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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Infectious & contagious diseases > HIV / AIDS

HIV/AIDS in South Africa - The Facts and The Fiction (Paperback): Chris Jennings HIV/AIDS in South Africa - The Facts and The Fiction (Paperback)
Chris Jennings
R510 Discovery Miles 5 100 Ships in 18 - 22 working days

Few people realize that the familiar HIV/AIDS global statistics are actually estimates. For example, UNAIDS estimated that the Republic of South Africa (RSA) had 140,000 HIV/AIDS deaths in 1997. However, after tabulating all deaths for 1997, the Republic of South Africa attributed only 6,635 deaths to HIV/AIDS. Such discrepancies are rarely noted. The Republic of South Africa (RSA) stands as the exemplar of these discrepancies. It is reputed to have the world's largest AIDS epidemic with an estimated 5.6 million people living with HIV/AIDS (PLWH) in 2008. Such PLWH estimates, as with the estimates of HIV/AIDS deaths, are highly questionable. HIV/AIDS in South Africa: The Facts and the Fiction clarifies the reasons behind these discrepancies by describing two common misunderstandings of HIV infection that contribute to poor mathematical modeling outcomes. Fully referenced, HIV/AIDS in South Africa: The Facts and the Fiction presents and compares raw numerical data on: ? the tabulated number of HIV/AIDS deaths in the RSA; ? the number of AIDS cases detected by RSA disease surveillance systems; ? UNAIDS/WHO estimates for AIDS deaths in the RSA; and ? UNAIDS/WHO estimates for the number of people living with HIV/AIDS in the RSA. The total cumulative numbers of HIV/AIDS cases in the United States and the cumulative totals for the continent of Africa are also presented for purposes of comparison, and to place the African and RSA data within appropriate epidemiological context. Overall, these data span from 1981 to 2009. Altogether, these data, plus additional information detailing the nature of HIV infection and heterosexual HIV transmission rates, explain why the hyperbolic mathematical estimates and HIV antibody test surveys the primary sources of HIV/AIDS data in Africa are simply implausible. Contents: 118 pages, 20 tables, several side boxes, and 240 references.

HIV/AIDS - The Facts and The Fiction (Paperback): Chris Jennings HIV/AIDS - The Facts and The Fiction (Paperback)
Chris Jennings
R802 Discovery Miles 8 020 Ships in 18 - 22 working days

"The theory that AIDS originated in African monkeys arose from an incident of laboratory contamination." ? The scientific literature is clear: (1) New York City is the epicenter of the AIDS epidemic; (2) the theory that HIV came from monkeys is a fallacy; the theory that AIDS originated in African monkeys arose from an incident of laboratory contamination; and (3) the African AIDS epidemic-as-holocaust never manifested. "The first Africans diagnosed with AIDS were residents of Belgium." ? Fully referenced, based on a forensic review of over 3000 scientific and medical journal articles, this book redefines global concepts for the prevalence and distribution of HIV infection. For many readers, each page contains a revelation as the Author not only deconstructs many myths and misconceptions, but also describes how the current misconceptions arose. "The first documented case of international HIV transmission occurred between New York City and Copenhagen." ? This book redefines global concepts for the prevalence and distribution of HIV infection, and has powerful implications for HIV/AIDS funding, research prerogatives, and global health care interventions. Chris Jennings (Harvard, B.A., Biology 1976/77) excels at writing scientific books that fulfill the needs of professionals while rendering the science accessible to the average reader. His prior book, Understanding and Preventing AIDS: A Book for Everyone, was favorably reviewed by the New England Journal of Medicine ? adopted for staff education by Massachusetts General Hospital, the hospital affiliated with Harvard Medical School; the U.S. Department of Health and Human Services (HHS); the National Institutes of Allergy and Infectious Diseases (NIAID); and Walter Reed Army Medical Institute ? sold in medical bookstores ? purchased by innumerable city and state health agencies ? and utilized as a textbook at colleges, nursing schools, and public health schools. Contents: 218 pages, 20 tables, innumerable side boxes, and 500 references.

