuries, a compilation of the experience of a high-yield centre of this kind of diseases, and logical techniques to lower the incidence of these injuries. This text is aimed at an audience composed of health care professionals involved in the integrative treatment of iatrogenic bile duct injuries. In a world where the best medical evidence defines the most effective therapeutic alternative, this book focuses on giving a solid and broad enough basis upon which medical teams can approach this disease.

In the last few years, human metabolic disorders have become some of the most prevalent and prejudicial diseases worldwide. Hepatic steatosis, among many health problems, has several risk factors related to the disease prognosis such as obesity, nutritional problems, diabetes, hypertension, hyperuricemia, and even sleep apnea. Alcohol abuse also can lead to a severe liver-steatosis state. The progression of hepatic steatosis can lead to complications such as cryptogenic cirrhosis and hepatocellular carcinoma. Drug therapy has instead been focused on the mitigation of risk factors, however new potential therapeutic perspectives are being discussed. This book presents the origins, diagnosis and epidemiology of hepatic steatosis with new perceptions. The authors also aimed to show the molecular basis and signaling involved in liver disorders, discussing the inflammatory process, lipid metabolism and angiogenesis mechanisms. The role of nutrition in the treatment and development of steatosis was also presented and new advances were highlighted. Recent studies revealed the need for the use of bariatric surgery, functional foods and the modulation of endogenous systems, such as the sirtuins and renin-angiotensin systems, to treat liver disease. In this context, we aimed to introduce, review and discusses one of the most widespread metabolic disorders in the world: hepatic steatosis and its repercussions.

Practical, handy and succinct, this full colour pocketbook provides clear-cut clinical guidance to the main symptoms that infants and children commonly present with in both primary and secondary care. Clearly divided into specific sections covering the GI tract, liver and nutrition, Professor Kelly and her team discuss how best to investigate and manage specific clinical problems such as vomiting, abdominal pain, acute diarrhoea, constipation and jaundice using a highly clinical problem-orientated approach. They cover the management of important clinical problems such as chronic liver disease, ascites, malnutrition, obesity, coeliac disease and inflammatory bowel disease, and provide advice on nutritional problems in premature infants and children including weaning and food aversion. Key points, potential pitfalls, and management algorithms allow for rapid-reference, and link with the latest evidence, guidelines and protocols from ESPGHAN and NASPGHAN providing coverage of the major professional society recommendations for clinical practice. Brought to you by the experts, Practical Approach to Gastroenterology, Hepatology and Nutrition is the perfect accompaniment for trainees in gastroenterology, hepatology and pediatrics, as well as nutritionists, GI nurses and GPs.

Dx/Rx: Liver Cancer is a quick and practical reference guide containing all aspects of the diagnosis and therapy of hepatocellular carcinoma (HCC), prognostic and staging systems, clinical management, molecular biology, current controversies, and future insights. Organized into a condensed, bulleted format, this concise reference offers precise and up-to-date information on the epidemiology, classification, diagnosis, treatment, and risk factors for cancers of the liver. Presented in a handy, easy-to-read format, Dx/Rx: Liver Cancer is a must-have resource for oncologists, internists, primary care physicians, and other health care professionals on the ward or in the clinic.

Hepatic hydatidosis is a worldwide disease with a high socio-economic cost in endemic areas. Until recently, only professionals working in these areas treated hydatidosis patients, but now, due to migration and increasing intercontinental travel, any medical doctor may have to attend to patients with hydatid disease. Therefore, proper training in the diagnosis and treatment of these patients is necessary, not just in endemic areas which already have extensive experience in managing the disease, but also in institutions in countries like the United States where hydatidosis is still rare. In this book, we update all the epidemiological, radiological, clinical and therapeutic topics in liver hydatidosis. The chapters are written by a multidisciplinary group of physicians involved in treatment of the disease: microbiologists, gastroenterologists, internists, radiologists and surgeons. We conduct a complete review of all the treatment options in hydatidosis, including antiparasitic drugs, PAIR and surgery.