Victory Deferred (Paperback): John-Manuel Andriote Victory Deferred (Paperback)
John-Manuel Andriote
R741 R670 Discovery Miles 6 700 Save R71 (10%) Ships in 18 - 22 working days

Compelled by his own 2005 HIV diagnosis, journalist John-Manuel Andriote revisits his acclaimed chronicle of the AIDS epidemic in this updated and expanded edition of the University of Chicago Press 1999 hardcover original. Andriote examines the impact of AIDS on individuals and on the gay civil rights movement, from the coming-out revelry of the 1970s to the post-AIDS gay community of the twenty-first century's first decade. Victory Deferred looks at how AIDS has changed both individual lives and national organizations. It tells the story of how a health crisis pushed a disjointed jumble of local activists to become a national visible and politically powerful civil rights movement, a full-fledged minority group challenging the authority of some of the nation's most powerful institutions. Based on hundreds of interviews with those at the forefront of the medical, political, cultural, civic, and national responses to the epidemic, Victory Deferred artfully blends personal narratives with institutional histories and organizational politics to show how AIDS forced gay men from their closets and ghettos into the hallways of power to lobby and into the streets to protest.

Tackling HIV-Related Stigma and Discrimination in South Asia (Paperback, New): Anne Stangl, Dara Carr, Laura Brady, Traci... Tackling HIV-Related Stigma and Discrimination in South Asia (Paperback, New)
Anne Stangl, Dara Carr, Laura Brady, Traci Eckhaus, Laura Nyblade
R766 Discovery Miles 7 660 Ships in 18 - 22 working days

Although overall HIV prevalence in South Asia is low, the widespread stigma attached to HIV and AIDS impedes efforts to reach people most in need of prevention, care, and treatment services. To address this challenge, the 2008 South Asia Region Development Marketplace partnership, led by the World Bank, launched a competitive grants program to support innovative community approaches. 'Tackling HIV-Related Stigma and Discrimination in South Asia' summarizes the monitoring, evaluation, and case study data and documents successful community innovations. Twenty-six community groups in Afghanistan, Bangladesh, India, Nepal, Pakistan, and Sri Lanka received funds. The initiatives involved a broad spectrum, including vulnerable groups as well as people living with HIV, the media, local government authorities, health workers, and religious leaders. The interventions used traditional cultural and media approaches to discuss taboo subjects. The reach of the initiatives was amplifi ed by involving opinion leaders. The strategies engaged marginalized groups to design and lead the interventions and to facilitate contact between groups experiencing stigma and the general public to reduce fears and misconceptions about transmission. Projects that combined economic and stigma reduction interventions helped the marginalized populations to overcome the internalized stigma and become empowered to advocate for their rights. 'Tackling HIV-Related Stigma and Discrimination in South Asia' identifies effective strategies to raise awareness and reports on shifts--albeit slow--of attitudes, norms, and behaviors. Through its recommendations for successful interventions to reduce barriers to effective HIV prevention, care, and treatment programs, the book provides a strong foundation on which to build stigma reduction efforts in the region and world.

Aging with HIV - A Gay Man's Guide (Paperback): James Masten, James Schmidtberger Aging with HIV - A Gay Man's Guide (Paperback)
James Masten, James Schmidtberger
R783 Discovery Miles 7 830 Ships in 10 - 15 working days