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. An intense, streamlined review for the gastroenterology board exam Gatroenterology and Hepatology Board Review: Pearls of Wisdom, 3e is a unique question and single-answer review for gastroenterology in-service and board exams. The book features about 3,500 questions with only the correct answer provided, reinforcing the answer students need to remember on exam day. Emphasis is placed on distilling key facts and clinical pearls essential for exam success. Features NEW chapter organization by anatomy to help poinpoint areas of weakness FULL COLOR image gallery NEW chapters on Radiography and Endoscopy

Chronic Hepatitis C virus (HCV) infection is a serious condition affecting over 180 million people world-wide. The virus infects the liver and while it is estimated that 20% of those infected clear the virus spontaneously, the virus persists in the majority of individuals leading to liver fibrosis, cirrhosis, and hepatocellular carcinoma. This book presents topical research in the study of the epidemiology, pathogenesis and treatment of Hepatitic C Virus including: genome-wide association studies regarding HCV infection; hepatic and blood dendritic cell subsets in patients with chronic HCV; bone metabolism disorders in HCV infection; Socs1 involvement in liver damage during HCV infection; asymptomatic low-level HCV persistence; and HCV infection as the leading cause of liver disease in renal transplant recipients.

Whether You're A Newly Diagnosed Patient, Survivor, Or Loved One Of Someone Suffering From Liver Cancer, 100 Questions & Answers About Liver Cancer, Third Edition Offers Essential And Practical Guidance. Providing Both Doctor And Patient Perspectives, This Completely Updated And Revised Edition Offers Authoritative Answers To The Most Commonly Asked Questions About Liver Cancer Including Diagnosis, Treatment, Post-Treatment Quality Of Life, And Coping Strategies. Written By A Medical Oncologist And A Gastrointestinal Surgeon, With Actual Patient Commentary, 100 Questions & Answers About Liver Cancer, Third Edition Is An Invaluable Resource For Anyone Coping With The Physical And Emotional Turmoil Of This Disease.

Primary human liver cancer, of which hepatocellular carcinoma (HCC) is by far the predominant type, is a major cause of cancer death world-wide, accounting for 700,000 deaths per year. The epidemiology of HCC is particular with both geographic and temporal patterns of incidence paralleling exposure to viral etiologic factors. The highest HCC incidence rates are areas endemic for chronic infection with Hepatitis B virus, mainly Asia and Africa. The pathways by which HCC develop are heterogeneous and influenced by a variety of environmental and host factors. This book is dedicated to hepatocellular carcinoma and includes contributions that span various aspects of the disease from epidemiology, mechanisms and viruses, to promising new biomarkers and targets for treatment.

This book provides a single reference for all transplant professionals involved in the care of HCV patients who have unique problems not encountered in other liver transplant patients. In the liver transplant community, it is well-known that decompensated cirrhosis from hepatitis C virus (HCV) is the leading indication for orthotopic liver transplantation (OLT) in the United States and most Western countries. Short-term results which initially seemed promising and comparable to other carefully selected liver transplant recipients now appear less encouraging with cirrhosis developing in 10-25% of patients by 5 years. Despite these concerns, there is an increased amount of data which supports re-transplantation in carefully selected patients.

The book describes in detail the technical aspects of Living Donor Liver Transplantation (LDLT), the routine practice of the world renowned Liver Transplant Team at Hong Kong's Queen Mary Hospital, and our views on various issues of the operation. The thorough review on the history and technical procedures of LDLT and discussion on various aspects of the operation and its future perspectives will serve as a unique reference for surgeons, researchers, nurses, medical students, patients and laypersons seeking information on LDLT.

This latest edition offers updated operative results from our center and the latest modifications of the technique. With contributions from a leading microvascular surgeon, a critical care clinician, a psychiatrist, and two anesthetists from the same liver transplant team, the LDLT experience at Queen Mary Hospital is depicted in an even greater extent.

In its Fifth Edition, this classic book retains its traditional strength of relating molecular physiology to understanding disease pathology and treatment as it explores the current state and future direction of hepatology.

Painstakingly revised, this edition includes 60 new chapters. As in previous editions, a section called Horizons summarizes advances of extraordinary nature in areas expected to have a substantial impact on hepatology. The Fifth Edition's Horizons section includes emerging topics such as tissue engineering of the liver, liver-directed gene therapy, decoding the liver cancer genome, and imaging cellular proteins and structure.