With improvements in the treatment of HIV disease, gay men in great numbers are surviving--and thriving--into middle and older age. While increased longevity brings new hope, it also raises unanticipated challenges, particularly for gay men who never thought they would live this long: How do I deal with all the physical changes? Who can I rely on as I get older? Is a relationship still in the cards for me? What about sex? How should I prepare for old age?
A one-of-a-kind guide for gay men aging with HIV, Aging with HIV offers an upbeat, down-to-earth approach for adapting to change, whether driven by age, AIDS, or both. Psychotherapist James Masten and physician James Schmidtberger shed light on the many common assumptions and fears of aging with HIV. Aging with HIV provides concrete solutions for facing midlife with a positive outlook, offering a wealth of advice for breaking unhealthy habits and coping mechanisms. The book describes the nine changes common to gay men as they age with HIV, discusses the four challenges of aging, and offers a unique ten-step path to optimal aging with HIV, helping the reader to tailor the book's suggestions to the realities of their lives. Woven throughout the book are first-person narratives from men who recount what worked--and did not work--for them. In addition, Rapid Research, Fast Fact, and Self-Reflection boxes highlight the latest research and challenge readers to take stock of the present--and plan for the future.
An invaluable tool to keep handy and to refer to often, Aging with HIV is an inviting, confident companion to navigating midlife and beyond with HIV.

I Am This One Walking Beside Me (Paperback, Limited ed.): Daniel Gebhardt I Am This One Walking Beside Me (Paperback, Limited ed.)
Daniel Gebhardt
R436 R402 Discovery Miles 4 020 Save R34 (8%) Ships in 18 - 22 working days

I Am This One Walking Beside Me is a moving collection of prayers written by Daniel Gebhardt, who has been living with HIV/AIDS for the past 20 years. What makes this book unique is that Gebhardt writes from both a Christian and a gay perspective, providing readers with insight into such topics as everyday living, medical issues, relationships, self-exploration, and death.Each topic contains several meditations, and each individual meditation is followed by a personal prayer. Gebhardt also includes prayers that relate to compassion and a global understanding of the disease that continues to spread, 20+ years after it was first identified.

Oxford Handbook of Genitourinary Medicine, HIV, and Sexual Health (2nd Revised edition): Richard Pattman, Nathan Sankar,... Oxford Handbook of Genitourinary Medicine, HIV, and Sexual Health (2nd Revised edition)
Richard Pattman, Nathan Sankar, Babiker Elawad, Pauline Handy, David Ashley Price
R539 Discovery Miles 5 390 Ships in 4 - 6 working days

The new edition of this successful handbook provides a balance of evidence-based information on Genitourinary Medicine (GUM), including HIV/AIDS. It provides high quality, digestible clinical detail and also practical information on the ever-increasing medico-legal, ethical, and procedural issues of growing importance when dealing with these complex topics. Designed primarily for the trainee in GUM, it is also a valuable reference and resource for the specialist physician, nurse, and other professionals working in the field of sexual health. The new edition remains relevant to those working in this field and features practical enhanced sections on contraception and genital dermatology written by specialist contributors, and information for general practitioners in order to provide services for STIs. The book consists of three easy-to-follow sections. The first section deals with routine management within GUM; medico-legal and ethical issues, the standard patient, special situations, and routine clinical and laboratory processes that include simple flow chart guidance on common clinical presentations. The second section details GUM conditions in a disease-orientated style, including STIs and also other genitourinary problems that may present. The third section on HIV provides a contemporary epidemiological overview of this infection, basic viral biology and pathogenesis, a disease-orientated description of conditions both directly related and opportunistic, and their management and data on special situations such as pregnancy. Finally guidance on commonly used abbreviations is shown together with a useful resource directory for staff. In essence this handbook provides a wealth of simple and easy to follow information on STIs and the principles of providing a service including administrative and medico-legal issues that are sometimes difficult to locate. This book will be of global use to all those with an interest in sexual health whatever their level of expertise and wherever they may practice.

Aiducation 20-10 Taking Control of AIDS (Paperback): Edwin Mavunika Mapara Aiducation 20-10 Taking Control of AIDS (Paperback)
Edwin Mavunika Mapara
R535 Discovery Miles 5 350 Ships in 18 - 22 working days
The Middle Choice - Haiti Through Revolution, Chaos, and Reconstruction Perspectives (Paperback): Rhodner J Orisma The Middle Choice - Haiti Through Revolution, Chaos, and Reconstruction Perspectives (Paperback)
Rhodner J Orisma
R513 Discovery Miles 5 130 Ships in 18 - 22 working days
ANAC's Core Curriculum For HIV / AIDS Nursing (Paperback, 3rd Revised edition): Association of Nurses in AIDS Care (ANAC) ANAC's Core Curriculum For HIV / AIDS Nursing (Paperback, 3rd Revised edition)
Association of Nurses in AIDS Care (ANAC)
R3,236 Discovery Miles 32 360 Ships in 18 - 22 working days