To preserve essential background information which has not changed while making room for the panoply of major new contributions to understanding of liver disease, 14 chapters from the previous edition are freely available online at gastrohep.com. To view these chapters visit - http: //www.gastrohep.com/theliver/

The Hepatic circulation is unique among vascular beds. The most obvious unique features include the dual vascular supply; the mechanism of intrinsic regulation of the hepatic artery (the hepatic arterial buffer response); the fact that portal blood flow, supplying two thirds of liver blood flow, is not controlled directly by the liver; the fact that 20% of the cardiac output rushes through the most vascularized organ in the body, driven by a pressure gradient of only a few millimeters of mercury; the extremely distensible capacitance and venous resistance sites; the unidirectional acinar blood flow that regulates parenchymal cell metabolic specialization; and the high concentration of macrophagic (Kupffer) cells filtering the blood. The liver is the only organ reported to have regional blood flow monitored by the autonomic nervous system. This mechanism, when dysfunctional, accounts for the hepatorenal syndrome and offers a mechanistic therapeutic target to treat this syndrome. The trigger for liver regeneration is dependent on hepatic hemodynamics so that chronic liver blood flow regulates liver cell mass. In severe liver disease, the whole body circulation is reorganized, by forming portacaval shunts, to accommodate the increased intrahepatic venous resistance. These shunts protect the venous drainage of the splanchnic organs but lead to loss of major regulatory roles of the liver. The development of knowledge of the hepatic vasculature is presented from a historical perspective with modern concepts summarized based on the perspective of the author's four decades of devotion to this most marvelous of organs. Table of Contents: Acknowledgements / Historical Perspectives / Overview / Fluid Exchange / Capacitance / Resistance in the Hepatic Artery / Resistance in the Venous System / Fetal and Neonatal Hepatic Circulation / In Vivo Pharmacodynamic Approaches / Nitric Oxide / Adenosine / Hepatic Nerves / Hepatic Circulation and Toxicology / Hepatorenal Syndrome / Integrative Hepatic Response to Hemorrhage / Blood Flow Regulation of Hepatocyte Proliferation / Multiple Mechanisms Maintaining a Constant Hepatic Blood Flow to Liver Mass Ratio / Pathopharmacology and Repurposing Drugs as a Research Strategy / References

Liver disease is a rapidly growing speciality, and nurses and health care professionals need to have the relevant knowledge and skills to care for patients with liver problems in a safe and effective way. "Liver Diseases" is a comprehensive, evidence-based, practical guide to the nursing care and management of patients with liver disease.

"Liver Diseases" explores a range of liver conditions, including cirrhosis, portal hypertension, alcoholic liver disease, viral hepatitis, autoimmune hepatitis, Wilson's disease and acute liver failure. It looks at the anatomy & physiology of the liver, assessment of liver function and diagnostic studies, acute and chronic liver disease, pregnancy related liver disease, liver transplantation and infectious liver diseases. For each condition the epidemiology, complications and nursing management are provided, along with illustrative case studies and further reading. "Liver Diseases" is an invaluable tool for all nurses and health care professionals working with people with liver disease.
SPECIAL FEATURESThe first UK book on care of the liver from a nursing and healthcare perspectiveWritten by a well-respected and renowned author in the fieldCovers a wide spectrum of liver diseases, with relevant nursing management guidelinesWith case studies, further reading and illustrations throughout

Busy clinicians need easily accessible information falling into two broad categories: diagnosis and management of patients with particular groups of symptoms; and comprehensive information on defined clinical problems. With this in mind, the Oxford Handbook of Gastroenterology and Hepatology has been structured in a unique way. The first section covers approaches to clinical problems detailing 29 of the most common problems in GI medicine, including infectious disease and gastrointestinal problems in developing countries. A key section of the handbook is a unique A-Z compendium of the specialty which includes information on 100s of topics in gastroenterology, from Abetalipoproteinaemia to Zieve's syndrome. Colour coded links enable readers to find information in related chapters quickly. Further sections include emergencies, and commonly used drugs used in gastroenterology and hepatology, with emphasis on practice tips and common complications. The result of this new approach is a handbook which is practical and informative, while being a pleasure to use.It is an essential guide to the management of common conditions and will be invaluable to all those involved in the care of patients with gastrointestinal disease.