The Association Of Nurses In AIDS Care (ANAC) Presents The Essential Information Needed By Every Nurse Working With HIV/AIDS Patients In Any Setting. The Text Provides An Educational Framework For HIV/AIDS Clinical Content And Serves Those Preparing For Specialty Certification In HIV/AIDS Training. The Text Covers: A) Infection, Transmission, And Prevention B) Clinical Management Of A Variety Of Patient Types C) Symptomatic Conditions And Symptom Management D) Special Populations E) Psychosocial Concerns For Patients. ANAC's Core Curriculum For HIV/AIDS Nursing, Third Edition Includes The Following New Topics: Updates To The Evidence Basis Underlying The Nursing Care Of Persons With HIV/AIDS. New Issues And Challenges Including The Care For Pediatric Patients And Adults With Giardia, Syphilis And Bipolar Disease. New Text Features Including Case Studies And Quizzes.

The Changing HIV/AIDS Landscape - Selected Papers for The World Bank's Agenda for Action in Africa, 2007-2011 (Paperback):... The Changing HIV/AIDS Landscape - Selected Papers for The World Bank's Agenda for Action in Africa, 2007-2011 (Paperback)
Elizabeth Laura Lule, Richard M. Seifman, Antonio C. David
R979 Discovery Miles 9 790 Ships in 10 - 15 working days

HIV/AIDS reverses life expectancy gains, erodes productivity, consumes savings and dilutes growth efforts, threatening the realization of the Millennium Development Goals (MDGs) in Africa.The report is the result of an extensive analytical and consultative process begun in 2006, that engaged more than 1,000 people from over 30 countries and many institutions mostly in Africa, as well as UN agencies, multilateral and bilateral donors, and foundations. The report reaffirms the Bank's commitment to combating HIV/AIDS in Africa, moving from its initial emergency response to the next phase, including the goal to provide at least US $250 million annually and to create an Africa HIV/AIDS Incentive Fund to enhance the evidence base, promote the multisectoral response and provide technical support, analysis and policy advice to countries.

HIV-Infected Pregnant Women (Paperback): Marlinda Quintana-Jefferson HIV-Infected Pregnant Women (Paperback)
Marlinda Quintana-Jefferson
R1,168 Discovery Miles 11 680 Ships in 18 - 22 working days
HIV and AIDS in South Asia - An Economic Development Risk (Paperback): Markus Haacker, Mariam Claeson HIV and AIDS in South Asia - An Economic Development Risk (Paperback)
Markus Haacker, Mariam Claeson
R903 Discovery Miles 9 030 Ships in 18 - 22 working days

'HIV and AIDS in South Asia: An Economic Development Risk' offers an original perspective on HIV and AIDS as major development issues for the region. Although the impact of HIV and AIDS on economic growth appears to be very small, three risks to development are associated with HIV and AIDS in South Asia: the risk of escalating concentrated epidemics, the economic welfare costs, and the fiscal costs of scaling up treatment. As the authors show, South Asian countries have relatively low estimated national HIV prevalence rates, but prevalence is growing rapidly among vulnerable groups at high risk, such as sex workers and their clients, men having sex with men, and injecting drug users and their partners. The cost benefits of targeted prevention programs are high, and the financing of prevention measures such as comprehensive harm reduction and condom use is a sound economic investment in low-prevalence countries with concentrated epidemics. Interventions that reduce the risks and stigma associated with HIV and AIDS have benefits beyond the cost of lives saved; they improve the welfare of those who are at risk and those who fear contracting HIV. Treatment for AIDS in South Asia is limited at present, with weak health systems contributing to low access to and use of services. The challenges of a comprehensive scaling up of antiretroviral treatment are substantial, underscoring the crucial role of effective prevention today. The authors conclude that the limited ability of many households to pay 'catastrophic' health expenses associated with treatment, as well as the negative consequences associated with poor adherence to treatment, suggest a large and central role for the public sector in the provision of antiretroviral therapy. 'HIV and AIDS in South Asia: An Economic Development Risk' will be of particular value to readers with interests in the areas of economic policy, microfinance, public health, and epidemiology.