Postoperative Syndrome sind ein besonders geeignetes Thema flir die interdisziplinare Gastroenterologie. Internist und Chirurg teilen sich in die Verantwortung flir die Entstehung derartiger Syndrome und die Crux ihrer Behandlung. Auch die Diagnostik ist eine gemeinsame Auf gabe, sowohl im Fa11e eines einzelnen Patienten mit Beschwerden als auch im Rahmen von Erfolgsbeurteilungen chirurgischer Eingriffe. Die postoperativen Syndrome haben bislang in der Literatur ein Schatten dasein geflihrt. Die wesentliche Ursache mag darin liegen, daB a11e Folge krankheiten nach chirurgischen Eingriffen zu leicht dem Chirurgen ange1astet worden sind. Viele postoperative Syndrome sind jedoch un vermeidliche, dem chirurgischen Eingriff zwangsIa ufig anhaftende F olgen. Mit diesem Buch solI eine objektive Wertung erfolgen. Das groBte Anliegen der Herausgeber besteht darin, geniigend Fakten flir eine sach bezogene Diskussion zu liefern und emotionellen Auseinandersetzungen den Boden zu entziehen. Die "Postsurgical Syndromes" erschienen 1979 .in den "Clinics in Gastroenterology" und wurden anIa13lich der deutschen Ubersetzung iiberarbeitet und erganzt. Der Dank der Herausgeber gilt Herrn Dr. F. Baumgartel flir die Mithilfe bei der Ubersetzung und dem Springer Verlag flir Hilfe und Entgegenkommen. Zurich J. R. SIEWERT A. L. BLUM Gottingen Friihjahr 1980 Inhaltsverzeichnis Kapitell Einleitung: Was ist ein postoperatives Syndrom? J. R. SIEWERT und A. L. BLUM. . . . . . . . . . . . . . . . . . .. . . 1 . ."

Surgery of the Liver, Bile Ducts and Pancreas in Children describes the modern approach to the diagnosis, management and surgery of childhood conditions of the liver, bile ducts and pancreas. The first edition was recognised worldwide as the textbook in this field; the second was expanded to include pancreatric diseases in children. This third edition has a new editor team from Kings College Hospital and the Children's Memorial Hospital in Chicago, both of which have considerable international reputations in diseases of the liver. It has been expanded and updated by an team of international experts.Key features: High qualilty operative line drawing will aid understandingEditorial team from the world-leading paediatric liver centers of Kings College Hospital and the Children's Memorial Hospital, ChigacoEach chapter is written by an expert of international renownFully revised section on Transplant SurgeryNow includes fully searchable ebookSurgery of the Liver, Bile Ducts and Pancreas in Children will be an invalulable resource for paediatric surgeons, gastroenterologists, paediatricians, nurses and anyone involved in the surgical care of children with liver, biliary, or pancreatic disorders, whether based at a specialist children's hospital or elsewhere. It will also appeal to trainees with limited experience in this area.

An easily accessible guide to diagnosing and managing critical situations, Emergencies in Gastroenterology and Hepatology aids doctors in dealing with acutely sick patients quickly and effectively. The book provides practical advice on how to make difficult decisions in an emergency situation. Areas covered include life and death emergencies, as well as the broad problems faced by on-call Gastroenterologists and Hepatologists on a daily basis. The focus throughout is on immediate management, but the book also includes reference to long term follow up for certain problems. Each chapter has an associated algorithm, which summarises the contents of the chapter, providing an aide memoir for the reader and facilitating learning, as well as being a quick reference tool. Bullet-point information for speed and clarity combined with the integral cross-referencing system, further enables quick access to the necessary information.

This book is a celebration of the emergence of knowledge in the field of pediatric hepatology and is written for primary care clinicians to help update their knowledge of the field. The current and future shortage of pediatric gastroenterologists and hepatologists necessitates steady, rejuvenated information on liver and gastrointestinal disorders for primary care clinicians as they care for children and adolescents with complex hepatologic/gastroenterologic dilemmas and disorders. In view of this shortage and the rapidly increasing knowledge in pediatric gastroenterology as well understanding indications for referral to pediatric gastroenterologists in the 21st century, au courant assiduous information aimed at primary care clinicians in these areas becomes increasingly important.