Genocide by Denial - How Profiteering from HIV/AIDS Killed Millions (Paperback): Peter Mugyenyi Genocide by Denial - How Profiteering from HIV/AIDS Killed Millions (Paperback)
Peter Mugyenyi
R1,409 Discovery Miles 14 090 Ships in 18 - 22 working days

Genocide by Denial: How Profiteering from HIV/AIDS Killed Millions traces the carnage of HIV/AIDS from its Ugandan epicentre in the villages of Kasensero, along the shores of Lake Victoria, through sub-Saharan Africa and onto the rest of the world. The author's involvement in the struggle against the virus started in 1989, soon after his return from a long exile in Europe and the Middle East. On arrival he found the disease devastating his country, compelling him to fight the modern-age plague. He became one of the leaders in a protracted fight against the scourge and an advocate for universal access to life-saving antiretroviral therapy. In this book the author exposes the incredible self-indulgence of the pharmaceutical companies and the cold-heartedness of the rich world that turned a blind eye until it was far too late, and then responded too slowly with too little. The book details his challenge to the powerful pharmaceutical companies that insisted on profitable business as usual, ignoring the lives of millions, and his call for more ethical and humanitarian ways of trade, involving crucial life-saving drugs, and a new world order to ensure entitlement of the poor to rapid humanitarian relief.

Touched by Grace (Paperback): Ann Showalter Touched by Grace (Paperback)
Ann Showalter
R326 Discovery Miles 3 260 Ships in 18 - 22 working days

Ann Showalter invites readers along on a roller coaster ride called AIDS. Showalter began her ride the Saturday afternoon her husband Ray said, "I have AIDS." After the first shock, Ray's revelation became a breath of fresh air for the couple. This is their story. "Along the way, Ann lets the reader overhear her own conversations and prayers about matters that are complicated, vexed, painful, and controversial. She invites our company, not necessarily our consent." -John Weborg, Twenty-Fourth Week of Pentecost, in the Foreword

Fear of the Invisible (Paperback): Janine Roberts Fear of the Invisible (Paperback)
Janine Roberts
R664 Discovery Miles 6 640 Ships in 18 - 22 working days

This book takes its readers on a journey into the very heart of the hunt for viruses - to the key experiments originally performed to prove that these invisibly small particles are the cause of diseases previously blamed on toxins or bacteria and into the latest research. It sheds light on the extraordinary assumptions that underlay much of this research - and on the vaccines that developed from this. The author, an investigative journalist who has researched and produced investigative films for the BBC, American and Australian television, was asked by parents with children severely ill after vaccination, to discover if the medical authorities were hiding anything from them. She agreed, but had no idea how long this search would take. She expected at best to uncover a small degree of contamination. On the ensuing decade-long journey of discovery, she learnt it is not just the added mercury that we have to worry about. She discovered that the top government scientists admit to colleagues that vaccines are contaminated with viruses from chickens, humans and monkeys, with RNA and DNA fragments, with 'cellular degradation products', and possibly 'oncogenes and prions.' They report alarmingly that it is impossible to commercially purify vaccines. They express great concerns, but the public is not told despite the possible consequences for long-term public health. A recent US court decision has linked autism with vaccine contamination. The author cites her sources by name - and gives references and Internet links where they are available. I She reveals evidence that the World Health Organisation has discovered the MMR vaccine is contaminated with chicken leukosis virus, but has decided not totell the public of this, and to continue to make the vaccine with eggs from contaminated chickens. She reports US biowarfare researchers tried to create new agents to destroy our immune systems - and worked on a bacterium to make it a hospital superbug. Did they manage to create HIV? A senior professor told her that the vaccine program was so contaminated that HIV might well have spread though it without any need for military intervention. She set out to find the evidence to resolve this, and to learn how HIV apparently spread so far and fast. She needed to know more about this virus so went to the foundation research widely held today to have found HIV and proved it caused AIDS. She was then rocked to discover that this same research was investigated for scientific fraud for a five year period by powerful US scientific institutions and by Congress, . Why is this not widely known? She found their reports and discovered they found major errors in this research, some so serious that these made it impossible to repeat these experiments and thus to verify them She reveals the evidence unearthed - reproducing key documents so the reader can assess them for themselves. This is explosive material. In the final part of this book the author reports recent research that is revolutionising biology and offering much hope for the future. These new developments shed new light on the relationships between our cells and viruses. They are not necessarily enemies. Readers may find these new developments radically change the ideas they have held about viruses since childhood. This book has over 500 references and includes several documents unearthed under Freedom of Information legislation. It has ascientific glossary and is fully indexed..

HIV / AIDS - Health Solutions (Paperback): Savitri Ramaiah HIV / AIDS - Health Solutions (Paperback)
Savitri Ramaiah
R120 R112 Discovery Miles 1 120 Save R8 (7%) Ships in 10 - 15 working days

This book is a useful guide to the history of HIV/AIDS, its mode of transmission, its symptoms, its prevention and treatment. It is immensely educative and helps to dispel several misconceptions which exist about the causes and mode of transmission of HIV/AIDS. The purpose of this book is to help you understand the disease better.

AIDS Vaccine Development - Challenges and Opportunities (Paperback, New): Wayne Koff, Patricia Kahn, Ian D. Gust AIDS Vaccine Development - Challenges and Opportunities (Paperback, New)
Wayne Koff, Patricia Kahn, Ian D. Gust
R5,183 Discovery Miles 51 830 Ships in 18 - 22 working days

The HIV/AIDS pandemic is the most devastating global public health crisis since the great plagues of the Middle Ages, with more than 14,000 new HIV infections and 8,000 deaths due to AIDS every day. Although successful vaccines have been developed for most common childhood diseases, the development of a vaccine against the AIDS virus is a much greater challenge. More than 20 years after the discovery of the virus, the goal of a licensed and globally accessible vaccine is still several years away. AIDS Vaccine Development reviews the scientific challenges that have impeded the search for an effective AIDS vaccine and discusses current novel research that is accelerating progress. In a series of mini-reviews by the world's leading experts in AIDS vaccine research, the book provides essential reading for everyone interested in the current progress and future direction of AIDS vaccine development.

Saving Africa from HIV/AIDS - We Can Do it (Paperback): Samuel V. Duh Saving Africa from HIV/AIDS - We Can Do it (Paperback)
Samuel V. Duh
R1,169 Discovery Miles 11 690 Ships in 18 - 22 working days

The author is trained in biology, microbiology, medicine and epidemiology in the US. His book is predicated on two main points: the Aids pandemic is so pervasive in Africa that drastic measures are needed; and that those measures must primarily depend on prevention. He discusses such a comprehensive approach and treatment, and stresses that the primary need is political will. The first four chapters deal with the general principles of history and epidemiology; and then focus on the effect of the epidemic in Africa and how to deal with it. Whilst a wealth of technical information is given, the language is accessible for the lay reader.

Memory Bank for HIV Drugs (Sheet map, rolled, New): Gail M Wilkes Memory Bank for HIV Drugs (Sheet map, rolled, New)
Gail M Wilkes
R1,427 Discovery Miles 14 270 Ships in 18 - 22 working days
Primary Care of Women and Children with HIV Infection - A Multidisciplinary Approach (Paperback, First): Patricia Kelly Primary Care of Women and Children with HIV Infection - A Multidisciplinary Approach (Paperback, First)
Patricia Kelly
R1,635 Discovery Miles 16 350 Ships in 18 - 22 working days

This book addresses the comprehensive health care needs of both women and children with HlV infection from a multidisciplinary perspective. The authors represent a wide range of disciplines including medicine, nursing, social work, anthropology, and epidemiology. This text is ide al for all health care practitioners who provide care to women and chi ldren with HlV infection, from physicians, nurses, and midwives to soc ial workers, counselors, and chaplains. Administrators and program pla nners will also find this book to be a valuable resource.