This book is written for the primary care clinician to help update knowledge of pediatric endocrinology (with an emphasis on diabetes) from both ancient and modern times. The current and future shortage of pediatric endocrinologists necessitates steady, rejuvenated information on diabetes and other endocrine disorders for primary care clinicians as they care for the child and adolescent with complex endocrine dilemmas and disorders. In view of this shortage and the rapidly increasing knowledge in pediatric diabetes as well as understanding indications for referral to pediatric endocrinologists in the 21st century, au courant assiduous information aimed at primary care clinicians in these areas becomes increasingly important.

This book discusses the diagnosis, treatment and management of liver disease. Chapter One reviews hepatic hydatidosis. Chapter Two explores the diagnosis, natural history, and management for patients with chronic hepatitis C (CHC). Chapter Three discusses scientific evidence that explains the relationship between metabolic syndrome, non- alcoholic fatty liver disease (NAFLD) and psoriasis and the treatment strategy for this co-morbid condition. Chapter Four examines the pathophysiology and treatment of liver cirrhosis. Chapter Five reviews surgical strategies to push up resection limits in liver disease and liver failure after surgery.

Bile acids (BAs) have received considerable attention as the key players of systemic metabolism. In the past, bile acids were known to play important roles in absorption of cholesterol, fat-soluble vitamins, and lipids. However, the new roles of bile acids as signaling molecules have been recognised in the last two decades because of discovery of bile acid receptors such as nuclear hormone receptor farnesoid X receptor (FXR) and the membrane receptor G-protein-coupled bile acid receptor 5 (Gpbar1, TGR5). As the metabolic regulators, BAs play pivotal roles in the regulation of bile acid, cholesterol, fatty acid, lipoprotein synthesis, glucose metabolism and energy metabolism. Therefore, BAs, bile acid derivatives, and bile acid sequestrants are potential therapeutic agents for treating a number of metabolic disorders, especially those related to the metabolic syndrome. The first chapter of this book summarises the basic information of bile acids but focuses on its new functions in different diseases. The next chapter discusses mixed micelles of bile acid salts and phospholipids starting from historical Smalls disc model up to the advanced version as "stacked disk" and "radial shell". The final chapter studies bile aspiration as a host factor for modulating chronic respiratory infection.

Textbook of Pediatric Hematology & Hemato-Oncology is a highly illustrated, comprehensive guide to diseases and cancers of the blood in paediatrics. Fifty chapters by internationally recognised paediatric haematologists and haemato-oncologists are grouped into seven sections, covering physiology, neonatal haematology, red blood cell and white blood cell disorders, bleeding disorders, transfusion medicine, haemato-oncology and other general topics. The haemato-oncology section covers cancers of the blood and includes lymphoblastic leukaemia, myeloid leukaemia (chronic and acute), juvenile myelomonocytic leukaemia, and bone marrow transplantation. The final 'general' section features discussion on gene therapy, monoclonal antibodies and biological response modifiers. Each chapter is peer-reviewed, with a list of references ensuring authoritative content, and the book is further enhanced by nearly 200 images and illustrations. Textbook of Pediatric Hematology & Hemato-Oncology is an indispensable resource for paediatricians, practitioners and trainees. Key Points Comprehensive guide to paediatric diseases and cancers of the blood 50 peer reviewed chapters with references 198 images and illustrations

The recently published article "The Burden of Liver Disease in Europe: A Review of Available Epidemiological Data" provides a few figures on the enormous problem that liver disease poses for Europeans. Liver disease is estimated to cause 170,000 deaths annually in Europe, 47,000 of which are attributed to liver cancer; 0.5%-0.7% of the European population is affected by chronic hepatitis B; and prevalence rates of hepatitis C virus (HCV) infection in the last decade in the European population ranged from 0.13 to 3.26%. These HCV-infected populations will develop complications in the years to come. It is of great concern that about 90% of people in Europe infected by viral hepatitis are unaware of their status. Alcoholic and non-alcoholic fatty liver disease (NAFLD) must also be added to the picture. NAFLD is becoming a major concern with the increasing incidence of obesity and type 2 diabetes in Europe. The burden of liver disease is not less pessimistic in North America, Asia and the rest of the world.