Spirituality, Sexuality and HIV/AIDS in Malawi - Theological Strategies for Behaviour Change (Paperback): Augustine Musopole Spirituality, Sexuality and HIV/AIDS in Malawi - Theological Strategies for Behaviour Change (Paperback)
Augustine Musopole
R1,213 Discovery Miles 12 130 Ships in 18 - 22 working days

It has now been twenty years since the Executive Commitee of the World Council of Churches (WCe meeting in Reykjavik, Iceland, called upon churches worldwide to urgently address the issue of HIV/AIDS. The call arose out of a consultation on the theme 'HIV/AIDS and the Church as a Healing Community'. This book is written with a view to providing culturally relevant theological reflection on the issue of HIV/AIDS and to act as a resource in the combat of HIV/AIDS particularly in bringing about meaningful behaviour change.

What Really Causes AIDS (Paperback): Harold D. Foster What Really Causes AIDS (Paperback)
Harold D. Foster
R502 R469 Discovery Miles 4 690 Save R33 (7%) Ships in 18 - 22 working days

WHAT REALLY CAUSES AIDS:
AN EXECUTIVE SUMMARY The AIDS pandemic is likely to become the greatest catastrophe in human history. Unless a safe, effective vaccine is quickly developed, or the preventive strategies outlined in this book are widely applied, by 2015 one sixth of the world's population will be infected by HIV-1 and some 250 million people will have died from AIDS. Its associated losses by then will be more than those of the Black Death and World War II combined, the equivalent of eight World War Is.1 This pandemic is only one of several ongoing catastrophes involving viruses that encode the selenoenzyme glutathione peroxidase.2 Indeed, the world is experiencing simultaneous pandemics caused by Hepatitis B and C viruses, Coxsackie B virus and HIV-1 and HIV-2. As these viruses replicate, because their genetic codes include a gene that is virtually identical to that of the human enzyme glutathione peroxidase, they rob their hosts of selenium. Paradoxically, however, they diffuse most easily in populations that are very selenium deficient,3 possibly because their members have depressed immune systems. It is no coincidence that such viruses are causing havoc at the beginning of the 21st century. The last 50 years have seen enormous expansions in the use of fossil fuels and deforestation by fire. The resulting pollutants have greatly increased the acidity of global precipitation, reducing selenium's ability to enter the food chain. This situation is being made worse by the widespread use of commercial fertilizers since their sulphates, nitrogen, and phosphorus all depress the uptake of selenium by crops. Deficiencies in this essential trace element are being felt most acutely inareas, such as sub-Saharan Africa, where soil selenium levels are naturally very low. Acid rain is making a bad situation worse, so increasing vulnerability to those viruses that encode glutathione peroxidase. Many populations are also being exposed to a thinning ozone layer, heavy metals such as mercury and cadmium, pesticides, and drug, tobacco, and alcohol abuse, all of which depress the human immune system, increasing vulnerability to viruses, including HIV-1 and HIV-2. In July 2000, physicians and scientists from around the world met in Durban, South Africa for the XIII International AIDS Conference. In a declaration, named after the city, 5,018 of them proclaimed that "HIV is the sole cause of AIDS."4 There are, however, at least seven anomalies that strongly suggest that this conventional wisdom is incorrect and that belief in it is blocking progress in the development of new treatments for AIDS and of novel ways of preventing its spread. To illustrate, despite widespread unprotected promiscuous sexual activity in Senegal, HIV- 1 is diffusing very slowly, if at all, amongst the Senegalese.5 It is very apparent that in Africa, differences in soil selenium levels are greatly influencing who becomes infected with HIV-1 and who does not. Indeed, the recently published Selenium World Atlas used the incidence of HIV-1 as a surrogate measure of soil selenium levels because actual levels are, as yet, poorly established in sub-Saharan Africa. A similar relationship has been documented in the United States6 where there has been an inverse relationship, especially in the Black population, between mortality from AIDS and local soil selenium levels. It is well established that individuals whoare HIV-positive gradually become more and more selenium deficient.7 This decline, which is known to undermine immune functions, is not unique to HIV-infection but is seen in almost all infectious pathogens.8 However, under normal circumstances, where death does not occur, selenium levels rebound soon after recovery. HIV-1, however, can effectively elude the defense mechanisms of the immune system, and can continue to replicate indefinitely, endlessly depressing serum selenium. As a result, the immune system is compromised, allowing infection by other pathogens that continue to deplete the host of selenium, allowing HIV-1 to replicate more easily, further undermining immunity. Therefore, this relationship between selenium and the immune system is one of positive feedback, in which a decline in either of these two variables causes further depression in the other. Termed the "selenium- CD4 T cell tailspin" by the author,9 it is the reason that serum selenium levels are a better predictor of AIDS mortality than CD4 T cell counts. Like other positive feedback systems, such as avalanches and forest fires, it is extremely difficult to control and gains momentum as it progresses. HIV-1, however, encodes the entire selenoenzyme, glutathione peroxidase. As it replicates, therefore, it depletes its host not only of selenium but also of the other three components of this enzyme: namely, cysteine, glutamine, and tryptophan.10 AIDS, therefore, is a nutritional deficiency illness caused by a virus. Its victims suffer from extreme deficiencies of all four of these nutrients which are responsible for such symptoms as depressed CD4T lymphocyte count, vulnerability to cancers (including Kaposi'ssarcoma), depression, psoriasis, diarrhea, muscle wasting, and dementia. Associated infections cause their own unique symptoms and increased risk of death. HIV-1 alone, therefore, does not cause AIDS. It involves a multiplicity of co-factors, specifically anything that either depletes serum selenium levels or depresses the immune system enough to permit viral replication. Manipulating the "selenium-CD4T cell tailspin" by adding this trace element to fertilizers and food stuffs opens new avenues for both prevention and treatment. This strategy has been shown to work on other viruses that encode glutathione peroxidase, such as Hepatitis B and C and the Coxsackievirus. The logical treatment of AIDS patients involves supplementation with selenium, cysteine, glutamine, and tryptophan, at least to levels at which deficiency symptoms associated with a lack of

Poison Pill (Paperback): Gordon Polk Poison Pill (Paperback)
Gordon Polk
R515 Discovery Miles 5 150 Ships in 18 - 22 working days

In 1994, the prospect of finding a cure for AIDS represented a dream that scientists and physicians hoped to realize by the new millennium. Despite advances in medicines and treatments, a single cure still remains elusive to this day. What goes on behind the scenes in the world of new drug development is often secretive and deceptive. This mystery reveals the motives of a pharmaceutical company that is on the cusp of launching a revolutionary treatment for AIDS. Patient access to the new drug KLX is hampered by deception, greed and murder. The societal impact of AIDS is poignantly outlined in this story about innocent humans who are affected by the actions of a few executives controlling a multi-billion dollar pharmaceutical market. From homeless people to politicians and government bureaucrats, conspiracies are created between unlikely allies. Only a young employee of Linfeld Pharmaceuticals has the courage to fight for the hope of thousands suffering from AIDS.

AIDS - The Final and Fatal Foreign Service Boondoggle: Memoirs of a Foreign Service Officer (Paperback): Philip E. Smart AIDS - The Final and Fatal Foreign Service Boondoggle: Memoirs of a Foreign Service Officer (Paperback)
Philip E. Smart
R698 Discovery Miles 6 980 Ships in 18 - 22 working days
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